Hawthorn Berry Extract 90045-52-6 Manufacturer Exporter MEDIOCON INC

 

 

Hawthorn Berry Extract  Manufactured by MEDIOCON INC     

 

   Name: Hawthorn Berry Extract

CAS No:  90045-52-6

Molecular Weight:  302.25g/mol

Molecular formula:   C₂₁H₂₀O₁₂

Synonyms:  Crataegus extract.

Appearance:  Yellow Brown Powder.

 Solubility : soluble in water.

Use :

Hawthorn berry extract is used for various health purposes, including:

Key Uses:

 Cardiovascular health: Supports heart function, blood pressure, and circulation.

Antioxidant properties: Rich in flavonoids and phenolic acids, which help protect against cell damage.

     Digestive health: May aid in digestion and reduce symptoms of indigestion.

 

Potential Benefits:

May help lower cholesterol levels

May improve exercise performance in heart failure patients

 May have anti-inflammatory and antimicrobial effects

 

Forms:

 Capsules

 Liquid extracts

Teas

Precautions:

Consult a healthcare professional before using hawthorn berry extract, especially if you have underlying medical conditions or take medications. 

How is  Hawthorn Berry Extract  manufactured by MEDIOCON INC Synthesized?

Hawthorn berry extract is synthesized through various methods, including¹ ² ³:

- Water-based extraction: This method involves extracting bioactive compounds from hawthorn using water as the solvent. The process can be optimized by adjusting factors like temperature, time and granulometry of the plant material.

- Microwave-assisted extraction: This eco-friendly method uses microwave energy to extract bioactive compounds from hawthorn leaves and fruits. It's a fast and efficient way to obtain high-quality extracts.

- Solid-phase extraction (SPE): SPE is a technique used to obtain highly bioactive preparations from hawthorn fruits, leaves and flowers. It involves using a solid phase to extract and concentrate the desired compounds.

- Ionic liquid-based extraction: This method uses ionic liquids to extract flavonoids from hawthorn. It's a one-step process that achieves high extraction rates while reducing the use of organic reagents.

- Green synthesis: Hawthorn extract can also be used for the green synthesis of metal nanoparticles, such as copper and silver nanoparticles. This method is environmentally friendly and cost-effective.

 

The extracted compounds can include:

- Phenolic compounds: Such as flavonoids, proanthocyanidins and phenolic acids, which have antioxidant and anti-inflammatory properties.

- Flavonoids: Like quercetin-3-O-galactoside, vitexin-2-O-rhamnoside and hyperoside, which have various health benefits.

- Triterpenoids: Such as ursolic acid and oleanolic acid, which have antioxidant and anti-inflammatory effects.

These extracts can be used in various applications, including pharmaceuticals, food additives and nutraceuticals.

What are the different  dosage forms  of   Hawthorn Berry Extract  Manufactured  by  MEDIOCON INC?

Hawthorn berry extract comes in various dosage forms, each with its own recommended dosage. Here are some of the different forms and their typical dosages:

- Capsules/Tablets: 160-900 mg daily, standardized to contain 18-20% oligomeric procyanidins or 2-3% flavonoids. For heart failure, 300-900 mg daily is often used.

- Liquid Extract: 0.5-1 ml orally three times daily.

- Tincture: 1-2 ml orally three times daily or 20 drops orally two to three times daily.

- Syrup: Half a spoon (dosage may vary depending on the product), taken 2-3 times a day.

- Tea: Brewed tea made from 1 teaspoon of leaves and flowers in 8 oz boiling water, taken three times daily after meals.

- Powder: 200-500 mg orally three times daily or 300-1000 mg orally three times daily.

- Solid Extract: 1/4-1/2 teaspoon orally once daily.

When choosing a hawthorn berry supplement, consider the following¹ ² ³:

- Look for products standardized to specific flavonoid or procyanidin content.

- Consult with a healthcare provider to determine the best dosage for your specific condition.

- Follow the recommended dosage on the product label, as potency can vary between brands.

 How Hawthorn Berry Extract  Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Hawthorn berry extract dosage forms are prepared through various methods depending on the desired form. Here's an overview of the preparation process for different forms:

Preparation Methods:

- Tinctures: Hawthorn berries, leaves, or flowers are soaked in alcohol or a water-alcohol mixture to concentrate the active ingredients. The mixture is left to sit for 2-4 weeks, then filtered to remove plant solids.

- Liquid Extracts: Similar to tinctures, but may use glycerin or vinegar instead of alcohol. They're suitable for those who prefer or need an alcohol-free option.

- Syrups: Hawthorn extract is combined with a sweetener, often honey or sugar, to create a palatable liquid form.

- Powders: Dried berries, leaves, or flowers are ground into a fine powder, which can be mixed into foods, smoothies, or drinks.

- Capsules/Tablets: Dried and powdered plant material or standardized extract is filled into capsules or compressed into tablets.

- Teas and Infusions: Hawthorn berries, leaves, or flowers are steeped in hot water to release their active compounds.¹

Standardization:

Many hawthorn berry extract products are standardized to contain specific amounts of flavonoids (2.2% or 18.75% oligomeric procyanidins) or OPCs. This ensures a consistent level of active ingredients across different batches.²

Dosage Considerations:

When preparing hawthorn berry extract dosage forms, it's essential to follow the recommended dosage guidelines. Typical dosages range from 160-1800 mg per day, divided into 2-3 doses. The minimum effective dose for adjunctive therapy in mild congestive heart failure is suggested to be 300 mg daily, with maximum benefit appearing after 6-8 weeks of therapy.

What are the appropriate Dosage forms of Hawthorn Berry Extract  Manufactured  by  MEDIOCON   INC?                

The appropriate dosage forms of Hawthorn Berry Extract include:

Common Forms:

- Capsules/Tablets: 160-900 mg daily, standardized to contain 18-20% oligomeric procyanidins or 2-3% flavonoids.

- Liquid Extract: 0.5-1 ml orally three times daily.

- Tincture: 1-2 ml orally three times daily or 20 drops orally two to three times daily.

- Syrup: Half a spoon (dosage may vary depending on the product), taken 2-3 times a day.

- Tea: Brewed tea made from 1 teaspoon of leaves and flowers in 8 oz boiling water, taken three times daily after meals.

Standardized Extracts:

- Look for products standardized to specific flavonoid or procyanidin content, such as 2.2% flavonoids or 18.75% oligomeric procyanidins.

Considerations:

- Consult with a healthcare provider to determine the best dosage form and amount for your specific condition.

- Follow the recommended dosage on the product label, as potency can vary between brands.

- Consider the individual's health status, age, and potential interactions with medications.

When should Hawthorn Berry Extract  Manufactured by MEDIOCON INC be taken?

The optimal time to take Hawthorn Berry Extract  depends on individual needs and goals. Here are some general guidelines:

- With meals: Taking Hawthorn Berry Extract  with meals may enhance absorption and reduce potential stomach upset.

- In the morning: Taking it in the morning may help support energy and overall well-being throughout the day.

- Before bedtime: Some people take Hawthorn Berry Extract  before bed, potentially supporting relaxation and sleep quality.

 

Consult a healthcare professional to determine the best timing and dosage for your specific needs. Always follow product label instructions and start with a low dose to assess tolerance.

 What are the effects And Side effects of Hawthorn Berry Extract  Manufactured by MEDIOCON INC?

Hawthorn berry extract can be taken at various times, depending on individual needs and health goals. Here are some general guidelines:

- With meals: Taking hawthorn berry extract with meals may help reduce digestive discomfort and enhance absorption.

- Consistency is key: Take hawthorn berry extract at the same time every day to maintain consistent levels of the active compounds in your system.

- Morning or evening: Some people prefer taking hawthorn berry extract in the morning to support cardiovascular health throughout the day, while others prefer taking it in the evening to promote relaxation.

- As directed: Follow the recommended dosage and timing on the product label or as advised by a healthcare professional.

 

Specific Timing for Certain Conditions:

 

- Heart health: Take hawthorn berry extract with meals, 2-3 times a day, to support cardiovascular health.

- Digestive issues: Take hawthorn berry extract with meals to help alleviate digestive discomfort.

- Stress and anxiety: Take hawthorn berry extract in the evening to promote relaxation and reduce stress.

 

Consult a Healthcare Professional:

- Before starting hawthorn berry extract, consult with a healthcare professional to determine the best dosage and timing for your specific needs and health goals.

- If you're taking medications or have underlying medical conditions, consult with a healthcare professional to ensure safe and effective use .

  How is Hawthorn Berry Extract  Manufactured by MEDIOCON  INC  Tested Qualitatively?

Hawthorn berry extract is tested qualitatively using various methods to identify and quantify its bioactive compounds. Here are some of the key testing methods:

 

- Spectrophotometry: This method is used to detect the presence of flavonoids and other phenolic compounds in hawthorn extracts.

- Liquid Chromatography-Mass Spectrometry (LC-MS): This technique is used to identify and quantify specific compounds in hawthorn extracts, such as flavonoids and phenolic acids.

- High-Performance Thin-Layer Chromatography (HPTLC): This method is used to analyze the chemical profiles of hawthorn extracts and identify specific compounds.

- Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC): This technique is used to quantify flavonoids in hawthorn extracts, such as vitexin-2-O-rhamnoside and acetyl vitexin-2-O-rhamnoside.

- Thin Layer Chromatography (TLC): This method is used to analyze the chemical profiles of hawthorn extracts and identify specific compounds.

- Total Phenolic Content (TPC) Assay: This method is used to measure the total phenolic content of hawthorn extracts.

- Antioxidant Activity Assays: These methods, such as the DPPH test, are used to evaluate the antioxidant activity of hawthorn extracts.¹ ²

 

These testing methods help ensure the quality and potency of hawthorn berry extracts, which are used in various applications, including dietary supplements and pharmaceuticals. Some manufacturers also conduct third-party testing and certification to ensure the purity and quality of their products.

   Which tests are performed on Hawthorn Berry Extract  Manufactured by  MEDIOCON INC ?

Hawthorn berry extract undergoes various tests to ensure its quality, safety and efficacy. Here are some of the key tests performed:

Chemical Tests:

- Spectrophotometry: Detects flavonoids and phenolic compounds

- Liquid Chromatography-Mass Spectrometry (LC-MS): Identifies and quantifies specific compounds like flavonoids and phenolic acids

- High-Performance Thin-Layer Chromatography (HPTLC): Analyzes chemical profiles and identifies compounds

- Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC): Quantifies flavonoids like vitexin-2-O-rhamnoside and acetyl vitexin-2-O-rhamnoside

Biological Tests:

- Antioxidant Activity Assays: Evaluate antioxidant properties using tests like DPPH

- Antimicrobial Tests: Assess effectiveness against bacteria, viruses and other microorganisms

- Anti-Inflammatory Tests: Measure reduction in inflammation and oxidative stress

Pharmacological Tests:

- Cardiovascular Tests: Evaluate effects on heart function, blood pressure and circulation

- Toxicity Tests: Assess safety and potential side effects¹ ²

Standardization:

- Flavonoid Content: Standardized to 2.2% flavonoids or 18.75% oligomeric procyanidins

- Procyanidin Content: Berries must contain at least 1% procyanidins, while leaves and flowers need a minimum flavonoid content of 1.5%

What are the challenges in Manufacturing of Hawthorn Berry Extract  Manufactured by MEDIOCON   INC API?

Manufacturing Hawthorn Berry Extract API involves several challenges, including:

- Raw Material Quality Control: Ensuring the quality and consistency of hawthorn berries, which can vary depending on factors like climate, soil, and harvesting methods.

- Standardization: Standardizing the extract to specific levels of bioactive compounds, such as flavonoids and oligomeric procyanidins, which is crucial for efficacy and regulatory compliance.

- Extraction Method: Choosing the optimal extraction method, such as solvent extraction, cold-pressing, or supercritical fluid extraction, to preserve the bioactive compounds and ensure high-quality extracts.

- Regulatory Compliance: Meeting regulatory requirements and standards for herbal extracts, which can vary across countries and regions.

- Quality Control and Assurance: Implementing robust quality control measures to detect and prevent contamination, adulteration, or degradation of the extract.

- Scalability and Cost-Effectiveness: Scaling up production while maintaining quality and reducing costs without compromising efficacy.

- Research and Development: Continuously conducting research and development to improve extraction methods, identify new bioactive compounds, and explore potential health benefits.

Additionally, manufacturers may face challenges related to¹ ² ³:

- Granulation and Powderization: Optimizing the granulation and powderization processes to preserve the bioactive compounds and ensure consistent quality.

- Stability and Shelf-Life: Ensuring the stability and shelf-life of the extract, which can be affected by factors like storage conditions, packaging, and handling.

- Certification and Compliance: Obtaining certifications, such as GMP or ISO, and complying with regulatory requirements, which can be time-consuming and costly.

What are the challenges in manufacturing of Hawthorn Berry Extract  Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Hawthorn Berry Extract dosage forms poses several challenges, including¹ ² ³:

- Raw Material Quality Control: Ensuring the quality and consistency of hawthorn berries, which can vary depending on factors like climate, soil, and harvesting methods.

- Standardization: Standardizing the extract to specific levels of bioactive compounds, such as flavonoids and oligomeric procyanidins, is crucial for efficacy and regulatory compliance.

- Regulatory Compliance: Meeting regulatory requirements and standards for herbal extracts, which can vary across countries and regions.

- Quality Control and Assurance: Implementing robust quality control measures to detect and prevent contamination, adulteration, or degradation of the extract.

- Scalability and Cost-Effectiveness: Scaling up production while maintaining quality and reducing costs without compromising efficacy.

- Stability and Shelf-Life: Ensuring the stability and shelf-life of the extract, which can be affected by factors like storage conditions, packaging, and handling.

- Interaction with Medications: Hawthorn berry extract can interact with certain medications, such as blood thinners, diabetes medications, and heart medications, which requires careful consideration in dosage form development.

- Dosage Form Variability: Different dosage forms, such as capsules, tablets, and liquid extracts, may have varying levels of bioavailability and efficacy.

- Clinical Efficacy: Ensuring the clinical efficacy of hawthorn berry extract dosage forms, as some studies have yielded mixed results.

- Safety and Toxicology: Ensuring the safety and toxicology of hawthorn berry extract dosage forms, particularly for long-term use or in specific populations, such as pregnant or breastfeeding women.

To overcome these challenges, manufacturers should⁴:

- Follow Good Manufacturing Practices (GMP): Ensure compliance with GMP guidelines to maintain quality and safety.

- Conduct Thorough Quality Control: Implement robust quality control measures to detect and prevent contamination or degradation.

- Standardize Extracts: Standardize extracts to specific levels of bioactive compounds to ensure efficacy and consistency.

- Provide Clear Labeling: Provide clear labeling and instructions for use to ensure safe and effective use.

What is the Packing for Hawthorn Berry Extract  Manufactured by MEDIOCON INC?

Hawthorn berry extract packing varies depending on the product and manufacturer. Here are some common packaging options:

- Bulk Packaging: 25 kg polybag packing inside HDPE plastic drum, suitable for wholesale or industrial use.

- Capsules: Available in bottles of 60 capsules or 120 capsules, often used for dietary supplements.

- Powder: Sold in packets or containers of 70g, often labeled as "Organic 10X Concentrated".

- Liquid Extracts: Available in 2 fl oz bottles, often alcohol-free and labeled as "tincture" or "liquid drops".

 

Some popular brands offer the following packaging options¹ ² ³:

- StayAlive Hawthorn Berry Capsules: 6-in-1 heart health formula in capsule form.

- aspkom Hawthorn Berry Extract: 70g powder pack with 10X concentration.

- Shri Hawthorn Berry Extract Tablets: 120-tablet pack.

- biotic Hawthorn Berry Capsules: 120-veg-capsule pack with 300mg hawthorn berry extract per capsule.

- Horbäach Hawthorn Berry Extract Tincture: 2 fl oz liquid extract in alcohol-free formula.

What is shelf life Of Hawthorn Berry Extract  Manufactured by MEDIOCON INC? 

The shelf life of Hawthorn Berry Extract varies depending on the product and storage conditions. Here are some general guidelines:

- Powdered Extract: Typically lasts 12-36 months when stored properly in a cool, dark place. Some manufacturers claim shelf lives of up to 18 months after purchase in sealed bags or 6-9 months after the seal is broken.

- Liquid Extract: Can last 1-2 years when stored correctly. Some products have a shelf life of 2 years or more.

- Capsules/Tablets: Usually have a shelf life of 12-24 months, depending on the manufacturer and storage conditions.

To maximize the shelf life of Hawthorn Berry Extract:

- Store in a cool, dark place, away from direct sunlight and moisture.

- Keep the container tightly sealed to prevent contamination.

- Follow the manufacturer's storage instructions and check the product label for specific guidance.

It's essential to note that the actual shelf life may vary depending on factors like storage conditions, handling, and packaging. Always check the product label or consult with the manufacturer for specific guidance.

What should the label claim for Hawthorn Berry Extract  Manufactured by MEDIOCON INC   Include?

The label claim for Hawthorn Berry Extract should include the following information:

- Product Name: Clearly state the product name, such as "Hawthorn Berry Extract" or "Hawthorn Supplement".

- Standardization: Specify the standardization of the extract, such as "Standardized to 1.8% Flavonoids" or "Contains 18% Oligomeric Procyanidins".

- Dosage Instructions: Provide clear dosage instructions, including the recommended daily intake and any specific guidance for use.

- Net Weight or Volume: State the net weight or volume of the product.

- Ingredients: List the ingredients used in the product, including any fillers, binders, or other additives.

- Warning Statements: Include any relevant warning statements, such as "Consult a healthcare professional before using if you are pregnant or breastfeeding" or "Not recommended for individuals with certain medical conditions".

- Storage Instructions: Provide storage instructions to maintain the product's potency and shelf life.

- Manufacturer Information: Include the manufacturer's name, address, and contact information.

- Batch Number and Expiration Date: Provide the batch number and expiration date to ensure quality control and tracking.

 

Some label claims may also include additional information, such as:

- Health Benefits: Claims related to cardiovascular health, blood pressure support, or other potential benefits.

- Certifications: Claims related to certifications, such as GMP, USDA Organic, or Non-GMO.

- Allergen Warnings: Warnings about potential allergens or contaminants.

Where can Hawthorn Berry Extract  Manufactured by MEDIOCON INC are procured?

Hawthorn Berry Extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Hawthorn Berry Extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Hawthorn Berry Extract  Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Hawthorn Berry Extract Manufactured by MEDIOCON INC product, regardless of the procurement source.