Hesperidin Methyl Chalcone 24292-52-2. Manufacturer Exporter MEDIOCON INC

 

 

Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC     

 

   Name: Hesperidin Methyl Chalcone

CAS No:  24292-52-2. 

Molecular Weight:  624.59g/mol

Molecular formula:  C₂₉H₃₆O₁₅.

Synonyms:  Hesperidine Methyl Chalcone, Methyl hesperidin chalcone, Hesperidin methyl chalone, Hesperidin chalcone

Appearance:  yellow, crystalline powder with a strong, characteristic yellow color

 Solubility : freely soluble in water, methanol, and ethanol, and sparingly soluble in ethyl acetate.

Use :

Hesperidin Methyl Chalcone (HMC) is a flavonoid derived from citrus fruits. It's often used in:

1. Venous health: HMC is used to support blood vessel health, particularly in treating conditions like chronic venous insufficiency.

2. Antioxidant properties: It helps protect against oxidative stress.

3. Anti-inflammatory effects: HMC may reduce inflammation.

Common applications include:

1. Dietary supplements

2. Pharmaceuticals

3. Cosmetics (for skin health)

 How is  Hesperidin Methyl Chalcone manufactured by MEDIOCON INC Synthesized?

Hesperidin Methyl Chalcone (HMC) is typically synthesized from hesperidin, a flavonoid found in citrus fruits. The process involves:

 

1. Extraction of hesperidin from citrus peels.

2. Hydrolysis to convert hesperidin into hesperetin.

3. Chalcone formation through a chemical reaction.

4. Methylation to produce Hesperidin Methyl Chalcone.

This process can be done through various chemical or enzymatic methods. The resulting HMC is then purified for use in supplements, pharmaceuticals, or cosmetics.

What are the different  dosage forms  of   Hesperidin Methyl Chalcone Manufactured  by  MEDIOCON INC?

Hesperidin Methyl Chalcone (HMC) is available in various dosage forms, including:

1. Tablets: Oral tablets containing HMC, often combined with other ingredients.

2. Capsules: Softgel or hard-shell capsules containing HMC powder or extract.

3. Powder: Pure HMC powder for supplementation or formulation.

4. Topical creams or gels: For skin application, often used for venous health or antioxidant benefits.

5. Dietary supplements: Various formulations, such as combination products with vitamins or minerals.

The dosage and form may vary depending on the intended use, such as venous health support or antioxidant benefits. Consult a healthcare professional for specific guidance.

 How Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC   Dosage Forms are prepared?

The preparation of Hesperidin Methyl Chalcone (HMC) dosage forms involves various steps depending on the desired form:

 

Tablets:

 

1. Weighing and mixing HMC powder with excipients (e.g., binders, fillers).

2. Granulation (wet or dry) to improve flow and compression.

3. Compression into tablets using a tablet press.

 

Capsules:

 

1. Weighing and filling HMC powder into capsule shells.

2. Adding excipients (e.g., fillers, lubricants) if needed.

3. Sealing capsules.

 

Powder:

 

1. Weighing and packaging HMC powder.

2. Ensuring proper particle size and flow.

 

Topical creams or gels:

1. Mixing HMC with other ingredients (e.g., emollients, preservatives).

2. Homogenizing the mixture.

3. Filling containers.

Quality control:

1. Testing for purity, potency, and stability.

2. Ensuring compliance with regulatory standards.

The specific preparation process may vary depending on the manufacturer and intended use.

 

What are the appropriate Dosage forms of Hesperidin Methyl Chalcone Manufactured  by  MEDIOCON   INC?                

The appropriate dosage forms of Hesperidin Methyl Chalcone (HMC) depend on the intended use:

 

For Oral Use:

 

1. Tablets: 100-500 mg per tablet, taken 1-2 times daily.

2. Capsules: 100-500 mg per capsule, taken 1-2 times daily.

For Topical Use:

1. Creams or gels: 0.1-5% HMC concentration, applied topically as needed.

Typical Dosage Ranges:

1. Venous health support: 500-1000 mg per day.

2. Antioxidant benefits: 100-500 mg per day.

It's essential to consult a healthcare professional to determine the best dosage form and regimen for specific needs.

When should Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC be taken?

The optimal timing for taking Hesperidin Methyl Chalcone (HMC) depends on the intended use and individual needs. Here are some general guidelines:

 

For Venous Health Support:

 

1. With meals: Taking HMC with meals may enhance absorption.

2. Morning and evening: Splitting the daily dose into morning and evening may help maintain consistent levels.

For Antioxidant Benefits:

1. Anytime: HMC can be taken at any time of day, with or without food.

General Recommendations:

1. Follow label instructions: Adhere to the recommended dosage on the product label.

2. Consult a healthcare professional: Determine the best timing and dosage for specific needs.

It's essential to consult with a healthcare professional before starting any supplement regimen.

 

 What are the effects And Side effects of Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC?

Hesperidin Methyl Chalcone (HMC) is a flavonoid derived from citrus fruits, and its effects and side effects are as follows:

 

Benefits:

 

- Improves venous health: HMC helps strengthen blood vessel walls, reducing inflammation and improving circulation.

- Antioxidant properties: It protects against oxidative stress and damage caused by free radicals.

- Anti-inflammatory effects: HMC reduces inflammation and cytokine expression, which can help with conditions like arthritis and skin damage.

- Skin health: Topical application of HMC can improve skin barrier function, reduce wrinkles, and inhibit melanin synthesis.

- Cardiovascular health: HMC may help lower blood pressure and improve lipid profiles.

 

Side Effects:

 

- Gastrointestinal issues: Stomach pain, upset stomach, diarrhea, and abdominal pain

- Headache: Some individuals may experience headaches when taking HMC

- Allergic reactions: Rare cases of rash, itching, swelling, and trouble breathing have been reported

- Bleeding risk: HMC may slow blood clotting, increasing the risk of bleeding, especially when taken with anticoagulant medications

- Interactions: HMC may interact with sedatives, antiplatelet medications, and blood pressure medications, so caution is advised when taking these combinations¹ ² ³

 

Precautions:

 

- Pregnancy and breastfeeding: HMC is possibly safe when taken with diosmin, but consult a healthcare provider before use.

- Bleeding disorders: Individuals with bleeding disorders should exercise caution when taking HMC due to its potential to slow blood clotting.

- Surgery: Stop taking HMC at least 2 weeks before scheduled surgery to minimize bleeding risks

  How is Hesperidin Methyl Chalcone Manufactured by MEDIOCON  INC  Tested Qualitatively?

Hesperidin Methyl Chalcone (HMC) is typically tested qualitatively using various analytical methods, including:

1. High-Performance Liquid Chromatography (HPLC): Separates and detects HMC based on its chemical properties.

2. Mass Spectrometry (MS): Identifies HMC by its molecular weight and fragmentation pattern.

3. Nuclear Magnetic Resonance (NMR) Spectroscopy: Determines HMC's molecular structure.

4. Thin-Layer Chromatography (TLC): Separates and identifies HMC based on its migration on a stationary phase.

These methods help ensure the identity, purity, and quality of HMC in various products.

   Which tests are performed on Hesperidin Methyl Chalcone Manufactured by  MEDIOCON INC ?

Various tests are performed on Hesperidin Methyl Chalcone (HMC) to ensure its quality, purity, and potency. These tests may include:

 

1. Identity testing: Verifying HMC's chemical structure and composition.

2. Purity testing: Determining the percentage of HMC in the sample.

3. Potency testing: Measuring HMC's biological activity or effectiveness.

4. Contaminant testing: Detecting heavy metals, pesticides, or other impurities.

5. Stability testing: Evaluating HMC's shelf life and stability under various conditions.

Some specific analytical methods used for HMC testing include:

1. HPLC (High-Performance Liquid Chromatography)

2. GC (Gas Chromatography)

3. MS (Mass Spectrometry)

4. NMR (Nuclear Magnetic Resonance) Spectroscopy

These tests help ensure HMC's quality and safety for use in dietary supplements, pharmaceuticals, or cosmetics.

What are the challenges in Manufacturing of Hesperidin Methyl Chalcone Manufactured by MEDIOCON   INC API?

Manufacturing Hesperidin Methyl Chalcone (HMC) API poses several challenges, including:

- Raw Material Availability: Hesperidin, the starting material for HMC synthesis, is naturally found in citrus fruits, which can lead to variability in quality and availability.

- Synthesis Complexity: The methylation process of hesperidin under alkaline conditions to produce HMC requires careful control of reaction conditions to ensure optimal yield and purity.

- Purification Challenges: HMC's complex structure and properties make purification a critical step, requiring efficient methods to remove impurities and achieve high purity.

- Quality Control: Ensuring the quality of HMC API is crucial, involving rigorous testing for identity, purity, potency, and contaminants.

- Scalability: Scaling up HMC production while maintaining consistency in quality and yield can be challenging.

- Stability and Storage: HMC's stability and storage requirements need to be carefully evaluated to prevent degradation and ensure shelf life.

- Regulatory Compliance: Manufacturers must comply with regulatory requirements, such as GMP guidelines, to ensure the quality and safety of HMC API.

These challenges highlight the need for expertise in flavonoid chemistry, process development, and quality control to ensure the successful manufacture of HMC API.

What are the challenges in manufacturing of Hesperidin Methyl Chalcone Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Hesperidin Methyl Chalcone (HMC) dosage forms poses several challenges, including:

- Raw Material Variability: Ensuring consistent quality of hesperidin, the starting material for HMC synthesis, can be difficult due to natural variability in citrus fruits.

- Synthesis Complexity: The methylation process to produce HMC requires careful control of reaction conditions to ensure optimal yield and purity.

- Purification Challenges: HMC's complex structure and properties make purification a critical step, requiring efficient methods to remove impurities and achieve high purity.

- Stability and Storage: HMC's stability and storage requirements need to be carefully evaluated to prevent degradation and ensure shelf life.

- Regulatory Compliance: Manufacturers must comply with regulatory requirements, such as GMP guidelines, to ensure the quality and safety of HMC dosage forms.

- Bioavailability and Solubility: HMC's poor solubility and bioavailability may require special formulation strategies to enhance its therapeutic effectiveness.

- Analytical Method Development: Developing and validating analytical methods for HMC quantification in dosage forms can be challenging due to its complex chemical structure.

To overcome these challenges, manufacturers may employ strategies like¹ ² ³:

- Quality by Design (QbD) Approach: Implementing QbD principles to ensure quality and consistency in HMC dosage forms.

- Advanced Purification Techniques: Utilizing advanced purification methods to achieve high purity and minimize impurities.

- Formulation Optimization: Optimizing formulation conditions to enhance HMC's bioavailability and solubility.

- Regulatory Collaboration: Collaborating with regulatory agencies to ensure compliance and address potential issues.

What is the Packing for Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC?

Hesperidin Methyl Chalcone packing varies based on customer requirements and supplier specifications. Here are some common packaging options:

- Vial Packaging: 10 mM * 1 mL in DMSO, suitable for laboratory research and testing.

- Container with Screw Cap: Used for storing and shipping Hesperidin Methyl Chalcone, ensuring safe handling and minimizing contamination risks.

- Custom Packaging: Some suppliers, like ChemFaces, offer packaging according to customer requirements, such as 5mg, 10mg, 20mg, and more, in various container formats.

- Storage Conditions: To maintain product stability, it's recommended to store Hesperidin Methyl Chalcone in a sealed vial at 2-8°C (36-46°F) for up to 24 months or as specified by the manufacturer.

 

When handling Hesperidin Methyl Chalcone, it's essential to follow proper storage and handling procedures to prevent degradation and ensure product efficacy.

What is shelf life Of Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC? 

The shelf life of Hesperidin Methyl Chalcone (HMC) varies depending on storage conditions and product formulation. Here are some general guidelines¹ ² ³:

- Powder Storage: HMC powder typically has a shelf life of 2 years when stored properly.

- Cosmetic Products: Products containing HMC, such as eye creams or serums, usually maintain stability and efficacy for 24-36 months when formulated and stored correctly.

- Storage Conditions: To maximize shelf life, HMC should be stored in a cool, dry place, away from moisture and sunlight, with optimal storage temperatures ranging from 8-12°C (46-54°F).

- Stability: HMC has shown remarkable thermal stability, maintaining over 90% integrity at 175°C (347°F), and its optimal stability range is pH 2.5-6.8.

Proper storage and handling can help ensure the quality and effectiveness of HMC products throughout their shelf life.

What should the label claim for Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC   Include?

The label claim for Hesperidin Methyl Chalcone (HMC) should include:

- Product Name: Hesperidin Methyl Chalcone or specific product name.

- Concentration/Amount: Specify the amount of HMC per serving or unit (e.g., mg per tablet or capsule).

- Ingredients: List HMC and other ingredients used in the product.

- Directions for Use: Provide instructions on how to use the product (e.g., dosage, frequency).

- Warnings/Precautions: Include any relevant warnings or precautions, such as interactions with medications or potential side effects.

- Storage Conditions: Specify storage conditions to maintain product stability (e.g., cool, dry place).

- Shelf Life: Include the expiration date or shelf life.

- Manufacturer Information: Provide the manufacturer's name and contact information.

- Regulatory Compliance: Ensure compliance with relevant regulatory requirements (e.g., GMP, FDA).

Where can Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC are procured?

Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Hesperidin Methyl Chalcone Manufactured by MEDIOCON INC product, regardless of the procurement source.