Valine 72-18-4 Manufacturer, Supplier, Exporter, MEDIOCON INC.

 

 

 

Valine Manufactured by MEDIOCON INC

 

   Name: Valine 

CAS No: 72-18-4

Molecular Weight: 117.15 g/mol

Molecular formula:  𝐶₅𝐻₁₁𝑁𝑂₂

 

Synonyms :  alpha-amino-isovaleric acid

Appearance : aline appears as a white, crystalline solid or powder, often in monoclinic crystals, and is generally colorless or nearly colorless. 

  

 Solubility : Valine is soluble in water, though often described as slightly or moderately so, and its solubility increases with temperature; it's generally insoluble in common organic solvents like ether, acetone, and nonpolar alcohols, but may show better solubility in polar solvents like ethanol or formic acid, especially with heating or mixing, as it's a nonpolar amino acid with limited water solubility compared to other amino acids. 

 

Uses : Key Uses & Benefits:

·       Muscle & Exercise: Promotes muscle growth, aids tissue repair, reduces soreness, and provides energy during workouts, making it popular for athletes.

·       Metabolism: Essential for maintaining nitrogen balance and serves as an energy source, especially in muscle tissue, generating ATP (energy).

·       Skin Health: Supports collagen synthesis for firmer, more elastic skin and helps with healing.

·       Cognitive Function: May improve cognitive function and is used in treatments for brain trauma.

·       Liver Support: Helps in the treatment of liver and gallbladder issues.

·       Nutritional Support: Treats deficiencies and helps with recovery from certain conditions like drug addiction.

·       Industrial/Research: Used in food flavorings, cosmetics (hair conditioning), veterinary drugs, and pesticides. 

Sources:

·       Dietary: Lean meats, dairy, eggs, soy, nuts, seeds, legumes, whole grains, and spirulina.

·       Supplements: Available in crystalline form, often combined with other BCAAs. 

Important Note:

While beneficial, valine intake should be balanced, as very high amounts might pose risks; consult a professional for medical advice. 

 

  How Valine is manufactured by MEDIOCON INC Synthesized?

Here's a breakdown of common industrial approaches:

1. Microbial Fermentation (Most Common for L-Valine)

·       Microorganisms: Genetically modified bacteria like Corynebacterium glutamicum or E. coli are used.

·       Process: These microbes are grown in large bioreactors with specific nutrients (like glucose) to overproduce L-valine through optimized metabolic pathways.

·       Recovery: The valine is then extracted and purified from the fermentation broth. 

2. Chemical Synthesis (Often for D-Valine or Specific Forms)

·       Strecker Synthesis: A classic route: isobutyraldehyde reacts with ammonia and hydrogen cyanide to form a nitrile, which is then hydrolyzed to racemic valine (a mix of D & L).

·       Catalytic Methods: Involving reactions of α-keto acids or other precursors.

·       Resolution (Crucial Step): To get pure L- or D-valine from the racemic mixture, a chiral resolving agent (like dibenzoyl-L-tartaric acid) is used to form diastereomeric salts that can be separated by crystallization, followed by acidification to release the pure enantiomer. 

 

 

 

What are the different  dosage forms of Valine  Manufactured  by  MEDIOCON INC?

Medical Dialogues (2023) lists Valine (an amino acid) in tablet, capsule, and oral powder forms with varying strengths (e.g., tablets: 450mg, 1000mg; capsules: 400mg, 450mg, 800mg; powders: 2000mg, 150g, 454g) but doesn't link these specific dosage forms to MEDIOCON INC; rather, it describes general Valine products. To find dosage forms specifically from MEDIOCON INC, you'd need to search their official product catalog or contact them directly, as general pharmaceutical sites list common forms, not necessarily one manufacturer's complete range. 

Here's what general information suggests for Valine:

·       Tablets: Common strengths include 450mg and 1000mg.

·       Capsules: Available in strengths like 400mg, 450mg, and 800mg.

·       Powders: Offered in bulk or single-dose sizes, such as 2000mg, 150g, or 454g. 

To confirm what MEDIOCON INC specifically manufactures, you should visit our official website or contact them directly for their product list.

 

 

 

 How Valine Manufactured by MEDIOCON INC Dosage Forms are prepared?

Manufacturing of Valine Active Pharmaceutical Ingredient (API) 

The valine active pharmaceutical ingredient (API) itself is typically manufactured through one of two main methods: 

·       Fermentation: This common method uses microorganisms to produce L-valine, the biologically active form of the amino acid.

·       Chemical Synthesis: Valine can also be synthesized chemically, often involving the cyanidation of isobutylaldehyde followed by hydrolysis and purification steps, which can include a resolution process to separate the L- and D- forms. 

Preparation of Dosage Forms

Once the valine API is produced and meets quality standards, it is incorporated into final dosage forms, such as: 

·       Injections/Sterile Liquid Formulations: This involves dissolving the valine and other components in water for injection under an inert gas (like nitrogen), adjusting the pH, filtering the solution (using 0.45 µm and 0.22 µm microfilters), filling sterile containers (e.g., infusion bottles), and sterilizing at high temperatures (105-121°C).

·       Solid Oral Dosage Forms (Tablets/Capsules): Valine can be mixed with various excipients (fillers, binders, disintegrants, lubricants, etc.) such as microcrystalline cellulose, corn starch, or lactose monohydrate. The mixture is then processed into tablets (via compression) or filled into capsules.

·       Other Forms: Valine might also be formulated into powders, emulsions, or gels, depending on the intended use, using standard pharmaceutical development techniques. 

 

 

What are the appropriate Dosage forms of Valine Manufactured  by  MEDIOCON   INC?

As a nutraceutical/pharmaceutical ingredient supplier, Mediocon typically offers L-Valine in bulk raw material forms, such as:

·       Crystalline powder — the common physical form of L-valine supplied for formulation into finished products (e.g., dietary supplements, sports nutrition formulas, parenteral solutions).

Important: Mediocon Inc does not normally sell branded, dosage-specified finished products like tablets or capsules directly to consumers. Instead, it provides the ingredient (L-Valine) itself, which manufacturers then formulate into appropriate dosage forms.

These are typical forms that amino acid valine is used in once supplied as an ingredient — and the forms manufacturers can make with Mediocon’s valine powder:

Powder (crystalline) — for mixing into:
• Oral powders and drink mixes
• Bulk blend for capsule/tablet filling
• Functional food/protein powder blends

Capsules — final product containing measured amounts of L-valine

Tablets — compressed solid dosages with L-valine + other ingredients

Liquid oral formulations — e.g., ready-to-drink amino acid supplements

Parenteral nutrition solutions (in clinical settings) — valine included as part of amino acid mixtures for intravenous nutrition (not directly Mediocon brand, but valine used in such solutions)

 

When should Valine  Manufactured by MEDIOCON INC be taken?

Understanding Mediocon's Valine:

·       Mediocon Inc is a manufacturer of pharmaceutical intermediates (chemicals used to make APIs), not finished consumer products.

·       Therefore, their Valine isn't for direct consumption but used in making other medications, like antiviral drugs. 

When to Take L-Valine (General Supplement Guidance):
If you are using a separate L-Valine supplement, consult your doctor for specific timing, but general guidelines suggest:

·       Between Meals: To avoid competition with other amino acids for absorption.

·       Before Bed: For overnight muscle repair and growth.

·       Around Exercise: Before, during, or after workouts to support muscle recovery and growth hormone release. 

Key Takeaway:
Since Mediocon's product is an intermediate, you should not take it directly. Instead, if you're considering L-Valine for health, speak with a healthcare provider about a suitable supplement and its optimal timing for your needs. 

 

 What are the effects And Side effects of Valine Manufactured by MEDIOCON INC

Common Effects and Uses

Valine is vital for normal human development and metabolism, and it is a popular supplement among athletes. 

·       Muscle Support: It aids in muscle growth, development, and tissue repair and helps prevent muscle breakdown during intense physical activity or conditions like fasting or aging.

·       Energy Production: Valine provides muscles with additional energy, converting into glucose to fuel activity and sustaining energy levels.

·       Physical Performance: It can enhance physical endurance and stamina, reduce post-workout fatigue and soreness, and improve recovery rates after injury or surgery.

·       Organ Function: It assists in removing excess nitrogen from the liver and transporting nitrogen to different parts of the body. It may also be used as a supplemental therapy for patients with chronic liver disease (cirrhosis) and some cases of hepatic encephalopathy.

·       Cognitive Function: Valine is involved in the production of neurotransmitters and may help improve cognitive function and mental clarity. 

Potential Side Effects

Valine is generally recognized as safe when taken in appropriate doses through diet or supplements. However, high doses or long-term single amino acid supplementation can lead to adverse effects. 

·       Gastrointestinal Issues: Common side effects include nausea, vomiting, diarrhea, stomach bloating, and upset stomach.

·       Neurological Effects: Excessive intake can cause fatigue, headaches, lack of muscle coordination, dizziness, poor balance, or, in rare cases, a crawling sensation on the skin or hallucinations.

·       Metabolic and Organ Stress: High doses, especially of a single amino acid supplement, can lead to negative nitrogen balance, make kidneys work harder, and interfere with liver function. It can also affect blood sugar levels.

·       Specific Conditions: People with certain conditions should avoid valine supplements:

o   Maple syrup urine disease (a rare, inherited disorder where the body cannot properly metabolize BCAAs).

o   Chronic liver or kidney disease/failure.

o   Pregnancy or breastfeeding.

o   Amyotrophic lateral sclerosis (ALS). 

It is recommended to consult a healthcare provider before starting valine supplements, especially if you have pre-existing medical conditions or are taking other medications, to ensure correct dosage and avoid potential interactions. 

 

 

 How is Valine  Manufactured by MEDIOCON  INC  Tested Qualitatively?

Identification & Purity:

·       HPLC (High-Performance Liquid Chromatography): Separates and quantifies L-Valine from impurities, confirming purity and concentration.

·       Chiral HPLC/GC: Uses a chiral column (like Chirasil-Val) to separate L-valine from its D-enantiomer, ensuring the correct optical isomer is present.

·       NMR Spectroscopy (Nuclear Magnetic Resonance): Confirms the molecular structure of L-Valine by analyzing proton and carbon environments.

·       Mass Spectrometry (MS): Determines the exact mass and fragmentation pattern, confirming the compound's identity.

·       FTIR Spectroscopy (Fourier-Transform Infrared): Identifies functional groups (amine, carboxyl) characteristic of Valine. 

Physical & Chemical Properties:

·       Specific Optical Rotation: Measures the rotation of polarized light, confirming the L-configuration (chirality).

·       Solubility Tests: Checks solubility in water, acidic, and basic solutions.

·       Melting Point/Decomposition Point: Compares the observed range to known values (around 296°C). 

Impurities & Contaminants:

·       Heavy Metals Testing: Uses methods like Atomic Absorption Spectroscopy (AAS) or ICP-MS to check for lead, mercury, arsenic, etc..

·       Loss on Drying/Moisture Content: Gravimetric method to find water content.

·       Residue on Ignition/Sulfated Ash: Checks for inorganic impurities. 

For Specifics:
To know exactly how Mediocon Inc. tests their Valine, you would need to request their Certificate of Analysis (CoA) or product specifications, which details the exact methods, standards (like USP/EP/JP), and acceptance criteria used. 

 

 

   Which tests are performed on Valine Manufactured by  MEDIOCON INC ?

While the exact proprietary testing protocols used by MEDIOCON INC are not publicly available, their product quality is consistently reviewed as excellent. The typical tests performed on L-Valine to ensure purity, identity, and safety generally include: 

·       Assay (Quantification): A test, often using perchloric acid titration or High Performance Liquid Chromatography (HPLC), to determine the L-Valine content, ensuring it meets the minimum specification (e.g., typically ≥ 98.0% or 99.0% on a dried basis).

·       Identity: Confirms the substance is indeed Valine, typically through physical characteristics like appearance (white crystalline powder), specific rotation, and infrared (IR) spectrum analysis.

·       Appearance of Solution: Checks that the product, when dissolved in a specified solvent (e.g., water), results in a clear and colorless solution.

·       Loss on Drying: Measures the amount of moisture and volatile matter in the sample, ensuring it is within limits (e.g., not more than 0.30%).

·       Residue on Ignition/Sulfated Ash: Determines the amount of inorganic impurities or non-volatile material remaining after ignition (e.g., not more than 0.10%).

·       Heavy Metals: Tests for the presence of toxic metal impurities, often specified as a limit (e.g., ≤ 0.001% as Pb).

·       Ammonium (NH₄) Content: Measures ammonium levels as an impurity (e.g., ≤ 0.01%).

·       Foreign Amino Acids/Related Compounds: Uses methods like Thin-Layer Chromatography (TLC) or HPLC to detect and quantify any other amino acids or related chemical substances that should not be present or must be below a certain threshold.

·       Microbiological Contamination/Endotoxins: For pharmaceutical use, tests for microbial limits including E. coli, Salmonella spp., and endotoxin activity (LPS) are performed to ensure safety. 

 

 

What are the challenges in manufacturing of Valine  by MEDIOCON  INC ’s Dosage forms?

Mediocon Inc primarily functions as a manufacturer of pharmaceutical intermediates and a wholesaler of various pharmaceutical medicines. Available information does not specifically indicate that Mediocon Inc manufactures pure Valine in dosage forms; rather, it appears to be an ingredient in some of the syrups they distribute, such as "Total 24 Syrup". 

If Mediocon Inc were to manufacture a Valine-containing dosage form, the general challenges in pharmaceutical manufacturing would apply, including: 

·       Formulation Challenges: Ensuring the Valine is evenly distributed, especially if it is a low-dose active pharmaceutical ingredient (API), to maintain product uniformity and accurate dosing.

·       Material Properties: Overcoming challenges related to the physical and chemical properties of Valine itself, such as potential hygroscopicity (water absorption) which can affect stability, manufacturing processes (e.g., tabletting), and storage requirements.

·       Excipient Compatibility: Selecting appropriate excipients (inactive ingredients) that do not interact negatively with Valine or other APIs in a fixed-dose combination, which can become complex with multiple ingredients.

·       Process Validation and Control: Validating all equipment and production methods to ensure consistent quality and compliance with Good Manufacturing Practices (GMP) and other regulatory guidelines.

·       Quality Control: Monitoring and managing related impurities that might arise during the manufacturing or degradation processes.

·       Supply Chain Management: Ensuring a consistent supply of quality-assured raw materials (Valine and excipients) to avoid production delays. 

 

 

 

What is shelf life Of Valine  by MEDIOCON INC

While specific shelf life for Valine by MEDIOCON INC isn't directly listed, general L-Valine powder (CAS 72-18-4) from suppliers offers a typical shelf life of 24 months (2 years) when stored properly in cool, dry conditions in sealed containers, as indicated by several trade sources for similar products. Always check the packaging from MEDIOCON INC for their exact expiry date and storage instructions.

 

What should the label claim for Valine Manufactured by MEDIOCON INC Include?

Essential Label Components:

1.      Product Name: Valine (or L-Valine)

2.      Key Feature: Branched-Chain Amino Acid (BCAA).

3.      Type: Essential Amino Acid (body doesn't produce it).

4.      Purity/Form: L-Valine (most common and biologically active form).

5.      Benefits (Claims):

1.                  Supports Energy Production.

2.                  Aids Muscle Metabolism/Repair (common BCAA benefit).

3.                  Essential for Protein Synthesis.

6.      Manufacturer: Manufactured by MEDIOCON INC.

7.      Net Quantity: Weight/Volume (e.g., 500mg, 100 capsules).

8.      Directions for Use: How much and when (e.g., "Take 1-2 capsules daily with water").

9.      Supplement Facts/Nutritional Panel:

0.      Serving Size.

1.      Servings Per Container.

2.      Amount of Valine per serving (mg).

10.  Ingredients List: Just Valine, any fillers/capsule material (e.g., cellulose, gelatin if not vegan).

11.  Allergen Info: "Manufactured in a facility that processes milk, soy, eggs..." (if applicable).

12.  Storage: Cool, dry place.

13.  Certifications: Kosher, Halal, GMP, Vegan (if applicable).

14.  Batch No. & Mfg./Exp. Dates. 

Key Considerations for Claims:

·       Regulatory Compliance: Ensure claims meet FDA (US) or FSSAI (India) guidelines for supplements, avoiding drug claims.

·       Transparency: State if it's fermentation-derived (non-animal).

·       Specificity: Emphasize "L-Valine" for clarity. 

By including these, the label effectively informs consumers about the product's quality, benefits, and usage. 

 

Where can Valine  Manufactured by MEDIOCON INC are procured?

Valine  Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Valine  Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Valine  Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Valine  Manufactured by MEDIOCON INC product, regardless of the procurement source.