Glycine, 56-40-6 Manufacturer, exporter, supplier by MEDIOCON INC

 

 

 

              Glycine,  Manufactured by MEDIOCON INC

 

 Name:   Glycine

CAS No  : 56-40-6

Molecular Weight 75.07 g/mol

Molecular formula C₂H₅NO₂

Synonyms: Aminoacetic acid, Aminoethanoic acid, Glycocoll, Glycolixir, H-Gly-OH, GAsparagic acid

Appearance : White crystals or crystalline powdercrystals

 Solubility:  Highly soluble in water (approximately 25 g/100 mL at 25 °C or 249.9 g/L at 25°C), soluble in pyridine, sparingly soluble in ethanol, and insoluble in ether 

·       Uses: Pharmaceuticals: Used in some medications, as a buffer for certain drugs, for treating conditions like schizophrenia and benign prostatic hyperplasia (BPH), and to protect the kidneys and liver from harmful side effects of certain medications or alcohol.

·       Food Industry: Used as a nutritional supplement, a flavor enhancer, and a sweetener (due to its sweet taste). It also has buffering and antioxidant effects when added to certain foods like butter, cheese, and meat products.

·       Biochemistry and Research: Used extensively in buffer solutions for molecular biology applications like polyacrylamide gel electrophoresis (PAGE) and Western blotting.

·       Industrial Applications: Used as a complexing agent for metals, an additive in cosmetics and toiletries, and as an intermediate in the production of various chemicals, including pesticides. 

What are the different  dosage forms  of   Glycine, , acid, Manufactured  by  MEDIOCON INC?

 How Glycine, , acid, Manufactured by MEDIOCON INC   Dosage Forms are prepared?

Glycine,  hydrochloride (acid form) dosage forms, like injections, are made by purifying L-glycine,  (often from fermentation or hydrolysis of keratinous materials like hair/feathers), converting it to a stable hydrochloride salt using acid, and then formulating it with sterile water, other amino acids, and pH adjusters for injectable solutions, ensuring high purity for safety, often via controlled steps like nitrogen sparging and filtration. 

General Preparation Steps (for injectable solutions):

Source & Purification: L-Glycine,  is obtained, commonly through fermentation or acid hydrolysis of natural sources (like hair/feathers), then purified.

Salt Formation: L-Glycine,  is reacted with hydrochloric acid (HCl) to form L-Glycine,  Hydrochloride, a more stable form.

Sterilization & Dissolution: The purified L-Glycine,  HCl is dissolved in Water for Injection (WFI) under sterile conditions, often with nitrogen sparging to remove oxygen.

Formulation: Other essential amino acids (like arginine, valine, etc.) and buffering agents are added, ensuring proper pH.

Filtration & Filling: The solution is filtered through sterile filters and

What are the appropriate Dosage forms of Glycine, , acid, Manufactured  by  MEDIOCON   INC?                

Mediocon Inc manufactures Glycine in a powder form. The company primarily supplies the active pharmaceutical ingredient (API), which is then used by other manufacturers to create various dosage forms for consumers. 

Common dosage forms of Glycine available generally (though not all are necessarily made by Mediocon Inc's specific customers) include: 

·       Powders: Often available in bulk to be mixed into liquids like shakes or smoothies.

·       Oral capsules/tablets: Typically provided in gel caps or tablet form for oral consumption.

·       Topical creams/ointments: Used in specific prescription formulations, such as for treating leg ulcers.

·       Injectable/Parenteral solutions: Used in hospital and clinical settings, such as for irrigation solutions or amino acid infusions.

·       Syrups/Liquids: Used in some combination products, particularly in nutraceuticals. 

For specific product details and availability from the manufacturer, you can visit the Mediocon Inc website or contact them through their listed phone numbers and email addresses on their Exporters India profile or IndiaMART

 What are the effects And Side effects of Glycine, , acid, Manufactured by MEDIOCON INC?

Glycine,  manufactured by MEDIOCON INC is an amino acid used in various applications, from food additives to potential therapeutic uses. The effects and side effects of glycine,  are generally dependent on dosage, individual sensitivity, and the specific form and method of use. 

Effects of Glycine,

Glycine,  is a non-essential amino acid that plays several vital roles in the body and is used in a range of commercial applications. 

• Neurotransmitter: In the brain, glycine,  (as glutamate) is the most abundant excitatory neurotransmitter, crucial for nerve cell communication, learning, and memory.
• Protein Synthesis: It is one of the primary building blocks for synthesizing proteins in the body.
• Metabolism and Energy: It plays a significant role in cellular metabolism and can serve as a source of fuel, particularly for the cells in the intestinal lining.
• Ammonia Detoxification: It helps detoxify the body and brain by removing excess ammonia from the bloodstream.
• Potential Therapeutic Uses (under study): Research has explored potential benefits in managing conditions such as epilepsy, muscular dystrophy, and cognitive impairment, though many of these remain unsubstantiated claims and require further research.
• Commercial/Industrial Uses: It is widely used as a flavor enhancer (as monosodium glutamate or MSG) and in the cosmetic industry for skin and hair care products. 

·       Glycine,  supplements can interact with medications for diabetes and high blood pressure, potentially causing blood sugar

  How is Glycine, , acid, Manufactured by MEDIOCON  INC  Tested Qualitatively?

Information on the specific qualitative testing procedures used by MEDIOCON INC is not publicly available in the provided search results. However, the general industry qualitative tests for glycine (an alpha amino acid) involve methods such as the ninhydrin test, which produces a characteristic color change. 

In a manufacturing setting, qualitative and quantitative analyses are part of the overall quality control process to ensure product specifications are met. 

General Qualitative Testing for Glycine

Common methods for the qualitative detection of amino acids like glycine in a laboratory or industrial setting include:

·       Ninhydrin Test: This is a standard test for detecting the presence of alpha amino acids. When heated with ninhydrin solution, glycine (and other amino acids) yields a purple-blue color, confirming its presence.

·       Solubility Tests: Glycine's solubility in different solvents (water, alcohol, etc.) is a physical characteristic used to assess purity and identity.

·       Isoelectric Point Determination: Glycine is amphoteric, and its behavior at specific pH levels can be used for identification and separation from impurities like ammonium chloride.

·       Melting Point Analysis: Pure crystalline glycine has a known melting point range. Determining the melting point of a sample can help confirm its identity and purity.

·       Spectroscopy: Techniques such as Nuclear Magnetic Resonance (NMR) or Mass Spectrometry (MS) are used in modern quality control to identify the molecular structure and detect trace impurities, though these often provide quantitative data as well. 

MEDIOCON INC, as a manufacturer of pharmaceutical intermediates, would employ stringent quality control (QC) procedures following Good Manufacturing Practices (GMP) standards, which likely include a combination of these tests to ensure product quality and consistency. 

   Which tests are performed on Glycine, , acid, Manufactured by  MEDIOCON INC ?

The specific quality control tests performed on Glycine manufactured by MEDIOCON INC are not publicly available in the search results. Manufacturers typically define their own product specifications and testing protocols, which often adhere to general pharmaceutical or food grade standards such as USP (United States Pharmacopeia) or EP (European Pharmacopoeia). 

Based on general industry practices and common specifications for the compound, tests typically performed on Glycine include:

·       Assay (Purity): Determining the concentration and purity of the glycine, often via perchloric acid titration or HPLC (High-Performance Liquid Chromatography).

·       Identity: Confirmation that the substance is indeed glycine, frequently using methods such as IR-spectrum analysis (Infrared Spectroscopy) or other characterization techniques like NMR spectroscopy and elemental analysis.

·       Physical Properties: Measurement of properties like appearance (e.g., white powder/crystals), solubility in water and other solvents, pH of a solution, and loss on drying/moisture content.

·       Impurity Analysis: Testing for limits of specific impurities and foreign substances, such as:

o   Chloride (Cl)

o   Sulfate (SO₄)

o   Heavy metals (e.g., Lead, Copper, Iron)

o   Ammonium (NH₄)

o   Foreign amino acids

o   Insoluble matter in water

o   Sulfated ash content 

For precise details regarding the testing of a specific batch of the product, it is recommended to contact MEDIOCON INC directly for their product's certificate of analysis (CoA) or technical data sheet. Their contact information can be found on their website at mediocon.com. 

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What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract as an API (Active Pharmaceutical Ingredient) for MEDIOCON INC likely faces challenges in standardizing natural variability, achieving high purity & yield, scaling up production while maintaining quality, ensuring regulatory compliance (like GMP), managing waste, and overcoming complexity in extracting specific bioactive compounds (like phenolics, fibers, vitamins) using sustainable methods like microwave-assisted extraction (MAE) or continuous processing. Specific issues involve controlling natural fluctuations from raw bananas, optimizing extraction parameters (pH, power, time, solvent ratio) for consistency, and developing efficient separation techniques. 

Key Challenges in Banana Extract API Manufacturing:

1.    Raw Material Variability: Bananas, being natural products, have inherent variations in bioactive compound content (phenolics, vitamins C & E, fibers, etc.) due to variety, ripeness, growing conditions, and post-harvest handling, making consistent API quality difficult.

2.    Extraction & Isolation Efficiency:

·       Bioactive Richness: Extracting specific compounds (e.g., antioxidants, specific phytochemicals) from the complex banana matrix (peels, blossoms, fruit) requires precise methods.

·       Optimizing Parameters: Finding the perfect balance for microwave power, temperature, extraction time, solvent, and solid-to-solvent ratio for maximum yield and purity is complex, often using techniques like Response Surface Methodology (RSM).

3.    Scale-Up Issues: Transitioning from lab-scale extraction (like Microwave-Assisted Extraction - MAE) to industrial scale can introduce new impurities or reduce yields unexpectedly, requiring careful process monitoring and design space definition.

4.    Purity & Impurity Control: Ensuring the final API meets stringent pharmaceutical purity standards, especially concerning residual solvents, heavy metals, or microbial contamination, is a significant hurdle.

5.    Sustainability & Waste Management: While banana biomass is abundant (peels, pseudostems), managing large volumes of byproduct and developing eco-friendly, cost-effective extraction processes (Green Chemistry) remains a challenge.

6.    Regulatory Compliance (GMP): Meeting Good Manufacturing Practices (GMP) for natural product extracts requires rigorous documentation, validation, and quality control, which can be more complex than synthetic APIs.

What is the Packing for Glycine, , acid, Manufactured by MEDIOCON INC?

 

While specific Mediocon Inc. packaging details aren't in the snippets, Glycine (aminoacetic acid) is typically packed in bulk by manufacturers like them in HDPE drums or laminated bags, often in quantities like 25kg, and stored in cool, dry conditions to maintain quality, with smaller pack sizes (like 500g/1kg) available for lab use. 

Here's a breakdown of common Glycine packaging:

·       Bulk Packaging: 25kg plastic drums or laminated bags for industrial/pharmaceutical use.

·       Lab/Smaller Quantities: Plastic bottles (e.g., for Glycine Hydrochloride) or smaller bags.

·       Material: HDPE drums, plastic bottles, or laminated bags.

·       Storage: Tightly closed containers, cool, dry, well-ventilated area, protected from moisture and sunlight, often below 30°C. 

To get exact details for Mediocon Inc., you'd need to check their product specifications or contact them directly, as they supply various grades (nutraceuticals, pharma, industrial). 

What should the label claim for Glycine, , acid, Manufactured by MEDIOCON INC   Include?

For a Glycine product by MEDIOCON INC, the label should include its identity (Glycine, Aminoacetic Acid), manufacturer (MEDIOCON INC), purity (e.g., 99%+ or Pharma Grade), physical form (white crystalline powder), chemical properties (formula C2H5NO2, smallest amino acid), intended use (cell culture, buffer, precursor), and compliance info (USP/EP tested if applicable), plus batch/expiry dates, storage, and directions, ensuring it meets regulatory standards for its specific application (food, pharma, lab). 

Essential Label Claims:

1.    Product Name: Glycine.

2.    Chemical Name: Aminoacetic Acid / Aminoethanoic Acid.

3.    Manufacturer: Manufactured by MEDIOCON INC.

4.    Purity/Grade: E.g., 99%+; Pharma Grade; Tested to USP/EP standards (if applicable).

5.    Chemical Formula: C2H5NO2.

6.    Net Weight/Quantity: (e.g., 100g, 1kg).

7.    Appearance: White crystalline powder.

8.    Intended Use/Application:

1. "For laboratory, research, or cell culture use" (if not for human consumption).
2. "Buffering agent," "Protein synthesis," "Neurotransmitter precursor" (functional claims).

9.    Storage Conditions: "Store in a cool, dry place," "Keep container tightly closed".

10. Batch Number & Expiry Date: Essential for traceability.

11. Safety/Handling: Appropriate hazard warnings (though generally safe, good practice).

12. Regulatory Info: FDA/ECHA registration if relevant to market. 

Example Layout:

·       MEDIOCON INC

·       Glycine (Aminoacetic Acid)

·       Purity: 99% min. (Pharma Grade)

·       Formula: C2H5NO2 | MW: 75.07 g/mol

·       Appearance: White powder

·       Use: Cell Culture, Buffer, Synthesis.

·       Batch: [Batch No.] | Expiry: [MM/YYYY]

·       Storage: Cool, dry place. 

This covers the core requirements, but specific regulations depend on whether it's for a food additive, pharmaceutical excipient, or lab chemical. 

Where can Glycine, , acid, Manufactured by MEDIOCON INC are procured?

Glycine, , acid, Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Glycine, , acid, Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Glycine, , acid, Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Glycine, , acid, Manufactured by MEDIOCON INC product, regardless of the procurement source.