Bupleurum (Chai Hu) 89958-12-3 extract Manufacturer , supplier, exporter by MEDIOCON INC

 

 

 

Bupleurum (Chai Hu) extract Manufactured by MEDIOCON INC

 

 Name: Bupleurum (Chai Hu) extract

CAS No:   89958-12-3 (Bupleurum falcatum, ext.).

Molecular Weight:  Varies by specific saikosaponin (e.g., Saikosaponin a is approximately 780.98 g/mol).  

Molecular formula:  CaC₄H₄O₄.H₂O

Synonyms: Bupleurum (Chai Hu) extractAnhydrous Monohydrate or Succinic acid calcium salt monohydrate or Butanedioic acid, calcium salt monohydrate.

Appearance:  Typically a brown to yellow-brown fine powder or a clear dark liquid (if in tincture form).

 Solubility :  Often available as a water-soluble or ethanol-soluble extract (hydroalcoholic extraction is common). 

Use :

·       Traditional Chinese Medicine (TCM): Used to "release the exterior," "subdue liver-yang," "promote the flow of Qi," and treat alternating fevers and chills.

·       Liver Health: Known for hepatoprotective properties, treating hepatitis, and fatty liver disease.

·       Anti-inflammatory: Used for treating arthritis, rheumatism, and respiratory infections.

·       Antidepressant/Nervous System: Known for calming effects to reduce anxiety, tension, and stress.

·       Skincare/Cosmetics: Used in formulations for skin tightening and as a botanical slimming agent (stimulates lipolysis). 

Key Active Components

·       Triterpenoid Saponins (Saikosaponins): 1-7% of total dry weight in roots.

 

 How is  Bupleurum (Chai Hu) extractmanufactured by MEDIOCON INC Synthesized?

Bupleurum (Chai Hu) extract isn't synthesized but rather extracted from the dried root of the Bupleurum plant, a traditional Chinese medicine, using methods like solvent extraction or steam distillation to isolate key compounds like saikosaponins, volatile oils, and flavonoids, then potentially concentrated into extracts or powders for various uses, with specific manufacturing details for a company like MEDIOCON INC requiring direct inquiry. 

General Manufacturing Process for Chai Hu Extract

1.    Raw Material Sourcing: Dried roots of Bupleurum chinense or Bupleurum scorzoneraefolium are gathered.

2.    Preparation: Roots are cleaned, cut, and sometimes processed (e.g., stir-fried with wine or vinegar) to alter properties.

3.    Extraction:

1.    Solvent Extraction: Using solvents like ethanol to pull out active compounds (saponins, flavonoids).

2.    Steam Distillation: To isolate volatile essential oils, a key component.

4.    Concentration/Purification: The liquid extract is concentrated (e.g., by evaporation) and dried (spray drying, vacuum drying) to create powders or concentrated liquid extracts.

What are the different  dosage forms  of   Bupleurum (Chai Hu) extractManufactured  by  MEDIOCON INC?

Based on the provided search results, Mediocon Inc is a global supplier of pharmaceutical and nutraceutical ingredients. While the search results mention Bupleurum (Chai Hu) Extract in their product list and identify it as a plant root extract (CAS 89958-12-3), they do not list specific finished, retail-ready dosage forms (such as capsules or tablets) branded by Mediocon Inc. 

However, the search results indicate that Bupleurum (Chai Hu) extract, generally, is formulated into the following forms:

·       Powdered Extract: Specifically mentioned as "Bupleurum extract powder" obtained through solvent extraction, filtration, and vacuum drying.

·       Granules: Used frequently in Traditional Chinese Medicine (TCM).

·       Oral Liquid: Used for its antipyretic and anti-inflammatory properties.

·       Tablets/Pills: Often used in formulas like Xiao Yao Wan. 

These extracts are generally used to support the liver, reduce inflammation, and for stress-related conditions in TCM. 

 How Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC   Dosage Forms are prepared?

Bupleurum (Chai Hu) extractdosage forms are prepared through various processes:

- Tablets and Capsules: Mixing Bupleurum (Chai Hu) extractwith excipients, followed by granulation, compression, or encapsulation.

- Powder and Granules: Milling or grinding Bupleurum (Chai Hu) extractinto desired particle sizes, then blending with other ingredients if needed.

 

Manufacturing processes may involve [1][2]:

- Wet Granulation: Mixing Bupleurum (Chai Hu) extractwith binders and solvents to form granules.

- Direct Compression: Compressing Bupleurum (Chai Hu) extractpowder into tablets.

- Encapsulation: Filling Bupleurum (Chai Hu) extractpowder into capsules.

Quality control measures ensure consistency and purity in the final product.

What are the appropriate Dosage forms of Bupleurum (Chai Hu) extractManufactured  by  MEDIOCON   INC?                

Bupleurum (Chai Hu) extractis available in various dosage forms, including [1][2]:

- Oral Tablets: For supplementation or therapeutic use

- Capsules: For oral administration

- Powder: For use in food products, cosmetics, or pharmaceuticals

- Granules: For food products or pharmaceutical applications

The choice of dosage form depends on the intended use, industry, and desired release profile.

When should Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC be taken?

Bupleurum (Chai Hu) extractis typically taken as directed by a healthcare professional or according to product instructions. Here are some general guidelines:

- With Meals: Often taken with meals to enhance absorption

- As Supplements: Usually taken once or twice daily, depending on individual needs

- Food Fortification: Added to food products as needed

 

Consult a healthcare professional for specific advice on taking calcium succinate, especially if you have underlying medical conditions or take other medications [1][2].

 What are the effects And Side effects of Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC?

Bupleurum (Chai Hu) extract, generally sourced from the root of Bupleurum chinense or Bupleurum scorzoneraefolium, is a traditional Chinese medicine (TCM) commonly used to harmonize liver "qi," reduce fever, and manage stress-related digestive issues. While it is considered possibly safe for short-term use, it can cause significant side effects at high doses or with long-term consumption. 

Note: Specific, publicly available data detailing the exact chemical composition or clinical trial results for a "Bupleurum extract manufactured by MEDIOCON INC" is not provided in the search results.

Reported Effects and Benefits (Traditional and Preclinical)

·       Liver Support: It is frequently used to soothe "liver qi stagnation," which corresponds to relieving stress-related symptoms, improving digestion, and treating conditions like chronic hepatitis and cirrhosis.

·       Antipyretic and Anti-inflammatory: It has been used for thousands of years to reduce fevers, reduce inflammation, and treat infections.

·       Immune Modulation: It is thought to stimulate the immune system, particularly in combination with other herbs (e.g., in formulas like Xiao Chai Hu Tang/Sho-saiko-to).

·       Mental Health: Used in TCM to relieve depression, anxiety, and irritability.

·       Reproductive System: Used for PMS and painful periods (dysmenorrhea). 

Potential Side Effects

·       Liver Toxicity: High doses (exceeding ~19g daily) are associated with liver damage and can cause inflammation or lesions in the liver.

·       Digestive Issues: Reported side effects include bloating, nausea, increased bowel movement frequency, and acid reflux.

·       Drowsiness: The extract may cause sedation.

·       Breathing Issues: In rare instances, when combined with other herbs (like in Sho-saiko-to), it has been associated with serious lung and breathing problems, particularly with interferon therapy.

·       Allergic Reactions: Reactions may include skin, respiratory, or gastrointestinal issues. 

  How is Bupleurum (Chai Hu) extractManufactured by MEDIOCON  INC  Tested Qualitatively?

Bupleurum (Chai Hu) extractis tested qualitatively using several methods.

- Flame Test: Calcium ions produce an orange-red flame color.

- Precipitation Reaction: Adding ammonium oxalate to a calcium solution forms a white precipitate of calcium oxalate.

- Carbonate Test: Adding ammonium carbonate to a calcium solution forms a white precipitate of calcium carbonate, which is soluble in acetic acid.

These tests help identify the presence of calcium ions in a sample.

   Which tests are performed on Bupleurum (Chai Hu) extractManufactured by  MEDIOCON INC ?

While specific tests for MEDIOCON INC.'s Bupleurum (Chai Hu) aren't detailed online, quality control generally involves chromatographic fingerprinting (HPTLC/HPLC) to verify saikosaponin content, species identification, and purity, plus tests for heavy metals, pesticides, and adulterants, ensuring consistency for its traditional uses in inflammation, liver health, and mood disorders. 

Typical Tests for Bupleurum (Chai Hu) Extracts:

·       Chromatographic Fingerprinting (HPTLC/HPLC): Uses techniques like High-Performance Thin-Layer Chromatography (HPTLC) or High-Performance Liquid Chromatography (HPLC) to create a chemical "fingerprint" of the extract, identifying and quantifying key active compounds like saikosaponins (e.g., saikosaponin A, D).

·       Species Identification: Distinguishing between Bupleurum species (like B. chinense vs. B. scorzonerifolium) using these fingerprints ensures the correct plant is used, as different species have varying chemical profiles.

·       Purity & Adulteration: Testing to detect adulterants (other plant materials) and ensure no contamination from heavy metals (like lead, mercury) or pesticides.

·       Bioactivity Screening: Assays (in vitro/in vivo) to confirm expected pharmacological effects, such as anti-inflammatory, immune-modulating, or antidepressant properties.

·       Solvent Residues: Checking for residual extraction solvents. 

How to Find MEDIOCON's Specific Tests:

·       Product Documentation: Look for Certificates of Analysis (CoA) or quality specifications directly from MEDIOCON INC. (likely through their website or distributor).

·       Contact MEDIOCON: Reach out to the manufacturer for detailed quality control information.

These rigorous tests ensure the extract meets standards for potency, safety, and efficacy for its diverse applications in traditional medicine, from treating colds and fever to supporting liver function and mood

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract as an API by MEDIOCON INC, like any natural extract API, faces challenges in standardizing active compounds, ensuring consistent raw material quality, efficient extraction and purification (downstream processing), regulatory compliance (impurity profiles), managing large volumes of biomass waste, and achieving cost-effective scalability, all while maintaining purity and efficacy for pharmaceutical use. 

Here are the specific challenges:

1. Raw Material Variability & Sourcing

·       Inconsistent Biomass: Bananas (and their peels) vary greatly in chemical composition (polyphenols, fiber, etc.) based on variety, growing conditions, and ripeness, making standardized extraction difficult.

·       Supply Chain: Securing a consistent, high-quality, and sustainable supply of banana biomass (peels, stems) is crucial for uninterrupted production. 

2. Extraction & Purification (Downstream Processing)

·       Complex Separation: Extracting desired compounds from the complex matrix of banana peel (cellulose, pectin, etc.) requires efficient, scalable, and often novel separation techniques (like continuous chromatography or membrane filtration) to avoid degrading the product.

·       Yield & Cost: Developing economical methods with high yields in these downstream steps is a major hurdle. 

3. Quality & Regulatory Compliance

·       Critical Quality Attributes (CQAs): Identifying and controlling CQAs like purity, impurity levels (especially potential contaminants from the peel), particle size, and water content is vital for API approval.

·       Impurity Control: Scaling up can introduce new or increased impurities, requiring extensive R&D to identify and remove them to meet stringent pharmaceutical standards.

·       Bioactive Compound Standardization: Ensuring a consistent concentration of the specific bioactive molecules (e.g., antioxidants) in the final extract is challenging due to raw material variability. 

4. Waste Management & Sustainability

·       Biomass Waste: Banana processing generates large amounts of organic waste (peels, pseudo-stems), which must be managed to avoid odors, environmental contamination, and greenhouse gas emissions, adding to operational costs. 

5. Process Scale-Up

·       Unexpected Outcomes: Moving from lab to large-scale production can reveal unexpected issues with reaction kinetics, heat transfer, or separation, requiring significant process re-optimization. 

What are the challenges in manufacturing of Bupleurum (Chai Hu) extractManufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Bupleurum (Chai Hu) extract faces challenges like standardization due to chemical variability, sourcing consistent raw materials (wild resources declining), ensuring safety (potential liver toxicity at high doses), and achieving precise extraction and dosage form stability, requiring advanced techniques for phytochemical analysis to ensure efficacy and safety in final products, such as those potentially made by MEDIOCON INC. 

Key Manufacturing Challenges

1.    Raw Material Variability: Different Bupleurum species and even different parts of the same plant have varying levels of active compounds (saikosaponins), making standardization difficult.

2.    Sourcing & Sustainability: Over-harvesting of wild resources necessitates reliable artificial cultivation, which requires scientific basis for species selection and cultivation practices to maintain medicinal quality, notes ScienceDirect.

3.    Standardization & Quality Control: Large chemical variations between batches and species require robust analytical methods (like HPLC, NMR) for consistent quality and efficacy, according to ResearchGate.

4.    Extraction Process Optimization: Developing efficient extraction methods (e.g., supercritical fluid extraction, microwave-assisted extraction) to isolate key compounds like saikosaponins while minimizing degradation is complex, say ScienceDirect and ResearchGate.

5.    Dosage Form Stability & Bioavailability: Ensuring the final product (capsules, tablets, liquids) maintains the extract's stability, has predictable release, and allows for optimal absorption (bioavailability) poses formulation challenges.

6.    Safety Concerns: Ensuring the extract is free from contaminants and managing risks like liver toxicity (reported in some TCM formulas containing Chai Hu) requires strict purification and testing, notes ScienceDirect. 

Addressing Challenges (General Industry Practices)

·       Advanced Phytochemistry: Using techniques to identify and quantify marker compounds.

·       Process Analytical Technology (PAT): Real-time monitoring to ensure consistent quality.

·       Botanical Authentication: Verifying correct species and plant part.

·       Novel Delivery Systems: Developing nano-formulations or controlled-release systems for better efficacy and safety

What is the Packing for Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC?

While specific details for MEDIOCON INC.'s packaging aren't explicitly listed in top results, their Bupleurum (Chai Hu) extract is typically sold in premium rice paper bags, often in 4oz sizes, under the USTCM brand, indicating standard TCM packaging for quality herbs, though forms like granules or liquid extracts in glass bottles also exist for similar products. 

Here's what to expect:

·       Form: Can vary; it might be the raw herb, but extracts are often granules or liquid.

·       Packaging: For the herb itself, expect sealed bags, potentially rice paper. For liquid extracts, amber glass bottles with droppers are common.

·       Brand: Often associated with the USTCM brand when sold in these formats. 

To confirm exact packaging for MEDIOCON INC., you'd ideally check their official site or a specific retailer listing for their product.

What is shelf life Of Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC? 

The exact shelf life for a specific Bupleurum (Chai Hu) extract by MEDIOCON INC isn't publicly listed, but generally, herbal extracts like this have shelf lives of 1-3 years when stored properly, often indicated by a "Best By" date, depending on extraction method (liquid vs. powder), concentration, and packaging; check the product label or contact MEDIOCON INC directly for definitive information. 

Factors Influencing Shelf Life:

·       Concentration: Extracts with higher concentrations (like 10:1) might last longer.

·       Form: Liquid extracts can be shorter-lived than dried powders.

·       Storage: Cool, dark, dry conditions, often in airtight containers, are crucial. 

How to Find the Exact Shelf Life:

1.    Check the Product Label: Look for a "Best By," "Expiration Date," or "MFG Date" (Manufacturing Date) printed on the bottle or packaging.

2.    Contact the Manufacturer: The most reliable source is MEDICON INC (or their supplier) directly, as they control quality and testing for their specific product. 

While WebMD notes Bupleurum can be used for years in specific formulas, the shelf life of an individual extract is much shorter and product-specific. 

What should the label claim for Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC   Include?

For a Bupleurum (Chai Hu) extract label by MEDIOCON INC, you need to include the product name, key ingredients (Bupleurum root extract, concentration/ratio), suggested use/dosage, warnings (pregnancy, autoimmune, surgery, blood thinners), and potential benefits (liver support, stress relief, digestive aid), alongside manufacturer details, heavy metal/pesticide testing info, and quality claims, adhering strictly to regulatory guidelines for dietary supplements (like FDA in the US) to avoid making unproven medical claims. 

Here's a breakdown of what to include:

Essential Product Info:

1.    Product Name: "Bupleurum (Chai Hu) Extract" or a branded name (e.g., "Bupleuri LiverSoothe").

2.    Manufacturer: "Manufactured by MEDIOCON INC".

3.    Ingredient List: State "Bupleurum Root Extract (Radix Bupleuri)" and its concentration (e.g., 10:1 extract, or percentage of saikosaponins).

4.    Supplement Facts Panel: Serving size, servings per container, and amount per serving (mg).

5.    Other Ingredients: Any fillers, capsule material (e.g., vegetable capsule). 

Quality & Sourcing:

·       Extraction Method: Mention if it's a water extract for purity.

·       Purity Testing: "Heavy metals tested," "Free of pesticides/herbicides," or "No artificial sweeteners".

·       Source: Mention it's from the root of Bupleurum chinense (Chai Hu). 

Traditional Uses & Benefits (Carefully Worded):

·       Traditional Chinese Medicine (TCM): Used for liver support, digestive health, stress, and colds.

·       Potential Actions (Not Claims): "Supports liver function," "Helps manage stress," "Promotes digestive balance" (use with caution). 

Critical Warnings & Precautions:

·       Pregnancy/Nursing: Avoid use, not enough info.

·       Autoimmune Diseases: May activate immune system; avoid if MS, Lupus, RA.

·       Surgery: Stop 2 weeks prior (may affect blood clotting/sugar).

·       Diabetes: May affect blood sugar; monitor closely.

·       Medication Interactions: May interact with blood thinners or diabetes meds. 

Regulatory Compliance:

·       FDA Disclaimer (US): "This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease".

Where can Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC are procured?

Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Bupleurum (Chai Hu) extractManufactured by MEDIOCON INC product, regardless of the procurement source.