Viburnum Opulus Extract Manufacturer Supplier Exporter MEDIOCON INC.

 

 

 

Viburnum Opulus Extract Manufactured by MEDIOCON INC

 

   Name: Viburnum Opulus Extract

CAS No:   90131-98-9

Molecular Weight:  NA

Molecular formula:  NA

·       Synonyms:  Cramp Bark, Guelder Rose, European Cranberrybush, High Cranberry, Water Elder, Snowball Tree, Cortex Viburni, Gilaburu.

 Appearance: a reddish liquid or powder, often with a strong, bitter, astringent smell and taste, ranging from dark red/brownish (fruit) to lighter tones

 Solubility : The solubility of Viburnum opulus (cramp bark or guelder-rose) extract varies significantly depending on the solvent used and the specific part of the plant extracted (berries, bark, or flowers), as the extract contains a complex mixture of compounds with differing polarities. 

Uses : Traditional and Homeopathic Uses

In traditional herbal medicine and homeopathy, Viburnum opulus extract is used for: 

·       Menstrual Pain (Dysmenorrhea): It is widely used to ease painful abdominal and pelvic cramps associated with menstruation.

·       Pregnancy and Postpartum Support: Traditionally, it has been used to help prevent habitual miscarriages, alleviate cramps and spasms during pregnancy, and provide relief from after-birth pains and excessive bleeding postpartum.

·       Muscle Spasms: Its antispasmodic properties are applied to various types of muscle tension and spasms throughout the body, including skeletal muscles, the gastrointestinal tract, and the bronchial system.

·       Urinary and Kidney Issues: The extract has been used to treat urinary conditions involving pain or spasms and to support healthy kidney function. The fruit is high in citrate, which may help prevent kidney stones.

·       Other Conditions: In traditional use, it has been applied to a range of other ailments, including high blood pressure, asthma, anxiety, tension headaches, and nervous disorders. 

Scientific Evidence and Modern Research

While Viburnum opulus has a long history of traditional use, scientific evidence supporting these uses in humans is limited, and most studies have been conducted in test tubes or on animals. 

·       Antispasmodic Action: The plant contains bioactive compounds like scopoletin and viopudial, which are believed to be responsible for its muscle-relaxant effects.

·       Antioxidant Properties: Extracts from the plant's bark, leaves, and berries are rich in antioxidants such as phenolic compounds and vitamin C, which can protect cells from damage and have potential anti-inflammatory, anti-diabetic, and cardioprotective effects in cell and animal studies.

·       Kidney Stones: A study in humans with small kidney stones showed promising results, where patients taking Viburnum opulus extract alongside standard medication passed stones more quickly and required less pain medication. 

Important Note: Viburnum opulus extracts are often sold as homeopathic remedies, which are not evaluated by the FDA for safety or efficacy. The information presented here is for informational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare professional before using Viburnum opulus extract for any health condition. 

 

  How Viburnum Opulus Extract is manufactured by MEDIOCON INC Synthesized?

Viburnum opulus (guelder-rose/gilaburu) extracts are made by extracting natural compounds (like chlorogenic acid) from its fruits/bark using methods like solvent extraction (water, acetone, ethanol) or fermentation, followed by purification/concentration, not by true chemical synthesis, to capture the plant's beneficial phytochemicals for uses like anti-cramp remedies or nanoparticle synthesis. 

General Manufacturing of Viburnum opulus Extracts in MEDIOCON :

1.      Raw Material Collection & Preparation: Fruits (often fermented) or bark are gathered, dried, and powdered.

2.      Extraction (Solvent-Based):

·       Water Extraction: A common method involves boiling or macerating plant material in distilled water, as seen in some studies.

·       Organic Solvents: Acetone, ethanol, or methanol are used to pull out specific phenolic compounds (like flavonoids, tannins).

·       Soxhlet Extraction: A continuous extraction method using a solvent to efficiently pull compounds.

3.      Concentration/Purification: Extracts are often concentrated using evaporation (e.g., rotary evaporator) under low pressure to remove solvents and increase potency, yielding a potent liquid or powder.

4.      Formulation: The extract can be further processed into different forms, such as:

·       Orodispersible Films (ODFs): Using techniques like solvent casting with polymers (carboxymethyl cellulose, chitosan) to create fast-dissolving films.

·       Nanoparticles: The extract itself can act as a reducing agent in "green synthesis" to create nanoparticles (e.g., silver nanoparticles). 

 

What are the different  dosage forms  of Viburnum Opulus Extract Manufactured  by  MEDIOCON INC?

Mediocon Inc manufactures and exports Viburnum Opulus Extract as a herbal raw material in bulk form, which is used as an ingredient for further pharmaceutical or nutraceutical formulation. The company primarily deals in B2B supply of ingredients and does not appear to manufacture finished, consumer-ready dosage forms of this specific

 

 How Viburnum Opulus Extract Manufactured by MEDIOCON INC Dosage Forms are prepared?

Information on the specific manufacturing process used by MEDIOCON or their Viburnum opulus extract is not publicly available in the search results. However, general industry methods involve solvent extraction and the resulting extracts are used in various dosage forms by pharmaceutical and supplement companies. 

General Manufacturing Process of Viburnum opulus Extract

The general process for obtaining Viburnum opulus extract often involves the following stages:

1.      Plant Material Preparation: Raw materials (typically fruits or bark) are harvested, cleaned, dried (sometimes in the shade), and ground into a powder.

2.      Extraction: The powdered material is mixed with a solvent to extract the active chemical constituents, such as chlorogenic acid and other phenolic compounds. Common solvents include water, ethanol, or acetone, often in specific ratios and at controlled temperatures.

3.      Filtration and Concentration: The mixture is filtered to separate the liquid extract from the solid plant residue. The liquid supernatant is then concentrated, often using a vacuum rotary evaporator to remove the solvent.

4.      Drying/Purification: The concentrated liquid is often further processed into a dry powder form, typically through freeze-drying (lyophilization). Further purification, such as solid-phase extraction (SPE), can be used to obtain a phenolic-rich fraction.

5.      Standardization: The final extract is analyzed to ensure consistency in its chemical composition, often by standardizing the content of key marker compounds like verbenalin or chlorogenic acid. 

 

What are the appropriate Dosage forms of Viburnum Opulus Extract Manufactured  by  MEDIOCON   INC?                

Generally, Viburnum opulus (cramp bark) extracts are available in various forms from different manufacturers, including: 

·       Liquid extracts and tinctures for oral use.

·       Decoctions prepared from the bark.

·       Pellets used in homeopathic preparations.

·       Tablets or capsules, sometimes as part of a multi-ingredient supplement.

·       Orally disintegrating films (ODFs), which are a newer, experimental dosage form. 

To determine the specific dosage forms offered by Mediocon Inc, it is recommended to contact the company directly through their official website or customer service channels

 

When should Viburnum Opulus Extract Manufactured by MEDIOCON INC be taken?

Viburnum Opulus extract should be taken as directed by a physician or qualified healthcare practitioner, as the appropriate timing and dosage depend heavily on the specific condition being treated, the product's concentration, and the individual's health status. The product label should also be read carefully for specific instructions. 

Before taking Viburnum opulus extract manufactured by MEDIOCON INC, or any other supplement, it is important to understand that information provided here is for general knowledge and should not be taken as medical advice. Always consult with a healthcare professional to determine the appropriate use for your specific needs

Consult a healthcare professional for specific advice on taking Viburnum Opulus Extract, especially if you have underlying medical conditions or take other medications [1][2].

 

 What are the effects And Side effects of Viburnum Opulus Extract Manufactured by MEDIOCON INC?

Information specific to a Viburnum Opulus extract manufactured by MEDIOCON INC is not publicly available. However, studies on Viburnum opulus (cramp bark) extracts in general indicate various potential effects and side effects. 

Viburnum opulus extract is rich in bioactive compounds like phenolic compounds, vitamin C, and iridoids, which contribute to its potential health benefits observed primarily in traditional medicine and preclinical studies. 

·       Antispasmodic Action: Traditionally, the bark has been widely used to relieve cramps and muscle spasms, particularly those related to menstruation (dysmenorrhea), pregnancy, and skeletal muscles (legs and back).

·       Anti-inflammatory and Antioxidant Properties: The extract contains potent antioxidants that can help protect cells from oxidative stress and have anti-inflammatory effects.

·       Antimicrobial Activity: In vitro studies suggest the extract may inhibit the growth of certain bacteria, including Staphylococcus aureus, and interfere with bacterial processes like biofilm formation.

·       Cardioprotective and Hypotensive Effects: The extract may help lower blood pressure and has shown protective effects on the cardiovascular system in some studies.

·       Other Traditional Uses: It has been used traditionally for a variety of conditions, including coughs, colds, ulcers, kidney stones, high blood pressure, and nervous disorders. 

While Viburnum opulus supplements have no widely reported common side effects in limited human use, there are some considerations. 

·       Digestive Upset: Ingesting large amounts of the raw berries is considered mildly toxic and may cause vomiting or diarrhea. Mild digestive upset may also occur with some extracts.

·       Pregnancy and Breastfeeding: Despite its traditional use for pregnancy-related spasms and preventing miscarriage, there is not enough reliable information on its safety during pregnancy and breastfeeding in a modern medical context. Consult a healthcare provider before use if pregnant or nursing.

·       Medication Interactions: The extract may interact with certain medications due to its properties:

o   Blood pressure-lowering drugs (due to potential hypotensive effects).

o   Antioxidant drugs or supplements.

o   Antibiotics (due to potential disinfectant properties).

o   Antispasmodic or anti-ulcer agents.

·       Lack of Scientific Evidence: Many of the health claims are based on traditional practice or in vitro/animal studies, and good scientific evidence in humans to support these uses is limited. 

Always consult a healthcare professional before starting any new supplement to ensure it is appropriate for your health conditions and to avoid potential interactions. 

 

 How is Viburnum Opulus Extract Manufactured by MEDIOCON  INC  Tested Qualitatively?

While specific details for MEDIOCON Inc. aren't public, Viburnum opulus (Guelder Rose) extract quality is tested qualitatively using advanced analytical methods like HPLC (High-Performance Liquid Chromatography) and GC-MS (Gas Chromatography-Mass Spectrometry) to identify and quantify key compounds (phenolics, flavonoids, acids, etc.) and physical properties (FT-IR, SEM) for purity, while biological assays (biofilm, enzyme inhibition) confirm functional activity, ensuring safety and efficacy for various applications. 

   Which tests are performed on Viburnum Opulus Extract Manufactured by  MEDIOCON INC ?

Typical Tests for Herbal Extracts (Likely Applied to Viburnum opulus)

·       Identification & Authentication: Ensuring it's actually Viburnum opulus (e.g., organoleptic tests, macroscopic/microscopic examination).

·       Phytochemical Analysis:

o   HPLC/HPTLC: To quantify key bioactive markers like Chlorogenic Acid, a major compound in V. opulus.

o   UPLC-MS: For detailed phenolic profiling and identifying other compounds.

·       Purity & Safety:

o   Heavy Metals: Testing for lead, mercury, arsenic, cadmium (ICP-MS).

o   Pesticide Residues: GC-MS/MS or LC-MS/MS.

o   Microbial Limits: Testing for total viable count, yeasts, molds, and specific pathogens (E. coli, Salmonella).

o   Solvent Residues: GC analysis (if solvents were used in extraction).

·       Physical Properties: Moisture content, ash content, solubility, particle size (for powders).

·       Biological Activity (For Research/Specific Claims):

o   Antioxidant assays: DPPH, FRAP.

o   Enzyme inhibition studies: Lipase, amylase, etc..

o   Cytotoxicity assays: MTT assay on cell lines (like HFF-1, cancer cells) to check safety and efficacy. 

To get exact tests for MEDIOCON INC's product, you'd need to check our specific product documentation or contact them directly, as manufacturers customize tests for their quality standards and intended use.

 

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

General API Manufacturing Challenges (Applicable to Banana Extract):

1.      Regulatory Compliance: Meeting stringent cGMP (current Good Manufacturing Practices) and other global standards for APIs is complex and costly.

2.      Process Scale-Up: Moving from lab to commercial scale can introduce new impurities or alter yields, requiring extensive process validation and monitoring.

3.      Supply Chain Variability: Ensuring a consistent, high-quality supply of raw bananas (or peels/waste) with stable bioactive content is difficult due to seasonality, pests, and weather.

4.      Impurity Control: Isolating the desired compounds while eliminating unwanted ones (from the fruit/peel) is a major technical hurdle, impacting safety and efficacy.

5.      Quality & Consistency: Maintaining batch-to-batch uniformity in the final extract's composition (e.g., specific antioxidant levels) is critical.

6.      Cost & Sustainability: High energy use, solvent consumption, and waste generation are significant concerns, demanding cost-effective, green methods. 

 

What are the challenges in manufacturing of Viburnum Opulus Extract Manufactured by MEDIOCON  INC ’s Dosage forms?

·       Batch-to-batch inconsistency: The chemical composition of plant-derived extracts can vary significantly depending on genetic factors, environmental conditions (soil, climate, altitude, rainfall), harvesting time and method, and post-harvest handling and processing techniques. This makes achieving a consistent, standardized product from batch to batch a primary challenge.

·       Complex composition: Viburnum opulus contains a complex mixture of phytochemicals, including phenolic compounds, organic acids, and anthocyanins. Identifying and quantifying all active ingredients or selecting appropriate chemical markers for quality control is difficult.

·       Lack of universal standards: There are often no widely recognized analytical reference standards for many herbal extracts, and regulatory requirements can differ significantly between countries, complicating international trade and quality control efforts. 

·        

What is the Packing for Viburnum Opulus Extract Manufactured by MEDIOCON INC?

MEDIOCON INC. packages their Viburnum Opulus (Cramp Bark) Extract in plastic containers (typically 5 kg), often as a solid, brown powder, but suppliers for similar extracts also use larger 25 kg HDPE Drums, suggesting flexible bulk options. 

Common Packaging Details for Viburnum Opulus Extract (General)

·       Bulk: 25 kg HDPE Drums are common for larger quantities.

·       Retail/Smaller Bulk: Plastic containers, often around 5 kg, are used.

·       Form: Usually a brown, solid powder.

·       Supplier Specifics (Vary): Other options might include fiber drums or vacuum-sealed packs. 

 

What is shelf life Of Viburnum Opulus Extract Manufactured by MEDIOCON INC? 

Viburnum Opulus Extract typical shelf life for such herbal extracts is 2-3 years, but research suggests stability around 16 months at room temperature, depending heavily on extraction method (like ethanol) and proper storage (dark, cool), so always check the manufacturer's label for exact dating. 

What should the label claim for Viburnum Opulus Extract Manufactured by MEDIOCON INC   Include?

For a Viburnum Opulus Extract label, you should include the Common Name (Cramp Bark), Botanical Name (Viburnum opulus), Source (Bark/Fruit), Traditional Uses (Cramp Relief, Menstrual Pain, Antispasmodic), Active Compounds (Phenolics, Coumarins), Manufacturer Details (MEDIOCON INC), Usage Instructions, Warnings (Pregnancy, Persistent Symptoms), and potential Regulatory Info (FSSAI, ISO), focusing on its traditional benefits for muscle spasms and menstrual cramps while avoiding unsubstantiated medical claims

Where can Viburnum Opulus Extract Manufactured by MEDIOCON INC are procured?

Viburnum Opulus Extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Viburnum Opulus Extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Viburnum Opulus Extract Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Viburnum Opulus Extract Manufactured by MEDIOCON INC product, regardless of the procurement source.