Aspartic acid 56-84-8 Manufacturer Supplier Exporter MEDIOCON INC

 

Aspartic acid Manufactured by MEDIOCON INC

 

   Name: Aspartic acid

CAS No:   56-84-8

Molecular Weight:  133.10 g/mol

Molecular formula:  C₁₀H₁₄N₂O₅

Synonyms:  Aminosuccinic acid, 2-Aminosuccinic acid, (S)-2-Aminosuccinic acid, β-Carboxyalanine, L-β-Carboxyalanine.                                                                                                         Appearance:   White to off-white crystalline powder                                                                                                                                                           Solubility :  Soluble in water. 

Use :

-      Component of proteins and enzymes

-      Involved in amino acid metabolism and urea cycle

-      Acts as an excitatory neurotransmitter

-      Used in nutritional supplements and medical nutrition

-      Raw material for aspartame production

-      Used in pharmaceutical and biochemical research

 How is Aspartic acid manufactured by MEDIOCON INC Synthesized?

Aspartic acid is synthesized through:

Microbial fermentation / enzymatic conversion

-       A common commercial route uses microorganisms and enzymes (such as aspartase) to convert precursors into aspartic acid.

-       One widely used process involves the fermentative conversion of fumaric acid and ammonia (or ammonium salts) into L-aspartic acid using aspartase-producing microbes under controlled aerobic conditions. After fermentation, aspartic acid is recovered by centrifugation and crystallization.

2 Enzyme-catalyzed processes

-      Immobilized enzyme systems or engineered microbes can catalyze the conversion of precursors (e.g., fumarate + NH₃) to aspartic acid with higher specificity and yield.

-      3. Chemical synthesis (less common for high-purity L-isomer)

-      Some older or less-specific chemical routes can produce DL-aspartic acid racemic mixtures, which may then be separated or used where optical purity is not critical.

What are the different  dosage forms  of   Aspartic acid Manufactured  by  MEDIOCON INC?

Aspartic acid is available in various dosage forms, including:

-      Powder (technical/food/pharma grade) — the most common form for amino acids supplied as raw material for further manufacturing.

-      Bulk crystalline powder — used by nutraceutical or pharmaceutical manufacturers to formulate final products (such as tablets, capsules, or solutions).

 How Aspartic acid Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Aspartic acid dosage forms are prepared through various processes, including:

o   Powder Formulation

-      Receive aspartic acid powder (raw ingredient).

-      Blend with excipients (like fillers or flow agents).

-      Pack directly as a finished powder (e.g., sachets or bulk powder supplement).

-      Minimal processing since the powder itself may be the marketed form.

o   Capsules (Oral Solid Dosage)

-      Mix aspartic acid powder with appropriate excipients (fillers, disintegrants).

-      Homogenize the blend for uniformity.

-      Fill into hard gelatin or vegetarian capsules using a capsule‑filling machine.

-      Package and label for distribution.
(Standard capsule preparation methodology)

o   Tablets

-      Combine aspartic acid with binders, fillers, and disintegrants.

-      Granulate the mixture to enhance compressibility.

-      Dry and sieve the granules.

-      Compress into tablets using a tablet press.

-      Apply coating if required (e.g., for stability or ease of swallowing).

-      Pack for sale.

What are the appropriate Dosage forms of Aspartic acid Manufactured  by  MEDIOCON   INC?                

Aspartic acid dosage forms include:

-      Crystalline Powder / Bulk Powder – main form supplied for further processing into products.

-      Food/Pharma Grade Raw Material – used by other companies to make finished products like:
• Capsules (dietary supplements)
• Tablets (nutraceutical formulations)
• Powder sachets (supplements)
• Blends in multivitamin/ amino‑acid complexes

 

When should Aspartic acid Manufactured by MEDIOCON INC be taken?

Aspartic acid supplied by Mediocon Inc is primarily a raw ingredient for supplements or pharmaceutical formulations, so the exact timing and dosage depends on the finished product it is formulated into. Mediocon itself does not provide instructions for direct consumption of the raw powder.

However, for aspartic acid-containing supplements (like D‑Aspartic Acid or L‑Aspartic Acid capsules/powders)

Typical Timing for Aspartic Acid Supplements

-      Orally, with water

-      Often taken in the morning or before exercise, depending on the purpose

o   Sports / bodybuilding use: commonly before workouts to support testosterone and muscle function

o   General amino acid supplementation: can be taken with meals to aid absorption

-      Dosage and timing should follow the finished product instructions, as concentration, form (L- or D-isomer), and intended effect vary.

 

 What are the effects And Side effects of Aspartic acid Manufactured by MEDIOCON INC?

Aspartic acid's effects and side effects include:

-      Effects:

-      Supports protein synthesis and enzyme function

-      Acts as an excitatory neurotransmitter

-      Aids amino acid metabolism and the urea cycle

-      May support muscle function and energy in supplements

-      Side Effects (high doses):

-      Gastrointestinal: nausea, bloating, diarrhea

-      Neurological: headache, fatigue

-      Can stress kidneys in those with kidney issues

-      Should be used under guidance in supplements

  How is Aspartic acid Manufactured by MEDIOCON  INC  Tested Qualitatively?

Aspartic acid is tested qualitatively through:

-      HPLC: compares sample with reference standard to confirm identity

-      Derivatization + Detection: e.g., ninhydrin reaction to detect amino groups

-      Spectroscopy: IR or other methods to confirm chemical structure

   Which tests are performed on Aspartic acid Manufactured by  MEDIOCON INC ?

Tests performed on Aspartic acid include:

o   Identity / Qualitative Tests

-      HPLC (High-Performance Liquid Chromatography): Confirms identity by comparing retention time with reference standard

-      IR Spectroscopy (Infrared): Verifies chemical structure

-      Ninhydrin Test: Confirms the presence of amino groups

o   Purity / Quantitative Tests

-      Assay by HPLC or titration: Measures % of aspartic acid in the sample

-      Moisture content: Determined by loss on drying (LOD) or Karl Fischer method

-      Ash content: Measures inorganic residue after burning

o   Contaminant / Impurity Tests

-      Heavy metals: Tested via ICP-MS or AAS to ensure safe limits

-      Microbial limits: Ensures absence of harmful bacteria, yeast, mold (for food/pharma grade)

-      Residual solvents: Checked if chemical synthesis was used

o   Physical Tests

-      Appearance: White/off-white crystalline powder

-      Solubility: Confirmed in water

-      pH of solution: Ensures proper acidity/alkalinity

What are the challenges in Manufacturing of Aspartic acid Manufactured by MEDIOCON   INC API?

Manufacturing Aspartic acid API poses challenges like:

-      Purity and Impurities

o   Controlling chemical impurities (from precursors or side reactions)

o   Removal of inorganic salts, residual solvents, or microbial contaminants

o   Achieving the correct enantiomeric purity (L‑Aspartic acid vs. D‑Aspartic acid)

-      Fermentation / Biocatalysis Challenges

o   Maintaining optimal microbial growth and enzyme activity

o   Controlling fermentation conditions (pH, temperature, aeration)

o   Avoiding contamination or batch-to-batch variability

-      Yield and Conversion

o   Ensuring high conversion of precursors (fumaric acid + ammonia) to aspartic acid

o   Minimizing losses during crystallization, filtration, and drying

-      Physical Properties

o   Achieving consistent crystal size and morphology for API stability and solubility

o   Controlling moisture content to prevent caking or degradation

-      Regulatory and Quality Compliance

o   Meeting pharmacopeial standards (USP/EP/JP) for API quality

o   Testing for heavy metals, microbial limits, and residual solvents

o   Ensuring traceability and documentation for GMP (Good Manufacturing Practice)

-      Scalability

o   Scaling laboratory or pilot processes to industrial-scale production without losing purity or yield

o   Managing energy, water, and waste streams efficiently

What are the challenges in manufacturing of Aspartic acid Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Aspartic acid dosage forms poses challenges like:

Challenges in Manufacturing Aspartic Acid Dosage Forms

-      Poor Flow Properties

o   Aspartic acid powder is hygroscopic and can clump, making tablet compression or capsule filling difficult.

o   Requires flow enhancers or excipients to ensure uniform filling.

-      Compressibility / Tablet Formation

o   Amino acids often have poor compressibility, leading to soft or friable tablets.

o   Granulation or binders may be needed to produce mechanically stable tablets.

-      Stability Issues

o   Aspartic acid can absorb moisture → reduces shelf life or causes caking in powders.

o   Sensitive to heat or light in certain formulations.

-      Dosage Uniformity

o   Ensuring consistent dosing in capsules or tablets is challenging because fine powders can segregate.

o   Requires proper mixing, blending, and particle size control.

-      Taste / Palatability

o   Aspartic acid has a slightly bitter taste, which may need coating or flavor masking in oral dosage forms.

-      Compatibility with Excipients

o   Some excipients may react or interact with aspartic acid, affecting stability or absorption.

o   Formulators must choose compatible fillers, binders, and disintegrants.

-      Regulatory & Quality Compliance

o   Finished dosage forms must meet weight variation, content uniformity, microbial limits, and stability standards.

What is the Packing for Aspartic acid Manufactured by MEDIOCON INC?

Aspartic acid is typically packed in various quantities, including:

Common Packaging Types

-       Multi‑layer industrial bags — often inner polyethylene + outer woven sacks for moisture protection and chemical safety.
 HDPE (high‑density polyethylene) drums — for larger volume supply (e.g., 25 kg per drum).
 Fiber drums with liners — sometimes used for export or pharma grade ingredients.
Sealed, labeled packaging with product details, batch number, and storage instructions.

-       Typical Sizes

-      5 kg, 10 kg, 25 kg (common practice for amino acid powders in bulk).

-      Larger bulk orders may be packed based on customer requirement (e.g., multiple 25 kg drums).

What is shelf life Of Aspartic acid Manufactured by MEDIOCON INC? 

-      2–3 years from the date of manufacture under proper storage conditions

-      Storage conditions:

-      Keep in a cool, dry, and well-ventilated place

-      Protect from moisture, heat, and direct sunlight

-      Keep the product in tightly sealed original packaging (HDPE drum, multi-layer bag, or fiber drum with liner)

What should the label claim for Aspartic acid Manufactured by MEDIOCON INC   Include?

-      Key Elements to Include on the Label

-      Product Name

o   Aspartic acid (L‑Aspartic acid if specified)

-      Grade / Type

o   Food grade, Pharma grade, or Nutraceutical grade

-      Net Weight

o   Example: 25 kg per bag/drum

-      Batch / Lot Number

o   For traceability and quality control

-      Manufacturing Date (Mfg. Date)

o   Clearly printed

-      Expiry / Shelf Life

o   Example: “Shelf life: 2 years from date of manufacture”

-      Storage Instructions

o   Cool, dry place; protect from moisture and sunlight

-      Manufacturer / Supplier Details

o   Mediocon Inc name, address, and contact information

-      Country of Origin

o   If required by regulatory authorities

-      Purity / Assay (Optional)

o   For pharma grade: “Assay: ≥99% L‑Aspartic acid”

-      Safety / Handling Instructions

o   Example: “Handle with care. Avoid inhalation of dust. Use protective equipment if required.”

-      Regulatory / Compliance Marks (Optional)

o   GMP, ISO, or pharmacopeial compliance (if applicable)

Where can Aspartic acid Manufactured by MEDIOCON INC are procured?

Aspartic acid Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Aspartic acid Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Aspartic acid Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Aspartic acid Manufactured by MEDIOCON INC product, regardless of the procurement source.