Glutamic acid 56-86-0 Manufacturer , supplier, exporter by MEDIOCON INC

 

 

 

              Glutamic acid Manufactured by MEDIOCON INC

 

 Name:   Glutamic acid,

CAS No  : 56-86-0

Molecular Weight:  147.13 g/mol

Molecular formula

C5H9NO4C sub

 

Synonyms: 2-Amino-3-sulfanylpropanoic acid, 2-amino-3-mercaptopropanoic acid, L-(+)-Glutamic acid, L-Cys, Half-cystine, E920 Aminosuccinic acid

·       Asparagic acid

·       Asparaginic acid

·       L-2-Aminobutanedioic acid

·       (S)-(+)-Aminosuccinic acid

·       H-Asp-OH 

 Appearance : White crystalline powder or colorless crystals White crystalline powder or colorless crystals

 Solubility :   8 Synonyms 

Common synonyms for glutamic acid include: 

• L-glutamic acid
• 2-Aminopentanedioic acid
• 2-Aminoglutaric acid

-Glutamic acid

• Glutacid
• Glutamate (its anionic form)
• Abbreviations:

Uses: Glutamic acid and its derivatives have a wide range of applications: 

·       Food Industry: Monosodium glutamate (MSG), a salt form of glutamic acid, is widely used as a flavor enhancer to impart an umami taste to foods.

·       Pharmaceuticals: It is used in drug development, particularly for neurological and psychiatric conditions, due to its role as a neurotransmitter.

·       Biotechnology: It is an important component in cell culture media to support cell growth for the production of proteins, enzymes, and other biologics.

·       Chemical Synthesis: Glutamic acid serves as a raw material for synthesizing various specialty chemicals, including surfactants and biodegradable polymers like polyglutamic acid (PGA).

·       Nutritional Supplement: It is used in clinical nutrition formulations and as a supplement to support immune function and gut health. 

•  

 How is  Glutamic acid, acid, manufactured by MEDIOCON INC Synthesized?

Glutamic acid is predominantly manufactured on an industrial scale using a process of microbial fermentation, typically involving the bacterium Corynebacterium glutamicum. 

While the specific, proprietary details of MEDIOCON INC's manufacturing process are not publicly available, they likely use this common fermentation method, as chemical synthesis has largely been supplanted due to efficiency and cost-effectiveness. 

General Fermentation Process

The glutamic acid fermentation process generally follows these steps:

1.    Fermentation: Microorganisms such as Corynebacterium glutamicum are grown in large bioreactors containing an inexpensive nutrient medium, usually a carbon source like glucose or molasses, and an ammonia source. The bacteria convert the carbon source and ammonia into glutamic acid.

2.    Crude Isolation: After fermentation is complete, the microbial cells and solid debris are removed from the liquid broth through processes such as centrifugation and filtration.

3.    Purification: The remaining solution undergoes purification steps, which can include ion exchange, evaporation, and decolorization, to isolate the glutamic acid.

4.    Crystallization and Drying: The purified solution is acidified to a specific pH (around 3.2) to induce the crystallization of glutamic acid, which is then dried and packaged. 

The resulting glutamic acid is often converted into its more soluble salt form, monosodium glutamate (MSG), for various commercial uses, especially as a flavor enhancer. 

What are the different  dosage forms  of   Glutamic acid, acid, Manufactured  by  MEDIOCON INC?

MEDIOCON INC. manufactures L-Glutamic acid Hydrochloride for injection, primarily as a stable, highly pure liquid composition in single-use containers, often used in parenteral nutrition for neonates and critically ill patients, though specific product names or broader dosage forms (capsules, powders) aren't detailed for this specific manufacturer in general searches. Common forms for Glutamic acid generally include injectables (solutions), powders, and potentially oral forms (capsules, tablets) for nutraceutical use, but MEDIOCON focuses on sterile injectable solutions. 

Key Dosage Form for MEDIOCON INC.:

Glutamic acid Hydrochloride Injection (USP): This is a sterile, aqueous solution, usually pH-adjusted with HCl, designed for intravenous use, often as a component in total parenteral nutrition (TPN). 

General Glutamic acid Dosage Forms (Beyond this Manufacturer):

Injectable Solutions: Standard for hospital use, especially for neonates and those unable to eat.

Powders: Can be dissolved for injection or used in supplements.

Capsules/Tablets: Common in the nutraceutical market for general supplementation. 

 How Glutamic acid, acid, Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Glutamic acid hydrochloride (acid form) dosage forms, like injections, are made by purifying L-glutamic acid (often from fermentation or hydrolysis of keratinous materials like hair/feathers), converting it to a stable hydrochloride salt using acid, and then formulating it with sterile water, other amino acids, and pH adjusters for injectable solutions, ensuring high purity for safety, often via controlled steps like nitrogen sparging and filtration. 

General Preparation Steps (for injectable solutions):

Source & Purification: L-Glutamic acid is obtained, commonly through fermentation or acid hydrolysis of natural sources (like hair/feathers), then purified.

Salt Formation: L-Glutamic acid is reacted with hydrochloric acid (HCl) to form L-Glutamic acid Hydrochloride, a more stable form.

Sterilization & Dissolution: The purified L-Glutamic acid HCl is dissolved in Water for Injection (WFI) under sterile conditions, often with nitrogen sparging to remove oxygen.

Formulation: Other essential amino acids (like arginine, valine, etc.) and buffering agents are added, ensuring proper pH.

Filtration & Filling: The solution is filtered through sterile filters and

What are the appropriate Dosage forms of Glutamic acid, acid, Manufactured  by  MEDIOCON   INC?                

Mediocon Inc primarily functions as a supplier of raw ingredients (Active Pharmaceutical Ingredients, intermediates, excipients, etc.) rather than a manufacturer of finished, consumer-ready dosage forms like specific glutamic acid tablets or capsules. Glutamic acid itself is commonly traded as a raw material in powder form. 

As a B2B supplier of ingredients, Mediocon Inc provides L-Glutamic acid to other companies for use in their own formulations. These customer companies then process the ingredient into various finished products. 

Common finished dosage forms for glutamic acid, when used as a nutritional supplement or food additive by other manufacturers, generally include:

·       Powders (often the primary form it is supplied in, and sometimes the final form for consumer use)

·       Tablets

·       Capsules 

To determine the exact dosage form of a product containing glutamic acid that originated as a raw material from Mediocon Inc, you would need to check the specific product information from the company that manufactured the final consumer-ready item.

When should Glutamic acid, acid, Manufactured by MEDIOCON INC be taken?

Specific instructions for when to take the Glutamic acid product manufactured by MEDIOCON INC require consulting the product's labeling or a healthcare provider, as this information is not publicly available in the search results. The appropriate timing depends heavily on the specific condition being treated and the formulation of the product. 

General information regarding glutamic acid suggests that the timing of supplementation may vary depending on the intended use. For certain gastrointestinal conditions, taking it with meals might be recommended. Alternatively, if used as a general supplement for cognitive enhancement or muscle recovery, taking it on an empty stomach could be considered to potentially maximize absorption. For some clinical applications, it may be suggested to take it multiple times daily with water. 

It is always advisable to follow the specific instructions on the product label or those provided by a doctor or pharmacist to ensure correct

 What are the effects And Side effects of Glutamic acid, acid, Manufactured by MEDIOCON INC?

Glutamic acid manufactured by MEDIOCON INC is an amino acid used in various applications, from food additives to potential therapeutic uses. The effects and side effects of glutamic acid are generally dependent on dosage, individual sensitivity, and the specific form and method of use. 

Effects of Glutamic Acid

Glutamic acid is a non-essential amino acid that plays several vital roles in the body and is used in a range of commercial applications. 

• Neurotransmitter: In the brain, glutamic acid (as glutamate) is the most abundant excitatory neurotransmitter, crucial for nerve cell communication, learning, and memory.
• Protein Synthesis: It is one of the primary building blocks for synthesizing proteins in the body.
• Metabolism and Energy: It plays a significant role in cellular metabolism and can serve as a source of fuel, particularly for the cells in the intestinal lining.
• Ammonia Detoxification: It helps detoxify the body and brain by removing excess ammonia from the bloodstream.
• Potential Therapeutic Uses (under study): Research has explored potential benefits in managing conditions such as epilepsy, muscular dystrophy, and cognitive impairment, though many of these remain unsubstantiated claims and require further research.
• Commercial/Industrial Uses: It is widely used as a flavor enhancer (as monosodium glutamate or MSG) and in the cosmetic industry for skin and hair care products. 

·       Glutamic acid supplements can interact with medications for diabetes and high blood pressure, potentially causing blood sugar

  How is Glutamic acid, acid, Manufactured by MEDIOCON  INC  Tested Qualitatively?

To qualitatively test L-Glutamic acid (acid form), manufacturers use methods targeting its reactive sulfhydryl (-SH) group, primarily the Sodium Nitroprusside test, which creates a color change (orange-red) for detection, or specialized techniques like Iodine Titration, UV-Vis Spectroscopy after derivatization (e.g., with OPA), or advanced qNMR for purity, ensuring it meets pharmaceutical standards for identity and quality, often involving sample prep like hydrolysis and purification steps. 

Here's a breakdown of common qualitative testing approaches:

1. Sodium Nitroprusside Test (Colorimetric)

·       Principle: Detects free sulfhydryl (-SH) groups.

·       Process:

o   Prepare glutamic acid samples (or hydrolyzed/reduced forms).

o   Adjust pH (e.g., to pH 9.2) and add Sodium Borohydride to ensure free -SH groups are available.

o   Add Sodium Nitroprusside, which reacts with the -SH group to form a characteristic orange-red colored product.

o   The color intensity (or presence/absence for qualitative) is assessed visually or using a smartphone/spectrophotometer. 

2. Ninhydrin Test (Colorimetric/Spot Test)

·       Principle: Reacts with amino acids, including glutamic acid, to produce a colored product (purple/blue).

·       Process: Glutamic acid samples are reacted with ninhydrin reagent, and the resulting color indicates the presence of amino acids, confirming purity or reaction completion (e.g., after oxidation to cystine). 

3. Iodine Titration (Okuda Method)

·       Principle: Quantifies the free thiol (-SH) groups using iodine.

·       Process: Glutamic acid is dissolved in acid, and iodine is used to titrate the reactive sulfur, indicating the amount of glutamic acid present. 

4. UV-Vis Spectroscopy with Derivatization

·       Principle: Glutamic acid itself has weak UV absorption; derivatization with reagents like OPA (ortho-phthalaldehyde) or Dansyl Chloride creates strongly fluorescent or UV-absorbing products.

·       Process: Sample is derivatized, then analyzed via UV-Vis or HPLC with a detector, showing peaks for identification and purity. 

5. Advanced Techniques (for Purity/Quantity)

·       Quantitative NMR (qNMR): Highly sensitive for verifying the actual amount and purity against standards, often more reliable than older titrimetric methods, notes ScienceDirect. 

Typical Steps for a Manufacturer (Qualitative)

1.    Sample Prep: Dissolve/extract glutamic acid in appropriate solvent (e.g., 0.2N HCl).

2.    Reaction: Apply one of the specific tests above (e.g., Nitroprusside, Ninhydrin).

3.    Observation: Confirm the expected color change or signal, indicating positive identification of L-Glutamic acid.

4.    Purity Checks: May involve checks for common impurities or related substances using chromatography or spectroscopy. 

By employing these methods, manufacturers like Mediocon Inc. can ensure their L-Glutamic acid products meet required quality and identity standards. 

   Which tests are performed on Glutamic acid, acid, Manufactured by  MEDIOCON INC ?

The specific quality control tests performed on

Glutamic acid manufactured by MEDIOCON INC are not detailed in publicly available search results. However, products of this nature typically undergo standardized testing to confirm their identity, purity, and compliance with industrial or pharmaceutical standards. 

General tests for L-Glutamic acid often include: 

• Purity Assessment: Determining the minimum L-glutamic acid content, often specified as not less than 98% on a dry matter basis. This can involve methods such as spectrophotometry or other chemical assays.
• Physical Property Analysis:
• Appearance: Visual confirmation of the substance (e.g., white crystalline powder).
• Solubility: Testing solubility in water and ethanol.
• Melting Point: Determining the decomposition temperature, typically around 199 °C (390 °F; 472 K).
• Identity and Structure Confirmation:
• Specific Optical Rotation: Measuring the optical rotation to confirm the presence and purity of the L-enantiomer, with a specific range for L-glutamic acid (+31.5° to +32.2° is typical).
• Chemical Formula Verification: Confirming the molecular formula (

C5H9NO4C sub 5 H sub 9 NO sub 4

C5H9NO4

).

• Spectroscopy: Techniques like Nuclear Magnetic Resonance (

1Hto the first power H

1H

NMR) or Fourier-Transform Infrared (FT-IR) spectroscopy may be used for structural characterization.

• Contaminant and Safety Testing:
• Microbial Contamination: Testing for total bacterial count, specific pathogens like Salmonella spp., E. coli, yeasts, and fungi.
• Heavy Metals/Impurities: Testing to ensure levels of impurities are within acceptable limits, though specific limits are product-dependent.
• Other Potential Tests (depending on application):
• Stability testing in various conditions (e.g., in water).
• Particle size analysis (especially for powders). 

For precise details, you would need to consult the specific Certificate of Analysis (CoA) or product data sheet provided by MEDIOCON INC for their glutamic acid product. You can contact them directly through their official channels for product specifications or documentation. 

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract as an API (Active Pharmaceutical Ingredient) faces challenges like maintaining consistent bioactives (phenolics, flavonoids) from variable raw material, efficient extraction methods (solvent use, waste), purification to remove impurities, scaling up without losing quality, ensuring stability, and meeting strict cGMP/regulatory standards for pharmaceutical use, especially regarding by-product management and environmental impact. 

Here's a breakdown of key challenges:

1. Raw Material Variability & Sourcing:

·       Inconsistent Composition: Natural products like bananas vary greatly in their beneficial compounds (phenolics, fibers, antioxidants) due to genetics, growing conditions, and ripeness, making consistent extract quality difficult.

·       Waste Management: Utilizing banana peels/blossoms (rich in useful compounds) creates a challenge in handling large volumes of waste material while avoiding odor and greenhouse gas issues from decomposition. 

2. Extraction & Purification:

·       Efficient Extraction: Developing green, cost-effective methods to extract specific compounds (like flavonoids, phenolics, or enzymes) without damaging them is complex.

·       Impurities: Separating desired actives from other plant components (chlorophyll, pectin, etc.) requires advanced purification, which adds cost and complexity.

·       Scaling Up: Processes that work in the lab often encounter new impurities or yield issues when scaled to commercial API production. 

3. Quality & Regulatory Compliance (API Specific):

·       cGMP & Validation: Meeting Good Manufacturing Practices (cGMP) for APIs requires rigorous process control, validation, and documentation.

·       Impurity Profiling: Identifying and controlling unwanted impurities (genotoxic impurities or those from solvents) is crucial for pharmaceutical safety.

·       Stability: Ensuring the extract remains stable and potent throughout its shelf life is a significant hurdle. 

4. Environmental & Sustainability:

·       Green Chemistry: Minimizing solvent use, energy consumption, and waste generation aligns with industry trends but adds technical challenges. 

5. Cost & Commercialization:

·       Economic Viability: Balancing extraction efficiency, purification costs, and regulatory compliance to make the final API product affordable and competitive. 

For MEDIOCON INC., these general API manufacturing challenges would be specific to their chosen extraction methods and the desired active compounds from bananas. 

What are the challenges in manufacturing of Glutamic acid, acid, Manufactured by MEDIOCON  INC ’s Dosage forms?

Information regarding specific manufacturing challenges of glutamic acid dosage forms by MEDIOCON INC is not publicly available in detail. MEDIOCON INC is identified as a manufacturer and wholesaler of pharmaceutical intermediates, suggesting they may supply raw materials rather than finished dosage forms like tablets or capsules. 

However, general challenges in the manufacturing and purification of glutamic acid and its dosage forms within the pharmaceutical industry include:

·       Production and Purification:

o   Cost-effective purification: Achieving high purity glutamic acid cost-effectively is challenging due to the numerous downstream processing steps involved, such as centrifugation, carbon adsorption, evaporation, crystallization, and ion-exchange.

o   Wastewater management: Conventional purification methods, especially those using ion exchange resins, produce a significant amount of wastewater, creating environmental pollution and disposal issues.

o   Membrane fouling: When using membrane filtration (microfiltration and ultrafiltration) for cell recycling or product recovery, membrane fouling by microbial cells and proteins is a major obstacle, which can decrease efficiency.

o   Maintaining optimum conditions: During fermentation, the concentration of glutamic acid can become inhibitory to the microbes, requiring continuous removal to maintain an optimum pH and ensure high productivity.

·       Dosage Form Manufacturing:

o   Polymorphism: Glutamic acid can crystallize into different forms (polymorphs), such as the alpha and beta forms of L-glutamic acid, which have different properties (e.g., solubility, crystal shape) and can pose operational challenges in crystallization and handling.

o   Stability: Ensuring the stability of glutamic acid in various dosage forms can be challenging, as it can be affected by physical factors such as pH, temperature, and humidity.

o   Formulation complexities: Developing patient-compliant dosage forms (e.g., oral liquids, tablets) requires careful formulation to address factors like taste-masking, ensuring proper disintegration, and maintaining the chemical stability of the active ingredient. 

What is the Packing for Glutamic acid, acid, Manufactured by MEDIOCON INC?

 

Mediocon Inc. supplies L-Glutamic Acid, often in bulk or specific industrial packaging like bags or drums, catering to pharma, food, and chemical sectors, though exact retail pack sizes (like 250g bottles) are more common from distributors like SD Fine, with Mediocon focusing on large-scale industrial solutions rather than small consumer packs. 

Key Details:

·       Supplier Focus: Mediocon Inc provides chemicals as solutions for industries, emphasizing global sourcing and timely delivery, suggesting larger industrial volumes.

·       Product Type: They supply L-Glutamic Acid (an amino acid) for applications in pharmaceuticals, food, and textiles.

·       Typical Packaging (Industry Standard): While Mediocon handles bulk, common industry packaging for Glutamic Acid (especially for quality-focused buyers) can be 25kg bags or fiber drums, but this varies greatly by customer need. 

To Get Exact Packing Info for Mediocon Inc.:
Contact Mediocon Inc directly through their website, as their packaging depends heavily on the client's industrial requirements (e.g., palletized bags, fiber drums, bulk bags). 

What is shelf life Of Glutamic acid, acid, Manufactured by MEDIOCON INC? 

While specific data for MEDIOCON INC.'s glutamic acid isn't available in general search, similar L-Glutamic acid products from other manufacturers (like HiMedia, Diagnocine) typically offer shelf lives of 3 to 4 years (36-48 months) when stored properly, usually between 10-30°C and away from direct light, so check the product label for exact expiry. 

Key Factors Influencing Shelf Life:

·       Purity & Grade: Higher purity grades might have different stability.

·       Form: L-Glutamic acid vs. its salt (MSG) or hydrate forms.

·       Storage Conditions: Crucial to keep it cool, dry, and away from light. 

To Find Your Exact Answer:

1.    Check the Label: The most reliable source is the expiry date printed on your specific MEDIOCON INC. product.

2.    Contact MEDIOCON INC.: Reach out to the manufacturer's technical support for detailed information. 

1.    date. 

What should the label claim for Glutamic acid, acid, Manufactured by MEDIOCON INC   Include?

For a Glutamic Acid product manufactured by MEDIOCON INC, the label must include

Product Name (Glutamic Acid/L-Glutamic Acid), Purity/Grade (e.g., USP, Food Grade), Quantity, Manufacturer (MEDIOCON INC), Batch Number, Manufacturing/Expiry Dates, Storage Conditions, and Key Specifications like Identity, Assay, & Impurities, adhering to regulatory standards (like ICH Q7 for APIs) for quality assurance, especially concerning chiral purity (L-form is common) and potential contaminants. 

Here's a breakdown of essential label claims: 

1. Product Identification: 

• Product Name: "Glutamic Acid" or "L-Glutamic Acid" (specify L-isomer if applicable, as it's the common biologically active form).
• Chemical Formula:

C5H9NO4C sub 5 H sub 9 NO sub 4

C5H9NO4

(for L-Glutamic Acid).

• CAS Number: 56-86-0 (for L-Glutamic Acid). 

2. Manufacturer & Quantity: 

• Manufactured By: MEDIOCON INC.
• Net Quantity: Weight (e.g., 1 kg, 25 kg). 

3. Quality & Purity (Crucial): 

• Grade: (e.g., Pharmaceutical Grade, Food Grade, Reagent Grade, USP/FCC/AJI compliant).
• Assay/Purity: e.g., $\ge$99.0% (L-Glutamic Acid).
• Appearance: White crystalline powder.
• Specific Tests: Conforms to USP/FCC/AJI standards (if applicable).
• Microbial Limits: (For pharmaceutical use). 

4. Regulatory & Safety Information: 

• Batch/Lot Number: For traceability.
• Date of Manufacture:.
• Expiry/Retest Date:.
• Storage Conditions: "Keep container tightly closed in a dry, well-ventilated place".
• Safety Warnings: Relevant handling precautions (e.g., avoid dust inhalation). 

5. For API/Pharmaceutical Use (ICH Q7 Guidelines): 

• If used as an Active Pharmaceutical Ingredient (API), the label must reflect strict GMP compliance, including details on chiral purity, residual solvents, and impurity profiles, as defined by ICH Q7 guidelines. 

Where can Glutamic acid, acid, Manufactured by MEDIOCON INC are procured?

Glutamic acid, acid, Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Glutamic acid, acid, Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Glutamic acid, acid, Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Glutamic acid, acid, Manufactured by MEDIOCON INC product, regardless of the procurement source.