Diaminomaleonitrile 98% 1187-42-4 Manufacturer ,supplier, exporter
Diaminomaleonitrile 98%Manufactured
by MEDIOCON INC
Name: Diaminomaleonitrile 98%
CAS No 1187-42-4
Molecular Weight: 108.10 g/mol
Molecular formula: C₄H₄N₄ (alternatively written as NCC(NH2)=C(NH2)CN)
o
Synonyms: 2,3-Diaminomaleonitrile
o
DAMN
o
Hydrogen
cyanide tetramer
o
Maleonitrile,
diamino-
o
(Z)-2,3-diaminobut-2-enedinitrile
Appearance: Typically a brown crystalline powder, though some
sources list it as a white solid
o
Solubility : Water: Soluble (around 5 g/L at 25°C)
o
Other
solvents: Soluble in methanol,
ethanol, DMF, and dimethyl sulfoxide; slightly soluble in ethyl ether and
dioxane; insoluble in benzene, acetone, xylene, toluene, and CS₂
Use :
It is
primarily used as a key intermediate and versatile building block in the
synthesis of complex organic molecules. Specific applications include:
o
Synthesis
of 1,4-diazepine-2,3-dicarbonitrile derivatives
o
Production
of pigments and dyes for textiles, plastics, and printing inks
o
Research
in medicinal applications due to potential biological activity
o
Development
of new pesticides, herbicides, or other agrochemicals
.
How is Diaminomaleonitrile
98%manufactured by MEDIOCON INC Synthesized?
Diaminomaleonitrile (DAMN) is generally synthesized
by the tetramerization of hydrogen cyanide (HCN), typically in the
presence of a basic catalyst and a solvent. MEDIOCON INC, as a manufacturer and
wholesaler of the 98% pure product, likely uses a variation of this established
industrial process.
Common industrial synthesis methods include:
·
HCN
Polymerization: This
is the most common method, where HCN is polymerized in a liquid phase. The
process often uses a polar aprotic solvent, such as dimethylsulfoxide (DMSO) or
dimethylformamide (DMF), and a basic catalyst like sodium cyanide (NaCN),
potassium cyanide (KCN), or a tertiary amine. The reaction is generally
conducted under controlled temperature (often between -40°C and 70°C) and
pressure conditions to achieve optimal yields and prevent the formation of
undesired polymers.
·
From
Ketone Cyanohydrin: Another
method involves reacting a ketone cyanohydrin (such as acetone cyanohydrin) to
produce DAMN. This reaction can also be carried out in the presence of a
catalyst and potentially an organic mercaptan co-catalyst to improve the yield.
·
From Aminomalononitrile: DAMN can also be prepared by the cyanation of
aminomalononitrile.
What are the
different dosage forms of Diaminomaleonitrile
98%Manufactured by MEDIOCON INC?
Diaminomaleonitrile (DAMN) 98% manufactured by
MEDIOCON INC is supplied as a solid,
crystalline powder. It is a chemical intermediate used in synthesis and
research, not a finished pharmaceutical product with established medicinal
dosage forms.
MEDIOCON INC and other suppliers typically provide
this product in standard chemical packaging for industrial or laboratory use,
such as:
·
Glass
bottles
·
Foil
bags
·
HDPE
drums
Diaminomaleonitrile is primarily used as a
versatile intermediate in organic synthesis for the production of various
heterocyclic compounds, pharmaceuticals, agrochemicals, and specialty
chemicals. It is a raw material for other manufacturing processes and is not
intended for direct use as a medication in a specific dosage form (e.g.,
tablet, capsule, cream, injection).
How Diaminomaleonitrile 98%Manufactured
by MEDIOCON INC Dosage Forms are prepared?
MEDIOCON INC is a manufacturer and wholesaler of
pharmaceutical intermediates, including Diaminomaleonitrile (DAMN) 98%. The
company supplies the active pharmaceutical ingredient (API) in
bulk form (likely powder) to other manufacturers, who then process it into
specific dosage forms.
The preparation of dosage forms from an API like
DAMN generally involves specialized pharmaceutical manufacturing techniques,
but the specific process is determined by the final intended product (e.g.,
tablet, capsule, or liquid). MEDIOCON INC would not typically be involved in
these final steps.
General
Methods for Preparing Dosage Forms from an API
Once the high-purity (98%) DAMN intermediate is
synthesized, purified, and provided as a solid, usually crystalline or powder,
subsequent processing into dosage forms involves these general methods:
·
Solid
Dosage Forms (Tablets, Capsules): The
DAMN powder would be mixed with excipients (binders, fillers, disintegrants,
lubricants, etc.). This mixture could then be directly compressed into tablets
using tablet press machines or filled into capsule shells, typically made of
gelatin, using manual or automatic capsule-filling machines. Granulation
processes (wet or dry) may be employed to improve the flow and compression
properties of the powder mixture before tableting or encapsulation.
·
Liquid
Dosage Forms (Solutions, Suspensions): For
liquid forms, the DAMN would be dissolved or suspended in a suitable solvent
system (e.g., water, alcohol, or a mixture) along with necessary additives like
buffers, colorants, sweeteners, and flavoring agents. This process requires
strict control, especially for sterile products like ophthalmic or parenteral
(injectable) solutions, which need an aseptic environment.
·
Specialized
Techniques: For specific drug
delivery profiles, techniques like hot melt extrusion (HME) might be used,
where the API is dispersed into a polymer matrix to create solid dispersions
that enhance bioavailability or provide controlled release.
What are the appropriate Dosage forms
of Diaminomaleonitrile 98%Manufactured by MEDIOCON INC?
Diaminomaleonitrile 98%is available in
various dosage forms, including [1][2]:
- Oral Tablets: For supplementation or
therapeutic use
- Capsules: For oral administration
- Powder: For use in food products,
cosmetics, or pharmaceuticals
- Granules: For food products or
pharmaceutical applications
The choice of dosage form depends on the
intended use, industry, and desired release profile.
When should Diaminomaleonitrile 98%Manufactured
by MEDIOCON INC be taken?
Diaminomaleonitrile (DAMN) (98% from MEDIOCON INC) is a pure chemical intermediate, not a
medicine to be "taken" by a person, but a building block used by
chemists in labs or industry for creating pharmaceuticals, agrochemicals, and
other specialty chemicals. You use it in specific chemical reactions, often dissolved
in solvents like water, DMSO, or ethanol, to synthesize new, more complex
molecules, so the "when" depends entirely on the scientist's reaction
schedule, not a patient's dosing time.
Key Uses
& Handling:
·
Chemical
Synthesis: It's a crucial precursor
for creating active pharmaceutical ingredients (APIs) and other organic
compounds.
·
Research: Used in organic chemistry labs for developing
new materials or drugs.
·
Solubility: It dissolves in water and polar solvents
(like methanol, ethanol, DMSO) for reactions.
·
Form: Typically a solid powder, often orange to
dark brown.
In
short, you don't "take" it; your chemist uses it to make something
else!.
·
Diaminomaleonitrile
at Best Price High-Purity Organic Intermediate
What are the effects And Side effects
of Diaminomaleonitrile 98%Manufactured by MEDIOCON INC?
Diaminomaleonitrile 98%is generally
considered safe when consumed in food amounts. However, there isn't enough
reliable information to determine its safety or potential side effects when
used in medicinal amounts.¹
Some possible uses of Diaminomaleonitrile
98%include:
- Symptoms of Menopause: Relief from
menopause symptoms
- Obesity: Weight management
- Rheumatoid Arthritis (RA): Management of
RA symptoms
- Sexual Problems: Addressing sexual satisfaction
issues
If you're considering taking Diaminomaleonitrile
98%supplements, consult a healthcare professional to discuss potential benefits
and risks.
In contrast, metoprolol succinate, a
different medication, has known side effects like² ³ ⁴:
- Common Side Effects: Tiredness,
dizziness, depression, diarrhea, shortness of breath, bradycardia, and rash
- Serious Side Effects: Severe heart
problems, respiratory issues, and depression
Always consult a healthcare professional
before taking any medication or supplement.
How is Diaminomaleonitrile
98%Manufactured by MEDIOCON INC Tested Qualitatively?
Diaminomaleonitrile 98%is tested
qualitatively using several methods.
- Flame Test: Calcium ions produce an
orange-red flame color.
- Precipitation Reaction: Adding ammonium
oxalate to a calcium solution forms a white precipitate of calcium oxalate.
- Carbonate Test: Adding ammonium carbonate
to a calcium solution forms a white precipitate of calcium carbonate, which is
soluble in acetic acid.
These tests help identify the presence of
calcium ions in a sample.
Which tests are
performed on Diaminomaleonitrile 98%Manufactured by MEDIOCON INC ?
Several tests are performed on Diaminomaleonitrile
98%to ensure its quality and purity:
- Identification Tests: Flame test,
precipitation reaction, and carbonate test to confirm calcium presence
- Purity Tests: Assay, heavy metals, and
impurities testing
- Physical Tests: Particle size, bulk
density, and flowability testing
- Microbiological Tests: Total viable count,
yeast and mold count, and pathogens testing
Specific tests may include [1][2]:
- Assay: Titration or HPLC to determine Diaminomaleonitrile
98%content
- Heavy Metals: Atomic absorption
spectroscopy (AAS) or inductively coupled plasma (ICP) testing
- Related Substances: HPLC or TLC testing
for impurities
What are the challenges in
Manufacturing of Banana Extract Manufactured by MEDIOCON INC
API?
Manufacturing
banana extract as an API (Active Pharmaceutical Ingredient) faces challenges
like maintaining
consistent quality & purity (impurities from raw
bananas/processes), scaling
up without introducing new issues, ensuring sustainability (solvent
use, waste), optimizing
extraction efficiency (yield vs. cost), and handling raw material variability (seasonal/regional
differences) while adhering to strict GMP/regulatory standards, all crucial
for effective APIs.
Here are the
specific challenges:
1. Quality
& Consistency (Batch-to-Batch):
·
Natural Variability: Banana quality changes with ripeness, variety, growing
conditions, affecting extract consistency.
·
Impurity Control: Scaling up can create new impurities; rigorous testing
needed to remove undesirable compounds.
·
Stability: Ensuring the extract's active compounds remain stable
during processing and storage.
2. Extraction Process Efficiency:
·
Yield vs. Purity: Balancing high extraction yield with high purity levels, a
key challenge in natural product extraction.
·
Solvent Use & Recovery: Using solvents (like ethanol) efficiently, recycling them,
and minimizing environmental impact.
·
Process Optimization: Finding ideal conditions (pH, temperature, enzymes) for
extraction/hydrolysis to maximize active compound recovery.
3. Scale-Up &
Engineering:
·
Unexpected Outcomes: Processes working in the lab might fail or produce
different results at industrial scale.
·
Equipment & Footprint: Large facilities, specific cleanroom needs, and long cycle
times are typical for APIs.
4. Sustainability &
Waste:
·
Biomass Waste: Banana cultivation generates significant waste (peels,
stems) that needs management or valorization.
·
Environmental Impact: Reducing energy use, solvent waste, and the overall
footprint of API production.
5. Regulatory & Documentation:
·
API Standards: Strict Good Manufacturing Practices (GMP) and FDA/EMA
regulations for APIs must be met, demanding extensive documentation.
6. Supply Chain & Sourcing:
·
Reliable Supply: Ensuring a consistent, high-quality supply of raw bananas,
especially with climate change impacting crops.
In essence, MEDIOCON INC, like any API manufacturer, must
overcome technical, economic, and regulatory hurdles to produce a reliable,
safe, and effective banana extract.
What are the challenges in
manufacturing of Diaminomaleonitrile 98%Manufactured by MEDIOCON INC
’s Dosage forms?
Diaminomaleonitrile (DAMN) 98% manufactured by
MEDIOCON INC is primarily a chemical intermediate used in
organic synthesis, not an active pharmaceutical ingredient (API) in an approved
commercial dosage form. MEDIOCON INC is a known supplier of pharma
intermediates.
The primary challenges in working with DAMN for any
potential downstream application, including the theoretical development of a
dosage form, stem from its inherent chemical properties and the complexities of
its reactions.
Key
Manufacturing Challenges
·
Instability
and Secondary Reactions: DAMN
is a highly reactive compound that readily undergoes various reactions,
including hydrolysis, oxidation, and polymerization, especially in aqueous and
protic solvent environments or when exposed to heat and UV light. This makes
typical pharmaceutical processes like aqueous granulation or film coating very
challenging, as the drug substance itself may degrade or transform into other
compounds.
·
Solubility
Issues: DAMN's solubility
varies significantly by solvent and temperature.
o
It is
only partially soluble in water, which complicates the development of
formulations that require aqueous processes.
o
While
soluble in some organic solvents like acetonitrile (MeCN) or DMSO, achieving
optimal processing conditions (temperature, solvent choice) while maintaining
stability and high yield is difficult.
·
Purity
Control: The tendency for side
reactions means maintaining high purity (the "98%" product is the
starting material for other syntheses) in a final dosage form is difficult.
Impurities or related compounds like DAFN (an isomer) or DISN (an oxidation
product) can form during processing, which is a major concern for
pharmaceutical quality control and regulatory compliance.
·
Processing
Conditions Sensitivity: Effective
polymerization or reaction of DAMN often requires specific, sometimes harsh,
conditions (e.g., high heat up to 170°C, strong thermal impulse) which are
generally incompatible with typical, milder pharmaceutical manufacturing
techniques for finished dosage forms.
·
Lack of
Established Pharmaceutical Use: As
it is primarily a chemical intermediate, there is a lack of established
"pharma
What is the Packing for Diaminomaleonitrile
98%Manufactured by MEDIOCON INC?
For
Diaminomaleonitrile (DAMN) 98%, manufacturers like MEDIOCON (through
distributors) often pack it as a crystalline powder in standard lab/industrial
sizes, commonly in 25g, 100g, and 1kg quantities,
typically in glass
bottles or fiber
drums, with larger bulk orders in 25 kg drums, ensuring
secure packaging for handling and transport, often under UN 3439
classification.
Common
Packaging Details:
·
Container Type: Glass bottles for smaller quantities, sealed fiber drums for
larger amounts.
·
Quantity: Available
in 25g, 100g, 1kg, and even 25kg drums.
·
Form: White to
pale yellow crystalline powder.
·
Safety: Classified
as a hazardous material (UN 3439, Class 6.1, Packing Group III).
What is shelf life Of Diaminomaleonitrile
98%Manufactured by MEDIOCON INC?
For Diaminomaleonitrile (DAMN)
98% from suppliers like Angle Bio Pharma (potentially related to Mediocon), a
typical shelf life under recommended storage (cool, dry place) is 24 months (2 years),
but this is specific to the manufacturer's stability data; always check the
Certificate of Analysis (CoA) or label for the exact expiry date from MEDIOCON INC for
confirmation.
Key Points:
·
General Stability: DAMN is a stable crystalline powder, but its shelf life
depends on storage.
·
Manufacturer Specific: The exact expiry date is set by the manufacturer (MEDIOCON
INC in your case) based on their stability testing.
·
Check Your Product: The most reliable source is the product's label or CoA for
the assigned expiry date or retest date, notes this
article from Amplelogic
The label claim for Diaminomaleonitrile 98%should
include the following information¹ ² ³:
- Statement of Identity: Clearly indicate
What should the label claim for Diaminomaleonitrile
98%Manufactured by MEDIOCON INC Include?
For a label claim of Diaminomaleonitrile
(DAMN) 98% by
MEDIOCON
INC, you need to include its identity (Name, CAS No. 1187-42-4), purity
(98%), manufacturer details (MEDIOCON INC, Aurangabad, India), and critical
safety info like GHS pictograms (Toxic/Irritant), Hazard Statements (H-codes),
Precautionary Statements (P-codes), physical state (solid powder), and basic
properties (Molecular Formula:
C4H4N4cap C sub 4 cap H sub 4 cap N sub 4
𝐶4𝐻4𝑁4
, MW: 108.10 g/mol, MP: ~178-182°C) for
safe handling, storage, and emergency response, as it's a key intermediate for pharmaceuticals/agrochemicals.
Key Label Information:
- Product Name: Diaminomaleonitrile (DAMN)
- Purity/Assay: ≥98% (or 98%)
- Manufacturer: Manufactured by MEDIOCON INC
- CAS Number: 1187-42-4
- Molecular Formula:
C4H4N4cap C sub 4 cap H sub 4 cap N sub 4
𝐶4𝐻4𝑁4
- Molecular Weight: 108.10 g/mol
- Appearance/Form: Solid/Powder
- Melting Point: 178-182 °C (decomposes)
- GHS Pictograms: Skull & Crossbones (Acute Toxicity) or
Exclamation Mark (Irritant).
- Hazard Statements (H-codes): Likely H301/H311/H331 (Toxic if swallowed/in
contact with skin/inhaled) or H302/H312/H332 (Harmful) and H315/H319/H335
(Skin/Eye Irritation).
- Precautionary Statements (P-codes): P261 (Avoid breathing dust), P280 (Wear
protective gloves/clothing/eye protection), P301+P310 (IF SWALLOWED: Immediately
call a POISON CENTER/doctor).
- Supplier/Distributor Info: MEDIOCON INC.
- Batch/Lot Number: For traceability.
Where can Diaminomaleonitrile 98%Manufactured
by MEDIOCON INC are procured?
Diaminomaleonitrile 98%Manufactured by
MEDIOCON INC can be procured from various sources, depending
on your location and requirements. Here are some options:
FOR API
MEDIOCON INC
Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO
CHATRAPATI SAMBHAJI NAGAR-431003,
MAHARASHTRA, INDIA
Mob/Whatsapp No:
+91-8007719681, +91-9309999757, +91-9834786939
Sales Department: Email: sales@mediocon.com
Purchase Department: Email: purchase@mediocon.com
Marketing Department: Email: mktg@mediocon.com
HR Department: Email: hr@mediocon.com
Accounts Department: Email: accounts@mediocon.com
Factory Address: Plot No 11, Shendra MIDC,
Aurangabad-431154, Maharashtra, India Website: www.mediocon.com
Email id:info@mediocon.com
GST No: 27DHUPM2366D1ZZ
For Dosage Forms :
- Online Marketplaces: You can find Diaminomaleonitrile
98%Manufactured by MEDIOCON INC products on online
marketplaces like Amazon or e- commerce websites specializing in
pharmaceuticals or skincare products.
Local Pharmacies or Skincare Stores: You
can also check with local pharmacies or skincare stores in your area for Diaminomaleonitrile
98%Manufactured by MEDIOCON INC products.
Remember to ensure the quality and
authenticity of the Diaminomaleonitrile 98%Manufactured by MEDIOCON INC
product, regardless of the procurement source.
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