Glycine 56-40-6 Manufacturer Supplier Exporter, MEDIOCON INC.
Glycine Manufactured by MEDIOCON INC
Name: Hyaluronic
Acid
CAS No: 56-40-6
Molecular Weight: 75.07 g/mol
Molecular formula: C₂H₅NO₂
Synonyms: Aminoacetic acid, Glycocoll, and Glycocol
Appearance : Glycine appears
as a white
crystalline solid or powder, sometimes described as
colorless, with a characteristic sweet taste, hence its name from the Greek word for sweet.
Solubility : Glycine is very
soluble in water (around 25 g/100 mL at 25°C, increasing with temperature) and
moderately soluble in polar organic solvents like pyridine, but sparingly
soluble in ethanol, acetone, and insoluble in ethers/hydrocarbons, reflecting its zwitterionic nature and ability
to form hydrogen bonds.
Uses : Glycine is an amino acid with crucial
roles as a building block for proteins and other key molecules in the body, and
it has various uses in the body, as a dietary supplement, and in medical and
industrial applications.
Biological and Health Uses
The human body naturally produces glycine, but it is often considered
conditionally essential, meaning the body's synthesis may be insufficient to
meet all metabolic needs, particularly during aging, illness, or high physical
stress.
· Protein synthesis: Glycine is a fundamental building block for all proteins, making up
a significant portion of the body's total protein content.
· Collagen formation: It is the primary amino acid in collagen, the structural protein
vital for healthy skin, joints, ligaments, tendons, and bones.
· Antioxidant production: Glycine is a key precursor to glutathione, a powerful antioxidant
that helps protect cells from oxidative damage and aids in liver
detoxification.
· Neurotransmission: It acts as an inhibitory neurotransmitter in the central nervous
system (spinal cord, brainstem, and retina), helping to regulate motor and
sensory signals and promoting calmness.
· Sleep quality: Supplementation
may improve sleep quality, reduce daytime sleepiness, and help you fall asleep
faster by lowering core body temperature and calming the nervous system.
· Muscle health: It contributes to
the production of creatine, which provides energy to muscles for short,
strenuous activity, and it plays a role in muscle growth, repair, and
protection against muscle loss.
· Metabolic and heart health: Research suggests a link between higher glycine levels and a lower
risk of conditions like type 2 diabetes, high blood pressure, and heart
disease, potentially by improving insulin sensitivity and reducing
inflammation.
· Digestion: It supports
digestive wellness by producing bile acids (which break down fats) and
strengthening the gut lining.
Medical and Industrial
Applications
·
Surgical irrigation: Glycine
solutions are used as an irrigant during urological surgeries (e.g., prostate
and bladder surgeries) to keep the surgical field clear of blood and tissue
fragments.
·
Food additive: It is used in
food chemistry as a flavorant (due to its sweet taste), to mask the aftertaste
of saccharine, and for its preservative properties.
·
Chemical feedstock: It serves as an
intermediate in the manufacture of various chemical products, including some
herbicides and antibiotics.
·
Laboratory use: Glycine is used
as a buffering agent in protein analysis methods like SDS-PAGE electrophoresis.
Dietary Sources
Glycine
is available through diet and supplements. Good food sources include:
·
Meat and fish
·
Dairy products
·
Legumes and spinach
·
Seeds and nuts
How Glycine by MEDIOCON INC
Synthesized?
Mediocon Inc. (MCI)
is a company focused on nutraceuticals, not primary chemical
synthesis of raw glycine; while they use glycine, they likely source it from
large manufacturers using the standard amination of
chloroacetic acid with ammonia, or perhaps newer
methods like Strecker synthesis or fermentation, but the core chemical route
involves chloroacetic acid (or its salts) reacting with ammonia/ammonium
carbonate, followed by purification. The synthesis process aims to create
glycine by replacing the chlorine in chloroacetic acid with an amino group.
Traditional Chemical Synthesis (Most Common Industrial Method):
- Reactants:
Monochloroacetic acid (or its salt) and ammonia (or ammonium carbonate)
are mixed in water.
- Reaction: The
chlorine atom is displaced by the ammonia, forming glycine and ammonium
chloride.
ClCH₂COOH + 2NH₃ → NH₂CH₂COOH (Glycine) + NH₄Cl- Purification: The resulting mixture is purified, often using activated charcoal to remove colored impurities and then methanol to precipitate the glycine, which is then washed and dried.
Other Methods (Less Common for Bulk):
- Strecker Synthesis: Involves aldehydes, ammonia, and cyanide, but less common
for glycine itself.
- Fermentation/Enzymatic: Some newer processes use specific enzymes or microbial
fermentation to produce glycine, offering greener alternatives, but
chemical synthesis remains dominant for cost-effectiveness.
What are the different dosage
forms of Glycine by MEDIOCON INC?
Mediocon Inc primarily manufactures and exports Glycine as a raw material in powder or
crystal form, rather than a finished pharmaceutical dosage form (such as
tablets or capsules) for direct patient use.
Mediocon Inc focuses on providing pharmaceutical Active Pharmaceutical
Ingredients (APIs) and intermediates, nutraceuticals, and raw materials to
other manufacturers who then create the final products.
Therefore, the main "dosage form" provided by Mediocon for
Glycine is:
· Powder/Crystalline solid (as an ingredient for further manufacturing).
Finished dosage forms containing glycine are likely manufactured by other
pharmaceutical companies using Mediocon's raw material. Glycine is commonly
used in various pharmaceutical and nutraceutical products, including:
· Oral solid dosage forms (e.g., tablets, capsules)
· Liquid formulations (e.g., syrups, solutions)
· Nutraceutical gummies
How Glycine by
MEDIOCON INC Dosage Forms are prepared?
MEDIOCON INC primarily operates as a manufacturer and exporter of
pharmaceutical Active Pharmaceutical Ingredients (API) intermediates, not the
final dosage forms themselves. Therefore, they produce the raw material glycine
powder, which is then sold to other pharmaceutical companies that prepare the
final dosage products.
Preparation of Glycine Dosage
Forms (General Process)
Glycine is a white, odorless, crystalline powder used in various medical
and cosmetic applications. It is highly water-soluble and has a sweet taste.
Pharmaceutical companies generally prepare glycine into different dosage
forms, such as tablets, powders for oral solution, and irrigation solutions,
using standard pharmaceutical manufacturing techniques.
Common Dosage Forms and
Preparation Methods:
· Oral Solid Dosage Forms (Tablets, Powders): Glycine is often used as an excipient (an inactive ingredient) in
oral solid dosage forms, particularly as a disintegration accelerator in
fast-disintegrating tablets due to its excellent wetting properties. The general
process for tablets involves:
o
Blending: Mixing the active ingredient and excipients (including glycine,
fillers, and binders) to form a uniform blend.
o
Granulation: Creating granules from the powder mixture, often using wet
granulation or melt granulation, to improve flow and compressibility.
o
Compression: Compressing the granules into tablets using high-speed machinery.
o
Quality
Control: Performing tests to ensure
tablet strength and proper disintegration time.
· Oral Lyophilizates (Rapidly Disintegrating
Tablets): Glycine is frequently used as a
co-freeze-dried excipient in the preparation of rapidly disintegrating oral
dosage forms. The process typically involves:
o
Solution/Suspension
Preparation: Forming an aqueous solution or
suspension of the active substance and carrier materials (like gelatin and
mannitol).
o
Dosing and
Freezing: Dispensing discrete units of the
liquid system into blister pockets and freezing them.
o
Freeze-Drying: Removing the water medium under vacuum (lyophilization) to create a
porous, solid network that disintegrates rapidly when placed in the mouth.
· Liquid Dosage Forms (Irrigation Solutions,
Injections): For liquid forms like irrigation
solutions (e.g., 1.5% glycine solution for urological procedures), glycine is
dissolved in appropriate aqueous diluents. These solutions must be stored in
single-dose containers, often type I or type II glass, to maintain stability
and sterility.
What are the appropriate Dosage
forms of Glycine by MEDIOCON INC?
· Mediocon Inc
is a supplier/manufacturer of raw chemicals, APIs, intermediates, and
nutraceutical ingredients, including amino acids such as glycine, to other pharmaceutical,
nutraceutical, and food companies.Mediocon Inc
·
They do not currently list branded finished products (like tablets,
capsules, powders) on their public website or in major pharma databases.
📦 Glycine Is Supplied by Mediocon Inc
Since Mediocon sells glycine as a raw material/API, the dosage form would depend on what the purchasing manufacturer/formulator creates. Typical finished
dosage forms for glycine used in pharmaceuticals and supplements include:
·
Powder (crystalline glycine in bulk
form, e.g., USP powder/API) used by formulators to make products.
·
Oral tablets or sublingual tablets containing
glycine (at various strengths) for supplement uses.Medixlife.com
·
Capsules with glycine
powder as a dietary supplement.
·
Dietary supplement powder sold
directly for mixing into liquids.
·
Custom formulations for
nutraceutical or pharmaceutical products.
(Note: these
are general glycine dosage forms — not specifically branded products by
Mediocon Inc.)
🧪 What You Can Expect From Mediocon’s Glycine
As a raw ingredient supplier, Mediocon’s glycine product is
likely:
·
Crystalline glycine powder (API grade).
·
Supplied in bulk containers for use by manufacturers.
·
Offered for formulation into tablets, capsules, sachets,
or other delivery forms by third-party product makers
When should Glycine by MEDIOCON
INC be taken?
Glycine" specifically manufactured by "MEDIOCON INC"; you might be referring to a brand like Glycomin (Glimepiride), a diabetes drug, which is taken as directed by a doctor, often with meals, but must be avoided in Type 1 Diabetes, kidney/liver issues, or ketoacidosis. For plain Glycine (an amino acid), it's generally safe up to 6g/day (like with meals for sleep/metabolism), but always confirm the exact product and consult your doctor for personalized timing and dosage, as it can interact with conditions or other meds.
If it's
Glycomin (Glimepiride):
· Timing: Usually taken once daily, often with the first
meal of the day, as advised by your doctor.
· When to Avoid: Do NOT take if you have Type 1 Diabetes, diabetic ketoacidosis, or severe kidney/liver problems.
If it's a plain Glycine
Supplement (Amino Acid):
· General
Use: Can be taken with meals or
before bed, depending on your goal (e.g., for sleep, digestion).
· Dosage: Up to 6 grams daily is generally safe, but start low.
Crucial Next Step:
· Check
the Label: Verify the exact
name and manufacturer on the bottle.
· Consult Your Doctor: The best time to take any supplement or medication depends on your specific health needs, so speak with your healthcare provider before starting.
What are
the effects And Side effects of Glycine by MEDIOCON INC?
MEDIOCON INC is a manufacturer and wholesaler of pharmaceutical
intermediates, not a producer of a consumer-ready Glycine product or
supplement; as a result, specific effects and side effects from a product of
that brand cannot be provided. Glycine is a naturally occurring amino acid, and
its general effects and side effects when used as a supplement or in medical
contexts are well-documented.
General Effects of Glycine
Glycine acts as an inhibitory neurotransmitter in the central nervous
system and is a fundamental building block for proteins and other crucial
molecules like collagen, creatine, and glutathione.
Common effects include:
· Improved sleep quality: Glycine supplementation before bed can help people fall asleep faster,
improve sleep efficiency, and feel more alert the next day without morning
grogginess.
· Support for mental health: As a calming neurotransmitter, it may help alleviate some symptoms of
anxiety and, when used as an adjunct therapy, some symptoms of schizophrenia.
· Enhanced muscle health and recovery: It is involved in creatine and collagen synthesis, supporting muscle growth
and joint health, and potentially reducing muscle soreness.
· Liver and heart protection: Glycine has antioxidant and anti-inflammatory properties and may help
protect the liver from damage and support cardiovascular health by improving
blood flow and lowering blood pressure.
· Metabolic support: It may help improve
insulin sensitivity and regulate blood sugar levels.
General Side Effects of Glycine
Glycine is generally considered safe and well-tolerated by most people
when taken in appropriate doses (typically 3-5 grams daily as a supplement).
Side effects are usually mild and temporary.
Common side effects may include:
· Nausea, vomiting, and stomach upset
· Diarrhea or soft stools
· Drowsiness, particularly if high doses are taken during the day
Serious side effects are rare but can occur with very high doses (e.g., as an irrigating fluid
during surgery) or in individuals with specific health conditions (like severe
kidney or liver disease). These may include allergic reactions, transient
visual disturbances, or heart failure symptoms.
It is always recommended to consult with a healthcare provider before
starting any new supplement, especially if you have existing health conditions
or are taking other medications.
How is Glycine by
MEDIOCON INC Tested Qualitatively?
Typical Qualitative Tests Used
for Glycine Identity
🔬 1. Ninhydrin Test
·
Purpose: Detects free amino acids.
·
Principle: Ninhydrin reacts with amino acids to form a colored
complex (usually purple/blue for amino acids like glycine).
·
Observation: Glycine gives a characteristic positive color change
when tested with ninhydrin reagent. This confirms the presence of a free α-amino
acid group. Scribd+1
🔬 2. Pharmacopoeial Identification Tests
Suppliers routinely follow
pharmacopoeia standards (USP/EP/BP/IP) for qualitative identity confirmation,
such as:
·
Solution
Appearance: A solution of the sample should
be clear and colorless without foreign particles. Nhà thuốc Ngọc Anh
·
pH Test: A 5 % aqueous solution should have an expected pH range
(often ~5.9–6.4). Nhà thuốc Ngọc Anh
·
Chromatographic
/ Spectroscopic Identity Checks:
o
TLC (thin-layer chromatography) to compare with a standard
reference.
o
FT-IR
spectroscopy to match the characteristic
glycine absorption pattern. Himedialabs
These tests are qualitative (presence/identity) rather than measuring
exact quantity.
🔬 3. Color and Physical Appearance
·
Qualitative inspection of the
physical form (crystalline, white or off-white powder) and solubility behavior
in water. These sensory checks are listed in pharmacopoeial identity tests.
Which tests are performed on Glycine
by MEDIOCON INC ?
To
get precise details, you'd typically check:
·
Manufacturer's Certificate of Analysis (CoA): This document lists the actual
tests and results for a specific batch.
·
Product Specifications Sheet: Outlines required tests and
acceptance criteria.
· Contact Mediocon Directly: For specific technical documents or quality information.
General
Tests for Pharmaceutical Grade Glycine (Likely Performed):
·
Identification: Infrared
Spectroscopy (IR), High-Performance
Liquid Chromatography (HPLC).
·
Assay (Potency): Titration or HPLC to confirm
Glycine content.
·
Purity: Related Substances (HPLC), Residual Solvents (GC),
Heavy Metals, Ash Content.
·
Physical Tests: Appearance, Solubility, pH, Loss on Drying, Chloride, Sulfate.
· Microbiological: Bacterial Endotoxins (if for injectables), Microbial Limits.
· ADynamicEvolution – Biocon
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