Hydroxypropyl Methyl Cellulose(HPMC) 9004-65-3 Manufacturer Supplier Exporter MEDIOCON INC

  

Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC

 

   Name: Hydroxypropyl Methyl Cellulose(HPMC)

CAS No:   9004-65-3

Molecular Weight:  1261.4 g/mol

Molecular formula:  C₉H₁₄N₄O₃

Synonyms: Cellulose, 2-hydroxypropyl methyl ether

Appearance:  lightly off-white to beige powder.

 Solubility :  practically insoluble in hot water, in acetone, in anhydrous ethanol and in toluene.

Use :

Hydroxypropyl methylcellulose (HPMC) is a versatile polymer with various applications:

- Pharmaceuticals: Used as an excipient, binder, film-former, and viscosity modifier in tablets, capsules, and ophthalmic solutions.

- Food industry: Employed as a thickener, stabilizer, and emulsifier in products like ice cream, sauces, and dressings.

- Cosmetics: Found in personal care products, such as creams, lotions, and shampoos, due to its moisturizing and thickening properties.

- Construction: Used as a water-retaining agent and thickener in cement-based products, such as tile adhesives and renders.

- Ophthalmic solutions: Used as a lubricant and thickening agent in eye drops.

 

HPMC is valued for its:

- Biocompatibility

- Non-toxicity

- Hydrophilicity

- Film-forming properties

Its applications continue to expand due to its versatility and safety profile.

 How is  Hydroxypropyl Methyl  Cellulose(HPMC) manufactured by MEDIOCON INC Synthesized?

Hydroxypropyl Methyl Cellulose (HPMC) synthesis involves:

- Cellulose treatment: Cellulose pulp is treated with sodium hydroxide (NaOH) to produce alkali cellulose.

- Methylation: Alkali cellulose reacts with methyl chloride to introduce methyl groups.

- Hydroxypropylation: The methylated cellulose reacts with propylene oxide to introduce hydroxypropyl groups.

- Purification: The resulting HPMC is washed, filtered, and dried to remove impurities.

- Grinding and packaging: The purified HPMC is ground into a powder and packaged for use.

 

The degree of substitution and molecular weight can be controlled by adjusting reaction conditions, allowing for customization of HPMC properties.

What are the different  dosage forms  of   Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured  by  MEDIOCON INC?

Hydroxypropyl Methyl Cellulose (HPMC) is available in various dosage forms, including:

- Oral tablets and capsules: Used as a binder, disintegrant, or sustained-release matrix.

- Extended-release matrices: HPMC's viscosity and swelling properties control drug release.

- Topical formulations: Creams, ointments, and gels utilize HPMC's thickening and stabilizing properties.

- Ophthalmic solutions: HPMC acts as a lubricant and thickener in eye drops.

- Suspensions and emulsions: HPMC stabilizes and thickens liquid formulations.

- Film coatings: HPMC provides a protective barrier and controlled release for tablets and capsules.

These dosage forms leverage HPMC's versatility, biocompatibility, and customizable properties.

 How Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Hydroxypropyl Methyl Cellulose (HPMC) dosage forms are prepared using various methods, depending on the desired formulation:

- Tablets: HPMC is mixed with active ingredients, binders, and excipients, then compressed into tablets using a tablet press.

- Capsules: HPMC is mixed with active ingredients and filled into capsules using a capsule filling machine.

- Extended-release matrices: HPMC is mixed with active ingredients and formed into matrices using techniques like granulation, compression, or extrusion.

- Topical formulations: HPMC is dissolved or dispersed in a solvent, then mixed with active ingredients and other excipients, and finally formulated into creams, ointments, or gels.

- Ophthalmic solutions: HPMC is dissolved in water and mixed with active ingredients, then sterilized and filled into bottles or vials.

- Film coatings: HPMC is dissolved in a solvent, then applied to tablets or capsules using various coating techniques, such as spray coating or pan coating.

 

The preparation process typically involves:

1. Weighing and mixing ingredients

2. Granulation or blending

3. Compression or filling

4. Coating (if applicable)

5. Quality control and packaging

 

The specific preparation method and equipment used may vary depending on the formulation and manufacturer.

What are the appropriate Dosage forms of Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured  by  MEDIOCON   INC?                

Hydroxypropyl Methyl Cellulose (HPMC) is suitable for various dosage forms, including:

- Immediate-release tablets and capsules: HPMC acts as a binder and disintegrant.

- Extended-release tablets and capsules: HPMC's viscosity and swelling properties control drug release.

- Sustained-release matrices: HPMC's hydrophilic matrix slows down drug release.

- Topical creams and ointments: HPMC's thickening and stabilizing properties enhance product stability and texture.

- Ophthalmic solutions: HPMC's lubricating and thickening properties soothe and protect the eyes.

- Film-coated tablets: HPMC provides a protective barrier and controlled release.

 

The choice of dosage form depends on the specific application, desired release profile, and route of administration. HPMC's versatility and customizable properties make it a popular choice for various pharmaceutical and food applications.

When should Hydroxypropyl Methyl  Cellulose(HPMC)  Manufactured by MEDIOCON INC be taken?

The timing of Hydroxypropyl Methyl Cellulose (HPMC) intake depends on its intended use:

- As a laxative or fiber supplement: Take HPMC with water, usually before meals or at bedtime, as directed.

- In pharmaceutical applications: Follow the specific dosing instructions provided by your healthcare provider or medication label.

- In ophthalmic solutions: Use eye drops as directed by your healthcare provider or according to the product label.

- In food and cosmetics: Follow product-specific instructions.

 

Consult your healthcare provider or product label for specific guidance on using HPMC products.

 What are the effects And Side effects of Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC?

Hydroxypropyl Methyl Cellulose (HPMC) is generally considered safe and well-tolerated. Here are its effects and potential side effects:

- Effects:

    - Laxative properties: HPMC can help promote regular bowel movements and relieve constipation.

    - Thickening and stabilizing properties: HPMC is used in various pharmaceutical and food applications to improve texture and stability.

    - Ophthalmic protection: HPMC can help soothe and protect the eyes.

- Side effects:

    - Gastrointestinal symptoms: Bloating, gas, stomach cramps, or diarrhea may occur in some individuals.

    - Allergic reactions: Rarely, some people may experience allergic reactions, such as hives, itching, or difficulty breathing.

    - Ophthalmic side effects: Blurred vision, eye irritation, or sensitivity to light may occur with ophthalmic HPMC products.

HPMC is generally considered safe when used as directed. However, it's essential to follow product instructions and consult with a healthcare professional if you experience any adverse effects or have concerns.

  How is Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON  INC  Tested Qualitatively?

Hydroxypropyl Methyl Cellulose (HPMC) is tested qualitatively using various methods, including:

- Visual inspection: Checking for appearance, color, and clarity.

- Solubility test: Evaluating HPMC's solubility in water and other solvents.

- Viscosity measurement: Determining the viscosity of HPMC solutions using viscometers.

- Infrared spectroscopy (IR): Identifying functional groups and confirming HPMC's chemical structure.

- pH determination: Measuring the pH of HPMC solutions.

- Moisture content analysis: Determining the moisture content using techniques like Karl Fischer titration.

- Ash content analysis: Evaluating the ash content after ignition.

- Particle size analysis: Determining particle size distribution using techniques like sieve analysis or laser diffraction.

 

These qualitative tests help ensure HPMC's identity, purity, and quality for various applications.

   Which tests are performed on Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by  MEDIOCON INC ?

Hydroxypropyl Methyl Cellulose (HPMC) undergoes various tests to ensure its quality and suitability for different applications. Here are some common tests performed on HPMC:

- Physical tests:

    - Appearance and color

    - Solubility

    - Viscosity

    - Particle size distribution

    - Moisture content

- Chemical tests:

    - Methoxyl and hydroxypropoxyl content

    - pH

    - Ash content

    - Heavy metal content

- Performance tests:

    - Film-forming properties

    - Gelation temperature

    - Gel strength

    - Sustained-release properties (for pharmaceutical applications)

 

These tests help evaluate HPMC's quality, functionality, and suitability for various applications, including pharmaceuticals, food, cosmetics, and construction

What are the challenges in manufacturing of Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Hydroxypropyl Methyl Cellulose (HPMC) dosage forms can pose several challenges, including:

- Raw material variability: Ensuring consistent quality and properties of HPMC raw material.

- Formulation difficulties: Achieving desired release profiles and stability.

- Viscosity and rheology: Managing HPMC's viscosity and rheological properties.

- Processing issues: Addressing challenges in granulation, compression, and coating.

- Scale-up and reproducibility: Ensuring consistent product quality during scale-up.

- Regulatory compliance: Meeting regulatory requirements and standards.

Overcoming these challenges requires careful formulation, process optimization, and quality control.

What is the Packing for Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC?

Hydroxypropyl Methyl Cellulose (HPMC) packing involves using materials that provide a strong barrier against moisture and contamination. HPMC packaging is known for its¹:

- Moisture protection: HPMC forms a tight seal around the product, preventing moisture from entering and causing damage.

- Contamination protection: HPMC acts as a physical barrier, preventing contaminants like dust, dirt, and microorganisms from coming into contact with the product.

- Versatility: HPMC packaging can be customized to meet specific requirements, such as size, shape, and thickness, making it suitable for various applications.

 

The packaging materials used for HPMC include:

- High-quality, moisture-resistant materials: Such as polyethylene or polypropylene, which provide a barrier against water vapor and other contaminants.

 

Some of the key benefits of HPMC packaging include²:

- Improved product stability: HPMC's barrier properties protect products from damage and extend their shelf life.

- Enhanced physical strength and durability: HPMC can be used as a coating or film-forming agent, providing a protective layer that improves the strength and resistance of the packaging.

- Sustainability: HPMC is biodegradable and compostable, making it an environmentally friendly option for packaging.

What is shelf life Of Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC? 

The shelf life of Hydroxypropyl Methyl Cellulose (HPMC) varies depending on the manufacturer and storage conditions, but typical shelf lives range from 1 to 2 years.

- Manufacturer-specific shelf life:

    - 1 year: Some manufacturers, like Sheng Da (China) New Materials Co., specify a shelf life of 1 year for their HPMC products.

    - 12 months: Hebei Yida Cellulose Co. Ltd. also specifies a shelf life of 12 months for their HPMC products.

    - 2 years: Kingmax Cellulose Co. Ltd. offers HPMC products with a shelf life of 24 months.

- Storage conditions: To ensure maximum shelf life, HPMC should be stored in a cool, dry place, away from moisture and direct sunlight. Room temperature storage is commonly recommended

It's essential to check the product label or consult with the manufacturer for specific shelf life information, as it may vary depending on the product's formulation and intended use.

What should the label claim for Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC   Include?

The label claim for Hydroxypropyl Methyl Cellulose (HPMC) should include:

- Product name and grade: Hydroxypropyl Methyl Cellulose (HPMC) and its specific grade or type.

- Viscosity specification: The viscosity range of the HPMC product.

- Chemical specifications: Methoxyl and hydroxypropoxyl content.

- Usage instructions: Directions for use, including recommended concentrations and applications.

- Storage conditions: Recommendations for storing the product to maintain its quality.

- Shelf life: The expiration date or shelf life of the product.

- Manufacturer's information: The name and contact details of the manufacturer or supplier.

- Safety information: Any relevant safety warnings or precautions.

- Regulatory compliance: Compliance with relevant standards or regulations.

The label should provide clear and accurate information to ensure the safe and effective use of HPMC.

Where can Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC are procured?

Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Hydroxypropyl Methyl  Cellulose(HPMC) Manufactured by MEDIOCON INC product, regardless of the procurement source.