Black Garlic Extract Powder 8008-99-9 Manufacturer Exporter MEDIOCON INC

 

 

Black Garlic Extract Powder Manufactured by MEDIOCON INC     

 

   Name: Black Garlic Extract Powder

CAS No:  8008-99-9

Molecular Weight: NA

Molecular formula: C₆H₁₀O₂S

Synonyms:   fermented garlic extract powder, aged black garlic extract powder, and simply black garlic powder. 

Appearance:  a fine powder, typically dark brown or black in color, with a characteristic aroma

 Solubility :  water-soluble.

Use :

Black garlic extract powder is a popular ingredient in the health and wellness industry, thanks to its numerous potential health benefits. Here are some of the uses of black garlic extract powder:

 

1. Cardiovascular Health: Black garlic extract powder may help lower cholesterol levels, triglycerides, and blood pressure, reducing the risk of heart disease.

2. Antioxidant Properties: Rich in antioxidants, black garlic extract powder helps protect against cell damage, inflammation, and oxidative stress.

3. Immune System Support: Black garlic extract powder may boost the immune system, preventing illnesses like the common cold and flu.

4. Anticancer Properties: Some studies suggest that black garlic extract powder may have anticancer effects, although more research is needed.

5. Digestive Health: Black garlic extract powder may aid digestion, alleviate symptoms of IBS, and support gut health.

6. Anti-Inflammatory: Black garlic extract powder may reduce inflammation, alleviating conditions like arthritis, asthma, and allergies.

7. Antibacterial and Antiviral: Black garlic extract powder may exhibit antimicrobial properties, combating infections and promoting wound healing.

8. Skin and Hair Care: Black garlic extract powder may improve skin health, reduce acne, and promote hair growth due to its antioxidant and anti-inflammatory properties.

9. Food Additive: Black garlic extract powder is used as a flavor enhancer in various dishes, sauces, and seasonings.

10. Supplements: Black garlic extract powder is available as a dietary supplement in capsule or powder form, often combined with other nutrients.

When using black garlic extract powder, ensure you follow the recommended dosage and consult with a healthcare professional if you have any underlying health conditions.

 How is  Black Garlic Extract Powder manufactured by MEDIOCON INC Synthesized?

Black garlic extract powder is synthesized through a multi-step process that involves fermentation, drying, and extraction. Here's a breakdown of how it's typically made:

 

Fermentation

Raw garlic is fermented under controlled conditions of temperature and humidity for a certain period, usually around 90 days. This process triggers a Maillard reaction, a chemical reaction between amino acids and reducing sugars that gives black garlic its distinct flavor, aroma, and color.¹ ²

 

Drying

After fermentation, the black garlic is dried to reduce its moisture content, which helps preserve the product and prevent spoilage.

 

Grinding

The dried black garlic is then ground into a fine powder, known as black garlic extract powder.

 

Extraction

The powder undergoes solvent extraction using purified water and medical-grade ethanol to extract the bioactive compounds, including S-allyl-Cysteine (SAC), which is renowned for its antioxidant potency and bioavailability. Other extraction methods include³:

- Microwave-assisted extraction: uses microwave energy to enhance extraction efficiency

- Ultrasonic-assisted extraction: utilizes ultrasound waves to increase solvent penetration

- Supercritical fluid extraction: employs high pressure and temperature to extract compounds

Purification

The extracted compounds are then purified using techniques like conventional column chromatography, HPLC semi-preparative chromatography, or high-speed countercurrent chromatography.

The resulting black garlic extract powder is rich in antioxidants, amino acids, and polyphenols, which contribute to its potential health benefits, including cardiovascular support, immune system modulation, and anti-inflammatory effects.

What are the different  dosage forms  of   Black Garlic Extract Powder Manufactured  by  MEDIOCON INC?

Black Garlic Extract Powder comes in various dosage forms to cater to different needs and preferences. Here are some of the common forms:

- Capsules: These typically contain a standardized extract of black garlic, with dosages ranging from 500-1000 mg per day, suitable for general health maintenance. Capsules often contain black garlic oil macerate or powder extracts.

- Tablets: Similar to capsules, tablets provide a concentrated dose of black garlic's active compounds, often taken orally for specific health benefits.

- Powder: Ground black garlic cloves can be used as a dietary supplement, sprinkled into food or drinks. The recommended dosage is around 800 mg (scant 1/3 tsp) once daily.

- Liquid Extracts: Liquid extracts or tinctures are another form, often used in cooking or taken sublingually (under the tongue).

- Topical Applications: Black garlic extracts are also used in creams, gels, pastes, and mouthwashes for localized benefits.

 

When choosing a dosage form, consider factors like convenience, desired health benefits, and personal tolerance. Always follow the product label instructions or consult a healthcare professional for personalized guidance.

 How Black Garlic Extract Powder Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Black Garlic Extract Powder dosage forms are prepared through a multi-step process that involves fermentation, drying, grinding, extraction, and purification. Here's an overview of how it's typically made:

 

Fermentation: Raw garlic is fermented under controlled conditions of temperature (60-90°C) and humidity (80-90%) for 4-12 weeks. This process triggers a Maillard reaction, which enhances the nutritional profile and flavor of garlic.

 

Drying: Fermented garlic is gently dried at low heat (40-50°C) to remove moisture, preserving the bioactive compounds.

Grinding: Dried black garlic is ground into a fine powder.

Extraction: The powder undergoes solvent extraction using purified water and medical-grade ethanol to extract beneficial compounds like S-allyl cysteine (SAC).

Purification: The extracted compounds are purified using techniques like conventional column chromatography, HPLC semi-preparative chromatography, or high-speed countercurrent chromatography.

Final Processing: The purified extract is then spray-dried or freeze-dried to create a shelf-stable powder. This powder can be further processed into various dosage forms like capsules, tablets, or liquid extracts.¹ ² ³

The resulting Black Garlic Extract Powder is rich in antioxidants, SAC, and polyphenols, offering potential health benefits like cardiovascular support, immune system modulation, and anti-inflammatory effects. When choosing a supplement, look for products with standardized SAC content (typically 0.1-1%) and follow the recommended dosage of 500-1000 mg per day

What are the appropriate Dosage forms of Black Garlic Extract Powder Manufactured  by  MEDIOCON   INC?                

Black Garlic Extract Powder comes in various dosage forms to suit different needs and preferences. Here are some common forms:

- Capsules: Typically contain 500-1000 mg of standardized black garlic extract, ideal for general health maintenance. Capsules often contain black garlic oil macerate or powder extracts.

- Tablets: Provide a concentrated dose of black garlic's active compounds, suitable for specific health benefits.

- Powder: Ground black garlic cloves can be used as a dietary supplement, sprinkled into food or drinks. A recommended dosage is around 800 mg (scant 1/3 tsp) once daily.

- Liquid Extracts: Liquid extracts or tinctures are another form, often used in cooking or taken sublingually (under the tongue).

- Topical Applications: Black garlic extracts are also used in creams, gels, pastes, and mouthwashes for localized benefits.

 

When choosing a dosage form, consider factors like convenience, desired health benefits, and personal tolerance. Always follow the product label instructions or consult a healthcare professional for personalized guidance.¹ ²

In terms of dosage, studies have investigated the benefits of taking 600–1,500 mg of black garlic extract daily for specific medical conditions. However, the best dose may vary depending on individual health conditions and reactions. It's essential to start with a lower dose and gradually increase it to assess tolerance

When should Black Garlic Extract Powder Manufactured by MEDIOCON INC be taken?

Black Garlic Extract Powder can be taken at any time of day, but it's best taken with food or a dietary source of fat to enhance absorption of its fat-soluble compounds. Taking it in the morning may be beneficial for those seeking cardiovascular benefits, immune system support, or digestive health improvements throughout the day.¹ ² ³

 

Some benefits of morning intake include⁴:

- Boosting Energy: Garlic's energizing effects can help kickstart your day.

- Supporting Digestion: Stimulating digestive enzymes can aid in nutrient breakdown and absorption.

- Immune System Support: Kickstarting your day with immune-boosting properties.

 

On the other hand, taking Black Garlic Extract Powder in the evening may support overnight healing processes. However, it's crucial to monitor your body's response and adjust timing accordingly, as some individuals may experience sleep disruptions or gastrointestinal discomfort.

 

When deciding on the best time, consider your:

- Daily Routine: Choose a time that fits seamlessly into your schedule.

- Health Goals: Align your intake with specific benefits, such as cardiovascular support or immune function.

- Personal Tolerance: Start with a small dose and adjust based on your body's response.

Consult with a healthcare professional to determine the optimal timing and dosage for your individual needs.

 What are the effects And Side effects of Black Garlic Extract Powder Manufactured by MEDIOCON INC?

Black Garlic Extract Powder offers numerous health benefits, including antioxidant, anti-inflammatory, and cardiovascular protective effects. It may help lower blood pressure, improve cholesterol levels, and reduce the risk of chronic diseases like heart disease, cancer, and neurodegenerative disorders.¹ ² ³

Potential Benefits:

- Cardiovascular Health: Black garlic extract may help reduce blood pressure, LDL cholesterol, and triglycerides, protecting heart health.

- Anti-Cancer Properties: It contains phytochemicals that may prevent cancer cell growth and reduce the risk of certain cancers.

- Immune System Boost: Black garlic extract can increase γδ-T cell count and natural killer cell activity, enhancing immune function.

- Anti-Aging Effects: Its antioxidant properties may help protect against oxidative stress, promoting healthy aging.⁴

Possible Side Effects:

- Digestive Issues: Nausea, vomiting, diarrhea, stomach cramps, and bloating may occur, especially in large amounts or sensitive stomachs.

- Allergic Reactions: Rare cases of itching, rash, swelling, difficulty breathing, and anaphylaxis have been reported.

- Blood Thinning: Black garlic extract may interact with blood-thinning medications, increasing bleeding risk.

- Interactions with Medications: Potential interactions with diabetes medications, blood pressure medications, and HIV medications may occur.⁵

Precautions:

- Consult a healthcare professional before taking black garlic extract, especially if you have underlying health conditions or take medications.

- Start with small doses (600-1200 mg) and gradually increase as needed.

- Monitor blood pressure and blood sugar levels regularly.

- Avoid excessive consumption, as it may cause toxicity or interact with medications.

  How is Black Garlic Extract Powder Manufactured by MEDIOCON  INC  Tested Qualitatively?

Qualitative testing of Black Garlic Extract Powder involves various methods to identify and analyze its phytochemical constituents. Here are some common tests used:

Phytochemical Screening

- Thin Layer Chromatography (TLC): Compares the chemical composition of black garlic with white garlic and onion to identify distinct compounds.

- Preliminary Qualitative Phytochemical Tests: Detects presence of carbohydrates, reducing sugars, flavonoids, and alkaloids.¹

Quantitative Analysis

- High-Performance Liquid Chromatography (HPLC): Measures the amount of specific compounds like S-allyl cysteine (SAC), a key bioactive compound in black garlic.

- Gas Chromatography-Mass Spectroscopy (GC-MS): Evaluates bioactive phytochemicals present in black garlic extract.

Antioxidant Activity Assays

- 2,2-Diphenyl-2-Picrylhydrazyl (DPPH) Radical Scavenging Activity: Measures antioxidant activity by assessing the ability of black garlic extract to scavenge DPPH radicals.

- Phenolic Content Analysis: Estimates the total phenolic content, which contributes to antioxidant properties.

Other Tests

- Proximate Analysis: Determines the nutritional composition, including moisture, ash, fat, protein, and fiber content.

- Microbial Contamination Tests: Ensures the product is free from harmful microorganisms.

These tests help ensure the quality, efficacy, and safety of Black Garlic Extract Powder for consumption.

   Which tests are performed on Black Garlic Extract Powder Manufactured by  MEDIOCON INC ?

Black Garlic Extract Powder undergoes various tests to ensure its quality, efficacy, and safety. Here are some common tests performed:

 

Physical Control Tests

 

- Appearance: Visual inspection to ensure the powder is fine and meets specifications.

- Color: Verification of the powder's color, which should be Yellowish Brown to Brown.

- Odor: Organoleptic test to confirm the characteristic odor.

- Taste: Evaluation of the powder's taste.

- Sieve Analysis: 100% pass 80 mesh screen test.

 

Chemical Control Tests

 

- Active Ingredients: Assay of S-Allyl Cysteine (SAC) content using HPLC, with specifications ranging from SAC >0.2% to SAC >5.0%.

- Heavy Metals: Testing for heavy metals like Arsenic (As), Mercury (Hg), and Lead (Pb) using Atomic Absorption.

- Pesticide Residues: Gas Chromatography to ensure compliance with USP standards.

Microbiological Control Tests

- Total Plate Count: Maximum 10,000 CFU/g.

- Yeast & Mold: Maximum 300 CFU/g.

- E. Coli, Salmonella, Staph Aureus, and Pseudomonas aeruginosa: Tested for absence.

Other Tests

- Loss on Drying: Maximum 8% loss.

- Ash Content: Maximum 5%.

- Antioxidant Activity: DPPH radical scavenging activity and total phenolic content analysis.

- Phytochemical Screening: Thin Layer Chromatography (TLC) and preliminary qualitative phytochemical tests for detecting carbohydrates, reducing sugars, flavonoids, and alkaloids.¹ ² ³

These tests help ensure the quality and safety of Black Garlic Extract Powder for consumption.

What are the challenges in Manufacturing of Ascophyllum Nodosum Extract Manufactured by MEDIOCON   INC API?

Manufacturing Ascophyllum Nodosum Extract API poses several challenges that impact its quality, efficacy, and consistency. Here are some key difficulties faced during production:

 

Raw Material Variability

 

The quality of Ascophyllum nodosum seaweed can vary depending on factors like geographical location, seasonal fluctuations, and harvesting methods. This variability affects the extract's composition, potency, and overall performance.¹

 

Extraction Method Optimization

 

Different extraction methods, such as aqueous extraction, enzymatic hydrolysis, or solvent-based extraction, can significantly influence the extract's bioactive compound profile and yield. Optimizing the extraction process to preserve sensitive compounds while ensuring scalability and cost-effectiveness is crucial.

 

Molecular Weight Distribution

 

The molecular weight distribution of carbohydrates in the extract impacts its efficacy. High temperatures during extraction can lead to degradation of high molecular weight polysaccharides, affecting the extract's performance.

 

Contamination and Quality Control

 

Ensuring the absence of contaminants, heavy metals, and pesticides is vital. Implementing stringent quality control measures throughout the manufacturing process helps maintain consistency and safety.

 

Standardization and Regulatory Compliance

 

Standardizing the extract to specific bioactive compound levels and complying with regulatory requirements, such as those set by the European Fertilising Products Regulation (FPR), poses additional challenges.

Drying and Preservation

Drying methods like vacuum drying, microwave drying, hot air drying, and freeze-drying impact the extract's color, microstructure, and polyphenol content. Optimizing drying techniques helps preserve the extract's bioactivity.²

Scalability and Cost-Effectiveness

Scaling up production while maintaining consistency and cost-effectiveness is essential for commercial viability. Manufacturers must balance production costs with the need for high-quality extracts.

Addressing these challenges requires careful optimization of extraction methods, drying techniques, and quality control measures to ensure the production of high-quality Ascophyllum Nodosum Extract API.

What are the challenges in manufacturing of Black Garlic Extract Powder Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Black Garlic Extract Powder dosage forms comes with several challenges that can impact product quality, efficacy, and safety. Here are some key difficulties faced during production:

 

Raw Material Variability and Sourcing

 

The quality of black garlic extract powder heavily relies on the raw materials used. Factors like geographical location, seasonal fluctuations, and harvesting methods can affect the composition and potency of garlic bulbs. Ensuring a consistent supply of high-quality raw materials is crucial.¹

 

Extraction Process Optimization

 

The extraction process is critical in preserving bioactive compounds like allicin. Optimizing extraction parameters such as solvent type, temperature, and time is essential for maximizing yield and potency while minimizing degradation.

 

Formulation and Stability Issues

Black garlic extract powder can be hygroscopic, deliquescent, or sensitive to light and moisture, which affects its stability and shelf-life. Proper packaging and storage conditions are necessary to maintain product quality.

Microbial Contamination and Heavy Metal Analysis

Microbial testing and heavy metal analysis are vital to ensure the product's safety and compliance with regulatory standards. Detecting contaminants like lead, arsenic, and cadmium is crucial to prevent adverse health effects.

Standardization and Regulatory Compliance

Standardizing the extract to specific bioactive compound levels and complying with regulatory requirements poses additional challenges. Manufacturers must adhere to guidelines set by regulatory authorities to ensure product legitimacy and safety.

Dosage Form-Specific Challenges

Different dosage forms, such as capsules, tablets, or liquid extracts, present unique challenges. For instance, ensuring content uniformity in capsules or tablets and maintaining stability in liquid extracts require careful formulation and manufacturing processes.² ³ ⁴

Scalability and Cost-Effectiveness

Scaling up production while maintaining consistency and cost-effectiveness is essential for commercial viability. Manufacturers must balance production costs with the need for high-quality extracts.

Addressing these challenges requires careful optimization of extraction methods, formulation techniques, and quality control measures to ensure the production of high-quality Black Garlic Extract Powder dosage forms.

What is the Packing for Black Garlic Extract Powder Manufactured by MEDIOCON INC?

Black Garlic Extract Powder packaging varies depending on the manufacturer and product specifications. Here are some common packaging options:

- Capsules: Available in bottles of 60 or 120 capsules, often in packs of 2 or more. For instance, Vitabowl's Black Garlic Capsules come in a pack of 2 x 60 capsules.

- Powder: Sold in packets or containers ranging from 100g to 1kg. Aaswad's Black Garlic Powder is available in 100g packets, while Bhumi Organic Black Garlic Powder comes in a 250g pack.

- Bulk Packaging: For commercial or industrial use, bulk suppliers offer larger quantities, sometimes up to several kilograms.

 

When selecting a product, consider the packaging size and material to ensure it meets your needs and preferences. Some products may come in airtight containers or resealable packets to maintain freshness and potency

What is shelf life Of Black Garlic Extract Powder Manufactured by MEDIOCON INC? 

Black Garlic Extract Powder's shelf life typically ranges from 1 to 2 years when stored properly in an airtight container, in a cool, dark place. Factors affecting its shelf life include exposure to moisture, air, heat, and light. To maximize its lifespan, consider purchasing smaller quantities if you don't use it frequently and utilize clean, dry utensils when handling the powder to prevent moisture absorption.¹

Storage Tips for Longer Freshness:

- Airtight Containers: Store in airtight containers to maintain freshness and prevent moisture buildup.

- Cool, Dark Place: Keep it away from direct sunlight, stovetops, ovens, or other heat sources.

- Low Humidity: Ensure the storage area has low humidity to prevent clumping and spoilage.

Signs of Spoilage:

- Dull or Off Odor: If the powder emits an unpleasant smell, it may be spoiled.

- Clumping: Moisture absorption can cause clumping, indicating potential spoilage.

- Mold: Visible mold or discoloration signifies the powder has gone bad.

When stored correctly and monitored regularly for signs of spoilage, Black Garlic Extract Powder can retain its potency and flavor for an extended period.

What should the label claim for Black Garlic Extract Powder Manufactured by MEDIOCON INC   Include?

The label claim for Black Garlic Extract Powder should include the following information:

 

Product Identity

 

- Product Name: Black Garlic Extract Powder

- Botanical Name: Allium sativum

 

Specifications

 

- SAC (S-Allyl Cysteine) Content: Specify the percentage of SAC, e.g., SAC >0.2% to SAC >5.0%

- Appearance: Describe the powder's color, e.g., Yellowish Brown to Brown

- Mesh Size: Specify the mesh size, e.g., 80 mesh

 

Manufacturing Information

 

- Manufacturing Date

- Expiry Date

- Batch Number

- Manufacturer's Name and Address

 

Usage and Storage

 

- Recommended Dosage

- Storage Conditions: Store in a cool, dry place, away from direct sunlight and moisture

- Handling Instructions: Use clean, dry utensils when handling the powder

 

Regulatory Compliance

 

- Compliance with Regulatory Standards: Mention compliance with relevant regulatory standards, such as USP or EU regulations

- Certifications: List any certifications, such as GMP, ISO, or Organic

Additional Information

- Country of Origin: Specify the country where the black garlic was sourced

- Net Weight: Declare the net weight of the product

- Warning or Caution: Include any necessary warnings or cautions, such as "Not recommended for pregnant or breastfeeding women.

Ensure the label claims are accurate, clear, and comply with relevant regulatory requirements.

Where can Black Garlic Extract Powder Manufactured by MEDIOCON INC are procured?

Black Garlic Extract Powder Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Black Garlic Extract Powder Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Black Garlic Extract Powder Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Black Garlic Extract Powder Manufactured by MEDIOCON INC product, regardless of the procurement source.