Arginine 74-79-3 manufacturer Supplier Exporter MEDIOCON INC

 

Arginine Manufactured by MEDIOCON INC

 

   Name: Arginine

CAS No:   74-79-3                                                                                                 Molecular Weight:  174.2 g/mol                                                               Molecular formula:  C₆H₁₄N₄O₂

Synonyms:  L‑Arginine, (S)‑2‑Amino‑5‑guanidinopentanoic acid, α‑Amino‑δ‑guanidinovaleric acid, Arginine monohydrochloride (for salt form

Appearance:   White or almost white crystalline powder                                                                                                                                                              Solubility :  Soluble in water

Use :

1. Pharmaceutical & Medical Uses

·       Cardiovascular health: Helps in producing nitric oxide (NO), which relaxes blood vessels → used for hypertension, angina, heart disease.

·       Erectile dysfunction: Improves blood flow by enhancing NO production.

·       Wound healing: Promotes collagen synthesis and tissue repair.

·       Immune support: Boosts lymphocyte function and general immunity.

·       Kidney function: Can be used in treatment of urea cycle disorders (helps remove ammonia).

2. Nutritional & Dietary Uses

·       Sports nutrition: Common in protein supplements for muscle growth, recovery, and performance.

·       Essential amino acid supplementation: Especially for infants, the elderly, or people with arginine deficiency.

3. Cosmetic & Topical Uses

·       Skin care: Used in creams and ointments for wound healing, anti-aging, and collagen production.

4. Biochemical / Laboratory Uses

·       Culture media: Used as a nitrogen source in microbiology.

·       Precursor for nitric oxide: Studied in research for cardiovascular and metabolic pathways.

 How is Arginine manufactured by MEDIOCON INC Synthesized?

 Microbial fermentation:

·       L‑Arginine is most commonly produced by fermenting sugars (e.g., glucose) using specific microorganisms such as Corynebacterium glutamicum or related strains that have been bred or engineered for high arginine production.

·       During fermentation, the microbes convert the carbon and nitrogen sources into L‑arginine through natural metabolic pathways (L‑glutamate → ornithine → citrulline → L‑arginine).

·       After fermentation, the broth is filtered to remove the cells, and L‑arginine is purified using ion‑exchange resins, activated carbon, concentration, crystallization, and drying steps to obtain high‑purity crystal amino acid.

Protein hydrolysis & chemical synthesis (less common):
Historically, amino acids including arginine were also obtained by protein hydrolysis of natural proteins or by complex chemical syntheses, but industrial production nowadays relies mostly on fermentation because it’s more efficient and scalable.

What are the different  dosage forms  of   Arginine Manufactured  by  MEDIOCON INC?

Arginine is available in various dosage forms, including:

·       Tablets (oral) — solid dose nutritional or pharmaceutical tablets containing arginine.

·       Capsules (oral) containing arginine.

·       Oral Powders / Sachets — dissolved in water before intake.

·       Granules / Oral Powders — for supplements.

·       Injectable solutions — in clinical settings with other components

 How Arginine Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Arginine dosage forms are prepared through various processes, including:

1. Tablets (Oral Solid Dosage Form)

Steps:

1. Blending – Mix L‑Arginine powder with excipients (binders, fillers, disintegrants, lubricants) to ensure uniformity.
2. Granulation – Wet or dry granulation may be used to improve flow and compressibility.
3. Compression – Compress granules into tablets using a tablet press.
4. Coating (optional) – Film coating for taste masking or stability.
5. Packaging – Bottles, blister packs, or bulk packs

2. Capsules (Oral Solid Dosage Form)

Steps:

1. Blend L‑Arginine powder with excipients to achieve uniform content.
2. Fill powder into hard gelatin or HPMC capsules using capsule-filling machines.
3. Seal (optional) and pack in bottles or blister packs

3. Oral Powders / Sachets

Steps:

1. Mix L‑Arginine with solubilizers, flavoring agents, or sweeteners.
2. Ensure uniform particle size and free-flowing powder.
3. Fill measured amounts into sachets or bulk containers.
4. Seal and label.

4. Injectable Solutions (IV)

Steps:

1. Dissolve L‑Arginine in sterile water or buffered solution under aseptic conditions.
2. Filter sterilize the solution.
3. Fill into vials or ampoules in sterile environment.
4. Seal, label, and conduct sterility testing.

What are the appropriate Dosage forms of Arginine Manufactured  by  MEDIOCON   INC?                

Arginine dosage forms include:

• Tablets – Oral solid dosage forms with excipients for stability, taste masking, and compressibility.
• Capsules – Hard gelatin or HPMC capsules filled with L‑Arginine powder.
• Oral powders / sachets – Powdered form for mixing with water or other beverages.
• Granules – For oral use or further formulation into tablets/capsules.
• Injectable solutions – Dissolved in sterile water/buffer for IV use (requires aseptic processing).
• Functional foods / nutraceuticals – Added to energy drinks, protein powders, or supplements.

When should Arginine Manufactured by MEDIOCON INC be taken?

Arginine administration depends on the specific indication and dosage form:

1. Oral tablets/capsules/powders:
• Often taken on an empty stomach for better absorption.
• Typical timing: 30–60 minutes before meals or as directed by a healthcare provider.
• Used for cardiovascular support, exercise performance, or dietary supplementation.
2. Injectable/IV formulations:
• Administered under medical supervision in hospitals or clinics.
• Dosing and timing depend on the patient’s condition (e.g., urea cycle disorder, cardiac therapy).
3. Nutritional / Sports Supplements:
• Usually taken before exercise or as per supplement label instructions.
• Dosage varies by intended use and formulation strength.

 

 What are the effects And Side effects of Arginine Manufactured by MEDIOCON INC?

Arginine's effects and side effects include:

Effects

• Improves blood flow and heart health (via nitric oxide).
• Supports wound healing and tissue repair.
• Enhances exercise performance and muscle recovery.
• Boosts immune function.
• Helps in urea cycle/metabolic support.

Side Effects

• Gastrointestinal: nausea, diarrhea, bloating.
• Blood pressure: may lower BP excessively in some.
• Rare: allergic reactions (rash, itching).
• High doses: possible electrolyte imbalance or interactions with medications.

  How is Arginine Manufactured by MEDIOCON  INC  Tested Qualitatively?

Arginine is tested qualitatively through:

·       IR / TLC / UV / optical rotation for identity,

·       Ninhydrin or guanidino-specific reactions,

·       Solubility and pH tests,

·       HPLC for qualitative confirmation of purity.

These tests ensure that the bulk API supplied is truly L‑Arginine and suitable for formulation into dosage forms.

   Which tests are performed on Arginine Manufactured by  MEDIOCON INC ?

Tests performed on Arginine include:

·       Identity: IR/FTIR, TLC, optical rotation, ninhydrin test

·       Purity / Assay: HPLC, titration, loss on drying

·       Physical: Appearance, color, odor, solubility, melting point

·       Chemical: pH, guanidino group confirmation

·       Safety / Contaminants: Heavy metals, residual solvents, microbial limits

What are the challenges in Manufacturing of Arginine Manufactured by MEDIOCON   INC API?

Manufacturing Arginine API poses challenges like:

·       Fermentation control: strain optimization, contamination, pH/nutrient management

·       Purification: removal of byproducts, crystallization, moisture/hygroscopicity issues

·       Batch consistency: maintaining uniform purity, optical rotation, and quality

·       Scale-up: industrial production without yield or purity loss

·       Regulatory compliance: cGMP, pharmacopeial standards, stability, and storage requirements

What are the challenges in manufacturing of Arginine Manufactured by MEDIOCON  INC ’s Dosage forms?

Challenges in Manufacturing Dosage Forms of Arginine

• Hygroscopic Nature
• Arginine is highly moisture-absorbing, which can cause clumping, sticking, or poor flow during tablet compression or capsule filling.
• Flow and Compressibility Issues
• Pure arginine powder has poor flowability and compressibility, making tablet uniformity or capsule filling difficult.
• Often requires granulation or flow enhancers.
• Taste Masking
• L‑Arginine has a bitter/salty taste, which is challenging for oral powders or chewable forms.
• Requires flavoring agents or coatings.
• Stability
• Sensitive to moisture and temperature, which can affect shelf life.
• Requires proper drying, packaging, and storage conditions.
• Solubility

• High solubility in water can lead to rapid dissolution or stickiness, complicating capsule or sachet preparation.
1. Dose Uniformity
• Ensuring consistent content per tablet, capsule, or sachet is critical due to low-dose vs. high-dose formulations.
2. Regulatory & Quality Compliance
• Dosage forms must meet pharmacopeial standards, stability requirements, and GMP compliance, adding complexity to manufacturing.

What is the Packing for Arginine Manufactured by MEDIOCON INC?

Arginine is typically packed in various quantities, including:

·       Outer packaging:
Heavy‑duty paper or laminated bags with an inner polyethylene (PE) liner to protect from moisture.

·       Drums / Bags:
Standard sizes like 25 kg or 50 kg net weight per bag/drum are typical for export and industrial supply.
(Many amino acid APIs use this format to prevent moisture ingress.)

·       Inner liners:
PE/laminate liners or sealed bags inside the outer container to ensure dryness and purity.

·       Labeling:
Includes product name, batch/lot number, net weight, manufacturer (MEDIOCON INC), storage conditions, and safety information.

What is shelf life Of Arginine Manufactured by MEDIOCON INC? 

Typical Shelf Life for L‑Arginine API

• About 2 years (24 months) from the manufacturing date when stored properly in sealed, dry, cool conditions — this is a common shelf life for pharmaceutical amino acid APIs.

Storage conditions that affect shelf life:

• Airtight packaging, cool (room temperature), dry environment
• Protection from moisture, heat, and direct light

What should the label claim for Arginine Manufactured by MEDIOCON INC   Include?

·       Product Name & Type

o   “L‑Arginine” or “Arginine USP/EP/Pharma Grade”

·       Manufacturer Information

o   Name: MEDIOCON INC

o   Address and contact details

·       Batch / Lot Number

o   For traceability and quality control

·       Net Weight

o   e.g., 25 kg, 50 kg per bag/drum

·       Manufacturing Date (Mfg Date)

·       Expiry Date / Shelf Life

·       Storage Conditions

o   e.g., “Store in a cool, dry place, protect from moisture and direct sunlight”

·       Purity / Assay

o   e.g., “L‑Arginine ≥ 99%”

·       Quality Standards / Reference Pharmacopoeia

o   e.g., “Complies with USP / EP / BP standards”

·       Handling / Safety Precautions

o   e.g., “Avoid inhalation, wear protective gloves/mask, keep container tightly closed”

·       Regulatory & Certification Marks (if applicable)

o   cGMP compliance, ISO certification, etc.

.

Where can Arginine Manufactured by MEDIOCON INC are procured?

Arginine Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Arginine Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Arginine Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Arginine Manufactured by MEDIOCON INC product, regardless of the procurement source.