Boswellia Serrata extract 97952-72-2 Manufacturer ,supplier, exporter by MEDIOCON INC

 

 

 

Boswellia Serrata extract Manufacturer,supplier, exporter chattrapati sambhajinagar  by MEDIOCON INC

 

   Name: Boswellia Serrata extract

CAS No:   97952-72-2

Molecular Weight: (Molecular Weight: ~456.7 g/mol)

Molecular formula: C30H48O3cap C sub 30 cap H sub 48 cap O sub 3

𝐶30𝐻48𝑂3

·       Synonyms: Indian Frankincense

·       Salai Guggal

·       Boswellic Acids

·       Olibanum Indicum 

·       Appearance:  Off-white to light yellow, pale brown, or cream-colored powder.

·       Characteristic odor. 

 

·        Solubility :  Soluble in ethanol (alcohol), acetone, DMSO, chloroform, and dichloromethane.

·       Insoluble in water. 

.

Use :

·       Dietary Supplements: Joint health, reducing arthritis/osteoarthritis pain, improving mobility.

·       Pharmaceutical Ingredient: Anti-inflammatory, anti-asthmatic, and potential cancer support.

·       Cosmetic Additive: Skin-soothing, anti-irritation, and anti-aging applications.

·       Other: Respiratory health support, gastrointestinal health. 

 

 How is  Boswellia Serrata extract manufactured by MEDIOCON INC Synthesized?

Based on the provided search results, Boswellia serrata extract, including specialized, high-potency, or AKBA-enriched varieties, is generally manufactured through a multi-stage process involving solvent extraction, purification, and standardization, rather than total chemical synthesis. 

The manufacturing process described for similar high-quality Boswellia extracts typically involves:

·       Raw Material Preparation: The oleo-gum resin is sourced, cleaned, and ground into granules to increase surface area.

·       Extraction: The resin is extracted using solvents, typically food-grade ethanol or methanol, which dissolves the resin and separates the active boswellic acids from other materials.

·       Purification (Removal of Impurities): The extract is filtered and purified to remove insoluble material.

·       Concentration: The liquid extract is concentrated under vacuum to remove the solvent, often using a rotary vacuum evaporator or similar technology.

·       Standardization (for AKBA-enriched grades): For high-potency extracts (e.g., 30%-65% AKBA), specialized separation techniques are used to concentrate specific compounds. This often involves converting lower-potency acids into Acetyl-11-keto-β-boswellic acid (AKBA) through oxidation and acetylation.

·       Drying: The final product is dried in a vacuum dryer to produce a fine light yellow to brown powder.

·       Quality Control: Each batch is verified using HPLC (High-Performance Liquid Chromatography) and titration to ensure consistent levels of boswellic acids. 

The process focuses on maximizing the concentration of active triterpenoid acids (boswellic acids)

What are the different  dosage forms  of   Boswellia Serrata extract Manufactured  by  MEDIOCON INC?

Based on the provided search results, there is no direct information listed regarding specific dosage forms of Boswellia Serrata extract manufactured by MEDIOCON INC.

The search results indicate that Mediocon Inc (founded in 2018) is a global supplier of chemicals and ingredients. 

Boswellia Serrata extract, when manufactured by various suppliers and manufacturers, generally comes in the following forms according to the search results:

·       Powder (often 65% or 80% concentration)

·       Capsules

·       Tablets

·       Dry Extracts

·       Liquid Extracts/Oil 

 How Boswellia Serrata extract Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Based on standard industry practices for manufacturing

Boswellia serrata extract, the production process involves extracting, purifying, and standardizing active boswellic acids from the gum resin of the Boswellia serrata tree. 

Manufacturing Process of Boswellia Serrata Extract 

The manufacturing generally follows these steps: 

1. Raw Material Preparation: The oleo-gum resin is collected, cleaned to remove impurities like bark, and then ground into a powder.
2. Extraction: The powder is extracted using solvents, commonly USP-grade ethanol or methanol, to dissolve the resin. Some modern processes use supercritical fluid extraction (CO₂) for a cleaner, non-toxic extraction.
3. Purification: The mixture is filtered, and the solvent is removed by vacuum evaporation, typically at temperatures between

60∘C60 raised to the composed with power C

60∘C

and

85∘C85 raised to the composed with power C

85∘C

.

4. Standardization: The resulting extract is standardized to contain specific percentages of active boswellic acids (such as 30–75% total acids or enriched for AKBA).
5. Quality Control: The final powder or resin is tested using High-Performance Liquid Chromatography (HPLC) and titration methods to ensure potency and purity

What are the appropriate Dosage forms of Boswellia Serrata extract Manufactured  by  MEDIOCON   INC?                

·       Capsules: A prevalent format for delivering boswellia extract.

·       Tablets: Often utilized for standardized extracts in formulations, such as those addressing joint pain.

·       Powder (Raw Extract): Available as a bulk powder, standardized for boswellic acids or specific active compounds like AKBA, typically intended for blending or encapsulation.

·       Liquid/Oil: Concentrated extracts used in particular applications. 

These forms are commonly used in dietary supplements for various purposes, including support for arthritis, inflammation, joint health, and respiratory function. 

Key Standardization/Quality Features commonly found:

·       Concentration: Often standardized to a certain percentage of boswellic acids or Acetyl-11-keto-β-boswellic acid (AKBA).

·       Grade: Available in pharmaceutical or nutraceutical grades.

·       Appearance: Typically presents as a fine powder, ranging in color from light yellow to brown. 

It is important to note that suppliers of raw ingredients like Mediocon Inc generally provide raw material to manufacturers, rather than finished, branded products available directly to consumers.

Disclaimer: This information is for general knowledge and should not be taken as medical advice. Consult with a healthcare professional before starting any new supplement regimen.

When should Boswellia Serrata extract Manufactured by MEDIOCON INC be taken?

Information on when to take Boswellia serrata extract manufactured by MEDIOCON INC would typically be found on the product packaging or through consultation with a healthcare provider. General guidelines for taking Boswellia serrata extracts, which are often used for their anti-inflammatory properties, suggest the following: 

·       With Meals: It is often recommended to take Boswellia extract with food. This can help improve the absorption of the active compounds and may also reduce the likelihood of digestive discomfort.

·       High-Fat Meals: Taking the extract with a meal that includes some fat may further enhance the bioavailability of boswellic acids. 

Important Considerations:

·       Always follow the specific instructions on the label provided by MEDIOCON INC, as product formulations can vary.

·       Consult a doctor if you are taking blood thinners or have a history of gastritis or acid reflux.

·       Boswellia is generally not recommended during pregnancy or while breastfeeding. 

Disclaimer: This information is for general knowledge and should not be taken as medical advice. Always consult with a healthcare professional before starting any new supplement regimen.

 What are the effects And Side effects of Boswellia Serrata extract Manufactured by MEDIOCON INC?

Boswellia serrata extract, commonly used as a natural anti-inflammatory, is used to manage pain and improve function in conditions like osteoarthritis and, in some cases, inflammatory bowel disease. It is generally considered safe for most adults when taken orally in recommended doses for up to 6 months. 

When Should It Be Taken?

·       With Meals: It is recommended to take Boswellia serrata capsules or tablets 1–3 times a day with meals to improve absorption and minimize potential gastric discomfort.

·       Timing for Relief: While it can be taken daily, improvements in symptoms can take 2 to 4 weeks to become noticeable, though some studies show effects as early as 5 days.

·       Duration: Clinical studies have often used it for periods up to 6 months. 

Effects

·       Anti-inflammatory and Analgesic: It acts as a potent anti-inflammatory agent, specifically reducing joint swelling and pain (particularly in osteoarthritis and rheumatoid arthritis) by inhibiting 5-lipoxygenase (5-LOX), an enzyme that causes inflammation.

·       Cartilage Protection: It helps prevent the degradation of cartilage, improving mobility.

·       Other Potential Effects: It is used in Ayurvedic medicine for respiratory issues (asthma), inflammatory bowel diseases (IBD), and occasionally, as a topical agent for skin conditions. 

  How is Boswellia Serrata extract Manufactured by MEDIOCON  INC  Tested Qualitatively?

Based on standard industry practices for high-quality botanical extracts and specifically for

Boswellia serrata manufacturers in India, the Boswellia Serrata extract produced by companies like MEDIOCON INC is qualitatively tested through a comprehensive range of analytical, physical, and phytochemical methods. 

The testing ensures the identity, purity, and standardization of the active boswellic acids (such as AKBA, KBA,

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-BA,

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-BA). 

Key Qualitative and Quantitative Testing Methods 

The following methods are used to test the quality, identity, and purity of Boswellia serrata extract: 

• High-Performance Liquid Chromatography (HPLC) & UPLC: This is the primary method for identifying and quantifying the specific boswellic acids (e.g., 3-O-acetyl-11-keto-

βbeta

𝛽

-boswellic acid - AKBA) in the extract. It is used to verify that the product matches the labeled concentration (e.g., 30%-65% total boswellic acids).

• Titration Analysis: Along with HPLC, volumetric titration is used to determine the total organic acids (calculated as boswellic acid) to confirm total potency.
• Thin Layer Chromatography (TLC/HPTLC): Used for qualitative identification to confirm the presence of key marker compounds and to check for the absence of adulterants or unexpected plant components.
• Organoleptic Examination: Preliminary qualitative checks are done to verify the appearance, color, and odor, which is typically a light yellow to brown powder with a characteristic aroma.
• Physicochemical Testing:
• Solubility: Tested for solubility in ethanol, which is characteristic of high-quality extracts.
• Moisture Content/Loss on Drying (LOD): Confirms the stability and proper drying, usually required to be within strict limits (e.g., NMT 2% to 8%).
• pH Analysis: Evaluated for consistency (typically around 4.0-6.0 for a 1% solution).
• Ash Value: Measures total ash and acid-insoluble ash to ensure purity and lack of mineral contamination. 

   Which tests are performed on Boswellia Serrata extract Manufactured by  MEDIOCON INC ?

Based on the product specifications for Boswellia Serrata extract (likely referring to the standardized extract produced by specialized manufacturers like Mediocon/Star Hi Herbs), the following tests are performed to ensure quality, potency, and safety: 

1. Quantitative Analysis (Active Compounds Verification) 

·       High-Performance Liquid Chromatography (HPLC): Used to determine the percentage of specific, active Boswellic Acids (typically 25% to 65% depending on grade) and AKBBA (Acetyl-11-keto-β-boswellic acid, typically 30% to 50%).

·       Titration Methods: Employed for the determination of total boswellic acid content (typically 50%–75%). 

2. Physical and Chemical Characterization

·       Appearance/Description: Verification of color and texture (fine light yellow to brown powder).

·       Odor: Characteristic odor test.

·       Solubility: Tested for solubility in ethanol and partial water solubility.

·       Moisture Content/Loss on Drying: To determine water content. 

3. Quality Control and Safety Testing

·       Heavy Metal Analysis: To ensure levels are within safe limits.

·       Microbial Analysis: Tests for total microbial count, yeast, and mold to ensure safety. 

4. Additional Analytical Techniques (Based on general industry standards for Boswellia) 

·       Thin Layer Chromatography (TLC): Used for fingerprinting to ensure identity.

·       Fourier-transform Infrared Spectroscopy (FT-IR): To confirm structural integrity. 

These tests are generally performed on products in a GMP-certified facility, often using USP-grade ethanol for extraction. 

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract as an API (Active Pharmaceutical Ingredient) faces challenges in raw material consistency (banana biomass variability), achieving high purity and yield from complex natural sources, scaling up efficient extraction/purification (downstream processing), controlling impurities, ensuring regulatory compliance (QbD, CQAs), managing waste biomass (peels, etc.), and developing sustainable, cost-effective processes using green chemistry for separation and catalysis. 

Specific Challenges for Banana Extract API:

1.    Raw Material Variability: Bananas, being natural products, vary significantly in chemical composition (polyphenols, starches, fibers) based on variety, ripeness, and growing conditions, impacting extract consistency.

2.    Extraction & Separation Efficiency: Isolating target APIs from fibrous biomass (peels, pseudostem) requires efficient, scalable, and cost-effective downstream processing (extraction, filtration, crystallization) that minimizes solvent use and maximizes yield, which is a major hurdle.

3.    Impurity Control: Banana biomass contains many compounds (cellulose, lignin, pigments) that can co-extract, leading to complex mixtures and potential impurities that must be removed to meet API standards, notes Bulat Pharmaceutical.

4.    Scale-Up Issues: Processes optimized in the lab often face unexpected impurity formation or yield drops when scaled, requiring careful monitoring of Critical Process Parameters (CPPs) like temperature, pressure, and mixing.

5.    Waste Management: Large volumes of biomass waste (peels, stems) are generated, requiring sustainable and odor-free disposal or valorization, say Taylor & Francis Online and MDPI.

6.    Environmental Impact: Traditional extraction methods often use harsh solvents, creating environmental concerns, pushing for green chemistry solutions like enzyme catalysis or innovative solvents. 

General API Manufacturing Challenges (Also Applicable):

·       Regulatory Compliance: Adhering to stringent global pharmaceutical standards (FDA, EMA) for quality (ICH guidelines) and documentation.

·       Quality by Design (QbD): Defining and controlling Critical Quality Attributes (CQAs) like purity, particle size, and water content.

·       Supply Chain: Ensuring consistent, quality supply of raw bananas and other reagents. 

What are the challenges in manufacturing of Boswellia Serrata extract Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Boswellia serrata extract (BSE) into dosage forms like tablets faces challenges in standardization (complex chemistry), poor physicochemical properties (low solubility, flow, compressibility), ensuring bioavailability, and quality control (heavy metals, contaminants), requiring advanced techniques like SFE, granulation, and excipient use to achieve consistent efficacy and stability for a product like MEDIOCON INC's. 

Key Manufacturing Challenges

1.    Chemical Complexity & Standardization:

·       Variability: The resin's complex mix of boswellic acids (like AKBA) varies greatly by species and origin, making consistent active ingredient levels difficult.

·       Detection: Identifying and quantifying minor but significant constituents requires advanced tools like UHPLC-HRMS, not just basic tests.

2.    Physicochemical Hurdles:

·       Poor Solubility: BSE's low water solubility hinders absorption and effective drug delivery.

·       Powder Issues: Raw extracts often have poor flowability, high hygroscopicity (moisture absorption), and poor compressibility, complicating tablet formation.

3.    Formulation & Bioavailability:

·       Low Bioavailability: Poor solubility and complex matrix can reduce how much of the active compound the body absorbs.

·       Drying & Granulation: Optimizing drying and granulation processes is crucial to create stable, uniform powder for tableting.

4.    Quality & Safety:

·       Contaminants: Ensuring the extract is free from heavy metals (like lead, cadmium) and microbial contamination is vital for safety.

·       Stability: Maintaining extract quality and activity during storage and formulation (e.g., preventing degradation) is a constant challenge. 

What is the Packing for Boswellia Serrata extract Manufactured by MEDIOCON INC?

While specific packaging details for MEDIOCON INC aren't directly listed, suppliers of Boswellia Serrata Extract commonly use 25 kg HDPE drums with double polybag liners, often with options for customization, for bulk powder, ensuring protection and shelf life. Expect your order to be in large, sealed containers for shipping, though retail sizes (like smaller bottles or pouches) are also available depending on the brand. 

Common Packaging Characteristics for Boswellia Serrata Extract:

·       Bulk: 25 kg HDPE (High-Density Polyethylene) drums with inner double polybags for powder forms.

·       Retail/Custom: Pouches, jars, or smaller packs for retail.

·       Protection: Sealed to prevent contamination and maintain potency, often adhering to quality standards (USFDA, TGA for some manufacturers). 

What is shelf life Of Boswellia Serrata extract Manufactured by MEDIOCON INC? 

While specific information for MEDIOCON INC isn't directly found, most reputable Boswellia Serrata extracts have a shelf life of 2 to 3 years (24 to 36 months), often stored in cool, dry, sealed conditions, but check the product's Certificate of Analysis (COA) or label for exact details, as some variations might differ, Tradeindia

General Guidelines for Boswellia Extract Shelf Life:

·       Typical Range: 24 months (2 years) to 36 months (3 years) is common for high-quality extracts.

·       Key Factors: Purity, extraction method (solvent vs. water), and stabilization processes influence shelf life.

·       Storage: Store in a cool, dry place, away from direct light, often in sealed containers.

·       Verification: Always look for the expiration date or batch-specific shelf life on the product label or ask the manufacturer (MEDIOCON INC) for their official Certificate of Analysis (COA). 

What should the label claim for Boswellia Serrata extract Manufactured by MEDIOCON INC   Include?

For a Boswellia Serrata extract label by MEDIOCON INC, include standardization (e.g., 65% Boswellic Acids), active marker identification (like AKBA), origin (India), purity (heavy metals, solvents), and compliance with regulatory standards (USP/EP), plus required details like net weight, lot number, and storage info, along with standard FDA disclaimers for supplements, stating it supports joint health but doesn't cure diseases. 

Where can Boswellia Serrata extract Manufactured by MEDIOCON INC are procured?

Boswellia Serrata extract Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Boswellia Serrata extract Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Boswellia Serrata extract Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Boswellia Serrata extract Manufactured by MEDIOCON INC product, regardless of the procurement source.