Citrus Bergamot Extract 89957-91-5 Manufacturer Supplier Exporter MEDIOCON INC

  

 

Citrus Bergamot Extract Manufactured by MEDIOCON INC     

 

   Name: Citrus Bergamot Extract

CAS No:  89957-91-5

Molecular Weight: NA

Molecular formula:   NA

Synonyms:  Citrus bergamia, Bergamot orange.

Appearance a fine powder, ranging from light yellow to off-white, with a mild citrus aroma.

 Solubility :  soluble in alcohol and oils but generally insoluble in water.     

Use :

Citrus Bergamot Extract has numerous uses, primarily due to its antioxidant, anti-inflammatory, and cardiovascular-protective properties. Here are some of the key benefits:

Cardiovascular Health

- Lowers LDL ("bad") cholesterol and triglycerides while increasing HDL ("good") cholesterol

- Supports healthy blood sugar levels and insulin sensitivity

- Reduces inflammation and oxidative stress in blood vessels

Metabolic Syndrome and Weight Management

- Helps regulate blood sugar and improve insulin sensitivity

- Supports weight loss and reduces body mass index (BMI)

- May aid in reducing fatty liver accumulation

 

Antioxidant and Anti-Inflammatory Effects

- Neutralizes free radicals and reduces oxidative stress

- Down-regulates inflammatory signaling molecules and protects against tissue damage

- May help manage autoimmune diseases and chronic inflammation

Other Potential Benefits

- Supports liver health and detoxification

- May aid in managing anxiety and stress

- Possesses antimicrobial properties, useful for skin and digestive health

- May promote hair growth and improve skin conditions like acne

Forms and Usage

Citrus Bergamot Extract is available in various forms, including capsules, tablets, powders, and essential oils. The recommended dosage typically ranges from 500mg to 1000mg per day, standardized to specific flavonoid levels.

When incorporating Citrus Bergamot Extract into your routine, consider consulting with a healthcare professional to determine the best dosage and form for your individual needs.

 How is  Citrus Bergamot Extract manufactured by MEDIOCON INC Synthesized?

Citrus Bergamot Extract is synthesized through a process that involves extracting the bioactive compounds from the fruit's juice and albedo. Here's an overview of the synthesis process:

 

Extraction Methods

 

- Cold Pressing: Bergamot essential oil is obtained through mechanical manipulation (cold pressing) of the exocarp (flavedo) of the hesperidium of Citrus limon (L.) Osbeck Bergamot Group. This process releases the oil cavities embedded in the flavedo, resulting in a high-quality essential oil rich in limonene, linalyl acetate, and non-volatile oxygen heterocyclic compounds like bergapten.¹

- Solvent Extraction: Bergamot extract is also obtained through solvent extraction, which involves using solvents like ethanol or water to extract the flavonoids and other bioactive compounds from the fruit's juice and albedo.

- Supercritical Carbon Dioxide Extraction: This method uses high-pressure carbon dioxide to extract the bioactive compounds from the fruit, resulting in a high-quality extract with minimal degradation of sensitive compounds.

 

Standardization

The extracted compounds are then standardized to ensure consistent levels of bioactive compounds like neoeriocitrin, neohesperidin, and naringin. Bergamonte, a patented extract, is standardized to >38% polyphenolic flavanoids consisting of naringin, neohesperidin, neoeriocitrin, 1% melitidin, and 2% brutieridin.

Purification

The extract is then purified to remove impurities and improve its stability and bioavailability. This may involve various techniques like filtration, centrifugation, and chromatography.

Final Product

The final product is a high-quality Citrus Bergamot Extract powder or oil, rich in bioactive compounds like flavonoids, limonene, and linalyl acetate. This extract is used in various applications, including dietary supplements, food products, and cosmetics.

What are the different  dosage forms  of   Citrus Bergamot Extract Manufactured  by  MEDIOCON INC?

Citrus Bergamot Extract comes in various dosage forms to suit different needs and preferences. Here are some of the most common forms:

 

- Capsules: Convenient and precise dosing, typically containing 500-1500 mg of citrus bergamot extract. Look for standardized extracts with 38-50% polyphenols for optimal benefits.

- Powders: Mixable and flexible dosing, allowing you to adjust the amount according to your needs. Ensure the powder is standardized to the desired polyphenol content.

- Teas: A flavorful and enjoyable way to consume citrus bergamot, although the concentration of active compounds may be lower compared to extracts.

- Gummies: Chewable and tasty, often containing 500 mg of citrus bergamot extract per serving. Great for those who struggle with capsules or tablets.

- Softgels: May contain a combination of citrus bergamot extract with other ingredients like plant sterols, CoQ10, and omega-3s for comprehensive cardiovascular support.

- Liquid Extracts: Concentrated forms that can be mixed with water or other beverages, often used for flexibility in dosing.

- Essential Oils: Used in aromatherapy, but not typically for internal consumption due to potential skin sensitivity and other safety concerns.

 

When choosing a dosage form, consider factors like convenience, taste preferences, and your specific health goals. Always consult with a healthcare professional to determine the best dosage and form for your individual needs.

 How Citrus Bergamot Extract Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Citrus Bergamot Extract dosage forms are prepared in various ways to suit different needs and preferences. Here are some common forms and their preparation methods:

- Capsules: Typically contain 500-1500 mg of citrus bergamot extract, standardized to 38-50% polyphenols. The extract is filled into gelatin or vegetarian capsules, often with other ingredients like plant sterols, CoQ10, and omega-3s for comprehensive cardiovascular support.

- Powders: Mixable and flexible, powders can be measured to deliver 500-1500 mg of citrus bergamot extract per serving. They're often used in smoothies or beverages.

- Teas: Provide an enjoyable way to consume citrus bergamot, although the concentration of active compounds may be lower compared to extracts.

- Gummies: Chewable and tasty, gummies typically contain 500 mg of citrus bergamot extract per serving.

- Softgels: May contain a combination of citrus bergamot extract with other heart health-supporting ingredients.

- Liquid Extracts: Concentrated forms that can be mixed with water or other beverages, often used for flexibility in dosing.

When preparing citrus bergamot dosage forms, manufacturers follow specific guidelines to ensure consistency and efficacy. The extract is typically standardized to contain a certain percentage of bioactive compounds like neoeriocitrin, neohesperidin, and naringin.¹ ² ³

To ensure quality and safety, it's essential to choose products from reputable manufacturers that adhere to good manufacturing practices (GMPs) and provide clear labeling and instructions. Always consult with a healthcare professional before starting any new supplement regimen.

What are the appropriate Dosage forms of Citrus Bergamot Extract Manufactured  by  MEDIOCON   INC?                

Citrus Bergamot Extract comes in various dosage forms to suit different needs and preferences. Here are some common forms and their typical dosages:

- Capsules: 500-1500 mg per day, convenient for precise dosing and easy to incorporate into daily routines. Look for standardized extracts with 38-50% polyphenols for optimal benefits.

- Powders: 500-1500 mg per day, mixable and flexible, allowing you to adjust the amount according to your needs. Ensure the powder is standardized to the desired polyphenol content.

- Teas: A flavorful option, although the concentration of active compounds may be lower compared to extracts. Enjoy a warm beverage while reaping the benefits.

- Gummies: Chewable and tasty, typically containing 500 mg of citrus bergamot extract per serving. Great for those who struggle with capsules or tablets.

- Softgels: May contain a combination of citrus bergamot extract with other heart health-supporting ingredients like plant sterols, CoQ10, and omega-3s.

- Liquid Extracts: Concentrated forms that can be mixed with water or other beverages, often used for flexibility in dosing.

 

When choosing a dosage form, consider factors like convenience, taste preferences, and your specific health goals. Always consult with a healthcare professional to determine the best dosage and form for your individual needs.¹ ²

 

In terms of specific dosage recommendations, research suggests:

- Cholesterol reduction: 500-1000 mg per day for 4-12 weeks.

- Blood sugar control: 500-1000 mg per day for 3-6 months.

- Inflammation: 300-1300 mg per day for long-term benefits.

 

Remember to start with a lower dose and adjust based on your individual health needs and goals. Taking citrus bergamot with food can enhance absorption and minimize side effects.

When should Citrus Bergamot Extract Manufactured by MEDIOCON INC be taken?

Citrus Bergamot Extract can be taken at any time of day, but consistency is key. Consider the following:

- With Meals: Taking it with meals may enhance absorption and minimize potential gastrointestinal side effects.

- Morning or Evening: Some people prefer taking it in the morning to support cardiovascular health throughout the day, while others prefer the evening to aid in relaxation.

- Consistency: Take it at the same time every day to maintain consistent levels of flavonoids in your system.

 

When deciding on the best time, consider your:

- Health Goals: Align your intake with specific benefits, such as cardiovascular support or immune function.

- Daily Routine: Choose a time that fits seamlessly into your schedule.

- Personal Preference: Experiment with different times to find what works best for you.

 What are the effects And Side effects of Citrus Bergamot Extract Manufactured by MEDIOCON INC?

Citrus Bergamot Extract has several potential health benefits, including lowering LDL ("bad") cholesterol and triglycerides while increasing HDL ("good") cholesterol, supporting weight loss, and reducing inflammation. However, like any supplement, it may cause side effects in some individuals.¹ ² ³

 

Common Side Effects:

 

- Gastrointestinal Issues: Nausea, vomiting, diarrhea, stomach cramps, and bloating due to its high fiber content or sensitivity to citrus fruits.

- Headaches: Possibly due to its blood-pressure-lowering effect or allergic reactions.

- Dizziness: Caused by the fruit's potential to lower blood pressure or interact with medications.

- Muscle Pain: Inflammation or allergic reactions might contribute to muscle soreness.

- Allergic Reactions: Itching, swelling, rash, and difficulty breathing in rare cases.

 

Serious Side Effects (Rare):

 

- Liver Damage: Potential risk for individuals with pre-existing liver disease due to bergamottin's interference with liver enzyme function.

- Increased Risk of Bleeding: Interaction with blood thinners like warfarin may enhance bleeding risk.

- Hypoglycemia: Bergamot might lower blood sugar levels, requiring caution for individuals with diabetes.

 

Precautions and Interactions:

- Pregnancy and Breastfeeding: Limited research available; consult a healthcare professional before use.

- Medications: Potential interactions with statins, blood thinners, antihistamines, and diabetes medications.

- Surgery: Discontinue use at least 2 weeks prior to surgery due to potential effects on blood sugar control.⁴

To minimize side effects, start with a low dose (500-1000 mg daily) and consult a healthcare professional before adding Citrus Bergamot Extract to your regimen.

  How is Citrus Bergamot Extract Manufactured by MEDIOCON  INC  Tested Qualitatively?

Citrus Bergamot Extract is tested qualitatively using various analytical methods to identify and quantify its bioactive compounds. Here are some of the key approaches:

 

Targeted Analysis

 

- LC-ESI/MS: Liquid Chromatography-Electrospray Ionization/Mass Spectrometry is used to identify specific compounds like flavonoids, limonoids, and coumarins.

- HPLC-UV: High-Performance Liquid Chromatography-Ultraviolet spectroscopy detects major flavonoids like neoeriocitrin, naringin, neohesperidin, melitidin, and brutieridin.¹ ²

 

Semi-Targeted Analysis

 

- Selective Search: This approach identifies specific compounds like 3-hydroxy-3-methylglutarate (HMG) derivatives, which contribute to the cholesterol-lowering activity of bergamot extract.

 

Untargeted Analysis

 

- LC-HRMS: Liquid Chromatography-High Resolution Mass Spectrometry helps identify unknown compounds and provides a comprehensive profile of the extract's chemical composition.

 

Other Tests

- Total Phenolic Content: Folin-Ciocalteu colorimetric method measures the total phenolic content, which indicates the extract's antioxidant activity.

- Antioxidant Activity: ORAC, DPPH, and ABTS assays evaluate the extract's antioxidant capacity.

- Proanthocyanidin Analysis: Methods like protein precipitation and tannin effect evaluation detect proanthocyanidins, if present.³

When selecting a citrus bergamot supplement, look for products with third-party testing for purity, potency, and adulteration. Ensure the extract is standardized to at least 38% Bergamot Polyphenol Fraction (BPF), which includes key polyphenols like neoeriocitrin, naringin, neohesperidin, brutieridin, and melitidin.

   Which tests are performed on Citrus Bergamot Extract Manufactured by  MEDIOCON INC ?

Citrus Bergamot Extract undergoes various tests to ensure its quality, purity, and efficacy. Here are some of the key tests performed:

Physical and Chemical Tests

- Total Polyphenol Content: Measures the overall antioxidant activity using the Folin-Ciocalteu colorimetric method.

- Flavonoid Profile: High-Performance Liquid Chromatography (HPLC) or Liquid Chromatography-Mass Spectrometry (LC-MS) analysis detects specific flavonoids like neoeriocitrin, naringin, and neohesperidin.

- HPLC-DAD-MS/MS: Identifies and quantifies individual flavonoids and other compounds.¹ ²

Biological Activity Tests

- Antioxidant Activity: Evaluates the extract's ability to neutralize free radicals using assays like ORAC, DPPH, and ABTS.

- Antimicrobial Activity: Tests the extract's effectiveness against pathogenic bacteria and its impact on beneficial gut bacteria.

- Lipid Profile Analysis: Measures the extract's ability to reduce total cholesterol, LDL-C, and triglycerides, and increase HDL-C levels.³

Clinical Tests

- Randomized Controlled Trials (RCTs): Assess the extract's efficacy and safety in humans, often measuring outcomes like lipid profiles, glucose metabolism, and liver enzymes.

- Double-Blind Placebo-Controlled Studies: Evaluate the extract's effects on cardiovascular health, metabolic syndrome, and other health conditions.⁴

Quality Control Tests

- Third-Party Testing: Verifies the product's purity, potency, and authenticity.

- Standardization: Ensures consistent levels of active compounds, like Bergamot Polyphenol Fraction (BPF), across batches.⁵

These tests help ensure the quality and efficacy of Citrus Bergamot Extract products, providing consumers with confidence in their potential health benefits.

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing Banana Extract API (Active Pharmaceutical Ingredient) poses several challenges that can be broadly categorized into raw material sourcing, extraction and processing, quality control, regulatory compliance, and market dynamics.

 

Raw Material Sourcing

 

Sourcing high-quality banana raw materials is crucial for producing consistent and effective extracts. Variability in banana quality, availability, and seasonality can impact the extraction process and final product quality. Ensuring sustainable and reliable sourcing practices is essential to mitigate these challenges.¹

 

Extraction and Processing

 

The extraction process itself presents several challenges, including:

- Optimizing Extraction Methods: Choosing the most effective extraction method, such as solvent extraction, cold pressing, or supercritical carbon dioxide extraction, requires careful consideration of factors like yield, cost, and product quality.

- Equipment Maintenance: Regular maintenance of extraction equipment is vital to prevent contamination, ensure consistent quality, and minimize downtime.

- Scalability: Scaling up extraction processes while maintaining efficiency and product quality can be a significant challenge.

 

Quality Control

Ensuring the quality and consistency of Banana Extract API is critical for pharmaceutical applications. Quality control measures include:

- Standardization: Standardizing the extract to specific levels of bioactive compounds, such as polyphenols or flavonoids.

- Contamination Control: Preventing contamination from heavy metals, pesticides, or microorganisms requires stringent quality control protocols.

- Stability Testing: Conducting stability testing to ensure the extract's shelf life and potency.

Regulatory Compliance

Banana Extract API manufacturers must comply with regulatory requirements, including Good Manufacturing Practices (GMP) and international standards. Ensuring compliance with evolving regulations and maintaining necessary certifications can be a challenge.²

Market Dynamics

The market for Banana Extract API is influenced by factors like demand for natural products, competition from synthetic alternatives, and fluctuations in raw material prices. Manufacturers must stay competitive by investing in research and development, improving process efficiency, and adapting to changing market trends.

Addressing these challenges requires a comprehensive approach, including investing in technology, process optimization, quality control, and regulatory compliance. By understanding and mitigating these challenges, manufacturers can ensure the production of high-quality Banana Extract API that meets pharmaceutical standards.

What are the challenges in manufacturing of Citrus Bergamot Extract Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Citrus Bergamot Extract dosage forms comes with several challenges that can impact product quality, efficacy, and safety. Some of the key challenges include:

 

Quality Control and Standardization

 

Ensuring consistency in bioactive content and efficacy across batches can be difficult due to variations in sourcing, extraction methods, and formulation. This variability can undermine consumer trust and regulatory compliance.¹

 

Raw Material Sourcing

 

Sourcing high-quality Citrus Bergamot raw materials is crucial, and variability in quality, availability, and seasonality can impact extraction and final product quality.

 

Extraction and Processing

 

Optimizing extraction methods, maintaining equipment, and scaling up production while ensuring efficiency and product quality can be significant challenges.

 

Regulatory Compliance

 

Manufacturers must adhere to Good Manufacturing Practices (GMP) and international standards, which can be complex and time-consuming.

 

Stability and Bioavailability

Citrus Bergamot Extract's stability and bioavailability can be affected by factors like pH, temperature, and light, which may impact its efficacy.

Potential Interactions and Side Effects

Citrus Bergamot Extract may interact with certain medications or exacerbate conditions like photosensitivity, so manufacturers must ensure clear labeling and instructions.

Adulteration and Contamination

Ensuring the authenticity and purity of Citrus Bergamot Extract is crucial, as adulteration with other citrus fruits or contaminants can compromise product quality and safety.²

Dosage Form-Specific Challenges

Different dosage forms, such as liquids, solids, or gummies, present unique manufacturing challenges, like stability issues, microbial contamination, or particle aggregation.³

Addressing these challenges requires a comprehensive approach, including investing in technology, process optimization, quality control, and regulatory compliance. By understanding and mitigating these challenges, manufacturers can ensure the production of high-quality Citrus Bergamot Extract dosage forms that meet consumer expectations and regulatory standards.

What is the Packing for Citrus Bergamot Extract Manufactured by MEDIOCON INC?

Citrus Bergamot Extract packing varies depending on the manufacturer and product specifications. Here are some common packaging options:

- Bottle Packaging: Many brands package their Citrus Bergamot Extract supplements in bottles, typically containing 60, 90, or 120 capsules. Each capsule usually has a specified amount of Citrus Bergamot Extract, such as 500mg, 1000mg, or 1400mg.

- Capsule Packaging: Citrus Bergamot Extract is often packaged in capsule form, with each capsule containing a concentrated dose of the extract. The capsules may be made from vegetarian or gelatin materials and are often designed for easy swallowing.

- Pack of 1: Most products come in a single pack containing the specified number of capsules or quantity of extract.

 

Some examples of Citrus Bergamot Extract packaging include¹ ² ³:

- StayAlive Citrus Bergamot Capsules: 120 capsules per bottle, with each capsule containing 250mg of Citrus Bergamot Extract (equivalent to 30,000mg).

- Humming Herbs Citrus Bergamot: 90 capsules per bottle, with each capsule containing 1100mg of Citrus Bergamot Extract.

- Citrus Bergamot Supplement: 60 capsules per bottle, with each capsule containing 1000mg of Citrus Bergamot Extract.

 

When purchasing Citrus Bergamot Extract, ensure to check the product label for packaging details, storage instructions, and shelf life to maintain product potency and safety.

What is shelf life Of Citrus Bergamot Extract Manufactured by MEDIOCON INC? 

Citrus Bergamot Extract's shelf life varies depending on the product formulation, storage conditions, and packaging. Generally, it can last anywhere from 6 months to 2 years or more if stored properly.

 

Typical Shelf Life Ranges:

 

- Powdered Extracts: 24 months when stored in vacuum-sealed bottles or drums, maintaining freshness and potency.

- Liquid Extracts: 6 months or longer if stored in cool, dry places in tightly sealed containers, protected from heat and light.

- Capsules: 24 months when kept in a cool, dry, dark location in tightly sealed containers.

 

Factors Affecting Shelf Life:

- Exposure to light, temperature changes, and air can degrade the extract's quality.

- Storage conditions, such as humidity and temperature, play a significant role in determining shelf life.

- Packaging quality and material can impact the extract's stability and longevity.¹ ² ³

Storage Tips:

- Store in airtight, dark glass containers to minimize oxidation.

- Keep in a cool, dry place, away from direct sunlight.

- Refrigeration can help extend shelf life.

It's essential to check the product label or manufacturer's guidelines for specific shelf life recommendations, as formulations and storage requirements may vary.

What should the label claim for Citrus Bergamot Extract Manufactured by MEDIOCON INC   Include?

The label claim for Citrus Bergamot Extract should include the following information:

Essential Information1. Product Name: Clearly state the product name, e.g., "Citrus Bergamot Extract".

2. Active Ingredients: Specify the active compounds, such as "Bergamot Polyphenol Fraction (BPF)" or "Neoeriocitrin, Naringin, Neohesperidin".

3. Concentration: Indicate the concentration of active compounds, e.g., "38% Polyphenols" or "500mg per serving".

4. Serving Size: Specify the recommended serving size, e.g., "1 capsule per day".

Health Benefits1. Cardiovascular Health: Claim support for healthy cholesterol levels, triglycerides, or blood pressure.

2. Antioxidant Properties: Mention antioxidant activity, free radical scavenging, or oxidative stress reduction.

3. Weight Management: Claim support for weight loss, appetite control, or metabolic health.

Safety and Precautions1. Allergen Warning: Indicate potential allergens, e.g., "Contains citrus".

2. Interactions: Warn about potential interactions with medications, e.g., "Consult a healthcare professional if taking statins".

3. Pregnancy and Lactation: Advise caution for pregnant or breastfeeding women.

Regulatory Compliance1. GMP Compliance: State compliance with Good Manufacturing Practices (GMP).

2. Third-Party Testing: Mention third-party testing for purity, potency, and contaminants.

Additional Information1. Storage Instructions: Provide storage guidelines, e.g., "Store in a cool, dry place".

2. Expiration Date: Include the expiration date or shelf life.

3. Manufacturer Information: Provide manufacturer details, including name, address, and contact information.

Where can Citrus Bergamot Extract Manufactured by MEDIOCON INC are procured?

Citrus Bergamot Extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Citrus Bergamot Extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Citrus Bergamot Extract Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Citrus Bergamot Extract Manufactured by MEDIOCON INC product, regardless of the procurement source.