ALPHA-CAROTENE 7488-99-5 Manufacturer, supplier, exporter by Mediocon INC

 

 

 

ALPHA-CAROTENE Manufactured by MEDIOCON INC

 

   Name :ALPHA-CAROTENE

CAS No:    7488-99-5

Molecular Weight  : 536.87 to 536.90 g/mol (average is 536.87 g/mol)

Molecular formula C40H56

Synonyms: 

(+)-α-Carotene, (6'R)-β,ε-Carotene, all-trans-α-Carotene, Hi-Alpha, Carotene, A-CAROTENE

 Appearance Deep orange to red crystalline powder/solid

 Solubility  :Insoluble in water; soluble in fats, oils, and organic solvents like DMSO and DMF..

Use :

A pro-vitamin A carotenoid (converted to retinol in the body) essential for vision and immune function; used as a natural colorant in food products; studied for its antioxidant and potential anti-cancer properties.

 How is  ALPHA-CAROTENEmanufactured by MEDIOCON INC Synthesized?

Mediocon Inc is a chemical supplier and manufacturer of nutraceutical ingredients, including α-carotene, but it does not publicly disclose a proprietary synthesis process on its website or materials. Their business involves producing and supplying chemical and nutraceutical compounds to pharma, food, and health industries, often under GMP-like quality standards, but specific reaction steps for each molecule aren’t detailed publicly. Mediocon Inc+1

📌 2. Typical Industrial Synthesis of α-Carotene

While information specific to Mediocon’s proprietary process isn’t available, industrial α-carotene production is similar in principle to carotenoid synthesis methods used in industry (as reflected in patent literature and carotene chemistry):

🔹 Chemical Synthesis via Wittig–Horner Condensation

A known patented chemical route to α-carotene (analogous to industrial carotene chemistry) uses a Wittig–Horner condensation between a C₁₅ phosphonate ester and a C₁₀ dialdehyde, forming the long C₄₀ conjugated polyene structure of α-carotene. This type of reaction is similar to those used industrially for β-carotene synthesis (e.g., Wittig or Grignard couplings) but adapted to the specific ionone ring pattern of α-carotene. Google Patents

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Alternatively, industrial production involves reacting succinic acid with calcium chloride, followed by heating, filtering, and crystallization.¹

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What are the appropriate Dosage forms of ALPHA-CAROTENEManufactured  by  MEDIOCON   INC?                

However, alpha-carotene as a compound is widely available in several common dosage forms across the general nutraceutical and pharmaceutical industries:

·       Softgel Capsules/Capsules: This is a very common form for carotenes, which are fat-soluble and often require an oil-based carrier for optimal absorption.

·       Tablets: Alpha-carotene can be found in various tablet formulations, including conventional and effervescent tablets.

·       Emulsions and Solutions: Liquid forms for oral or, in some specific medical cases, injectable/parenteral administration also exist.

·       Gummies, Stick Packs, and Beverages: Newer, ready-to-use delivery formats are also available for nutraceutical applications. 

For information on which specific dosage form Mediocon Inc might supply their alpha-carotene ingredient for, it is best to directly consult the manufacturer. You can contact them via their official website at mediocon.com or via email at info@mediocon.com. 

·       Intermediate Mediocon Product List | PDF | Ester - Scribd

6 Nov 2020 — MEDIOCON INC. * INTERMEDIATES PRODUCT LIST. * Chemical Name Cas No API Intermediates. tert-Butyl (4R-cis)-6-[(acetyloxy)

 

Scribd

 

·       Mediocon Inc

Mediocon Inc-Company Profile. Founded in 2018, Mediocon Inc is a global supplier of high-quality chemicals and ingredients. With a...

 

When should ALPHA-CAROTENEManufactured by MEDIOCON INC be taken?

• With Meals: Since alpha-carotene (like other carotenoids) is fat-soluble, taking it with a meal containing some fat improves its absorption.
• Consistency: For best results in supporting overall health, including anti-aging and cellular protection, consistent daily intake is key, notes MDPI and ScienceDirect.com.
• Purpose: It functions as an antioxidant, protects against UV damage, and converts to Vitamin A, benefiting skin and eyes, according to ScienceDirect.com and ScienceDirect.com. 

·       . 

 What are the effects And Side effects of ALPHA-CAROTENEManufactured by MEDIOCON INC?

Alpha-carotene is a type of carotenoid pigment found in orange/yellow vegetables (e.g., carrots, pumpkins) that the body can convert into vitamin A (retinol). It acts as an antioxidant and supports several body processes. ScienceDirect+1

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✅ Potential Benefits / Effects

1. Antioxidant Protection
Alpha-carotene helps neutralize free radicals in the body, which can reduce oxidative stress and may support overall cellular health. ScienceDirect

2. Vitamin A Precursor
Like other provitamin A carotenoids, it is converted into vitamin A, which is essential for:

·       Vision (especially low-light vision)

·       Immune system support

·       Skin and mucous membrane health

·       Cell growth and differentiation Office of Dietary Supplements

3. Diet and Long-Term Health
Higher dietary intakes of alpha-carotene from foods have been associated with lower risks of some chronic diseases and possibly lower all-cause mortality. Horticulture
(Note: much of the research is observational and related to diet, not supplements.)

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 How is ALPHA-CAROTENEManufactured by MEDIOCON  INC  Tested Qualitatively?

Identity / Qualitative Confirmation

Qualitative testing is about confirming what the substance is — i.e., that the sample contains α-carotene and not an unrelated compound:

a. Chromatographic Identification

·       High-Performance Liquid Chromatography (HPLC) is the standard method used to confirm the presence of α-carotene by separating it from other carotenoids based on retention time. Authentic standards of α-carotene are run alongside the sample to compare peaks. Benchchem

b. Retention Time Matching

·       When the sample is injected into the HPLC system, the α-carotene compound should elute (appear) at the same retention time as the α-carotene reference standard. This provides qualitative identity confirmation. Benchchem

c. Spectral Confirmation

·       Detection is usually by UV-Visible or Photodiode Array (PDA) detectors that record absorption spectra. Carotenoid compounds have characteristic UV-Vis absorption patterns, so matching the sample’s spectrum to α-carotene’s confirms identity. Benchchem

🔬 2. Thin-Layer Chromatography (TLC)

·       In some screening labs, TLC plates can separate carotenoids qualitatively. A sample spotted onto the plate will separate into bands, and the position (retention factor) and color can be compared to an α-carotene standard. This is a quicker, lower-resolution method than HPLC.

   Which tests are performed on ALPHA-CAROTENEManufactured by  MEDIOCON INC ?

Measures the α-carotene content — how much of the active substance is present.

·       Usually done by High-Performance Liquid Chromatography (HPLC).

·       Typical specifications are expressed as a percentage of purity (e.g., ≥95–97 %). Sigma-Aldrich

2. Identification Tests

Confirm the identity of the substance using chromatographic or spectroscopic methods:

·       HPLC retention time match vs standard

·       UV-Vis absorbance profile (carotenoids show characteristic spectra)

·       Infrared (IR) or Mass Spectrometry (if available)

3. Purity and Impurity Tests

Evaluate what other substances are present:

·       Related carotenoid impurities (other carotenoids that should be low)

·       Degradants/isomers (cis/trans isomer content)

·       Residual solvents (if organic solvents were used in production)

4. Physical Properties

Basic parameters to ensure consistency and quality:

·       Appearance (color, form)

·       Melting point

·       Moisture content / loss on drying

5. Heavy Metals

Determine levels of toxic metals such as lead, arsenic, mercury, cadmium, etc.
(This is especially important for nutraceutical/food grade materials.)

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract as an API (Active Pharmaceutical Ingredient) by a company like MEDIOCON INC faces challenges in standardizing raw materials, ensuring consistent quality, meeting strict pharmaceutical regulations (GMP, FDA), managing complex extraction processes for purity, scaling up efficiently, handling environmental impact (waste, solvents), and maintaining a stable, high-quality supply chain for banana biomass, all while balancing cost-effectiveness. 

Here are the key challenges:

1. Raw Material Variability & Supply Chain

·       Inconsistent Biomass: Bananas vary in composition (bioactives, moisture) due to variety, growing conditions, and ripeness, making consistent extraction difficult.

·       Supply Chain Stability: Ensuring a steady, large-scale supply of specific banana types (peels, pseudostems) is challenging, impacting production continuity. 

2. Extraction & Purification

·       Complex Bioactives: Isolating specific desired compounds from the complex plant matrix requires advanced, often costly, techniques (chromatography, specific enzymes).

·       Solvent Use & Recovery: Efficient extraction often uses solvents (ethanol, water), requiring careful handling, recycling, and disposal to meet environmental and cost goals.

·       Yield vs. Purity: Balancing high extraction yields with the stringent purity levels needed for an API is a continuous challenge, as seen with maceration needing long times or enzymes for improvement. 

What are the challenges in manufacturing of ALPHA-CAROTENEManufactured by MEDIOCON  INC ’s Dosage forms?

However, general manufacturing challenges for substances like Alpha-carotene (a type of carotenoid used in supplements) typically relate to their chemical properties: 

·       Stability: Carotenoids are sensitive to light, oxygen, and heat, which can lead to degradation during processing and storage.

·       Solubility and Bioavailability: Alpha-carotene is a fat-soluble compound, so formulating it into various dosage forms (especially water-based ones) to ensure proper absorption and bioavailability in the body can be complex.

·       Formulation Consistency: Achieving a uniform distribution of the active ingredient within the final dosage form (like tablets or capsules) requires careful process control, especially when scaling up production.

·       Excipient Compatibility: Ensuring that the inactive ingredients (excipients) used in the formulation do not interact with the Alpha-carotene and compromise its stability or efficacy is a key development challenge

What are the challenges in manufacturing of ALPHA-CAROTENEManufactured by MEDIOCON  INC ’s Dosage forms?

 Here are the key challenges in manufacturing dosage forms of α-carotene (e.g., supplements) such as those that Sigma‑Aldrich α‑Carotene might be used for — note: the challenges below apply broadly to carotenoid-based products (including α-carotene), whether produced by a company like MEDIOCON INC or other nutraceutical/pharmaceutical manufacturers:

What is the Packing for ALPHA-CAROTENEManufactured by MEDIOCON INC?

Alpha-Carotene by Mediocon Inc. likely comes in plastic PET bottles, similar to other products from the Alpha Group (which Mediocon might be part of), packaged under strict pharma norms in a sterile, automated environment, often customized for clients, replacing traditional glass bottles for many applications. 

Here's what we know about Alpha's packaging:

·       Material: Primarily PET (Polyethylene Terephthalate) plastic bottles, known for being a large-scale alternative to glass.

·       Technology: Uses advanced machinery from ASB Nissei (Japan) and Husky for preforms, ensuring high-quality, consistent bottles.

·       Standards: Manufactured and packed under strict pharmaceutical (Pharma) norms in a Class 10,000 cleanroom.

·       Customization: Offers customized packaging solutions for its clients, suggesting various sizes and designs are possible. 

To get exact details for a specific order, you'd need to check the product label or contact Mediocon/Alpha directly, but expect pharmaceutical-grade PET bottles. 

What is shelf life Of ALPHA-CAROTENEManufactured by MEDIOCON INC? 

Typical Shelf Life for α-Carotene / Carotenoid Powders

·       Pure carotenoid powders (like α-carotene or β-carotene) are generally stable for 24–36 months when stored properly (cool, dry, protected from light and oxygen). Ingredients Network

·       Some carotenoid technical products list 24 months shelf life. Handom Chemicals

·       Others (mixed carotenoid raw materials) quote ≈36 months shelf life.

 

What should the label claim for ALPHA-CAROTENEManufactured by MEDIOCON INC   Include?

Bismuth(III) Oxide Powder by MEDIOCON INC, you'll need standard chemical info like Chemical Name, Formula (Bi2O3), CAS No. (1304-76-3), Purity (e.g., ≥99%), Physical Form (Yellow powder), plus Safety Data (Hazards, Handling, Storage) and Manufacturer details, plus its intended use (e.g., Pigment, Ceramic additive, Pharma intermediate), as required by regulations like GHS/REACH for industrial chemicals, ensuring compliance and user safety. 

Essential Label Claims (GHS/Safety Data Sheet Info) 

• Product Identifier: Bismuth(III) Oxide, Bismuth Trioxide.
• Chemical Formula:

Bi2O3cap B i sub 2 cap O sub 3

𝐵𝑖2𝑂3

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• CAS Number: 1304-76-3.
• EC Number: 215-134-7.
• Manufacturer: MEDIOCON INC (with contact info).
• Purity/Assay: e.g., ≥99%, 99.9% (Trace Metals Basis).
• Physical Appearance: Yellow powder, fine powder.
• Intended Use: Specify application (e.g., Pigment, Ceramic Additive, Pharmaceutical Intermediate, Electronics). 

Safety & Handling (GHS Pictograms/Statements) 

• Hazard Statements (H-Statements): Check SDS for specific hazards (may include skin/eye irritant, environmental hazard, etc.).
• Precautionary Statements (P-Statements): (e.g., P280: Wear protective gloves/eye protection; P261: Avoid breathing dust; P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.).
• Pictograms: As determined by hazard assessment (e.g., Exclamation Mark for irritant). 

Storage & Shelf Life 

• Storage: Store in a cool, dry, well-ventilated place, in a tightly closed container.
• Shelf Life: e.g., 2 years. 

Where can ALPHA-CAROTENEManufactured by MEDIOCON INC are procured?

ALPHA-CAROTENEManufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find ALPHA-CAROTENEManufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for ALPHA-CAROTENEManufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the ALPHA-CAROTENEManufactured by MEDIOCON INC product, regardless of the procurement source.