Asparagine ( Manufacturer 70-47-3, supplier, exporter by MEDIOCON INC

 

 

 

              Asparagine Manufactured by MEDIOCON INC

 

   Name: Asparagine

CAS No  70-47-3 (anhydrous); 5794-13-8 (monohydrate)

Molecular Weight:  132.12 g/mol (anhydrous

Molecular formula C₄H₈N₂O₃

Synonyms: Asn; L-Aspartic acid 4-amide; (S)-2-Aminosuccinic acid 4-amide; α-aminosuccinamic acid; Asparamide; Aspartamic acid

 Appearance White crystals or crystalline powder

·        Solubility :   Soluble in water (approx. 2.94 g/100 mL at 25 °C), and soluble in acids and bases, but practically insoluble in methanol, ethanol, ether, and benzene.

 Use :

o   Biological Processes: Plays a crucial role in protein synthesis, the regulation of nitrogen metabolism, and maintaining the function of the nervous system.

o   Cell Culture: Used as a component in cell culture media, particularly in the production of recombinant proteins and monoclonal antibodies.

o   Food Industry: Used as a food additive and flavor enhancer; it reacts with reducing sugars during heating (such as baking or frying) to produce acrylamide, a substance found in foods like french fries and potato chips.

o   Medical/Research: Used as an active ingredient in some medications and dietary supplements to support immune function and assist in ammonia detoxification. L-asparaginase, an enzyme that cleaves asparagine, is a chemotherapy drug used to treat acute lymphoblastic leukemia (ALL). 

 

 How is  Asparaginemanufactured by MEDIOCON INC Synthesized?

Asparagine is the amino acid with the formula (H₂N)(HN)CN(H)(CH₂)₃CH(NH₂)CO₂H. The molecule features a guanidino group appended to a standard amino acid framework. At physiological pH, the carboxylic acid is deprotonated (−CO₂⁻) and both the amino and guanidino groups are protonated, resulting in a cation. Only the l-asparagine (symbol Arg or R) enantiomer is found naturally.^[1] Arg residues are common components of proteins. It is encoded by the codons CGU, CGC, CGA, CGG, AGA, and AGG.^[2] The guanidine group in asparagine is the precursor for the biosynthesis of nitric oxide.^[3] Like all amino acids, it is a white, water-soluble solid.

What are the different  dosage forms  of   AsparagineManufactured  by  MEDIOCON INC?

Mediocon Inc. is a supplier of ingredients, not a finished drug manufacturer, so they don't produce specific dosage forms like tablets or capsules; instead, they provide Asparagine as a Nutraceutical Ingredient, which other companies then use to create products like capsules, powders, or solutions. If you're looking for Asparagine products, check supplement brands, as Mediocon supplies the raw amino acid for various pharmaceutical/nutraceutical uses, not finished drugs. 

What Mediocon Inc. Provides:

·       Ingredients: They supply amino acids (like Asparagine), vitamins, minerals, and herbal extracts as raw materials.

·       Pharmaceutical Chemicals: This includes Active Pharmaceutical Ingredients (APIs) and excipients for drug formulation. 

How to Find Asparagine Products:

·       Look for brands selling nutritional supplements (e.g., "L-Asparagine supplements").

·       These brands purchase raw Asparagine (like from Mediocon) and formulate it into dosage forms such as:

o   Capsules

o   Tablets

o   Powders (for mixing)

o   Liquid formulations (less common for Asparagine). 

 How AsparagineManufactured by MEDIOCON INC   Dosage Forms are prepared?

·  Manufacturing Asparagine (or any drug) dosage forms involves creating tablets, capsules, liquids, etc., using processes like wet/dry granulation, direct compression, or melt granulation for solids, combining the active ingredient (Asparagine) with excipients (binders, fillers, disintegrants, flavors) and forming them into specific shapes/liquids, with complexity depending on whether it's immediate or modified release, often using specialized equipment for mixing, heating, and shaping. 

Here's a breakdown of general pharmaceutical preparation methods for different forms:

1. Solid Dosage Forms (Tablets/Capsules)

·       Direct Compression: Mixing Asparagine powder with excipients (like lactose, microcrystalline cellulose) and directly compressing into tablets.

·       Wet Granulation: Mixing drug/excipients, adding a binder solution (e.g., PVP), forming granules, drying, sizing, and compressing into tablets.

·       Melt Granulation: Using a meltable binder (like PEG) heated with the drug/excipients to form granules, then cooling and compressing (good for heat-sensitive drugs).

·       Capsules: Filling powders or granules into gelatin/HPMC shells. 

What are the appropriate Dosage forms of AsparagineManufactured  by  MEDIOCON   INC?                

Medicon Inc likely offers Asparagine in common pharmaceutical forms like tablets, capsules, and potentially oral powders/solutions, as these are standard for L-Asparagine, but you'll need to check their specific product catalog for exact details, as they are a contract manufacturer offering diverse dosage development. Common forms for Asparagine include oral tablets (immediate/extended release), capsules, powders for solution, and sometimes specialized delivery systems, focusing on patient convenience and bioavailability. 

Common Dosage Forms for Asparagine:

·       Tablets: Immediate-release, chewable, or modified-release (extended/delayed) tablets are popular.

·       Capsules: Filled with powder or pellets.

·       Powders: Often sold for mixing into drinks (solutions/suspensions).

·       Oral Solutions/Suspensions: Liquid forms for easy intake, especially for higher doses or those with swallowing difficulties. 

When should AsparagineManufactured by MEDIOCON INC be taken?

Asparagine from Mediocon Inc, a chemical supplier, isn't a consumer supplement to take at specific times; rather, Mediocon provides L-Asparagine raw material for pharmaceutical, nutraceutical, and food companies to manufacture their own products, so timing depends entirely on the final product's instructions (e.g., a protein powder, supplement pill) or industrial use, requiring consultation with that product's label or a professional. 

Key Takeaway:

·       Mediocon Inc is a bulk supplier: They sell ingredients, not finished consumer goods, so there's no set time for "Mediocon's Asparagine".

·       Check the Product Label: If you bought a supplement containing Mediocon's Asparagine, follow the dosage and timing (morning, evening, with food, etc.) on that specific product's label or ask a doctor. 

In Summary: Look at the label of the supplement you purchased, not the chemical supplier, for when to take it. 

 What are the effects And Side effects of AsparagineManufactured by MEDIOCON INC?

These are general effects of asparagine in the body — not specific to any particular supplement brand:

▪ Supports Protein Metabolism

Asparagine helps with building and repairing proteins, especially during periods of growth or recovery.

▪ Nervous System Function

It influences some neurotransmitter pathways, so it’s involved in brain signaling and can affect mood or energy metabolism.

▪ Immune Function

Asparagine contributes to immune cell activation and adaptation to metabolic stress.

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⚠️ Possible Side Effects or Risks

Even though asparagine is a natural amino acid, supplementation — especially high doses — may cause effects or risks similar to other amino acid supplements. These are potential side effects reported with supplemental amino acids or amino acid imbalance:

📌 Common Mild Side Effects

·       Digestive discomfort: nausea, bloating, cramps, mild diarrhea — especially if taken on an empty stomach or at high doses.

·       Headache or mood effects: possible with imbalance of amino acids.

·       Altered sleep or irritability: rarely reported.

📌 Rare or Specific Risks

·       Allergic reactions: true allergy to an amino acid is rare but possible; rash, itching, swelling, or difficulty breathing require stopping the supplement and getting medical help.

·       Liver or kidney strain: any extra amino acid burden can theoretically add metabolic load to these organs, especially if there’s pre-existing disease.

·       Interference with neurotransmitters: because amino acids influence brain chemistry, excessive imbalance may impact mood or sleep patterns.

·       Special conditions: in rare genetic disorders affecting asparagine metabolism, supplementation might worsen symptoms (e.g., worsening seizures in asparagine synthetase deficiency).

  How is AsparagineManufactured by MEDIOCON  INC  Tested Qualitatively?

There’s no publicly available detailed quality-control procedure specific to “Asparagine manufactured by MEDIOCON INC” (e.g., COA or test protocol issued by the manufacturer) in the sources indexed online. MEDIOCON INC is a supplier of chemicals including amino acids like asparagine, but they do not publicly publish the exact qualitative testing protocols for their products on their website.

So instead, I’ll describe how asparagine as a chemical substance is typically tested qualitatively in laboratory quality control, especially as per accepted analytical standards for amino acids / pharmaceutical chemical ingredients — which would be the kind of testing labs use when checking incoming raw materials.

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🧪 Typical Qualitative Testing Methods for Asparagine

In quality control (QC) of a pure amino acid like asparagine, qualitative tests are used to confirm identity and purity of the substance — i.e., that what you have is indeed asparagine and not some contaminant or different molecule.

1. Chromatographic Identity (HPLC / TLC)

A standard way to qualitatively confirm asparagine is to check that its retention time or spot position matches a known standard.

·       High-Performance Liquid Chromatography (HPLC):
The sample is run through an HPLC system and the retention time of the asparagine peak is compared with a reference standard. If the peak matches, that confirms identity. This is commonly included in pharmacopoeial identity tests for amino acids.

·       Thin-Layer Chromatography (TLC):
Another qualitative tool where sample and standard are spotted on a plate and separated; the sample band is compared with the standard band. For example, commercial suppliers list TLC purity ≥ 99% meaning the main spot matches asparagine.

   Which tests are performed on AsparagineManufactured by  MEDIOCON INC ?

Most amino acid suppliers (including those serving pharmaceutical, nutraceutical or lab-use markets) perform tests to confirm identity, purity, and absence of impurities. Common ones include:

✅ 1. Identity Confirmation

These tests verify that the compound is actually asparagine.

·       Chromatographic Identification (HPLC or TLC):
Compares the sample’s retention time (HPLC) or spot pattern (TLC) with a certified asparagine standard. A match confirms identity.

·       Spectroscopic Methods:
Infrared (IR) or other spectral analyses confirm functional groups consistent with asparagine’s structure (amine, amide, carboxyl).

·       Chemical Reactions:
Qualitative chemical tests like a ninhydrin reaction, which detects free amino acids, help confirm presence.

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract as an API involves challenges like securing consistent, quality banana feedstock (peels/flowers), developing efficient, scalable extraction/purification (downstream processing) to isolate specific compounds, managing large volumes of organic waste, ensuring process sustainability (green chemistry), maintaining batch-to-batch consistency for pharmaceutical standards, and navigating complex regulatory compliance, especially for novel botanical extracts, needing advanced testing and waste management. 

Feedstock & Raw Material Challenges

·       Supply Chain: Ensuring a continuous, high-quality, and affordable supply of banana peels or blossoms, which are agricultural byproducts.

·       Variability: Raw material quality can vary due to climate, pathogens (like nematodes), and post-harvest handling, affecting extract consistency.

·       Waste Management: Handling large volumes of organic waste (peels) generated during processing, which can cause odor and greenhouse gas issues if not managed properly. 

Extraction & Purification Challenges (Downstream Processing)

·       Efficiency: Developing economical and efficient methods to extract desired bioactive compounds (phenolics, fibers, etc.) from the complex biomass.

·       Purity: Isolating the specific API from other plant components without degrading it, requiring advanced separation techniques like membrane filtration or continuous crystallization.

·       Scalability: Transitioning from lab-scale extraction to industrial-scale production while maintaining yield and purity. 

What are the challenges in manufacturing of AsparagineManufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Asparagine (likely referring to L-Asparaginase, a protein drug) by a company like MEDIOCON INC. faces challenges common in biophonics: ensuring protein stability (preventing aggregation/degradation), achieving consistent high purity, managing complex sterile fill-finish (syringeability, viscosity for injections), navigating strict regulations (cGMP, FDA), scaling production while maintaining quality (scale-up), and controlling costs in a specialized supply chain. Specific issues involve maintaining protein integrity during formulation, lyophilization (freeze-drying), and handling high-potency requirements, needing advanced technology and process control. 

Here are the key challenges in manufacturing such complex dosage forms:

1. Protein Stability & Formulation:

·       Aggregation/Degradation: Asparaginase, being a protein, is prone to unfolding and clumping (aggregation) or breaking down (degradation), affecting efficacy and safety.

·       Viscosity: High protein concentrations can make the solution very viscous, creating "syringeability" issues (hard to push through a needle), impacting patient acceptance.

·       Lyophilization: If freeze-dried (lyophilized) for stability, challenges include optimizing cycles to maintain protein structure and ensuring rapid, complete reconstitution. 

What is the Packing for AsparagineManufactured by MEDIOCON INC?

Mediocon Inc. supplies various chemical ingredients, including amino acids like Asparagine, often as raw materials (APIs/Intermediates) for pharmaceutical/nutraceutical use, so their "packing" varies by order, typically in bulk drums or bags (e.g., 25kg), but specific product packaging details (like inner liners, material) depend on the specific purchase order, not a fixed retail format. 

To Get Specific Packing Details:

1.    Contact Mediocon Directly: Visit their website Mediocon.com and use their contact/inquiry forms for their Asparagine product.

What is shelf life Of AsparagineManufactured by MEDIOCON INC? 

The shelf life for Asparagine made by MEDIOCON INC isn't in the general search, but shelf life depends on its form (powder, liquid) and storage, requiring you to check the product's label for the exact expiry date and follow specific storage like "protect from light," with liquids often 28 days after opening, and powders (like some antibiotics) having specific dates after reconstitution. Always check the packaging or consult the manufacturer for definitive shelf life details for your specific product. 

Key Factors for Asparagine Shelf Life:

·       Product Type: Is it a powder, solution, or other form? Powders reconstituted into liquids have different timelines.

·       Storage Conditions: "Protect from light," refrigeration, or room temp.

·       Manufacturer's Instructions: The label is crucial; it states the expiry date and post-opening use-by date (e.g., 28 days for some eye/ear drops). 

To Find Your Answer:

1.    Check the Bottle/Box: Look for printed dates and storage instructions.

2.    Contact MEDIOCON INC: Reach out to them directly if the packaging is unclear. 

What should the label claim for AsparagineManufactured by MEDIOCON INC   Include?

The label claim for Asparagineshould include the following information¹ ² ³:

- Statement of Identity: Clearly indicate the product name, such as "Calcium Succinate"

- Amount of Active Ingredient: Specify the amount of Calcium Succinate, usually in milligrams (mg) or percentage (%)

- Form of Active Ingredient: Indicate the form of Calcium Succinate, such as powder or capsules

- Health Claims: Include approved health claims, like "Calcium may reduce the risk of osteoporosis"

- Nutrient Content Claims: Specify nutrient content, such as "Good source of calcium"

- Serving Size: Clearly state the serving size and number of servings per container

- Daily Value: Include the percentage of Daily Value (%DV) for calcium

 

Some examples of label claims for Asparagineinclude⁴:

- "Good source of calcium": Indicates the product contains a significant amount of calcium

- "Calcium for healthy bones and teeth": Highlights the role of calcium in maintaining bone health

- "Diets high in calcium may reduce the risk of osteoporosis": Approved health claim linking calcium to osteoporosis prevention

Where can AsparagineManufactured by MEDIOCON INC are procured?

AsparagineManufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find AsparagineManufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for AsparagineManufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the AsparagineManufactured by MEDIOCON INC product, regardless of the procurement source.