BISMUTH(III) OXIDE POWDER 1304-76-3 ,Manufacturer ,Exporter, supplier, MEDIOCON INC

 

 

 

BISMUTH(III) OXIDE POWDER, Manufactured by MEDIOCON INC

 

   Name: BISMUTH(III) OXIDE POWDER

CAS No:    1304-76-3

Molecular Weight 465.96 g/mol

Molecular formula: Bi2o3

Synonyms: 

·       Bismuth oxide

·       Bismuth trioxide

·       Dibismuth trioxide

·       Bismite (mineral form)

·       Bismuth sesquioxide

·       C.I. 77160 

 Appearance:  Yellow, odorless powder or crystals. 

 Solubility :  Insoluble in water and hydroxide solutions; soluble in acids (e.g., HCl, HNO3.

Use :

Bismuth(III) oxide is used in a variety of industrial and specialized applications: 

·       In the production of ceramics, glass, and pigments.

·       As a component in solid-oxide fuel cells and in varistor and ceramic capacitor formulations.

·       As a catalyst in certain chemical reactions and organic synthesis.

·       In fireproofing of papers and polymers as a flame retardant and synergist.

·       In disinfectants and for the vulcanization of rubber.

·       To create the "dragon's eggs" effect in fireworks as a replacement for red lead. 

 

 How is  BISMUTH(III) OXIDE POWDER,manufactured by MEDIOCON INC Synthesized?

·  Direct Oxidation of Bismuth Metal: This is a common and simple industrial method. High-purity metallic bismuth is crushed into a powder and then heated in a rotary oxidation furnace under a flow of air or pure oxygen to promote a thorough oxidation reaction. The temperature is strictly controlled (e.g., around 670°C) to ensure a complete reaction while preventing the powder from sintering or melting.

·  Chemical Precipitation Method: This method involves dissolving metallic bismuth to form a soluble bismuth salt solution (typically bismuth nitrate in nitric acid), followed by the addition of a precipitating agent. The resulting precipitate (e.g., bismuth hydroxide or bismuth subcarbonate) is then filtered, washed, and calcined (heated at high temperatures, typically 400°C to 550°C) to decompose it into the final

Bi2O3Bi sub 2 O sub 3

Bi2O3

powder. This approach offers good control over the final powder's characteristics, such as particle size and morphology.

·  Thermal Decomposition of Bismuth Compounds: Various bismuth compounds, such as bismuth nitrate, bismuth oxalate, or bismuth hydroxide, can be heated in a furnace to decompose them into bismuth oxide powder. 

Alternatively, industrial production involves reacting succinic acid with calcium chloride, followed by heating, filtering, and crystallization.¹

What are the different  dosage forms  of   BISMUTH(III) OXIDE POWDER,Manufactured  by  MEDIOCON INC?

Bismuth(III) oxide (Bi₂O₃) manufactured by MEDIOCON INC is supplied as a powder for use as a general chemical reagent, not a pharmaceutical product. It is primarily intended as a raw material or catalyst for industrial applications. 

Therefore, there are no specific medicinal or ingestible dosage forms (e.g., tablets, capsules, suspensions) of the BISMUTH(III) OXIDE POWDER manufactured by this specific company. 

 How BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC   Dosage Forms are prepared?

MEDIOCON INC manufactures Bismuth(III) Oxide powder for use as an active pharmaceutical ingredient (API), which is then used by other pharmaceutical companies to create specific dosage forms like tablets or capsules. The specific process for creating the final dosage form involves standard pharmaceutical manufacturing techniques such as granulation, mixing with excipients, and compression. 

Manufacturing of Bismuth(III) Oxide Powder

MEDIOCON INC produces high-purity bismuth oxide powder, likely using methods involving the oxidation of bismuth metal or the thermal decomposition or precipitation of other bismuth compounds (e.g., bismuth nitrate or bismuth hydroxide). The key features of the manufactured powder include high purity and specific particle size/morphology, which are critical for its use in downstream pharmaceutical production. 

What are the appropriate Dosage forms of BISMUTH(III) OXIDE POWDER,Manufactured  by  MEDIOCON   INC?                

BISMUTH(III) OXIDE POWDER,is available in various dosage forms, including [1][2]:

- Oral Tablets: For supplementation or therapeutic use

- Capsules: For oral administration

- Powder: For use in food products, cosmetics, or pharmaceuticals

- Granules: For food products or pharmaceutical applications

The choice of dosage form depends on the intended use, industry, and desired release profile.

When should BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC be taken?

Bismuth(III) oxide powder is primarily used in industrial applications such as ceramics, electronics, and pigments, and is not typically a direct-to-consumer oral medication. While some bismuth compounds are used in pharmaceuticals, you must consult the prescribing doctor or pharmacist for specific instructions on when and how to take a prescribed medication. 

Bismuth(III) oxide powder manufactured by MEDIOCON INC is likely an industrial or research-grade chemical, not a finished over-the-counter (OTC) or prescription drug. Bismuth compounds used in medicine, such as bismuth subsalicylate (the active ingredient in Pepto-Bismol®) or bismuth citrate, are formulated into specific, safe dosage forms (tablets, liquids) with defined instructions for use. 

Important Precautions

·       Do not ingest this product without explicit medical direction. Ingesting unapproved forms or large amounts of bismuth can be toxic and may lead to kidney failure or nerve damage.

·       Verify the product's intended use with a healthcare professional or review the official product documentation (such as a Safety Data Sheet or product insert) from MEDIOCON INC to confirm if it is a pharmaceutical grade suitable for human consumption.

·       Follow dosage instructions precisely for any doctor-recommended bismuth treatment, as instructions vary widely based on the condition (e.g., H. pylori infection, diarrhea, ulcers) and the specific bismuth salt used. 

 What are the effects And Side effects of BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC?

Colloidal bismuth subcitrate (CBS) is widely used to treat peptic ulcer and diarrhea but its toxic effects are rarely reported in the clinic because of the very low amounts of bismuth absorbed from the gastrointestinal tract. There are only few cases on nephrotoxicity after over-dosage of CBS (Table 2 ). In one case, even the gastric lavage was performed initially, a 2-year-old boy suffered from an acute renal failure (ARF) associated with uremia and oliguria after ingestion of 28 De-Nol tablets (CBS, 8.4 g) for 2 days. After ingestion of CBS for 10 days, bismuth levels in both the blood and urine were 739 and 693 μgl⁻¹, respectively. With the treatment of peritoneal dialysis, his urine volumes increased and plasma BUN and creatinine levels decreased gradually. After 100 days of admission, the patient recovered and his bismuth level in blood went back to normal. 

 How is BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON  INC  Tested Qualitatively?

BISMUTH(III) OXIDE POWDER,is tested qualitatively using several methods.

- Flame Test: Calcium ions produce an orange-red flame color.

- Precipitation Reaction: Adding ammonium oxalate to a calcium solution forms a white precipitate of calcium oxalate.

- Carbonate Test: Adding ammonium carbonate to a calcium solution forms a white precipitate of calcium carbonate, which is soluble in acetic acid.

These tests help identify the presence of calcium ions in a sample.

   Which tests are performed on BISMUTH(III) OXIDE POWDER,Manufactured by  MEDIOCON INC ?

For Bismuth(III) Oxide (Bi₂O₃) powder, typical quality control tests focus on its purity, crystal structure, particle characteristics (size/morphology), and functional properties, using techniques like XRD (structure), SEM/TEM (morphology), FTIR (functional groups/purity), UV-Vis/DRS (optical/band gap), and TGA (thermal stability), though specific tests for Bismuth Trioxide Bi2O3 Powder (CAS No.1304-76-3) (like heavy metals, loss on drying) ensure safety and quality for various applications, from electronics to pharma. 

Common Characterization Tests (for research/new batches):

·       Powder X-Ray Diffraction (PXRD): Confirms the crystalline phase (e.g., monoclinic, cubic) and purity.

·       Scanning Electron Microscopy (SEM) & Transmission Electron Microscopy (TEM): Reveals particle size, shape, and surface morphology (nanoparticles often show agglomeration).

·       Energy-Dispersive X-Ray Spectroscopy (EDX/EDS): Verifies elemental composition (Bi and O) and stoichiometry.

·       Fourier-Transform Infrared Spectroscopy (FTIR): Identifies functional groups and confirms the presence of Bi-O bonds.

·       UV-Vis Diffuse Reflectance Spectroscopy (DRS): Determines the optical band gap (Eg).

·       Thermogravimetric Analysis (TGA): Measures weight loss with temperature, indicating thermal stability and decomposition stages. 

Quality Control Tests (for commercial/pharmaceutical grade):

·       Purity/Assay: Titration or Atomic Absorption Spectroscopy (AAS) for bismuth content.

·       Heavy Metals: Tested to ensure safety for medical/food-related applications.

·       Loss on Drying (LOD): Measures moisture content.

·       Residue on Ignition/Loss on Ignition: Checks for inorganic impurities.

·       Particle Size Distribution (PSD): Laser diffraction or microscopy for consistent performance. 

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract as an API faces challenges in consistent raw material quality, maintaining purity & stability (preventing degradation), adhering to strict regulatory standards (GMP), scaling up efficient extraction (often needing green chemistry like enzyme tech), managing complex separation processes, ensuring batch to-batch consistency -, and dealing with supply chain issues and environmental impact, all while competing on cost for a high-quality, stable API. 

Key Challenges in Manufacturing Banana Extract API:

1.    Raw Material Variability: Natural products like bananas vary in composition (bioactive compounds, moisture) due to ripeness, variety, and growing conditions, making consistent API quality difficult.

2.    Extraction Efficiency & Purity: Extracting desired compounds (like polyphenols, polysaccharides) without degrading them or introducing impurities requires advanced techniques (e.g., enzyme-assisted extraction, chromatography) that are complex and costly.

3.    Stability & Degradation: Banana components can be sensitive to heat, light, and oxidation, leading to loss of potency or formation of undesirable byproducts, requiring careful handling and storage.

4.    Regulatory Compliance (GMP): Meeting stringent global standards (FDA, EMA) for APIs demands significant investment in quality systems, validation, documentation, and infrastructure, increasing costs.

5.    Batch-to-Batch Consistency: Ensuring every batch of extract has the same concentration and profile of active ingredients is a major hurdle, often requiring extensive testing.

6.    Green Chemistry & Waste: Reducing solvent use, managing wastewater containing APIs, and adopting sustainable practices add complexity and cost, as highlighted by environmental concerns in API manufacturing.

7.    Scalability: Transitioning from lab-scale extraction to large-scale commercial production while maintaining quality and efficiency is technically demanding.

8.    Cost-Effectiveness: Balancing high-quality production with market competition requires process optimization to keep costs down. 

Potential Solutions (General API Industry Practices):

·       Adopting advanced quality management systems (QMS).

·       Investing in automation and digital monitoring.

·       Using green extraction technologies (enzymes).

·       Combining separation techniques for purity.

·       Focusing on sustainable sourcing and waste management. 

What are the challenges in manufacturing of BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON  INC ’s Dosage forms? Information specific to MEDIOCON INC's manufacturing process for Bismuth(III) Oxide powder and its associated dosage forms is proprietary and not publicly available in the search results. However, general challenges in the pharmaceutical manufacturing of Bismuth(III) Oxide and powder-based dosage forms are widely documented and likely apply. 

Key challenges in the manufacturing process generally include:

·       Particle Size and Morphology Control: Bismuth oxide particles, especially nanostructured forms, tend to exhibit strong agglomeration and irregular morphology. Achieving a uniform and stable particle size distribution is critical for consistent dosage and efficacy.

·       Pressure Sensitivity: Bismuth oxide active pharmaceutical ingredient (API) is sensitive to pressure during the manufacturing process, such as tablet compression. This pressure can significantly damage the API particles, leading to an unintended decrease in particle size and potentially affecting the product's performance.

·       Powder Flowability: As with many pharmaceutical powders, ensuring good flowability of Bismuth(III) Oxide powder and its blends with excipients is a major challenge. Poor flowability can lead to inconsistent filling of dosage forms, which impacts content uniformity and manufacturing efficiency.

·       Formulation Stability and Compatibility: Bismuth(III) compounds can interact with various ligands (oxygen, nitrogen, sulfur) and other ingredients (excipients) in a formulation, which may affect the product's integrity, color, and smell. Compatibility testing is essential to prevent adverse chemical interactions that could compromise the final product's safety and effectiveness.

·       Synthesis Byproducts: Some traditional synthesis methods for bismuth oxide use halogens or metalloids, which may need to be eliminated or reduced to ensure the high purity required for pharmaceutical applications and to avoid background signals in certain testing methods.

·       Biocompatibility Balance: When Bismuth(III) oxide is incorporated into novel materials (e.g., in biomedical applications like bone repair), a key challenge is balancing its desired properties (like radiopacity or antimicrobial effects) with retaining bioactivity and ensuring long-term biocompatibility without deleterious effects. 

What are the challenges in manufacturing of BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON  INC ’s Dosage forms?

What is the Packing for BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC?

BISMUTH(III) OXIDE POWDER,is typically packed in various sizes, including:

- 25Kg Bag: Commonly used for industrial and pharmaceutical applications

- 20 Kg Bag: Also available for specific requirements

- 100g, 500g, and 2Kg: Smaller packs for laboratory and research purposes

- Drum: Used for larger quantities, often in pharmaceutical manufacturing

The packaging may vary depending on the supplier and intended use

What is shelf life Of BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC? 

While specific data for Mediocon Inc.'s Bismuth(III) Oxide powder isn't directly listed, general industrial grades often have a 1-year shelf life, but this depends heavily on storage conditions (cool, dry, sealed); always check the manufacturer's Certificate of Analysis (COA) or product documentation for precise dates and storage guidelines. 

Key Factors for Bismuth Oxide Shelf Life:

·       Purity: Higher purity grades (like 99.999%) might have different stability than industrial grades (like 99%).

·       Storage: Keep it tightly sealed in a dry place away from light and moisture to prevent degradation.

·       COA: The Certificate of Analysis from the manufacturer is the most reliable source for expiration or retest dates. 

Recommendation:
Contact Mediocon Inc. directly or check the Certificate of Analysis (COA) that came with your product for the definitive shelf life. 

 

What should the label claim for BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC   Include?

For

Bismuth(III) Oxide Powder by MEDIOCON INC, you'll need standard chemical info like Chemical Name, Formula (Bi2O3), CAS No. (1304-76-3), Purity (e.g., ≥99%), Physical Form (Yellow powder), plus Safety Data (Hazards, Handling, Storage) and Manufacturer details, plus its intended use (e.g., Pigment, Ceramic additive, Pharma intermediate), as required by regulations like GHS/REACH for industrial chemicals, ensuring compliance and user safety. 

Essential Label Claims (GHS/Safety Data Sheet Info) 

• Product Identifier: Bismuth(III) Oxide, Bismuth Trioxide.
• Chemical Formula:

2𝑂3

.

• CAS Number: 1304-76-3.
• EC Number: 215-134-7.
• Manufacturer: MEDIOCON INC (with contact info).
• Purity/Assay: e.g., ≥99%, 99.9% (Trace Metals Basis).
• Physical Appearance: Yellow powder, fine powder.
• Intended Use: Specify application (e.g., Pigment, Ceramic Additive, Pharmaceutical Intermediate, Electronics). 

Safety & Handling (GHS Pictograms/Statements) 

• Hazard Statements (H-Statements): Check SDS for specific hazards (may include skin/eye irritant, environmental hazard, etc.).
• Precautionary Statements (P-Statements): (e.g., P280: Wear protective gloves/eye protection; P261: Avoid breathing dust; P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.).
• Pictograms: As determined by hazard assessment (e.g., Exclamation Mark for irritant). 

Storage & Shelf Life 

• Storage: Store in a cool, dry, well-ventilated place, in a tightly closed container.
• Shelf Life: e.g., 2 years. 

Where can BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC are procured?

BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the BISMUTH(III) OXIDE POWDER,Manufactured by MEDIOCON INC product, regardless of the procurement source.