Glutamine 56-85-9 Manufacturer supplier exporter MEDIOCON INC

 

Glutamine Manufactured by MEDIOCON INC

 

   Name: Glutamine

CAS No:   56-85-9                                                                                             Molecular Weight:  146.15 g/mol                                                                     Molecular formula:  C₅H₁₀N₂O₃                                                                                                   Synonyms:  L‑Glutamine, 2‑Amino‑4‑carbamoylbutyric acid, α‑L‑Glutamine, (S)-2-Amino-4-carbamoylbutanoic acid,  Glutamic acid amide.

Appearance:   White or almost white crystalline powder                                                                           Solubility :  Freely Soluble in Water.

Use :

-      Supports muscle recovery and growth – commonly used by athletes and bodybuilders

-      Promotes gut health – helps maintain intestinal lining and function

-      Boosts immune system – aids in infection resistance and recovery

-      Supports recovery after illness, surgery, or trauma – often used in clinical nutrition

-      Helps maintain nitrogen balance in the body

-      May improve exercise performance and reduce fatigue

 How is Glutamine manufactured by MEDIOCON INC Synthesized?

Glutamine is synthesized through:

        Fermentation-Based Production (Primary Method)

-       Microbial fermentation using specially selected bacterial strains (often mutants of Brevibacterium, Corynebacterium or E. coli optimized for high glutamine yield) is the standard industrial approach for producing L-Glutamine.
 In this process, glucose and ammonia (or other suitable carbon and nitrogen sources) are provided in a controlled bioreactor. The bacteria convert these substrates into L-Glutamine under optimized conditions of temperature, pH, aeration, and nutrient balance.
After fermentation, the broth is harvested, and purification steps (such as filtration, ion-exchange, crystallization) are used to isolate high-purity L-Glutamine suitable for pharmaceutical and nutraceutical use.

-      ➡ This biological approach is preferred because it delivers high yields, cost efficiency, and better stereochemical purity (the biologically active L-form) compared to purely chemical synthesis.

Chemical or Enzymatic Routes (Less Common)

-      In addition to fermentation, there are chemical synthesis routes where L-glutamine can be made by chemical modification of glutamic acid (e.g., esterification followed by amidation), or by enzymatic conversion using purified enzymes like glutamine synthetase. These methods can be more complex, less efficient, or more expensive for large-scale production compared to fermentation.

What are the different  dosage forms  of   Glutamine Manufactured  by  MEDIOCON INC?

Glutamine is available in various dosage forms, including:

-      Powder (Crystalline Powder API / Excipient)

-      High-purity L-Glutamine powder for use in pharmaceutical formulations, nutraceutical blends, food applications, and supplement manufacturing.

-      This is the standard form used by formulators to create tablets, capsules, sachets, beverages, or other finished dosage forms.

-      Bulk Crystalline Substance

-      White to off-white crystalline powder which can be incorporated into various dosage forms in further processing.

 How Glutamine Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Glutamine dosage forms are prepared through various processes, including:

Glutamine supplied by MEDIOCON INC is provided mainly as a high-purity L-glutamine powder (API).
The dosage forms are prepared by finished-product manufacturers as follows:

-       Powder / Sachets: The glutamine powder is weighed, blended (if needed), and packed into sachets or bulk containers.

-       Capsules: The powder is filled directly into hard gelatin or HPMC capsules.

-       Tablets: The powder is mixed with excipients, granulated if required, and compressed into tablets.

-       Oral solutions: The powder is dissolved in a suitable solvent and packaged.

-       Injectable forms (rare): Special sterile formulations using stabilized glutamine derivatives.

What are the appropriate Dosage forms of Glutamine Manufactured  by  MEDIOCON   INC?                

Glutamine dosage forms include:

-      Powder (bulk or sachets) – most common; taken orally after mixing with water or food

-      Capsules – powder filled into hard gelatin or HPMC capsules

-      Tablets – compressed powder with suitable excipients

-      Oral solution / suspension – powder dissolved in liquid (less common)

-      Parenteral/clinical nutrition forms – usually as stabilized glutamine derivatives (specialized use)

 

When should Glutamine Manufactured by MEDIOCON INC be taken?

Glutamine (manufactured/supplied by MEDIOCON INC) is usually taken orally, and the timing depends on the purpose of use:

-       Between meals or on an empty stomach – for better absorption

-       After exercise – commonly used to support muscle recovery

-       Before bedtime – sometimes used to support gut health and recovery

-       As directed by a doctor – in medical or clinical nutrition use

Consult a healthcare professional for personalized dosing instructions and schedule.

 What are the effects And Side effects of Glutamine Manufactured by MEDIOCON INC?

Glutamine effects and side effects include:

Effects (Benefits):

-       Supports muscle recovery

-       Improves gut health

-       Boosts immune function

-       Helps recovery after illness or surgery

Side Effects:

-       Nausea

-       Bloating or stomach upset

-       Diarrhea (at high doses)

-       Rare allergic reactions

  How is Glutamine Manufactured by MEDIOCON  INC  Tested Qualitatively?

Glutamine is tested qualitatively through:

-      Appearance test: White or almost white crystalline powder

-      Solubility test: Freely soluble in water, practically insoluble in alcohol

-      Ninhydrin test: Produces a purple/violet color, confirming an amino acid

-      Infrared (IR) spectroscopy: Matches the reference spectrum of L-glutamine

-      Optical rotation test: Confirms the L-form of glutamine

-      Thin Layer Chromatography (TLC): Spot matches reference standard

   Which tests are performed on Glutamine Manufactured by  MEDIOCON INC ?

Tests performed on Glutamine include:

-      Identification (IR spectroscopy, Ninhydrin test)

-      Appearance & solubility

-      pH

-      Loss on drying (moisture)

-      Assay (L-glutamine content)

-      Impurities / related substances

-      Heavy metals

-      Microbial limits

What are the challenges in Manufacturing of Glutamine Manufactured by MEDIOCON   INC API?

Manufacturing Glutamine API poses challenges like:

Stability Issues

-      L‑Glutamine is chemically unstable in aqueous solutions, especially at high temperatures or extreme pH.

-      It can degrade to pyroglutamic acid, affecting purity and shelf life.

            Fermentation Challenges

-      Most industrial L‑glutamine is produced by microbial fermentation, which requires:

-      Strict control of strain selection

-      Optimized fermentation conditions (pH, temperature, nutrient supply)

-      Avoiding contamination

            Purification Difficulties

-      After fermentation, L‑glutamine must be purified to high pharmaceutical grade.

-      Challenges include removing impurities, by-products, and residual solvents without reducing yield.

            Drying & Crystallization

-      The powder form must be uniform and free-flowing.

-      Improper drying can lead to caking, poor solubility, or degradation.

            Quality Control

-      Requires strict QC testing (assay, heavy metals, microbial limits, identity tests) to meet pharmacopeial standards

What are the challenges in manufacturing of Glutamine Manufactured by MEDIOCON  INC ’s Dosage forms?

Manufacturing Glutamine dosage forms poses challenges like:

-       Stability: Degrades in water or heat.

-       Handling: Hygroscopic powder, can clump.

-       Taste: Bitter, needs masking in oral forms.

-       Dose accuracy: Ensuring uniform content in capsules/sachets/tablets.

-       Dissolution: Must dissolve properly for absorption.

-       Packaging: Requires moisture-proof packaging.

-       Regulatory compliance: Must meet GMP, purity, and microbial standards.

What is the Packing for Glutamine Manufactured by MEDIOCON INC?

Glutamine is typically packed in various quantities, including:

Primary form: High-purity crystalline powder (API)

Packing types:

-       Bulk packing: Polyethylene (PE) bags inside fiber drums or cartons

-       Sachets: Individual portioned packets for oral use (if formulated by other manufacturers)

-       Capsules/Tablets: Packaged in bottles or blister packs (when formulated)

What is shelf life Of Glutamine Manufactured by MEDIOCON INC? 

Typical shelf life: 2–3 years from the date of manufacture

  Storage conditions:

-       Store in a cool, dry place

-       Keep away from moisture, heat, and direct sunlight

-       Store in tightly sealed, moisture-proof containers

What should the label claim for Glutamine Manufactured by MEDIOCON INC   Include?

The label claim for Glutamine should include:

-       Product name: L‑Glutamine

-       Purity / Assay: e.g., ≥99%

-       Net weight

-       Batch / Lot number

-       Manufacturing date & Expiry date

-       Storage instructions: Cool, dry place, protect from moisture

-       Manufacturer details: MEDIOCON INC, address/contact

-       Usage statement / caution: For pharmaceutical or nutraceutical use

Where can Glutamine Manufactured by MEDIOCON INC are procured?

Glutamine Manufactured by MEDIOCON INC can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Glutamine Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for GlutamineManufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the GlutamineManufactured by MEDIOCON INC product, regardless of the procurement source.