Cycloserine 68-41-7 Manufacturer Exporter Supplier MEDIOCON INC

 

 

Cycloserine Manufactured by MEDIOCON INC     

 

   Name: Cycloserine

CAS No:   68-41-7

Molecular Weight:  102.09 g/mol

Molecular formula:   C₃H₆O₂N₂

Synonyms:  D-cycloserine, Seromycin, Oxamycin, and D-4-Amino-3-isoxazolidinone

Appearance:  white to off-white  crystalline hygroscopic powder. 

 Solubility :  soluble in water and slightly soluble in methanol and propylene glycol

Use :

Cycloserine is an antibiotic used to treat various bacterial infections. Here are its main uses:

- Tuberculosis (TB): Cycloserine is used as part of a combination treatment for active pulmonary and extrapulmonary TB, especially for drug-resistant strains.

- Urinary Tract Infections (UTIs): It treats certain types of UTIs caused by susceptible bacteria, such as Enterobacter species and Escherichia coli.

- Bacterial Skin Infections: Cycloserine is effective against bacterial skin infections.

- Conjunctivitis: It treats conjunctivitis caused by susceptible bacteria.

 

Cycloserine works by inhibiting bacterial cell wall synthesis, making it effective against a range of bacterial infections.

 How is  Cycloserine manufactured by MEDIOCON INC Synthesized?

Cycloserine is synthesized through various methods, including biosynthesis and chemical synthesis.

 

Biosynthesis- Cycloserine is produced biosynthetically from actinomycetes like Streptomyces garyphalus, Streptomyces orchidaceus, and Streptomyces lavendulae.

- The process involves a ten-gene cluster, converting L-serine and L-arginine into O-ureido-L-serine, then O-ureido-D-serine, and finally cycloserine through cyclization.

Chemical Synthesis- Cycloserine can be synthesized chemically from D-serine methyl ester.

- The process involves replacing the hydroxyl group with a chlorine atom using phosphorous pentachloride, followed by reaction with hydroxylamine to form cycloserine.

- Other methods include using protection-deprotection strategies, starting with D-serine, and employing cyclization reactions as key steps.

Recent Developments- Researchers have developed efficient and facile synthesis methods, achieving high yields (up to 61%) and purity (>99%).

- These methods involve simple treatment and mild reaction conditions, making them attractive for large-scale production.

What are the different  dosage forms  of   Cycloserine Manufactured  by  MEDIOCON INC?

Cycloserine is available in the following dosage forms:

- Capsules: 250 mg

- Oral Capsules: 250 mg

 

The dosage of Cycloserine varies depending on the condition being treated, patient's age, weight, and renal function. Here are some general guidelines¹ ² ³:

- Adults: 250-500 mg orally every 12 hours, up to a maximum of 1 g/day

- Children: 10-20 mg/kg/day orally in divided doses, up to a maximum of 1 g/day

- Renal Impairment: Dosage adjustment is necessary; consult a healthcare professional for guidance

 

It's essential to follow the prescribed dosage and administration instructions to ensure effective treatment and minimize side effects.

 How Cycloserine Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Cycloserine dosage forms, specifically capsules, are prepared through a series of steps:

- Blending: The active pharmaceutical ingredient (API), cycloserine, is blended with excipients like fillers, disintegrants, and lubricants.

- Encapsulation: The blended mixture is then filled into empty capsule shells using an encapsulation machine.

- Quality Control: The filled capsules undergo quality control checks, including weight variation, disintegration, and dissolution tests.

- Packaging: The capsules are packaged in containers or blister packs, labeled, and prepared for distribution.

 

The preparation process may vary depending on the manufacturer and specific formulation. Some common excipients used in cycloserine capsules include [1][2]:

- Fillers: Microcrystalline cellulose, lactose monohydrate

- Disintegrants: Croscarmellose sodium, crospovidone

- Lubricants: Magnesium stearate, stearic acid

It's crucial to follow Good Manufacturing Practices (GMP) and ensure the quality of the final product.

What are the appropriate Dosage forms of Cycloserine Manufactured  by  MEDIOCON   INC?                

Cycloserine is available in the following dosage forms:

- Capsules: 250 mg

- Oral Capsules: 250 mg

The dosage of Cycloserine varies depending on the condition being treated, patient's age, weight, and renal function. Here are some general guidelines:

- Adults: 250-500 mg orally every 12 hours, up to a maximum of 1 g/day

- Children: 10-20 mg/kg/day orally in divided doses, up to a maximum of 1 g/day

- Renal Impairment: Dosage adjustment is necessary; consult a healthcare professional for guidance

When should Cycloserine Manufactured by MEDIOCON INC be taken?

Cycloserine should be taken according to the following guidelines:

- Oral Administration: Take cycloserine orally, usually every 12 hours.

- With or Without Food: Cycloserine can be taken with or without food.

- Consistency: Take cycloserine at the same time(s) every day to maintain consistent blood levels.

- Duration: Continue taking cycloserine for the full prescribed duration, even if symptoms improve.

 

Specific Timing- Adults: 250-500 mg every 12 hours.

- Children: 10-20 mg/kg/day in divided doses every 12 hours.

Important Considerations- Renal Impairment: Dosage adjustment is necessary; consult a healthcare professional.

- Monitoring: Regular monitoring of blood levels, renal function, and neurological status is recommended.

 What are the effects And Side effects of Cycloserine Manufactured by MEDIOCON INC?

Cycloserine is an antibiotic used to treat tuberculosis (TB) and urinary tract infections (UTIs). Here are its effects and potential side effects:

 

Effects:- Antibacterial: Cycloserine is effective against Mycobacterium tuberculosis and certain bacteria causing UTIs, such as Enterobacter species and Escherichia coli.

- Bactericidal/Bacteriostatic: Depending on concentration, cycloserine kills bacteria or inhibits their growth.

 

Side Effects:- Common:

    - Anxiety, confusion, dizziness, drowsiness

    - Headache, irritability, mood changes

    - Numbness, tingling, or burning sensations

    - Speech difficulties, tremors

- Less Common:

    - Convulsions (seizures), coma

    - Depression, psychosis, suicidal thoughts

    - Elevated liver enzymes, heart failure

    - Vitamin B12 deficiency, anemia

 

Precautions:- Contraindicated: Severe kidney impairment, epilepsy, severe anxiety, psychosis, chronic alcoholism

- Use with Caution: History of seizures, mental disorders, kidney or liver disease

- Avoid Alcohol: Increases risk of seizures and adverse reactions

 

Consult a healthcare professional for personalized guidance on using Cycloserine

  How is Cycloserine Manufactured by MEDIOCON  INC  Tested Qualitatively?

Cycloserine is tested qualitatively using a simple test based on its deterioration. When cycloserine deteriorates, it forms a yellow solution when dissolved in dilute alkali. This test is particularly useful in humid tropical climates where cycloserine may degrade quickly.

To perform this test, a sample of cycloserine is dissolved in dilute alkali. If the solution turns yellow, it indicates that the cycloserine has deteriorated.¹ ² ³

Additionally, other methods like UPLC (Ultra-Performance Liquid Chromatography) and LC-MS (Liquid Chromatography-Mass Spectrometry) can be used to analyze cycloserine solutions and detect degradation.

   Which tests are performed on Cycloserine Manufactured by  MEDIOCON INC ?

Several tests are performed on Cycloserine to ensure its quality and purity. Some of these tests include:

 

- Identification Test: A simple test based on the deterioration of Cycloserine, where a yellow solution is formed when dissolved in dilute alkali.

- Purity Tests: To detect impurities and degradation products.

- Assay: To determine the potency and concentration of Cycloserine.

- UPLC (Ultra-Performance Liquid Chromatography): To analyze Cycloserine solutions and detect degradation.

- LC-MS (Liquid Chromatography-Mass Spectrometry): To analyze Cycloserine solutions and detect degradation.

- Dissolution Test: To ensure the Cycloserine capsules dissolve properly.

- Disintegration Test: To ensure the Cycloserine capsules disintegrate properly.

- Weight Variation Test: To ensure the Cycloserine capsules have uniform weight.

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing Banana Extract API comes with several challenges:

- Extraction Efficiency: Optimizing extraction methods to maximize yield and minimize degradation of bioactive compounds.

- Standardization: Ensuring consistent quality and potency of the extract.

- Contamination Risk: Preventing contamination during processing and storage.

- Scalability: Scaling up production while maintaining quality and efficiency.

- Regulatory Compliance: Meeting regulatory requirements for API manufacturing.

Additionally, banana-based products face challenges like¹ ² ³:

- Seasonal Variability: Managing fluctuations in raw material availability and quality.

- Waste Management: Utilizing banana waste effectively to reduce environmental impact.

- Cost Competitiveness: Balancing production costs with market demand and competition.

Addressing these challenges requires innovative solutions, efficient processes, and adherence to quality standards.

What are the challenges in manufacturing of Cycloserine Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Cycloserine dosage forms comes with several challenges:

- Stability Issues: Cycloserine degrades over time, affecting potency and safety.

- Poor Solubility: Cycloserine has limited solubility, impacting bioavailability.

- Microbial Contamination: Risk of contamination, particularly in liquid forms.

- Product Uniformity: Ensuring consistent potency and quality.

- Regulatory Compliance: Meeting stringent regulatory standards.

- Specialized Equipment: Requires specific equipment for handling and processing.

- Packaging and Storage: Needs proper packaging and storage to maintain stability.

What is the Packing for Cycloserine Manufactured by MEDIOCON INC?

Cycloserine is packed in various sizes, including¹ ² ³:

- 10X6 Capsules: A common packaging size for Cycloserine 250mg capsules

- 10X10 Capsules: Another popular packaging size for Cycloserine 250mg capsules

- 1X10 Capsules: A smaller packaging size for Cycloserine 250mg capsules

- 30 Capsules: Available in blister packs or bottles

- Box of 3X10 Capsules: A larger packaging size for Cycloserine 250mg capsules

Some manufacturers also offer customized packaging options. The packaging is designed to maintain the stability and efficacy of the medication.

What is shelf life Of Cycloserine Manufactured by MEDIOCON INC? 

Cycloserine's shelf life varies depending on storage conditions and packaging. Here are some general guidelines¹ ² ³:

- Powder Form: 60 months when stored at 2-8°C (refrigerated)

- Specific Products:

    - TSC Agar: 12 months at 2-30°C

    - Cycloserine-Cefoxitin Fructose Agar: 90 days from manufacture date

    - TSC Agar Supplement: Limited shelf life, expiry date on label

To extend shelf life, store Cycloserine in⁴:

- Cool, dry places

- Airtight containers

- Away from direct sunlight and moisture

What should the label claim for Cycloserine Manufactured by MEDIOCON INC   Include?

The label claim for Cycloserine should include the following information:

- Product Name and Description: Clearly indicate the product name, such as "Cycloserine Capsules, 250mg"

- Active Ingredient: Specify the active ingredient, Cycloserine

- Strength: Indicate the strength, 250mg

- Dosage Form: Specify the dosage form, capsules

- Ingredients: List all ingredients, including inactive ingredients like magnesium oxide, talc, and gelatin

- Warnings and Precautions: Include warnings about CNS toxicity and other potential risks

- Directions for Use: Provide clear instructions on how to take the medication

- Manufacturer Information: Include the manufacturer's name, address, and contact information

- NDC Number: Specify the National Drug Code (NDC) number, such as 33342-462-06

- Packaging Information: Describe the packaging, such as "30 Capsules, Non-Child Resistant"

- Bar Code: Include a bar code for accurate scanning

- Statement of Identity: Include a statement of identity, such as "Cycloserine Capsules USP, 250 mg"

Where can Cycloserine Manufactured by MEDIOCON INC are procured?

Cycloserine Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Cycloserine Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Cycloserine Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Cycloserine Manufactured by MEDIOCON INC product, regardless of the procurement source.