Banaba (lagerstroemia speciosa) extract 4547-24-4 (Corosolic Acid) Manufacturer, supplier, exporter by MEDIOCON INC

 

 

 

Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC

 

   Name: Banaba (lagerstroemia speciosa) extract

CAS No: 4547-24-4 (Corosolic Acid)

Molecular Weight: .470g/mol (Corosolic Acid)

Molecular formula:  C₃₀H₄₈O₄

SynonymsGiant Crape-myrtle extract, Queen's Crape-myrtle extract, Pride of India extract, Jarul,

AppearanceGreenish Brown to brown-yellow powdersoluble in ethanol, ether acetone and glycerol.

·       Solubility: Partially water-soluble; soluble in hydroalcoholic solvents

 

Use :

o   Diabetes Management: Helps regulate blood sugar levels, improves insulin sensitivity, and reduces postprandial blood sugar spikes.

o   Weight Management: Aids in controlling appetite and improving fat metabolism.

o   Antioxidant/Anti-inflammatory: High antioxidant content protects against oxidative stress.

o   Pharmaceuticals/Nutraceuticals: Used in capsules, tablets, and functional foods, often standardized to 1%–20% Corosolic Acid. 

 How is  Banaba (lagerstroemia speciosa) extract manufactured by MEDIOCON INC Synthesized?

Based on the available information, Banaba (

Lagerstroemia speciosa) extract, including products standardized for high corosolic acid content by manufacturers, is produced through a systematic extraction and purification process designed to concentrate its bioactive components, primarily corosolic acid. 

Manufacturing Process for Banaba Extract (Corosolic Acid Focus) 

1. Raw Material Preparation: The process begins with the collection of Lagerstroemia speciosa leaves, which are cleaned, dried, and ground into a powder.
2. Extraction: The powder is subjected to solvent extraction.
• Solvents: Ethanol, methanol, or water-based mixtures are typically used.
• Method: The extraction is often carried out using methods like percolation, refluxing, or hot water extraction (around

60∘C60 raised to the composed with power C

• Refinement: To increase the concentration of corosolic acid, some processes use a two-step approach: first, hot water to remove impurities, followed by an alcohol-based extraction to isolate triterpene acids.
2. Purification: The crude extract is refined to increase the concentration of corosolic acid, targeting concentrations of 1% – 20% (or higher, such as 25% or more).
• Degreasing: The extract is often treated with non-polar solvents (like chloroform or hexane) to remove fat-soluble impurities.
• Adsorption: Non-ionic resins (such as Amberlite XAD-2) may be used to remove sugar and inorganic salts, boosting purity.
3. Concentration and Drying: The purified extract is concentrated using a vacuum evaporator and then dried (e.g., spray-drying or freeze-drying) to form a fine powder, often using carriers like maltodextrin.
4. Quality Control: The final product is tested, generally using High-Performance Liquid Chromatography (HPLC), to ensure standardization to the desired level of corosolic acid (e.g., 1%–20%). 

What are the different  dosage forms  of   Banaba (lagerstroemia speciosa) extract Manufactured  by  MEDIOCON INC?

While specific details for MEDIOCON INC. aren't in the snippets, Banaba (Lagerstroemia speciosa) extract is commonly available as capsules, softgels, and tablets, often standardized for corosolic acid, and used in various dietary supplements, with softgels (18% corosolic acid) being a popular form for blood sugar support, sometimes taken before meals. 

Common Dosage Forms & Details:

·       Capsules/Softgels: These are very common, often containing 18% corosolic acid and used in formulations for type 2 diabetes support, taken before meals.

·       Tablets: Also available, often in similar standardized extracts.

·       Extracts: The raw material is an extract from the leaves, standardized for its active compounds like corosolic acid. 

How to Find MEDIOCON INC.'s Specifics:

·       Search for "MEDIOCON INC Banaba extract" on their website or through supplement retailers.

·       Look at the product labels for mentions of "corosolic acid" and dosage forms (capsules, softgels, tablets). 

 How Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Based on the provided search results, Banaba (

Lagerstroemia speciosa) leaf extract is manufactured using methods designed to standardize the content of bioactive compounds, particularly corosolic acid (1%–20%) and tannins (10%–15%), typically produced in GMP-certified facilities. 

Manufacturing and Preparation Process
The production of Banaba leaf extract, often as a fine powder, involves several steps: 

• Raw Material Preparation: Leaves of Lagerstroemia speciosa are collected, dried, and ground.
• Extraction: The powdered leaves are subjected to hydroalcoholic extraction (a mixture of water and alcohol/ethanol). Another method involves extraction with hot water (

60∘C60 raised to the composed with power C

60∘C

to

100∘C100 raised to the composed with power C

100∘C

), followed by filtration.

• Concentration and Purification: The extract is concentrated under vacuum. To increase corosolic acid concentration, techniques such as treatment with activated carbon are used.
• Drying: The concentrated liquid is dried, often via spray drying or vacuum drying, to produce a fine powder.
• Standardization: The resulting extract is standardized using HPLC (High-Performance Liquid Chromatography) to ensure consistent levels of corosolic acid, typically 1% to 20%. 

Dosage Forms and Preparation
The Banaba extract is prepared into various dosage forms for nutraceutical and pharmaceutical applications: 

• Dry Powder/Extract: The primary form is a fine, yellowish-brown or green powder, often water-dispersible.
• Capsules/Soft Gels: The powder is encapsulated, sometimes in a soft gel format designed for improved absorption, with dosages often including 16mg of extract or standardized amounts of corosolic acid.
• Tablets: The extract is formulated into tablets for oral consumption.
• Liquid/Extracts: The extract can be prepared in liquid form, often with a 1%–10% concentration for inclusion in beverages.
• Tea: Dried leaves are used for brewing tea. 

These products are generally manufactured in adherence to GMP (Good Manufacturing Practices) to ensure purity and effectiveness, particularly for blood sugar and metabolic health. 

What are the appropriate Dosage forms of Banaba (lagerstroemia speciosa) extract Manufactured  by  MEDIOCON   INC?                

Based on the product portfolio of Mediocon Inc—a manufacturer and trader of herbal extracts, nutraceutical ingredients, and pharmaceutical ingredients—the appropriate, commercially available dosage forms of Lagerstroemia speciosa (Banaba) extract typically include: 

·       Powder/Extract Powder: Often standardized to 1%–20% corosolic acid, suitable for further formulation into capsules or tableting.

·       Capsules: A commonly used, convenient oral dosage form for nutritional supplements.

·       Tablets: Used in dietary supplements for blood sugar management.

·       Liquid Extracts: Sometimes used for dietary, metabolic support. 

Key Considerations for Mediocon Inc's Banaba Products:

·       Active Ingredients: Mediocon Inc handles herbal extracts, with Banaba usually standardized to Corosolic Acid (typically 1%–20%) for its metabolic health benefits.

·       Quality Standards: Products are generally produced to meet industry standards, including those suitable for nutraceuticals.

·       Applications: The extract is commonly intended for dietary supplements, capsules, and functional foods. 

When should Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC be taken?

The timing of taking Banaba (Lagerstroemia speciosa) extract, which is often used to support healthy blood sugar levels, is an important consideration. Based on general guidelines for this type of supplement, the extract is typically recommended to be taken with meals. 

Some sources suggest that taking the extract about 30 minutes before meals may be beneficial for managing blood sugar levels, particularly in relation to carbohydrate consumption. Common practices involve taking the supplement once or twice daily. It is often advised to take the capsule with water or milk. 

Important Considerations:

·       Consult a Professional: Always follow the specific instructions on the product label from the manufacturer or as advised by your healthcare provider.

·       Safety & Precautions: Banaba can potentially affect blood sugar and blood pressure, so caution is advised if you are taking medications for diabetes or hypertension.

·       Contraindications: It is generally recommended to avoid banaba if you are pregnant or breastfeeding. It is also often advised to discontinue use at least two weeks before scheduled surgery. 

 What are the effects And Side effects of Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC?

Banaba (Lagerstroemia speciosa) extract, including standardized extracts often used by manufacturers like Mediocon Inc (typically containing 1%–20% corosolic acid), is primarily used for its potent blood sugar-lowering effects, often referred to as "natural plant insulin". 

Effects (Benefits)

·       Blood Sugar Regulation: The main active component, corosolic acid, enhances insulin sensitivity, increases cellular glucose uptake, and inhibits alpha-glucosidase (an enzyme that digests carbs), which helps reduce both fasting and postprandial (after-meal) blood sugar levels.

·       Weight Management: It may aid in weight loss by curbing appetite and reducing the formation of fat cells (adipogenesis).

·       Antioxidant and Anti-inflammatory: It contains high levels of tannins (like lagerstroemin) and polyphenols that neutralize free radicals, reducing oxidative stress and inflammation.

·       Cardiovascular Health: It may help lower blood cholesterol and triglycerides.

·       Kidney Protection: Some studies suggest a protective effect on kidneys against damage. 

Side Effects and Precautions

·       Hypoglycemia (Low Blood Sugar): Because of its high efficacy, taking banaba with other diabetic medications (like metformin) or insulin may cause blood sugar to drop too low.

·       Gastrointestinal Issues: High doses might cause nausea, diarrhea, or abdominal discomfort.

·       Headaches and Dizziness: Reported, especially at high doses.

·       Allergic Reactions: Potential for skin rashes, itching, or swelling.

·       Potential Kidney Interaction: A single study suggested that, in rare cases of impaired kidney function, it might cause issues when combined with certain NSAIDs like diclofenac. 

  How is Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON  INC  Tested Qualitatively?

Banaba (Lagerstroemia speciosa) extract, particularly when sourced from manufacturers following GMP and stringent quality standards like Mediocon Inc, is primarily used to manage blood sugar levels and metabolic health, often standardized to contain corosolic acid. 

Manufacturing and Qualitative Testing (Mediocon Inc / Similar GMP Manufacturers)

·       Manufacturing Process: Banaba extract is generally produced through hydroalcoholic extraction (using water and alcohol) of the leaves to obtain a fine, brown, water-dispersible powder.

·       Standardization: The extract is usually standardized to contain specific levels of Corosolic Acid (1%–20%).

·       Qualitative & Quantitative Testing: To ensure purity and identity, manufacturers employ several methods:

o   High-Performance Liquid Chromatography (HPLC): The primary method to determine the concentration of the active marker compound, corosolic acid.

o   High-Performance Thin Layer Chromatography (HPTLC): Used for fingerprinting to identify the presence of specific compounds like corosolic acid, ellagic acid, or tannins.

o   UV Spectrophotometry: Employed for checking the concentration of compounds.

o   Phytochemical Screening: Qualitative tests for alkaloids, carbohydrates, glycosides, saponins, terpenes, steroids, phenols, and flavonoids.

o   Safety Testing: Microbial and Heavy Metal testing ensures the product meets safety benchmarks. 

Effects of Banaba Extract

Banaba extract is rich in bioactive compounds, most notably corosolic acid and ellagitannins, which contribute to its medicinal properties. 

·       Blood Sugar Regulation: Acts as a natural "plant insulin," lowering blood sugar levels within 60 minutes to 2 hours by enhancing insulin sensitivity and increasing cellular glucose uptake.

·       Weight Management: Promotes weight loss by reducing appetite, increasing fat metabolism, and inhibiting adipogenesis (formation of fat cells).

·       Antioxidant & Anti-inflammatory: Helps protect the liver and body from oxidative stress and reduces inflammation.

·       Cholesterol Management: Studies indicate it can improve lipid profiles and lower cholesterol levels. 

Side Effects and Precautions

While banaba is generally considered safe for short-term use (e.g., up to 2 weeks), potential side effects and interactions exist. 

·       Hypoglycemia (Low Blood Sugar): Because of its potent sugar-lowering ability, it may cause blood sugar to drop too low, especially if taken alongside conventional diabetes medications.

·       Gastrointestinal Distress: High doses might cause stomach upset, nausea, diarrhea, or cramps.

·       Dizziness and Headache: Reported as potential minor side effects.

·       Drug Interactions:

o   Diabetes Medications: Increased risk of hypoglycemia (e.g., metformin).

o   Blood Pressure Drugs: May cause blood pressure to drop too low.

o   Diclofenac/NSAIDS: There is a report that corosolic acid combined with diclofenac could cause kidney damage in sensitive individuals.

·       Pregnancy/Breastfeeding: There is insufficient data, so it is recommended to avoid use. 

   Which tests are performed on Banaba (lagerstroemia speciosa) extract Manufactured by  MEDIOCON INC ?

·       Active Ingredient Assay (Corosolic Acid): The most critical test is the quantification of Corosolic Acid, often standardized to levels ranging from 1% to 20% or higher, determined using High-Performance Liquid Chromatography (HPLC).

·       Total Tannins/Phenolics: Analysis of other active constituents, such as tannins, which may be tested using titration methods.

·       Physical Characterization:

o   Appearance and Color: Visual inspection for a fine powder, typically brown to yellowish-brown.

o   Odor and Taste: Organoleptic evaluation to confirm the characteristic smell and taste.

o   Particle Size: Testing for mesh size (e.g., 100% pass through 80 mesh).

·       Purity and Safety Tests:

o   Loss on Drying (Moisture Content): To ensure the stability of the powder, typically limited to a maximum of 5%.

o   Ash Content: To determine the inorganic impurity levels.

o   Heavy Metals: Testing for limits on heavy metals (e.g., NMT 10 ppm).

o   Arsenic and Lead: Specific testing for contaminants.

o   Microbiological Controls: Tests for Total Plate Count, Yeast & Mold, and pathogens like S. aureus, E. Coli, and Salmonella.

·       Solvent Residue: Testing for residual solvents to ensure compliance with standards. 

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract API faces several challenges:

- Raw Material Availability: Limited supply of banana plants, primarily grown for fruit, causing fluctuations in availability and pricing.

- Processing Difficulties: Labor-intensive extraction and cleaning processes require specialized equipment, increasing production costs.

- Quality Control: Variability in harvesting and processing leads to inconsistent fiber quality, affecting suitability for various applications.

- Environmental Impact: Chemical treatments generate waste, necessitating careful management to minimize pollution.

- Market Perception: Banana fiber products are relatively niche, requiring consumer education to promote awareness and adoption.

- Pest Susceptibility: Banana plants are vulnerable to pests, impacting raw material quality and availability.

These challenges impact efficiency, quality, and market viability, requiring improved extraction techniques, processing methods, and supply chain management.

What are the challenges in manufacturing of Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Banaba (lagerstroemia speciosa) extract dosage forms comes with several challenges, including¹ ² ³:

- Stability Issues: Ensuring the stability of Banaba (lagerstroemia speciosa) extract throughout the manufacturing process and shelf life.

- Poor Solubility: Banaba (lagerstroemia speciosa) extract's solubility can be a challenge, affecting bioavailability.

- Raw Material Sourcing: Sourcing high-quality Banaba (lagerstroemia speciosa) extract and excipients can be difficult.

- Regulatory Compliance: Meeting stringent regulatory requirements for excipient manufacturing, transportation, and storage.

- Quality Assurance: Ensuring integrity and purity throughout the supply chain.

- Cost and Supply Chain Management: Balancing cost considerations with high-quality excipients.

- Manufacturing Process Failures: Deficiencies in manufacturing processes can lead to defective products.

- Particle Aggregation: Solid particles can aggregate, causing sedimentation and inconsistent dosing.

To overcome these challenges, manufacturers can leverage advanced technologies, such as 3D printing and nanotechnology, and collaborate with regulatory agencies and excipient suppliers.

What is the Packing for Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC?

For Banaba (Lagerstroemia speciosa) extract, manufacturers like MEDIOCON INC typically perform tests for active compounds (especially Corosolic Acid and Tannins), phytochemical screening (flavonoids, saponins, etc.), and quality control (moisture, ash content, heavy metals, microbes) to ensure potency and safety, packaging it in light-protected, airtight containers to preserve quality. While MEDIOCON INC's specific details aren't in these snippets, these are standard industry practices following guidelines like WHO/USP for herbal extracts. 

Key Tests Performed on Banaba Extract:

1.    Assay/Potency Testing:

·       Corosolic Acid: Measured by HPLC, often targeted at 1-5% or higher, as it's a key anti-diabetic compound.

·       Tannins: Assayed by titration, typically 10-15%.

2.    Phytochemical Screening:

·       Tests for presence of phenolic compounds, flavonoids, saponins, alkaloids, carbohydrates, and triterpenoids to confirm plant identity and active ingredients.

3.    Pharmacognostic & Physicochemical Tests (WHO/USP Standards):

·       Moisture Content: To prevent degradation.

·       Total Ash & Acid-Insoluble Ash: Checks for inorganic impurities.

·       Extractive Values: Determines the concentration of soluble compounds in different solvents.

4.    Microbiological & Heavy Metal Testing:

·       Ensures the extract is free from harmful bacteria, molds, yeasts, and heavy metals (lead, mercury, arsenic, cadmium) for consumer safety.

5.    TLC Fingerprinting:

·       Provides a unique profile of the extract, verifying consistency and quality. 

What is shelf life Of Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC? 

For MEDIOCON INC's Banaba (Lagerstroemia speciosa) extract, typical quality tests involve HPLC for Corosolic Acid, physicochemical tests (moisture, ash, extractive values), and phytochemical screening (phenolics, flavonoids, tannins), while the general shelf life for such extracts is often 12 to 24 months, depending on formulation and storage, but you must check MEDIOCON's specific product documentation. 

Common Tests for Banaba Extract

·       HPLC (High-Performance Liquid Chromatography): To quantify the active compound, Corosolic Acid (CRA), as seen with 1%-20% CRA specifications from suppliers.

·       Physicochemical Tests: Determines moisture content, total ash, acid-insoluble ash, and extractive values for purity and consistency.

·       Phytochemical Screening: Tests for tannins, flavonoids, steroids, and other plant compounds, often using assays like DPPH for antioxidant activity.

·       Microbiological Tests: To ensure absence of harmful bacteria, yeasts, and molds, crucial for supplement safety.

·       Heavy Metals & Pesticides: To meet regulatory standards for food/supplement ingredients. 

Typical Shelf Life

·       Many suppliers list shelf lives from 12 months to 2 years (24 months), often stored in sealed containers (like HDPE drums) away from light and moisture.

·       Actual stability depends heavily on the extract's concentration, processing, packaging, and storage conditions. 

What should the label claim for Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC   Include?

For a Banaba (Lagerstroemia speciosa) extract label by MEDIOCON INC, include the botanical name, key active ingredient (Corosolic Acid), its percentage (e.g., 1-20% by HPLC), origin (Banaba leaf), benefits (blood sugar, weight management, antioxidants), manufacturer info, GMP compliance, dosage guidance, and required dietary supplement/food labeling (supplement facts, warnings). Key claims focus on supporting healthy blood sugar levels and weight management, backed by corosolic acid content. 

Essential Label Components:

1.    Product Name: Banaba Leaf Extract (or similar)

2.    Botanical Name: Lagerstroemia speciosa (L.) Pers.

3.    Manufacturer: Manufactured by MEDIOCON INC.

4.    Key Active Ingredient: Corosolic Acid.

5.    Ingredient Strength: Specify percentage of Corosolic Acid (e.g., "Standardized to 1% Corosolic Acid by HPLC").

6.    Benefits/Claims (Use cautious language):

1.    "Supports healthy blood sugar levels".

2.    "Aids in weight management and appetite control".

3.    "Rich in antioxidants".

4.    "Promotes fat metabolism".

7.    Directions for Use: "Take one capsule daily with water" (example).

8.    Supplement Facts Panel: Standard nutrition info, serving size, servings per container.

9.    Warnings: "Consult a healthcare provider before use if pregnant, nursing, have medical conditions, or taking medications".

10. Quality Assurance: Mention GMP certified, if applicable. 

Example Claim Structure:
"Banaba Leaf Extract (Lagerstroemia speciosa) - Supports Healthy Blood Sugar & Weight Management". 

 Where can Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC are procured?

Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Banaba (lagerstroemia speciosa) extract Manufactured by MEDIOCON INC product, regardless of the procurement source.