Aspartic acid,56-84-8 Manufacturer, exporter, supplier by MEDIOCON INC

 

 

 

              Aspartic acid,  Manufactured by MEDIOCON INC

 

   Name: Aspartic acid,  

CAS No  : 56-84-8 (L-form); 617-45-8 (DL-form)

Molecular Weight:  132.12 g/mol (anhydrous

Molecular formula C₄ H₇ NO ₄

Synonyms: Common synonyms for aspartic acid include: 

·       Aminosuccinic acid

·       Asparagic acid

·       Asparaginic acid

·       L-2-Aminobutanedioic acid

·       (S)-(+)-Aminosuccinic acid

·       H-Asp-OH 

 Appearance : White crystalline powder or colorless crystals

 Solubility :   
Soluble in water (approx. 4.5 to 5 g/L at 25 °C); insoluble in ethanol

·        Use :

Aspartic acid has a variety of biological and industrial uses: 

·       Protein Synthesis It is one of the 20 standard proteinogenic amino acids, serving as a building block for proteins in living organisms.

·       Metabolism It is involved in nitrogen metabolism, gluconeogenesis (glucose synthesis), and the synthesis of other amino acids like asparagine, methionine, and lysine.

·       Neurotransmission L-aspartic acid can function as an excitatory neurotransmitter in the central nervous system.

·       Industrial/Commercial It is used as a food additive (flavoring agent, nutritional fortifier), a component in sports nutrition supplements, a pharmaceutical ingredient, and for cell culture in manufacturing processes. The polymerized form, polyaspartic acid, is used as a biodegradable substitute for polyacrylate in applications like superabsorbent polymers. 

 

 How is  Aspartic acid, manufactured by MEDIOCON INC Synthesized?

Aspartic acid is generally produced industrially using enzymatic conversion of fumaric acid and ammonia, or through chemical synthesis, but the specific method used by MEDIOCON INC is not publicly disclosed in the available information. 

Common Industrial Synthesis Methods

The primary methods for manufacturing L-aspartic acid (the biologically active form used in most industrial applications) are:

·       Enzymatic Conversion: This is the currently favored method due to high efficiency and the ability to produce the desired L-isomer exclusively.

o   Process: Fumaric acid is reacted with high concentrations of ammonia in the presence of the enzyme L-aspartate ammonia-lyase (aspartase), often produced by microorganisms like E. coli or Corynebacterium glutamicum. The enzyme is typically immobilized in a gel matrix for continuous production.

o   Advantage: This method yields a highly pure L-aspartic acid product without creating a racemic mixture (equal parts of L- and D-forms).

·       Chemical Synthesis: This method involves the use of high temperature and pressure conditions and typically uses starting materials such as diethyl sodium phthalimidomalonate, or methanol and carbon dioxide.

o   Disadvantage: This process yields a racemic mixture of both L- and D-aspartic acid, requiring extra, potentially expensive, steps to separate the desired L-isomer

What are the different  dosage forms  of   Aspartic acid, Manufactured  by  MEDIOCON INC?

Aspartic acid is industrially produced primarily through enzymatic conversion or chemical synthesis, but the specific method employed by MEDIOCON INC is not detailed in publicly accessible information [1]. The most common industrial methods are: 

Enzymatic Conversion

This method is currently preferred due to its efficiency and the ability to produce the biologically active L-isomer exclusively [1]. 

·       Process: Fumaric acid reacts with high concentrations of ammonia in the presence of the enzyme L-aspartate ammonia-lyase (aspartase). This enzyme is often derived from microorganisms like E. coli or Corynebacterium glutamicum and is typically immobilized for continuous production [1].

·       Advantage: It yields highly pure L-aspartic acid without creating a racemic mixture (equal parts of L- and D-forms), avoiding further costly separation steps [1]. 

Chemical Synthesis

This traditional method involves high temperature and pressure and uses starting materials such as diethyl sodium phthalimidomalonate, or methanol and carbon dioxide [1]. 

 How Aspartic acid, Manufactured by MEDIOCON INC   Dosage Forms are prepared?

MEDIOCON INC primarily acts as a manufacturer and supplier of the L-aspartic acid powder/intermediate, which is then used by other companies to produce final dosage forms. The specific final dosage form (e.g., tablets, capsules, injections) is prepared using standard pharmaceutical manufacturing techniques, of which MEDIOCON INC would only be responsible for the initial active ingredient. 

The general processes for manufacturing L-aspartic acid powder and then converting it into dosage forms are outlined below.

Manufacturing of L-Aspartic Acid (Active Ingredient)

Industrially, L-aspartic acid is commonly produced by an enzymatic process using L-aspartate ammonia-lyase (aspartase) to convert fumaric acid and ammonia into L-aspartic acid. A general process involves the following steps: 

1.    Fermentation/Reaction: Aspartase-forming bacterial strains, such as E. coli or Corynebacterium glutamicum, are grown in a nutrient medium containing fumaric acid and ammonia. The enzyme then converts the fumaric acid to L-aspartic acid, which accumulates in the broth.

2.    Separation: The bacterial cells are removed from the fermentation broth using separation techniques such as centrifugation and filtration.

3.    Purification and Crystallization: The remaining solution undergoes ion exchange chromatography for extraction and purification. The purified solution is concentrated by evaporation, which leads to the formation of L-aspartic acid crystals.

4.    Drying and Packaging: The crystals are filtered, washed, and dried in a vacuum to obtain the final L-aspartic acid powder, which is then packaged as the raw material for various applications. 

What are the appropriate Dosage forms of Aspartic acid, Manufactured  by  MEDIOCON   INC?                

Mediocon Inc. primarily acts as a supplier of pharmaceutical raw materials, including Aspartic acid in powder form, which is then used by other companies to manufacture finished dosage forms. They do not appear to manufacture finished, ready-to-use dosage forms of Aspartic acid under their own brand for direct sale to consumers or patients. 

Aspartic acid products are generally available on the market in the following common dosage forms: 

·       Powders: This is the most common form in which Mediocon and other suppliers deal, typically for use as an active pharmaceutical ingredient (API) or nutraceutical ingredient. These powders are often mixed with excipients and further processed into finished products.

·       Capsules

·       Tablets

·       Oral solutions/syrups 

These finished products are typically produced by other pharmaceutical or nutraceutical companies that source the raw material from suppliers like Mediocon Inc. Consumers can find general information on the uses and typical dosages for these products on health information websites like WebMD. 

When should Aspartic acid, Manufactured by MEDIOCON INC be taken?

The specific timing for taking Aspartic acid manufactured by MEDIOCON INC should be determined by the directions on the product label or as advised by a healthcare professional. Manufacturers often provide specific instructions based on the intended use and formulation of their product. 

General information about D-aspartic acid (DAA) supplements, which are sometimes used for athletic performance, suggests a few common practices. 

For optimal guidance on when to take Aspartic acid manufactured by MEDIOCON INC, always refer to the instructions on the product label or consult with a healthcare professional. 

 What are the effects And Side effects of Aspartic acid, Manufactured by MEDIOCON INC?

Effects and Benefits

Aspartic acid exists in two forms, L-aspartic acid and D-aspartic acid, each with different functions and benefits. 

L-Aspartic Acid:

·       Protein Synthesis: L-aspartic acid is a building block for proteins and other amino acids.

·       Energy Production: It plays a role in the Krebs cycle (energy production process) and helps reduce fatigue and increase endurance.

·       Detoxification: It helps remove excess ammonia from the body and supports liver function.

·       Immune Function: It is involved in producing antibodies and supports the immune system. 

D-Aspartic Acid (DAA) (commonly used in supplements):

·       Hormone Regulation: DAA is primarily involved in the synthesis and release of hormones, including luteinizing hormone (LH) and testosterone.

·       Male Fertility: Studies have suggested that DAA supplementation can improve sperm count and motility in men with fertility problems.

·       Muscle Mass (Disputed): While popular in bodybuilding supplements, studies have yielded mixed results regarding its effectiveness for increasing muscle mass and strength in resistance-trained men.

·       Cognitive Function: It may play a role in brain development, memory, and learning processes. 

  How is Aspartic acid, Manufactured by MEDIOCON  INC  Tested Qualitatively?

MEDIOCON INC's specific qualitative testing procedures for aspartic acid are proprietary, but the company likely uses a combination of standard pharmaceutical quality control (QC) methods such as

High-Performance Liquid Chromatography (HPLC) and Fourier-transform Infrared (FT-IR) spectroscopy, along with physical property tests to ensure the identity and purity of its product. 

General Qualitative Testing Methods 

Common qualitative testing methods used in the pharmaceutical industry for amino acids like aspartic acid include: 

• Infrared (IR) Absorption Spectrum Analysis: Comparing the IR spectrum of the manufactured sample against a qualified reference standard helps confirm the compound's identity.
• High-Performance Liquid Chromatography (HPLC): This is a primary method used to identify and separate components in a mixture. Qualitative analysis involves comparing the retention time of the sample's peak with that of a known standard. It can also detect the presence of impurities or related substances.
• Melting Point Determination: A pure crystalline substance has a unique, specific melting point. Impurities will change the melting point, typically causing it to melt over a range of temperatures.
• Loss on Drying (LOD) and Residue on Ignition (ROI): These tests help determine physical properties related to purity, such as water content and inorganic residues, by measuring weight changes after drying or ignition.
• Specific Rotation (

.

• General Amino Acid Identification Tests: Traditional qualitative chemical tests can be used for general identification, though instrumental methods are preferred for pharmaceutical grade products:
• Ninhydrin Test: This test is used for the detection of all alpha-L-amino acids, producing a characteristic deep blue or purple color.
• Xanthoproteic Test: This test detects the presence of aromatic amino acids (though less specific to just aspartic acid) by forming a yellow color upon heating with concentrated nitric acid. 

MEDIOCON INC's quality control procedures are described as "consistently excellent," indicating adherence to stringent pharmaceutical quality standards, likely involving these types of sophisticated analytical techniques. 

   Which tests are performed on Aspartic acid, Manufactured by  MEDIOCON INC ?

MEDIOCON INC, as a manufacturer and supplier of Active Pharmaceutical Ingredients (APIs) and food chemicals, performs standard quality control (QC) tests on its Aspartic acid product to ensure it meets pharmacopoeial standards like USP, BP, EP, and FCC. While the specific test methods used by the company are proprietary, the industry-standard tests for Aspartic acid (L-aspartic acid) are based on these official monographs. 

Physical and Chemical Characterization

• Appearance and Color: Visual inspection to ensure the product is a white or almost white crystalline powder or colorless crystals.
• Identification: Tests to confirm the substance is indeed aspartic acid, often involving techniques such as:
• Infrared (IR) Absorption Spectrophotometry: Comparing the sample's spectrum to a reference standard.
• Chromatography: Checking the position, color, and size of the principal spot against a reference solution, often using thin-layer or high-performance liquid chromatography (HPLC).

·       reaction, which detects free amino acids, help confirm presence.

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract as an API involves challenges like securing a consistent raw material supply (banana biomass), optimizing extraction & purification (downstream processing) for yield and purity, scaling up production without introducing new impurities, managing waste and environmental impact, ensuring regulatory compliance (GMP), and controlling costs, especially with biomass variability and complex separation steps. 

Key Manufacturing Challenges

1.    Raw Material & Supply Chain:

·       Substrate Availability: Ensuring a continuous, high-quality supply of banana biomass (peels, flowers, etc.) can be difficult due to agricultural factors like weather, pests (nematodes), and post-harvest losses, notes scielo.sa.cr and ResearchGate.

·       Biomass Variability: Natural variations in the fruit's composition affect extraction efficiency and final product consistency, requiring robust quality control, says Bulat Pharmaceutical.

2.    Extraction & Purification (Downstream Processing):

·       Complex Separations: Extracting desired bioactive compounds from complex biomass is technically demanding, with recovery and purification processes significantly impacting yield and cost, notes National Institutes of Health (NIH).

·       Impurity Control: Developing efficient, economical methods to remove unwanted compounds (phenolics, fibers) without degrading the target API is crucial, say ScienceDirect.com and ScienceDirect.com.

3.    Scale-Up & Process Optimization:

·       Impurity Introduction: Scaling up can unexpectedly generate new impurities or increase existing ones, requiring constant R&D monitoring, says Bulat Pharmaceutical.

·       Continuous vs. Batch: Transitioning from batch to continuous manufacturing for better consistency and lower costs presents its own separation and integration challenges, notes DrugPatentWatch.

4.    Environmental & Regulatory Factors:

·       Waste Management: Banana production generates large amounts of biomass waste, requiring sustainable disposal or valorization to prevent pollution, note ResearchGate and MDPI.

·       Green Chemistry: Implementing sustainable practices and adhering to stringent pharmaceutical regulations (like GMP) adds complexity and cost, state Salvavidas Pharma and Dolphin Pharmaceutical.

What are the challenges in manufacturing of Aspartic acid, Manufactured by MEDIOCON  INC ’s Dosage forms?

Mediocon Inc is primarily a supplier and wholesaler of active pharmaceutical ingredients (APIs) and intermediates, rather than a manufacturer of its own branded, finished dosage forms of aspartic acid. Aspartic acid is a widely available amino acid, not a proprietary drug, so the manufacturing challenges are generic to the industry rather than specific to Mediocon Inc's products. 

Key challenges in the general manufacturing and formulation of aspartic acid and similar amino acids into dosage forms include:

·       Stability and Degradation: Aspartic acid and its derivatives (like the sweetener aspartame) are sensitive to external conditions such as temperature, moisture, and pH changes, which can lead to degradation during processing and storage. For example, aspartame decomposes at temperatures around 40°C.

·       Formulation Complexities:

o   Excipient Compatibility: Selecting compatible excipients is critical to maintain the stability, safety, and efficacy of the final product. Inappropriate choices can lead to unwanted interactions or reduced shelf life.

o   Physical Properties: Challenges exist in managing the physical properties of the powder, such as flowability and compressibility, which are vital for creating uniform tablets or capsules, especially when dealing with unrefined or natural ingredients.

o   Solubility Issues: The aqueous solubility and hydrophilicity of amino acids can present challenges in developing certain dosage forms, such as fast-dissolving tablets, and may require specific formulation techniques like lyophilization (freeze-drying).

What is the Packing for Aspartic acid, Manufactured by MEDIOCON INC?

 

MEDIOCON INC's Aspartic Acid is commonly packed in bulk for industrial/pharmaceutical use, typically in 25kg bags or fiber drums, as a pure, white crystalline powder, though specific details for MEDIOCON might need direct contact, as similar suppliers use 25kg/Fiber Drums for general grade or customized sizes for research, but standard is bulk. 

Common Packaging for Aspartic Acid (General Industry):

·       25kg Fiber Drums/Bags: A frequent standard for food, pharma, or industrial grade.

·       HDPE Drums: Also used for bulk powder.

·       Bulk Bags: For large industrial quantities. 

For MEDIOCON INC specifically:

·       Check their official website or product sheets for the exact specifications (e.g., Pharmaceutical Grade vs. Technical Grade).

·       If purchasing for R&D, smaller quantities (grams/kilograms) in sealed bottles are common. 

In summary, expect standard pharmaceutical packaging like 25kg drums or bags unless you're buying research quantities, which will be smaller. 

What is shelf life Of Aspartic acid, Manufactured by MEDIOCON INC? 

While specific data for MEDIOCON INC.'s Aspartic Acid isn't readily available in general searches, typical commercial Aspartic Acid powders often have shelf lives of 1 to 3 years, depending on formulation (e.g., food vs. pharma grade) and storage, with general purity remaining high for long periods in powder form. For the most accurate shelf life for a MEDIOCON INC. product, check the product's Certificate of Analysis (CoA) or contact the manufacturer directly, as shelf life varies by purity and intended use. 

General Shelf Life Factors for Aspartic Acid:

·       Form: Powdered forms are generally stable.

·       Purity: Higher purity (e.g., pharmaceutical grade) might have specific handling, but usually retains stability.

·       Storage: Cool, dry conditions are crucial for maintaining quality. 

What should the label claim for Aspartic acid, Manufactured by MEDIOCON INC   Include?

For a label claim of Aspartic Acid (likely L-Aspartic Acid), manufactured by MEDIOCON INC, you need to include its chemical name (L-Aspartic Acid, 2-aminobutanedioic acid), purity (e.g., 99%+), CAS number (56-84-8), form (white crystalline powder), its function (non-essential amino acid, building block for proteins/collagen/elastin), intended use (nutraceutical, supplement, cosmetic ingredient), manufacturer details (MEDIOCON INC), and potentially key benefits like energy metabolism support, detoxification, skin conditioning, or hormonal balance, all while ensuring compliance with relevant regulations (FDA/EFSA) for health/cosmetic claims. 

Here's a breakdown of what to include:

I. Product Identification & Composition

·       Product Name: L-Aspartic Acid (or just Aspartic Acid).

·       Purity: e.g., "99% Pure" or "99.5%+".

·       Manufacturer: MEDIOCON INC.

·       Net Weight/Quantity: (e.g., 500mg, 100 capsules).

·       Appearance: White crystalline powder.

·       CAS Number: 56-84-8 (for L-Aspartic Acid). 

II. Key Ingredients / Nutritional Information (if applicable)

·       Serving Size: (e.g., 1 capsule, 2g).

·       Servings Per Container: (e.g., 60, 120).

·       Amount Per Serving: (e.g., 500mg L-Aspartic Acid).

·       Other Ingredients: (e.g., capsule material, fillers). 

III. Function & Benefits (Use with Caution & Substantiation)

·       Function: "Non-essential amino acid," "Protein Building Block," "Skin Conditioning Agent," "Hydrator,".

·       Potential Benefits (Regulatory Compliant):

o   Supports skin's natural defense system.

o   Hydrates skin.

o   Supports energy metabolism & reduces fatigue (for supplements).

o   Aids in ammonia detoxification (liver support).

o   Precursor to glutathione (antioxidant support). 

IV. Directions & Warnings

·       Directions: "As a dietary supplement, take 1-2 capsules daily..." or "For cosmetic use, incorporate into formulations...".

·       Warnings: "Keep out of reach of children," "Consult a healthcare professional if pregnant/nursing...".

·       Storage: "Store in a cool, dry place." 

V. Manufacturer Details

·       Manufactured by: MEDIOCON INC.

·       Address/Contact Info: (Required by many regulations)

Where can Aspartic acid, Manufactured by MEDIOCON INC are procured?

Aspartic acid, Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Aspartic acid, Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Aspartic acid, Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Aspartic acid, Manufactured by MEDIOCON INC product, regardless of the procurement source.