VITAMIN C Manufactured Supplier Exporter by MEDIOCON INC

 

     VITAMIN C Manufactured by MEDIOCON INC     

Name: VITAMIN C

CAS No:  50-81-7

Molecular Weight: - β-Sitosterol: ~414.7 g/mol (C₂₉H₅₀O)

- α-Amyrone: ~426.7 g/mol (C₃₀H₅₀O)

- Quercetin: ~302.2 g/mol (C₁₅H₁₀O₇)

- 7-Oxo-stigmasterol (example keto-steroid): ~426.7 g/mol (C₂₉H₄₆O₂)

Molecular formula:   - β-Sitosterol: C₂₉H₅₀O

- α-Amyrone: C₃₀H₅₀O

- Quercetin: C₁₅H₁₀O₇

- 3-Keto Steroids (e.g., 7-oxo-stigmasterol): No specific CAS, varies.

Synonyms:  - Veldt Grape

- Devil’s Backbone

- Bone Setter (Hindi: Hadjod)

- Cissus Extract

- CQ Extract

- Asthisamharaka (Ayurvedic)

- Quadrangular Vine

Appearance:  - Fine Powder:

    - Color: Light brown to beige.

    - Texture: Free-flowing, slightly gritty.

    - Odor: Mild, characteristic herbal smell.

    - Taste: Bitter, astringent.

 Solubility :  - Partially Soluble in Water (~1–3 mg/mL, depending on pH).

- Soluble in:

    - Ethanol (20–50 mg/mL, 95%).

    - Methanol.

    - DMSO (dimethyl sulfoxide).

- Sparingly Soluble in:

    - Non-polar solvents (e.g., hexane, chloroform).

- pH Dependence:

    - Better solubility in slightly acidic to neutral pH (5–7).

Use :

- Bone Health:

    - Supports fracture healing, boosts collagen synthesis. 🌟

- Weight Management:

    - May reduce fat, curb appetite (ketosteroids).

- Joint & Inflammation Relief:

    - Anti-inflammatory, eases arthritis pain.

- Antioxidant Support:

    - Scavenges free radicals (quercetin).

- Digestive Health:

    - Traditionally for ulcers, gut health.

 How is  VITAMIN C manufactured by MEDIOCON INC Synthesized?

MEDIOCON INC manufactures Vitamin C (Ascorbic Acid) primarily through the Reichstein process, a well-established chemical synthesis. Here’s a concise breakdown:

- Key Steps:

    1. Starting Material:

    - D-Glucose (from corn starch) → hydrogenation → D-Sorbitol.

    2. Fermentation:

    - Acetobacter bacteria oxidize sorbitol → L-Sorbose (90–95% yield).

    3. Chemical Conversion:

    - Sorbose → 2-Keto-L-Gulonic Acid (2-KGA): Acetone protection, oxidation (NaOCl/KMnO₄).

    - 2-KGA → Ascorbic Acid: Esterification + Lactonization (HCl/MeOH, heat).

    4. Purification:

    - Crystallization (water/ethanol), filtration, drying → 99%+ pure crystals.

- Why This Process?

    - Scalable, Cost-Effective: ~60% overall yield.

    - Consistent Purity: Meets USP/EP standards.

- Challenges & Trends:

    - Environmental Impact: Chemical waste, energy use.

    - Shifts to Biotech: Genetically modified microbes (E. coli, yeast) → greener, 2-step fermentation (R&D focus).

- MEDIOCON INC Focus:

    - cGMP Compliance, strict HPLC testing.

    - Forms: Crystalline powder (API), tailored for tablets, liquids, etc.

 

 

What are the different  dosage forms  VITAMIN C Manufactured  by  MEDIOCON INC?

MEDIOCON INC’s Vitamin C (Ascorbic Acid) comes in these dosage forms:

- Oral Solids:

    - Tablets: 100 mg, 500 mg, 1,000 mg – plain or film-coated.

    - Chewable Tablets: 500 mg, 1,000 mg – flavors, sweeteners 😋.

    - Effervescent Tablets: 1,000 mg – fizzy in water, citrus twist 🥤.

    - Capsules: 500 mg, 1,000 mg – gelatin/vegetarian.

- Powder:

    - Sachets: 1 g, 2 g – mix in water/juice, travel-friendly 💧.

- Liquids:

    - Oral Syrup: 500 mg/5 mL – pediatric, flavors.

    - Drops: 100 mg/mL – graduated dropper, kids 👶.

    - IV Solution (Clinical): 500 mg/mL, 1,000 mg/mL – sterile, ampoules/vials 💉.

- Topical:

    - Creams/Gels (5–20%): 15 g, 30 g – skin brightening, opaque tubes 🌸.

 

Key Highlights:

- Strengths: 50–1,000 mg (oral), customizable.

- Excipients: No preservatives (orally), pH buffers (liquids), flavors (chewables).

- Packaging: Airtight, light-resistant (see 👈)

 How VITAMIN C Manufactured by MEDIOCON INC   Dosage Forms are prepared?

MEDIOCON INC’s Vitamin C (Ascorbic Acid) dosage forms are prepared with care to ensure stability and efficacy. Here’s a quick breakdown:

- Tablets (Oral/Chewable/Effervescent):

    - Process:

        - Mix: Vitamin C powder + excipients (binders, disintegrants, flavors).

        - Granulation: Wet/dry granulation for compression.

        - Compression: Form tablets (100–1,000 mg).

        - Coating (optional): Film/sugar coat for taste-masking.

    - Effervescent: Adds citric acid, sodium bicarbonate → fizzes in water 🥤.

- Capsules:

    - Fill: Vitamin C powder into gelatin/vegetable shells (500–1,000 mg).

    - Seal: Airtight, moisture-proof.

- Powder (Sachets):

    - Blend: Pure ascorbic acid + fillers (e.g., maltodextrin).

    - Pack: Single-dose foil sachets (1–2 g).

- Liquid (Syrup/Drops):

    - Dissolve: Vitamin C in water + stabilizers (e.g., citrates).

    - pH Adjust: ~3.5 (preserves potency).

    - Filter, Fill: Amber bottles, child-resistant caps.

- IV Solution (Clinical):

    - Sterile Dissolve: In water for injection + pH adjusters (5.5–7).

    - Filter (0.22 µm): Aseptic fill in vials/ampoules (500–1,000 mg/mL).

- Topical Creams/Gels (5–20%):

    - Mix: Ascorbic acid + emulsifiers, humectants (e.g., glycerin).

    - pH Adjust: ~3.5–5 (skin-friendly).

    - Fill: Opaque tubes (15–30 g).

 

Key Challenges & Fixes:

- Stability: Oxidation → antioxidants (EDTA), cool storage (<25°C), airtight packaging.

- pH: Acidic (3.5) → buffers for liquids, creams.

- Moisture: Hygroscopic → desiccants, moisture barriers.

- Compliance: cGMP, sterility (IV), no heavy metals.

 When should VITAMIN C Manufactured by MEDIOCON INC be taken?

 MEDIOCON INC’s Vitamin C (Ascorbic Acid)—here’s when to take it for max benefits 😊:

- Best Time:

    - With Meals: Reduces stomach upset (it’s acidic!). 🍴

    - Morning/Afternoon: Boosts energy, avoids sleep interference.

- Why Not At Night?

    - Mild diuretic → might disrupt sleep if sensitive.

    - Absorption’s fine anytime—just avoid empty stomach.

- Specific Needs:

    - Immunity Boost: 1,000 mg/day (split doses, meals).

    - Cold/Flu: 1,000–2,000 mg/day (consult doc for high doses).

    - Skincare (topical 5–20%): Night, clean skin 🌸.

    - Iron Absorption: Take with plant-based meals (e.g., lentils).

- Dosage Reminder:

    - RDA: 40–90 mg (adults). Supplements: ≤2,000 mg/day (avoid GI issues).

    - Consult a doc if pregnant, kidney issues, or on meds (e.g., blood thinners).

Which tests are performed on VITAMIN C Manufactured by  MEDIOCON INC ?

MEDIOCON INC’s Vitamin C (Ascorbic Acid) undergoes these key tests to ensure quality:

- 1. Assay (HPLC):

    - Purpose: Measures potency (99.0–101.0% of label claim).

    - Method: High-Performance Liquid Chromatography (UV detection).

- 2. Physical Tests:

    - Appearance: White to slightly yellow, crystalline powder.

    - Solubility: Checks water solubility (~330 mg/mL).

    - pH (1% solution): 2.1–2.6 (acidic).

- 3. Purity & Impurities:

    - Related Substances (HPLC): <0.5% (e.g., dehydroascorbic acid).

    - Heavy Metals: <10 ppm (Pb, Cd, Hg, As).

    - Residue on Ignition: <0.1%.

- 4. Microbial Limits:

    - Total Aerobic Count: <1,000 CFU/g.

    - E. coli, Salmonella, Yeast/Mold: Absent.

- 5. Identification:

    - IR Spectroscopy: Matches standard ascorbic acid spectrum.

    - Specific Rotation: +20.5° to +21.5° (1% solution).

- 6. Packaging Tests:

    - Leakage, Labeling: Airtight, light-resistant containers.

    - Stability Studies: Real-time/accelerated (25°C/40°C, 6–12 months).

- 7. Additional (dosage-specific):

    - Dissolution (Tablets): >80% in 30 mins (pH 1.2 buffer).

    - Sterility (IV): USP <71> compliant.

    - Uniformity (Tabs/Capsules): Weight/content variation.

What are the challenges in Manufacturing of VITAMIN C  Manufactured by MEDIOCON   INC API?

MEDIOCON INC’s Vitamin C (Ascorbic Acid) API manufacturing faces these key challenges:

- *1. *Oxidation & Degradation 🌟

    - Issue: Air, light, heat, metals (Fe, Cu) → loss of potency.

    - Fix: Airtight containers, antioxidants (e.g., EDTA), cool storage (<25°C).

- *2. *pH Sensitivity ⚖️

    - Issue: Unstable in alkaline (pH > 5) → degradation.

    - Fix: Acidic buffers (pH 3–4), stabilizers.

- *3. *Hygroscopic Nature 💧

    - Issue: Absorbs moisture → caking, hydrolysis.

    - Fix: Dry processing, desiccants, moisture-proof packaging.

- *4. *Cost & Scalability 💲

    - Issue: Reichstein process (6–7 steps) is energy-heavy, costly.

    - Trend: Exploring biotech fermentation (genetically modified microbes) → greener, cheaper.

- *5. *Purity & Impurities 🧪

    - Issue: Related substances (e.g., dehydroascorbic acid) → strict HPLC tests.

    - Fix: Optimize synthesis, refine purification.

- *6. *Regulatory Compliance 📜

    - Issue: cGMP, ICH Q7 → documentation, validation, audits.

    - Fix: Robust QC, batch tracking, certifications (USP, EP).

- *7. *Environmental Impact 🌎

    - Issue: Chemical waste, solvents → sustainability push.

    - Fix: Green chemistry, solvent recycling, bioprocesses.

What is the Packing for VITAMIN C Manufactured by MEDIOCON INC?

MEDIOCON INC’s Vitamin C (Ascorbic Acid) packing—here’s the lowdown 📦:

- Tablets/Capsules:

    - HDPE Bottles: 30/60/100/500 tabs, airtight, moisture-resistant.

    - Blister Packs: Alu-Alu or Alu-PVC, 10/14 tabs per strip.

    - Label: "Vitamin C, 500 mg", batch #, expiry, store cool & dry 🌟.

- Powder (Sachets):

    - Aluminum Foil Sachets: 1 g/2 g, 1/5/10 per box.

    - Outer Box: Printed, moisture-proof liner.

- Liquid (Syrup/Drops):

    - Amber Glass Bottles: 60/120 mL, child-resistant cap.

    - Dropper (drops): Graduated, tight seal.

    - Label: "Refrigerate, shake well".

- IV Solution (Clinical):

    - Glass Vials (10/20 mL): Rubber stopper, aluminum seal.

    - Carton: 1/5/10 vials, sterile, light-protected.

- Topical Creams/Gels:

    - Aluminum Tubes: 15/30 g, airtight, opaque.

    - Carton: Printed instructions.

- Bulk API:

    - HDPE Drums (25/50 kg): Double-lined polybags, sealed.

    - Label: "Store <25°C, protect light".

 

What is shelf life Of VITAMIN C Manufactured by MEDIOCON INC? 

MEDIOCON INC’s Vitamin C (Ascorbic Acid) typically has this shelf life, depending on the form:

- Tablets/Capsules:

    - 24–36 months (unopened, <25°C, 60% RH).

    - Open: Use within 1 year, keep airtight.

- Powder (Sachets):

    - 18–24 months (sealed, <25°C, dry).

    - Post-open: 1 month, reseal tightly.

- Liquid (Syrup/Oral Drops):

    - 12–18 months (unopened, 2–8°C ⬇️).

    - Open: 1 month (refrigerate), check clarity before use.

- IV Solution (Clinical):

    - 12–18 months (sealed, <25°C, dark).

    - Use immediately post-open, discard if cloudy.

- Topical Creams/Gels (5–20%):

    - 12–24 months (tube, <25°C, avoid sunlight).

    - Open: 6 months, check texture.

- Bulk API:

    - 36 months (sealed drums, <25°C, dry, dark).

 

Key Notes:

- Factors Affecting:

    - Oxidation (air/light/heat) → yellow/brown.

    - Moisture → caking (powder), fizz-loss (effervescents).

- Storage:

    - Airtight, cool (<25°C), dark.

    - No freezing (liquids).

- Tests:

    - HPLC assay (99–101% at expiry).

    - Re-test if >6 months open.

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find VITAMIN C Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for VITAMIN C manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of VITAMIN C Manufactured by MEDIOCON INC product, regardless of the procurement source.