Cysteine 52-90-4 Manufacturer Supplier Exporter MEDIOCON INC

 

Cysteine Manufactured by MEDIOCON INC

 

   Name: Cysteine

            CAS No:   52-90-4                                                                                         Molecular Weight:  121.16 g/mol                                                                  Molecular formula:  C₃H₇NO₂S                                                                                                     Synonyms:  L-Cysteine, 2-Amino-3-mercaptopropanoic acid, β-Mercaptoalanine, Cys (abbreviation in peptides/proteins,

Appearance:   White to off-white crystalline powder with a faint sulfur odor.                                                                                                                                                      Solubility :  Soluble in water

Use :

-       Antioxidant support – boosts glutathione production

-       Detox & liver health – helps remove toxins

-       Skin, hair, and nails – supports keratin synthesis

-       Respiratory health – acts as a mucolytic

-       Supplement & pharmaceutical precursor – used in NAC and other formulations

-       Food & cosmetic industry – dough conditioner, stabilizer, hair/skin products

 How is Cysteine manufactured by MEDIOCON INC Synthesized?

Cysteine is synthesized through:

            Fermentation (Preferred Industrial Method)

-       Microbial production using strains like E. coli or Corynebacterium engineered to overproduce cysteine.

-       Carbon and nitrogen sources (like glucose and ammonium salts) are fed to microbes.

-       Cysteine is secreted into the medium, then extracted, purified, and crystallized.

-       Advantages: high purity, more environmentally friendly, suitable for pharma/nutraceutical grade.

            Chemical Synthesis

-       Historically, from serine or acrolein with sulfur sources.

-       Requires careful reaction control to produce L-Cysteine specifically.

-       Less commonly used today due to lower selectivity and environmental concerns.

            Hydrolysis from Proteins

-       Rarely, cysteine is obtained from hydrolyzed keratin-rich proteins (feathers, hair).

-       Further purified to pharmaceutical grade.

What are the different  dosage forms  of   Cysteine Manufactured  by  MEDIOCON INC?

Cysteine is available in various dosage forms, including:

-      Tablets – compressed powder with excipients for oral use

-      Capsules – filled with Cysteine powder for accurate dosing

-      Powder / Sachets – for mixing in beverages or nutritional formulations

-      Effervescent tablets/powders – dissolve quickly in water for faster absorption

-      Injectable solutions – sterile formulations for medical applications (requires strict GMP conditions)

 How Cysteine Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Cysteine dosage forms are prepared through various processes, including:

Tablet Preparation

-      Blending: Cysteine powder is mixed with excipients (binders, fillers, disintegrants, lubricants).

-      Granulation: Wet or dry granulation improves flow and compressibility.

-      Compression: Powder granules are compressed into tablets.

-      Coating (optional): Film coating masks taste, improves stability, or controls release.

 

 Capsule Preparation

-      Blending: Cysteine is mixed with flow enhancers or fillers for uniformity.

-      Filling: Powder is filled into hard gelatin or vegetarian capsules.

-      Sealing (optional): Capsules may be sealed or enteric-coated for stability.

 

 Powder / Sachet Form

-      Mixing: Cysteine is blended with excipients or flavoring agents.

-      Filling: Packed into sachets or bulk powder containers.

-      Sealing: Protected from moisture and light to maintain stability.

 Effervescent / Solution Form

-      Blending: Mixed with effervescent agents (citric acid, sodium bicarbonate).

-      Packing: Formulated into tablets or powders for quick dissolution in water.

-      Stability Control: Protected from moisture until use.

What are the appropriate Dosage forms of Cysteine Manufactured  by  MEDIOCON   INC?                

Cysteine dosage forms include:

-      Tablets – compressed with suitable excipients for oral use

-      Capsules – filled with Cysteine powder for controlled dosing

-      Powders / Sachets – for mixing in drinks or formulations

-      Effervescent formulations – sometimes used for faster dissolution

-      Injectable solutions – for clinical applications (requires strict sterile manufacturing)

 

When should Cysteine Manufactured by MEDIOCON INC be taken?

-      Oral Supplements (capsules or powders)

o   Often taken in the morning or between meals for better absorption.

o   Some formulations are taken before workouts or physical activity if targeting antioxidant support or detox.

-      Mucolytic / Medical Use

o   L‑Cysteine (or N‑acetylcysteine derivatives) may be taken as directed by healthcare professionals, usually spread across the day.

 What are the effects And Side effects of Cysteine Manufactured by MEDIOCON INC?

Effects

-      Antioxidant support – precursor to glutathione, a key cellular antioxidant

-      Detoxification – supports liver function and heavy metal detox

-      Skin, hair, and nail health – contributes to keratin synthesis

-      Respiratory support – used in formulations as a mucolytic (reduces mucus)

-      Metabolic functions – involved in amino acid metabolism and protein synthesis

Possible Side Effects

-      Gastrointestinal: nausea, vomiting, diarrhea

-      Odor: may cause a slight sulfur smell in urine or sweat

-      Neurological / systemic: headaches or fatigue in sensitive individuals

-      Allergic reactions: rare but possible in susceptible individuals

  How is Cysteine Manufactured by MEDIOCON  INC  Tested Qualitatively?

Cysteine is tested qualitatively through:

-      HPLC (High-Performance Liquid Chromatography)

o   Confirms the presence of L‑Cysteine by comparing retention time with a reference standard.

-      Infrared (IR) Spectroscopy

o   Verifies the chemical structure of Cysteine.

-      Ninhydrin Test

o   Detects amino groups, producing a characteristic color reaction confirming amino acid presence.

-      UV Spectroscopy (optional)

o   Confirms identity based on absorbance profile in solution.

   Which tests are performed on Cysteine Manufactured by  MEDIOCON INC ?

Tests performed on Cysteine include:

Identity / Qualitative Tests

-       HPLC (High-Performance Liquid Chromatography) – Confirms the presence of L‑Cysteine by comparing retention time with a reference standard.

-       Infrared (IR) Spectroscopy – Verifies the chemical structure.

-       Ninhydrin Test – Detects amino groups, indicating the presence of cysteine.

-       UV Spectroscopy – Sometimes used for confirming identity in solution.

 Purity / Quantitative Tests

-       Assay by HPLC or titration – Measures % of L‑Cysteine in the sample (typically ≥98% for pharma grade).

-       Moisture content – Determined by loss on drying (LOD) or Karl Fischer titration.

-       Ash content – Determines inorganic residue after combustion.

Impurity / Safety Tests

-       Heavy metals – Measured via ICP-MS or AAS to ensure safe limits.

-       Residual solvents – Checked if chemical synthesis is used.

-       Microbial limits – Ensures absence of harmful bacteria, yeasts, or molds (for food/pharma grade).

Physical Tests

-       Appearance – White to off-white crystalline powder.

-       Solubility – Soluble in water.

-       pH of solution – Confirms appropriate acidity/alkalinity.

-       Melting point / crystallinity – Ensures consistent physical properties.

What are the challenges in Manufacturing of Cysteine Manufactured by MEDIOCON   INC API?

Manufacturing Cysteine API poses challenges like:

Chemical / Biochemical Synthesis Challenges

-       Cysteine is often produced via fermentation or chemical synthesis.

-       Controlling reaction conditions (temperature, pH, catalysts, or microbial growth) is critical to avoid side reactions and low yields.

-       Maintaining high enantiomeric purity (L-Cysteine) is important for pharmaceutical applications.

 Oxidation Sensitivity

-      Cysteine readily oxidizes to cystine during processing.

-      Requires careful oxygen control, inert atmosphere, or antioxidants during production and drying.

 Purity and Impurities

-       Removal of residual solvents, salts, and microbial contaminants is essential.

-       Achieving pharma-grade purity (typically ≥98%) without degradation is challenging.

 Crystallization and Physical Properties

-       Controlling crystal size, shape, and moisture content is critical for API stability and downstream processing.

-       Poor crystallization can affect solubility and tablet/capsule formulation.

  Yield Optimization

-       Losses can occur during filtration, washing, and drying steps.

-       Optimizing yield while maintaining purity and physical properties is a key challenge.

Regulatory Compliance

-       API must meet GMP (Good Manufacturing Practices), pharmacopeial standards (USP/EP/JP), and quality testing requirements.

-       Includes heavy metals, microbial limits, and residual solvent control.

What are the challenges in manufacturing of Cysteine Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Cysteine dosage forms poses challenges like:

-      Hygroscopic Nature

-      Cysteine powder absorbs moisture easily, leading to clumping or caking.

-      Makes tablet compression or capsule filling difficult without anti-caking excipients.

-      Poor Flow Properties

-      Fine powder tends to segregate during mixing or filling, affecting dose uniformity.

-      Requires flow enhancers or granulation for consistent dosing.

-      Stability Issues

-      Cysteine is prone to oxidation → can turn into cystine or degrade.

-      Sensitive to heat, light, and moisture, reducing shelf life in formulated products.

-      May require antioxidants or protective coatings in tablets or capsules.

-      Compressibility / Tablet Formation

o   Amino acids like cysteine have poor compressibility, which may produce soft or friable tablets.

o   Granulation and binders may be needed to improve tablet strength.

-      Taste / Palatability

o   Cysteine has a slightly unpleasant sulfur-like taste, which may require coating or flavor masking in oral formulations.

-      Compatibility with Excipients

o   Can react with certain excipients, affecting stability, solubility, or bioavailability.

o   Requires careful selection of fillers, disintegrants, and binders.

-      Regulatory and Quality Compliance

o   Finished dosage forms must meet weight variation, content uniformity, microbial limits, and stability standards.

 

What is the Packing for Cysteine Manufactured by MEDIOCON INC?

-      Typical Packing Types

-      Multi-layer industrial bags – usually an inner polyethylene layer for moisture protection and an outer woven bag for strength

-      HDPE (High-Density Polyethylene) drums – common for larger volumes (e.g., 25 kg per drum)

-      Fiber drums with liners – often used for pharma-grade or export products

-      Sealed and labeled packaging – includes product name, batch number, weight, manufacture and expiry dates

What is shelf life Of Cysteine Manufactured by MEDIOCON INC? 

-      Typical Shelf Life

-      2–3 years from the date of manufacture under proper storage conditions

-      Storage conditions:

o   Store in a cool, dry, and well-ventilated place

o   Protect from moisture, heat, and direct sunlight

o   Keep the product in tightly sealed original packaging (HDPE drum, multi-layer bag, or fiber drum with liner)

What should the label claim for Cysteine Manufactured by MEDIOCON INC   Include?

The label claim for Cysteine should include:

-      Key Elements for the Label

-      Product Name

o   Cysteine (specify form if needed, e.g., L-Cysteine HCl, L-Cysteine Monohydrate)

-      Grade / Type

o   Food grade / Pharma grade / Nutraceutical grade

-      Net Weight

o   Example: 25 kg per bag/drum

-      Batch / Lot Number

o   For traceability and quality control

-      Manufacturing Date (Mfg. Date)

o   Clearly printed

-      Expiry / Shelf Life

o   Example: “Shelf life: 2 years from date of manufacture”

-      Storage Instructions

o   Keep in a cool, dry place

o   Protect from moisture, heat, and sunlight

o   Keep tightly sealed

-      Manufacturer / Supplier Details

o   Mediocon Inc name, address, and contact info

-      Country of Origin

o   If required by regulatory authorities

-      Purity / Assay (Optional but recommended)

o   Example: “Assay: ≥98% L-Cysteine”

-      Safety / Handling Instructions

o   “Handle with care. Avoid inhalation of dust. Use protective equipment if required.”

-      Regulatory / Compliance Marks (Optional)

o   GMP, ISO, or pharmacopeial compliance symbols if applicable

Where can Cysteine Manufactured by MEDIOCON INC are procured?

Cysteine Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Cysteine Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Cysteine Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Cysteine Manufactured by MEDIOCON INC product, regardless of the procurement source.