CISSUS EXTRACT Manufactured Supplier Exporter by MEDIOCON INC

 

CISSUS EXTRACT  Manufactured by MEDIOCON INC     

Name: CISSUS EXTRACT

CAS No:  897-06-3

Molecular Weight: - β-Sitosterol: ~414.7 g/mol (C₂₉H₅₀O)

- α-Amyrone: ~426.7 g/mol (C₃₀H₅₀O)

- Quercetin: ~302.2 g/mol (C₁₅H₁₀O₇)

- 7-Oxo-stigmasterol (example keto-steroid): ~426.7 g/mol (C₂₉H₄₆O₂))

Molecular formula - β-Sitosterol: C₂₉H₅₀O

- α-Amyrone: C₃₀H₅₀O

- Quercetin: C₁₅H₁₀O₇

- 3-Keto Steroids (e.g., 7-oxo-stigmasterol): No specific CAS, varies.

Synonyms:  - - Veldt Grape

- Devil’s Backbone

- Bone Setter (Hindi: Hadjod)

- Cissus Extract

- CQ Extract

- Asthisamharaka (Ayurvedic)

- Quadrangular Vine)

Appearance:  - Powder: Brown to yellowish-brown powder

- Liquid extract: Dark brown to reddish-brown liquid

 Solubility :  - - Fine Powder:

    - Color: Light brown to beige.

    - Texture: Free-flowing, slightly gritty.

    - Odor: Mild, characteristic herbal smell.

    - Taste: Bitter, astringent.

- Form:

    - Particle Size: 80–100 mesh (≤150 μm).

    - Solubility: Partially soluble in water, soluble in ethanol/methanol.

 

- Capsules/Tablets (if formulated):

    - Filled in veg capsules or compressed tablets, as per dosage.

Use :

Cissus Quadrangularis Extract (MEDIOCON INC) is commonly used for:

- Bone Health:

    - Supports fracture healing, boosts collagen synthesis. 🌟

- Weight Management:

    - May reduce fat, curb appetite (ketosteroids).

- Joint & Inflammation Relief:

    - Anti-inflammatory, eases arthritis pain.

- Antioxidant Support:

    - Scavenges free radicals (quercetin).

- Digestive Health:

    - Traditionally for ulcers, gut health.

- Forms:

    - Capsules/Tablets: 300–500 mg, 1–2× daily.

    - Powder: Mix in drinks, smoothies.

    - Topical: Creams for pain relief (less common).

 How is  CISSUS EXTRACT   manufactured by MEDIOCON INC Synthesized?

MEDIOCON INC’s Cissus Quadrangularis Extract is typically manufactured through this process:

- Raw Material Sourcing:

    - Cissus quadrangularis stems (wild/cultivated, India/Southeast Asia).

    - Dried, cleaned, milled into coarse powder.

- Extraction:

    - Solvent: Hydro-ethanol (30–70% ethanol + water).

    - Method: Maceration/percolation (50–60°C, 2–4 hours).

    - Extract filtered, concentrated (vacuum evaporation, <50°C).

- Standardization:

    - Markers: 3–10% ketosteroids (e.g., 7-oxo-stigmasterol), HPLC assay.

    - Adjust potency, blend if needed.

- Purification:

    - Decolorization: Activated carbon (optional).

    - Filtration: 0.45 µm, remove solvents.

- Drying:

    - Spray drying (inlet 120°C, outlet 70°C) → fine powder.

    - Moisture: <5%.

- Milling & Sieving:

    - Particle size: 80–100 mesh (≤150 μm).

- Packaging:

    - HDPE drums (25 kg), food-grade liners. Labelled with batch, expiry.

 

Key Controls:

- HPLC Testing: Ketosteroids, flavonoids.

- Microbial Limits: <10,000 CFU/g, no E. coli, Salmonella.

- Heavy Metals: <10 ppm (WHO/FSSAI).

- cGMP, ISO 22000 compliance.

What are the different  dosage forms  CISSUS EXTRACT  Manufactured  by  MEDIOCON INC?

MEDIOCON INC’s Cissus Quadrangularis Extract typically comes in these dosage forms:

- Capsules:

    - 250 mg / 500 mg extract per capsule.

    - Use: Swallow with water, 1–2× daily.

    - Excipients: cellulose, magnesium stearate.

- Tablets:

    - 500 mg (chewable or swallow).

    - Use: Bone/joint health, weight management.

- Powder / Sachets:

    - 1 g / 5 g sachets.

    - Use: Mix in 100–200 mL water/juice, smoothies.

- Liquid Extract (Tincture):

    - 1:1 or 1:2 (g/mL), 20–50% ethanol.

    - Use: Drops (10–30 drops, 2× daily), dilute.

- Topical Creams/Gels (less common):

    - 2–5% extract in base (e.g., aloe vera).

    - Use: Joint pain, massage.

 

Key Notes:

- Standardization: Often 3–10% ketosteroids.

- Packaging: HDPE bottles (capsules), sachets, glass dropper bottles (liquid).

- Label: "Take with food," consult a doctor.

 How CISSUS EXTRACT   Manufactured by MEDIOCON INC   Dosage Forms are prepared?

MEDIOCON INC’s Cissus Quadrangularis Extract dosage forms are prepared as follows:

 

1. *Capsules*

- Process:

    - Blend: Mix extract powder (250/500 mg) with excipients (dicalcium phosphate, microcrystalline cellulose, magnesium stearate).

    - Fill: Automatic capsule filler (size 0/1/2).

    - Polish: Remove dust, seal in HDPE bottles (30/60/120 count).

    - Label: Dosage, expiry (e.g., "1 capsule, 2× daily").

- Controls: Weight variation, disintegration (<30 min).

 

2. *Tablets*

- Process:

    - Granulation: Wet mix extract + binders (PVP, starch), dry (40°C), sieve (≤1 mm).

    - Compression: Rotary press (500 mg/tablet, ±5% accuracy).

    - Coating (optional): Film coat (hypromellose) for taste-masking.

    - Blister pack: 10/20 tablets, foil-sealed.

- Tests: Hardness (4–8 kg), friability (<1%).

 

3. *Powder/Sachets*

- Process:

    - Blend: Extract + fillers (maltodextrin, 1–5 g/sachet).

    - Fill-Seal: Automatic sachet machine (3–5 g, foil-laminated).

    - Pack: Carton (10/30 sachets).

- Use: Mix 1 sachet in 100–200 mL water.

 

*_4. *Liquid Extract (Tincture)_*

- Process:

    - Dissolve: Extract in ethanol-water (20–50%), filter (0.45 µm).

    - Standardize: Adjust to 1:1 or 1:2 (g/mL), HPLC check.

    - Fill: Amber glass bottles (30/50 mL), dropper cap.

    - Label: "10–30 drops, 2× daily, dilute."

- Tests: Ethanol %, pH (4–6).

 

**5. Topical Cream/Gel (less common)

- Process:

    - Blend: 2–5% extract in base (aloe vera, carbomer, emulsifiers).

    - Homogenize (3000 rpm, 5 min), pH adjust (5–6).

    - Fill: Tubes (30/50 g), sealed.

- Tests: Viscosity, microbial limits.

 

Common Controls:

- HPLC Assay: 3–10% ketosteroids.

- Microbial: <10,000 CFU/g, no pathogens.

- Stability: 24-month shelf life (25°C, <60% RH).

- cGMP, ISO 22000 compliance.

 When should CISSUS EXTRACT  Manufactured by MEDIOCON INC be taken?

MEDIOCON INC’s Cissus Quadrangularis Extract—here’s when to take it, generally:

- For Bone/Joint Health:

    - Post-meals: 1–2 capsules (250–500 mg each), with food, 2× daily (morning, evening).

    - Example: After breakfast and dinner for fracture recovery, arthritis relief.

- For Weight Management:

    - Before meals: 1 capsule (500 mg), 30–60 mins pre-lunch/dinner.

    - With water: No caffeine/alcohol nearby.

- For General Wellness:

    - Morning + night: 1 capsule, with meals.

- Liquid Extract (Tincture):

    - 10–30 drops, in water/juice, 2× daily (meals).

- Topical Cream (if pain relief):

    - 2–3× daily, massage gently on joints.

 

Key Notes:

- Consult a doctor:

    - Pregnancy/breastfeeding.

    - Diabetes, medications (interacts with blood thinners?).

    - No food restrictions, but avoid empty stomach (nausea risk).

- Cycle: Try 8–12 weeks, monitor progress. Pause if discomfort.

- Storage: Keep dry, <25°C. No expiry tweaks—check label! 

Which tests are performed on Spinach Extract Manufactured by  MEDIOCON INC ?

MEDIOCON INC’s Spinach Extract typically undergoes these quality tests (may vary by product/specification):

- Identification Tests:

    - HPLC Fingerprint: Matches spinach phytochemicals (e.g., ecdysterone, flavonoids).

    - Organoleptic: Green-brown powder, mild odor, astringent taste.

- Purity & Potency:

    - Assay (HPLC): % Ecdysterone (e.g., 10–20%), lutein, chlorophyll.

    - Moisture: ≤5.0% (Karl Fischer).

    - Ash: ≤10.0% (total), ≤2.0% (acid-insoluble).

- Contaminants:

    - Heavy Metals (AAS): Pb ≤1 ppm, Cd ≤0.5 ppm, As ≤1 ppm, Hg ≤0.1 ppm.

    - Pesticides (GC-MS): <0.1 ppm (WHO limits).

    - Microbial Limits:

        - Total Plate Count: <10,000 CFU/g.

        - E. coli, Salmonella: Absent (per 10 g).

- Physical Tests:

    - Particle Size: 80–100 mesh (≤150 μm).

    - Solubility: Partial in water, soluble in ethanol.

- Stability:

    - Accelerated Testing (40°C, 75% RH, 6 months).

    - Shelf Life: 24 months (sealed, <25°C, <60% RH).

- Certificates:

    - cGMP, ISO 22000, FSSAI compliance.

    - Non-GMO, Halal, Kosher (if applicable).

- Additional (if specific):

    - Nutrients: Iron, vitamins (A, C, K), fiber.

    - Allergen Test: Gluten-free, soy-free.

What are the challenges in Manufacturing of CISSUS EXTRACT  Manufactured by MEDIOCON   INC API?

Manufacturing Cissus Quadrangularis Extract (API) by MEDIOCON INC faces these key challenges:

- 1. Raw Material Variability:

    - Plant Source: Quality depends on region, season, harvesting. Active compounds (ketosteroids, flavonoids) fluctuate.

    - Solution: Standardize sourcing, test incoming batches (HPLC).

- 2. Extraction Efficiency:

    - Solvent Choice: Balancing yield vs. safety (ethanol-water mix optimal, but costly).

    - Heat Sensitivity: Compounds degrade >50°C. Need gentle extraction (percolation, 40–50°C).

- 3. Standardization:

    - Markers Vary: No universal "ketosteroid" assay. Ensure 3–10% via HPLC, adjust batches.

    - Complexity: Multiple actives (β-sitosterol, quercetin)—hard to quantify.

- 4. Solubility & Bioavailability:

    - Poor Water Solubility: Need excipients (cyclodextrins) for tablets/capsules.

    - Particle Size: Micronization (≤150 μm) boosts dissolution.

- 5. Contaminants & Purity:

    - Pesticides, Heavy Metals: Strict testing (GC-MS, AAS); supplier audits.

    - Microbes: Sterilize (steam, filtration), monitor CFU (<10,000/g).

- 6. Stability:

    - Moisture Sensitivity: <5% moisture, airtight packaging (HDPE drums).

    - Oxidation: Add antioxidants (e.g., ascorbic acid), test shelf-life (24 months).

- 7. Regulatory Compliance:

    - Documentation: cGMP, ISO 22000, FSSAI. Batch records, COA.

    - Label Claims: Vague "traditional use"—need science-backed data.

- 8. Cost & Scale-Up:

    - Yield Loss: ~5–10% in extraction. Optimize solvent reuse, energy.

    - Equipment: Stainless steel, explosion-proof (ethanol).

- 9. Testing Complexity:

    - HPLC Validation: Method development for ketosteroids. Outsourced labs?

    - Batch-to-Batch Consistency: In-process checks.

 

Mitigation:

- Partner with farms for traceability.

- Optimize 70% ethanol, 45°C, 3-hour extraction.

- In-house HPLC, third-party audits.

- Desiccants in packs, expiry monitoring.

What is the Packing for CISSUS EXTRACT  Manufactured by MEDIOCON INC?

MEDIOCON INC’s Cissus Quadrangularis Extract typically uses this packing:

- Primary Packaging:

    - HDPE Drums (25 kg net):

        - Food-grade, moisture-resistant liner (LDPE).

        - Sealed, tamper-evident with screw cap.

        - Label: Product name, batch no., expiry (MM/YYYY), storage (15–25°C, <60% RH).

    - Double-Layer Poly Bags (1–5 kg for small batches):

        - Heat-sealed, airtight, labelled.

- Secondary Packaging (for retail):

    - Capsules/Tablets:

        - HDPE bottles (30/60/120 count) with silica gel.

        - Blister packs (10/20 units), foil-sealed.

    - Powder/Sachets:

        - 1–5 g sachets (foil-laminated, zip-lock).

        - Cartons (10/30 sachets), printed labels.

    - Liquid Extract:

        - Amber glass bottles (30/50 mL), dropper cap.

        - Carton box, leaflet insert.

- Labels & Markings:

    - Batch No., Expiry (24 months), storage, dosage.

    - Symbols: ⛔ Moisture, 🌞 Light protection.

    - Regulatory: cGMP, FSSAI, ISO 22000 logos.

- Transport:

    - Palletized drums (25 kg), shrink-wrapped.

    - Cartons (retail): Stackable, moisture-proof.

- Special Notes:

    - Desiccant Packs inside drums/bottles.

    - COA, MSDS included with shipment.

What is shelf life Of CISSUS EXTRACT  Manufactured by MEDIOCON INC? 

The shelf life of Cissus Quadrangularis Extract manufactured by MEDIOCON INC is typically:

- 24 months (2 years) from the date of manufacture when stored properly:

    - Storage Conditions:

        - Temperature: 15–25°C (avoid heat).

        - Humidity: <60% RH (moisture-sensitive).

        - Packaging: Sealed, airtight containers (HDPE drums, glass bottles).

        - Light Protection: Keep in original packaging, avoid direct sunlight.

 

- Specifics:

    - API (Bulk Powder): 24 months in HDPE drums with desiccant.

    - Capsules/Tablets: 18–24 months, check label.

    - Powder (Sachets): 24 months, use after opening within 3 months.

    - Liquid Extract (Tincture): 12–18 months (amber glass, sealed).

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find CISSUS EXTRACT  Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for CISSUS EXTRACT  manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of CISSUS EXTRACT  Manufactured by MEDIOCON INC product, regardless of the procurement source.