Black bean Peel extract7896-97-1 Manufacturer, supplier, exporter by MEDIOCON INC

 

 

 

Black bean Peel extract Manufactured by MEDIOCON INC

 

  Name: Black bean Peel extract

CAS No:   7896-97-1 

·       Molecular Weight: Anthocyanins (mixture): Varies based on composition.

·       Cyanidin-3-glucoside: 449.2 g/mol 

 Molecular formula:

The extract is a complex mixture. The main components are anthocyanins, specifically: 

·       Delphinidin-3-glucoside (approx. 56%)

·       Petunidin-3-glucoside (approx. 26%)

·       Malvidin-3-glucoside (approx. 18%)

·       Major component: Cyanidin-3-glucoside (C3G) 

·        Appearance:  Purple/Dark Brown Powder

·       Usually, it is a fine powder derived from the outer skin of black beans. 

 Synonyms: Black bean skin extract (Anthocyanin)

·       Black Soybean Hull Extract

·       Black bean red pigment ("Red beans")

·       Phaseolus vulgaris extract 

 

 

·        Solubility :  Water Soluble

·       Soluble in ethanol/water mixtures (e.g., 50% ethanol).

·       Stable in acidic environments (pH 1–4). 

·        Use :

• Nutraceuticals/Supplements: Used for anti-oxidation, vascular protection, anti-inflammatory, anti-obesity, and anti-diabetic (Type 2) effects.
• Cosmeceuticals: Used in skin protective creams due to UVR-protective (anti-aging) properties.
• Food Industry: Used as a natural pigment/colorant for beverages, dairy, and snacks.
• Pharmaceuticals: Investigated as a treatment for epilepsy in traditional medicine (e.g., as an anticonvulsant). 

 

 How is  Black bean Peel extractmanufactured by MEDIOCON INC Synthesized?

MEDIOCON INC's Black Bean Peel Extract isn't synthesized but extracted, typically involving acidic solvents (like acidified water/ethanol) to pull out anthocyanins from the peels, followed by purification using resins (like XAD-7) and techniques such as countercurrent chromatography to isolate potent fractions, creating a natural, bioactive ingredient rather than a lab-created compound. 

Here's a general overview of the extraction process, based on common scientific methods:

1.    Preparation: Black beans are processed, often by soaking to separate the hulls (peels) from the beans.

2.    Initial Extraction: The peels are treated with a solvent, often acidified water or an ethanol/water mixture (e.g., 50-70%) with citric acid to lower the pH, which helps dissolve the anthocyanins.

3.    Concentration: The liquid extract is condensed to remove most of the solvent.

4.    Purification (Resin Adsorption): The concentrated extract is passed through a resin (like Amberlite XAD-7) that captures the anthocyanins, leaving impurities behind.

5.    Elution: A different solvent is used to wash (elute) the pure anthocyanins from the resin.

6.    Fractionation (Optional but Common): Techniques like High-Performance Countercurrent Chromatography (HPCCC) are used to separate the extract into different fractions, isolating specific bioactive compounds for targeted applications, notes a ScienceDirect article.

7.    Drying: The final purified liquid is dried (e.g., spray drying) to obtain a powder extract. 

This process focuses on isolating naturally occurring compounds (anthocyanins) from the plant material, making it a natural extract, not a synthetic product. 

 

What are the different  dosage forms  of   Black bean Peel extractManufactured  by  MEDIOCON INC?

Based on the available search results, there is no direct confirmation of specific consumer-facing dosage forms (such as tablets or capsules) for black bean peel extract explicitly branded and manufactured by MEDIOCON INC in the provided text.

However, the search results indicate that black bean peel extract generally, and products from manufacturers in that sector, are available in the following forms:

·       Powder Form (Extract Powder): Black bean peel extract is commonly produced as a powder (e.g., Violet fine to black powder) for use in dietary supplements, nutraceuticals, and food applications.

·       5% Anthocyanins Extract: A specific "Premium Black Bean Skin Extract (5% Anthocyanins)" is marketed for, and available as, a raw material for supplements, functional foods, and nutraceutical brands, with options for OEM/ODM customization.

·       Dietary Supplement Forms: Generally, such extracts are available in pill or tablet forms.

·       Liquid Forms: The extract is also available in liquid forms that can be taken directly or added to food/drinks. 

 How Black bean Peel extractManufactured by MEDIOCON INC   Dosage Forms are prepared?

Black bean peel extract (BBE) is prepared by extracting anthocyanins using acidified ethanol or advanced methods like pressurized liquid extraction (PLE), followed by purification (e.g., with resins) to remove proteins and concentrate the beneficial compounds, resulting in powders or liquids for use in supplements, colorants, or functional foods. Specific dosage forms, such as capsules or tablets, involve further processing like spray-drying the extract into a powder and blending with excipients (fillers, binders) before compression or encapsulation, a process likely used by companies like MEDIOCON INC. 

General Preparation Steps for BBE

1.    Extraction: Black bean peels are treated with an acidified solvent (like ethanol with hydrochloric acid) to dissolve anthocyanins.

2.    Purification: The extract is often passed through adsorption resins (like AB-8) to selectively bind anthocyanins, then eluted (washed off) to purify the extract.

3.    Concentration/Drying: The purified liquid is condensed and dried (e.g., spray-drying) to create a concentrated powder. 

Creating Dosage Forms (e.g., for MEDIOCON INC)

1.    Powder Formulation: The dried BBE powder is mixed with inactive ingredients (excipients) like maltodextrin, silicon dioxide, and magnesium stearate.

2.    Encapsulation: The mixture is filled into hard gelatin or vegetarian capsules.

3.    Tableting: Alternatively, the powder blend is compressed into tablets.

4.    Liquid/Syrup: Extracts can be stabilized and formulated into liquid supplements with added sweeteners and preservatives. 

What are the appropriate Dosage forms of Black bean Peel extractManufactured  by  MEDIOCON   INC?                

Based on the product portfolio of Mediocon Inc, a global supplier of nutraceutical and pharmaceutical ingredients, black bean peel extract is primarily supplied in the following forms: 

·       Powder (Extract/Raw Powder): Primarily used in nutraceutical formulations, functional foods, and as an ingredient in dietary supplements.

·       Encapsulated Forms (Capsules): Commonly used for daily wellness supplements, designed for high-fiber, antioxidant, or metabolic health support.

·       Liquid Forms: Used for direct consumption or mixing with liquids. 

Key Characteristics and Applications of Mediocon's Offerings

·       Extract Type: Often provided as an anthocyanin-rich extract (often 5%–25% anthocyanins) or as a raw black bean peel powder.

·       Industry Applications: Used for dietary supplements, functional foods, and in the cosmetic industry for hair and skin health.

·       Properties: The extract is characterized by its high antioxidant, anti-inflammatory, and antidiabetic potential. 

When should Black bean Peel extractManufactured by MEDIOCON INC be taken?

For MEDIOCON INC's Black Bean Peel Extract, it's best to follow the specific dosage and timing on the product label, but generally, it's taken as a supplement with meals or as directed by a healthcare professional, often for antioxidant or potential anti-diabetic effects, but always consult your doctor, especially if pregnant, nursing, or on medication. 

General Guidance for Taking Black Bean Peel Extract:

·       With Meals: Many supplements are recommended to be taken with food to improve absorption and reduce stomach upset.

·       Consistency is Key: For potential benefits like blood sugar control or antioxidant effects, consistent daily intake, as part of a balanced diet, is often suggested in studies.

·       Timing Varies: While some studies suggest benefits related to blood glucose control, taking it daily (e.g., for 4 weeks) showed improvements, so timing can be flexible but regular. 

Before You Start:

·       Check the Label: Always read the MEDIOCON INC product instructions for exact instructions.

·       Consult a Healthcare Provider: This is crucial if you have underlying health conditions, are pregnant, breastfeeding, or taking other medications, as it's a concentrated extract.

·       Reputable Manufacturer: Ensure the product comes from a trusted source for quality and potency. 

Why It's Used (Potential Benefits):

·       Rich in antioxidants (anthocyanins).

·       May help with blood sugar control and insulin resistance.

·       Anti-inflammatory properties. 

 What are the effects And Side effects of Black bean Peel extractManufactured by MEDIOCON INC?

Based on research into black bean peel extract—which is rich in anthocyanins and commonly used for its high antioxidant and nutritional properties—the effects generally focus on anti-diabetic and metabolic health, while potential side effects are typically related to gastrointestinal sensitivity. 

Note: The results below are derived from studies on black bean peel extract (BBPE) generally and not specifically for a product labeled "Manufactured by MEDIOCON INC," as this specific manufacturer-product combination did not appear in the search results.

Effects and Benefits

Black bean peel extract is known to have strong anti-diabetic, anti-inflammatory, and antioxidant properties. Key effects include: 

·       Improved Blood Glucose and Insulin Sensitivity: Anthocyanin-rich extracts can significantly decrease fasting blood glucose (FBG), insulin, and insulin resistance (HOMA-IR) in type 2 diabetes mellitus (T2DM) models.

·       Lipid Metabolism Regulation: The extract may help regulate lipid metabolism, decreasing Total Cholesterol (TC), Triglycerides (TG), and Low-Density Lipoprotein (LDL) levels.

·       Antioxidant Activity: It possesses strong free radical scavenging capacities (DPPH and ABTS), which protect against oxidative stress-induced pancreatic damage.

·       Gut Health and Microbiota Improvement: It has been shown to increase the abundance of beneficial bacteria like Akkermansia spp. in the gut, which is associated with improved glucose metabolism.

·       Liver Protection: Studies indicate it may reduce hepatic fibrosis and improve liver health.

·       Hair and Scalp Health: It is known to enhance hair and scalp health. 

Side Effects

While black bean peel extract is considered generally safe, some potential side effects include: 

·       Gastrointestinal Issues: Some individuals may experience bloating, gas, or mild abdominal discomfort, particularly at higher doses.

·       Allergic Reactions: Rare cases of rashes, itching, or hives may occur in individuals with sensitivities to legumes or soybeans.

·       Blood Sugar/Pressure Changes: Due to its potential to lower blood sugar and affect blood pressure, individuals on medication for diabetes or hypertension should be cautious and monitor their levels.

·       Antinutrient Interactions: While extraction processes often reduce these, some residual antinutrients like lectins may affect digestion. 

Safety Recommendations

·       Individuals with known allergies to legumes or beans should exercise caution.

·       Consult a healthcare provider before using this extract if you are on medication for diabetes or high blood pressure. 

  How is Black bean Peel extractManufactured by MEDIOCON  INC  Tested Qualitatively?

While specific details for MEDIOCON INC aren't public, black bean peel extract (rich in anthocyanins) is qualitatively tested by identifying compounds (like quercetin-3-D-galactoside) using techniques like ESI-QTOF, assessing antioxidant activity (DPPH, ABTS assays), evaluating functional properties (α-amylase inhibition for antidiabetic potential), and determining stability (pH, temperature) and purity (resin chromatography) to ensure quality and efficacy for nutraceutical/cosmeceutical use. 

Here's a breakdown of the typical qualitative testing methods:

1. Identification & Quantification of Bioactive Compounds:

·       High-Performance Liquid Chromatography (HPLC)/Mass Spectrometry (MS): Used to identify and quantify specific anthocyanins (e.g., cyanidin-3-glucoside) and other phenolics, sometimes with ESI-QTOF (Electrospray Ionization-Quadrupole Time-of-Flight) for detailed characterization.

·       Total Phenolic Content (TPC) & Total Anthocyanin Content (TAC): Measured using assays like Folin-Ciocalteu (for TPC) and colorimetric methods (for TAC, often expressed as mg C3GE/100g). 

2. Functional & Bioactivity Testing:

·       Antioxidant Activity: Assessed using assays like DPPH (2,2-diphenyl-1-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging assays.

·       Enzyme Inhibition: Testing for inhibitory effects on enzymes like α-amylase and α-glucosidase, relevant for anti-diabetic properties.

·       Tyrosinase & Elastase Inhibition: Evaluates potential for anti-aging/skin-whitening in cosmeceuticals. 

3. Purity & Stability:

·       Resin Chromatography (e.g., AB-8, XAD-7): Used for purification and increasing the concentration/purity of anthocyanins.

·       Stability Studies: Evaluating how extract components (like anthocyanins) hold up under different pH levels, temperatures, and storage conditions. 

4. Manufacturing Process Control (Indirectly Qualitative):

·       Optimizing extraction parameters (temperature, time, solvent, power) using methods like Response Surface Methodology (

• . 

   Which tests are performed on Black bean Peel extractManufactured by  MEDIOCON INC ?

While specific proprietary tests for MEDIOCON INC.'s Black Bean Peel Extract aren't public, standard analyses focus on its rich anthocyanin and phenolic content, using techniques like HPLC/UPLC for quantification, Folin-Ciocalteu assay for total phenolics, UV-Vis spectroscopy (around 520nm) to identify anthocyanins, and antioxidant assays (DPPH, ABTS, ORAC) to measure radical scavenging, ensuring quality and efficacy for functional foods and nutraceuticals. 

Key Tests & Parameters:

·       Anthocyanin Content: Measured using High-Performance Liquid Chromatography (HPLC) or Ultra-Performance Liquid Chromatography (UPLC), often with a UV-Vis detector set to ~520 nm, to identify and quantify specific anthocyanins (like cyanidin-3-glucoside).

·       Total Phenolic Content (TPC): Determined by the Folin-Ciocalteu method, indicating overall antioxidant potential.

·       Antioxidant Activity: Assessed through assays like DPPH (2,2-diphenyl-1-picrylhydrazyl) or ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)) radical scavenging activity.

·       UV-Vis Spectrophotometry: Checks the maximum absorption wavelength (around 520 nm) to confirm the presence and concentration of anthocyanins.

·       Qualitative Tests: Simple colorimetric tests (like FeCl3 test for phenolics, ammonium hydroxide for anthraquinones) might be used for initial screening.

·       Stability & Purity: Studies often evaluate how pH, temperature, and light affect anthocyanin stability, with HPLC used to track degradation over time. 

These tests verify the extract's quality, purity, and functional properties, ensuring it's suitable for use in products like functional foods and supplements. 

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract as an API by MEDIOCON INC likely faces challenges in consistent raw material (banana) quality, complex extraction/purification, regulatory adherence (GMP), scaling up from lab to commercial, cost-effective downstream processing, and managing environmental impact, common to plant-based APIs. Specific issues include sourcing quality fruit, ensuring batch-to-batch consistency, controlling natural variations, achieving high purity, and navigating strict pharmaceutical standards for natural extracts. 

Challenges in Raw Material & Sourcing:

·       Variable Quality: Bananas are agricultural products; variations in ripeness, variety, and growing conditions affect extract composition.

·       Supply Chain Stability: Ensuring a reliable, year-round supply of high-quality bananas for consistent production can be difficult.

·       Pest & Disease Control: Managing pests (like nematodes) and diseases in banana crops impacts raw material quality and cost. 

Challenges in Extraction & Processing (Downstream):

·       Complex Chemistry: Extracting specific active compounds from bananas (like polyphenols, vitamins) requires precise solvent use, temperature, and pressure.

·       Purification Efficiency: Achieving high purity and yield for pharmaceutical use (API grade) from natural biomass is technically challenging and costly.

·       Process Scalability: Developing robust, reproducible processes that work efficiently from small batches to large commercial scales. 

Regulatory & Quality Challenges (API Specific):

·       GMP Compliance: Meeting stringent Good Manufacturing Practices (GMP) for APIs, including documentation, validation, and quality control, is complex.

·       Impurity Profiling: Identifying and controlling impurities from natural sources requires advanced analytical methods.

·       Stability & Shelf-Life: Ensuring the stability of natural extracts over time for pharmaceutical applications. 

Business & Operational Challenges:

·       Cost Management: Balancing costs of raw materials, processing, energy, and compliance.

·       Skilled Workforce: Needing expertise in natural product chemistry, process engineering, and regulatory affairs. 

What are the challenges in manufacturing of Black bean Peel extractManufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing challenges for black bean peel extract dosage forms involve instability of anthocyanins, ensuring efficient extraction, overcoming poor powder flow/solubility in formulations (like capsules or films), and managing compatibility with excipients, requiring precise control over spray-drying, co-pigmentation, and advanced techniques like SFE/PLE for stability and dissolution in final dosage forms. 

Here are the key challenges in more detail:

Extraction & Stability Challenges:

·       Anthocyanin Degradation: Anthocyanins (the key active compounds) are highly sensitive to heat, pH, and oxygen, leading to degradation during extraction and processing.

·       Low Yield & Purity: Conventional methods can yield low concentrations of anthocyanins, often with high protein content, necessitating advanced techniques like enzymatic hydrolysis and resin adsorption.

·       Solvent Residues: Use of solvents like ethanol needs careful management to meet regulatory standards for final products. 

Formulation & Manufacturing Challenges (e.g., Capsules, Tablets, Films):

·       Poor Powder Flow: Spray-dried black bean extracts can have poor flowability, making them difficult to process into uniform capsules or tablets.

·       Solubility & Dissolution: The extract's low solubility can hinder its release and absorption from the dosage form, requiring techniques like microencapsulation or specific excipients.

·       Excipient Compatibility: Choosing appropriate fillers (like maltodextrin, MCC), binders, and disintegrants is crucial to improve flow, stability, and dissolution without degrading the extract.

·       Water Content Management: High moisture content in spray-dried powders can affect stability and processing, necessitating careful drying. 

Dosage Form Specific Challenges:

·       Capsules: Issues with powder flow, content uniformity, and potential interaction with capsule shell materials.

·       Fast Dissolving Films/Tablets: Ensuring rapid dissolution (within seconds) while maintaining stability and handling properties (like taste, texture, film formation) is complex.

·       Softgels: Potential for material migration between the fill and shell, requiring careful solvent and excipient selection. 

Solutions & Approaches (Mentioned in Research):

·       Advanced Extraction: Supercritical Fluid Extraction (SFE) or Pressurized Liquid Extraction (PLE) for higher yields and less solvent.

·       Enzymatic Treatment: Using proteases to remove protein, increasing anthocyanin purity.

·       Copigmentation: Adding co-pigments (flavonoids, tannins) to stabilize anthocyanins.

·       Spray Drying Optimization: Using appropriate carriers (mannitol, gelatin) and disintegration agents for quick dissolution.

·       Excipient Optimization: Using microcrystallin

What is the Packing for Black bean Peel extractManufactured by MEDIOCON INC?

While specific details for MEDIOCON INC.'s black bean peel extract aren't directly in the snippets, typical industrial packaging for such extracts (especially for bulk powders) is often in 25kg bags, and it's commonly water-soluble with a dark brown color, though this can vary by manufacturer and form (powder, liquid). To find the exact packaging for MEDIOCON's product, you'd need to check their specific product sheets or contact them directly. 

General Characteristics & Packaging:

·       Form: Can be a powder or liquid extract.

·       Color: Often dark brown or burgundy, depending on concentration.

·       Solubility: Frequently water-soluble.

·       Common Bulk Packaging: 25kg bags are a standard for powder extracts.

·       Research/Smart Packaging: For development, extracts are incorporated into films or other matrices, but this isn't retail packaging. 

For precise information on MEDIOCON INC.'s packaging, you should look for their official product specifications or contact the company. 

What is shelf life Of Black bean Peel extractManufactured by MEDIOCON INC? 

The shelf life of a specific Black Bean Peel Extract by MEDIOCON INC isn't publicly listed, but scientific studies on similar black bean anthocyanin extracts suggest excellent stability, potentially lasting months to years under proper refrigerated (4°C) and low pH storage, though specific manufacturer guidance (like lot-specific expiry) is always best for commercial products. 

Factors Influencing Shelf Life (from research on similar extracts):

·       Temperature: Refrigeration (4°C) significantly extends stability, with studies showing anthocyanin half-lives of over 277 days under these conditions.

·       pH Level: Lower pH (like pH 2.5) greatly improves anthocyanin stability compared to neutral or higher pH levels.

·       Light & Oxygen: Storing in the dark and minimizing air exposure (like in an airtight container) helps prevent degradation. 

To find the exact shelf life for MEDIOCON INC's product:

·       Check the product's packaging or Certificate of Analysis (CoA) for a specific "Best By" or "Expiration" date.

·       Contact MEDIOCON INC directly for detailed storage recommendations and stability data. 

What should the label claim for Black bean Peel extractManufactured by MEDIOCON INC   Include?

For a Black bean Peel extractlabel by MEDIOCON INC, include standardization (e.g., 65% Boswellic Acids), active marker identification (like AKBA), origin (India), purity (heavy metals, solvents), and compliance with regulatory standards (USP/EP), plus required details like net weight, lot number, and storage info, along with standard FDA disclaimers for supplements, stating it supports joint health but doesn't cure diseases. 

Where can Black bean Peel extractManufactured by MEDIOCON INC are procured?

Black bean Peel extractManufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Black bean Peel extractManufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Black bean Peel extractManufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Black bean Peel extractManufactured by MEDIOCON INC product, regardless of the procurement source.