L-Ascorbic acid 50-81-7 Manufacturer, Supplier, Exporter, MEDIOCON INC

 

 

L-Ascorbic acid Manufactured by MEDIOCON INC

 

   Name: L-Ascorbic acid 

CAS No: 50-81-7

Molecular Weight: 176.12 g/mol

Molecular formula:  C₆H₈O₆

Synonyms : Synonyms for L-Ascorbic acid primarily revolve around its common name, Vitamin C, but also include its chemical forms like Ascorbic Acid, its stereochemical identifiers like L(+)-Ascorbic acid, its role as an Antiscorbutic vitamin, and various brand names like Cecon, Cevitamic acid, or C-Long, plus Latin/French/Spanish terms such as Acidum ascorbicum, Acide ascorbique, and Acido ascorbico. 

Appearance : L-Ascorbic acid (Vitamin C) appears as a white to very pale yellow crystalline powder or colorless crystals, is odorless, and has a sharp, acidic taste. It's known for being easily oxidized, meaning it gradually darkens or turns yellowish upon exposure to light, air, heat, and humidity, and is freely soluble in water, forming mildly acidic solutions. 

 Solubility : L-Ascorbic acid (Vitamin C) is highly soluble in water due to its polar nature, dissolving freely to form acidic solutions, with solubility increasing with temperature (around 176 g/L or 330 mg/mL at 20°C). It's also soluble in polar organic solvents like methanol and ethanol, but poorly soluble in nonpolar solvents such as ether, chloroform, benzene, and oils, reflecting its polar structure with multiple hydroxyl groups.

Uses : L-Ascorbic acid (Vitamin C) is used as a powerful antioxidant to protect cells, boost collagen for skin firmness, brighten skin tone, and reduce dark spots. It also supports immune function, enhances iron absorption, aids wound healing, and is used in food as a preservative, with applications in skincare (anti-aging, UV protection), supplements (preventing deficiency/scurvy), and even as a bowel prep agent in medicine. 

Skincare & Dermatology

·       Collagen Synthesis: Essential for producing collagen, improving skin elasticity and firmness, and reducing fine lines.

·       Brightening & Dark Spots: Inhibits melanin production, reducing pigmentation, dullness, and post-acne marks.

·       Antioxidant Protection: Neutralizes free radicals from UV rays, pollution, and stress, preventing cellular damage and photoaging.

·       Wound Healing: Supports tissue repair and recovery from laser treatments. 

Dietary & Health Supplements

·       Vitamin C Deficiency: Prevents and treats scurvy, with symptoms like fatigue and poor healing.

·       Immune Support: Boosts the immune system.

·       Iron Absorption: Enhances the absorption of non-heme iron from plant-based foods.

·       Antioxidant Effects: Protects cells from oxidative stress, potentially playing a role in heart disease and cancer prevention. 

Food & Other Uses

·       Food Preservative: Prevents oxidation, extending shelf life.

·       Bowel Prep: Used in some FDA-approved fluids (like MoviPrep) for colonoscopy preparation. 

How it's Used in Skincare

·       Applied topically in serums (often 3-20%).

·       Can be mixed with moisturizers or hyaluronic acid serums.

·       Best used with sunscreen for enhanced photoprotection. 

 

 

  How L-Ascorbic acid  is manufactured by MEDIOCON INC Synthesized?

Mediocon Inc. manufactures L-ascorbic acid (vitamin C) using an industrial process that likely involves the Reichstein process or a modern two-step fermentation method, with the key intermediate being 2-keto-L-gulonic acid (KLG). The specific details of their synthesis method are proprietary, but the general industry methods are well established. 

General Manufacturing Processes

Industrial production of L-ascorbic acid largely relies on variations of the original Reichstein process, which combines chemical and fermentation steps starting from D-glucose. 

The Classic Reichstein Process
The traditional method involves several steps:

1.      D-glucose is hydrogenated to D-sorbitol.

2.      D-sorbitol undergoes microbial oxidation (fermentation) to L-sorbose.

3.      L-sorbose is chemically protected (acetal formation).

4.      The protected L-sorbose is oxidized to 2-keto-L-gulonic acid (KLG).

5.      Finally, KLG is cyclized (often using an acid catalyst in an organic solvent) to form L-ascorbic acid, which is then purified by crystallization. 

Modern Two-Step Fermentation Method
Many current industrial producers, particularly in China where most of the world's supply originates, use an improved two-step fermentation process that is more environmentally friendly. This method: 

·       Bypasses several chemical steps by using a second bio-oxidation step with bacteria like Ketogulonicigenium vulgare to convert D-sorbitol directly to the intermediate 2-keto-L-gulonic acid (KLG).

·       The final conversion of KLG to L-ascorbic acid remains an acid-catalyzed cyclization and purification process. 

 

 

What are the different  dosage forms of L-Ascorbic acid  Manufactured  by  MEDIOCON INC?

Mediocon Inc manufactures L-Ascorbic acid (Vitamin C) in various dosage forms, including tablets, effervescent tablets, and powder. 

The specific L-Ascorbic acid dosage forms offered by Mediocon Inc are:

·       Tablets: Available in different strengths.

·       Effervescent Tablets: Offered in 1000 mg strength.

·       Powder: The company lists Ascorbic Acid Powder as a product, likely for use as an Active Pharmaceutical Ingredient (API) or a general vitamin powder. 

 

 

 How L-Ascorbic acid  Manufactured by MEDIOCON INC Dosage Forms are prepared?

MEDIOCON INC is a manufacturer and wholesaler of active pharmaceutical ingredients (APIs) and fine chemicals, including L-ascorbic acid, which it primarily offers in powder or crystal form. The specific final dosage forms (e.g., tablets, injections, solutions) are prepared by other certified pharmaceutical entities using these raw materials and are not directly manufactured by MEDIOCON INC. 

The general preparation methods for dosage forms using L-ascorbic acid API are as follows:

·       Tablets: For tablets, the crystalline or powder L-ascorbic acid is mixed with excipients and binders, such as polyvinylpyrrolidone and microcrystalline cellulose, and then compressed into the desired form.

·       Injections/Liquid Solutions: For injectable or oral liquid solutions, the L-ascorbic acid powder is dissolved in water (often with stabilizing agents like metaphosphoric acid to prevent oxidation) and ethanol, filtered, and sterilized. These solutions require careful handling due to the compound's sensitivity to heat and light.

·       Topical Gels/Creams: For topical applications, L-ascorbic acid (or its more stable derivatives) can be incorporated into polymeric matrices or gels. 

 

 

What are the appropriate Dosage forms of L-Ascorbic acid  Manufactured  by  MEDIOCON   INC?

Mediocon Inc primarily manufactures and exports L-Ascorbic acid as an Active Pharmaceutical Ingredient (API) in powder form, which is then used by other companies to create various finished dosage forms. They also produce some finished products such as effervescent tablets and syrups that contain ascorbic acid. 

The main appropriate dosage forms of L-Ascorbic acid manufactured by Mediocon Inc are:

·       Powder (API): Mediocon Inc lists Ascorbic Acid Powder as one of its core vitamin API products. This raw powder is the primary form they provide to other manufacturers.

·       Effervescent Tablets: They manufacture effervescent tablets containing Vitamin C in a strength of 1000 mg.

·       Syrup (Component): Ascorbic acid is also listed as an ingredient in their "TOTAL 24 Syrup", a multivitamin and amino acid preparation. 

 

 

When should L-Ascorbic acid  Manufactured by MEDIOCON INC be taken?

L-Ascorbic acid manufactured by MEDIOCON INC is a general vitamin C supplement and can be taken at any time of the day, with or without food. The specific timing is less important than consistently taking it as part of your daily routine. 

General Guidance

·       Follow Label Instructions: The most important instruction is to follow the directions on the product packaging or prescription label provided by MEDIOCON INC.

·       With or Without Food: Ascorbic acid is a water-soluble vitamin, so it doesn't need to be taken with food for absorption. However, if it causes an upset stomach, taking it with a meal can help.

·       Consistency: For best results, take the medication at regular intervals, ideally at the same time each day, to maintain consistent levels in your body.

·       Dosage: Do not take more or less of it or take it more often than recommended by your doctor or the product label. The dosage depends on age and gender, as well as the reason for supplementation. 

 

 

 What are the effects And Side effects of L-Ascorbic acid  Manufactured by MEDIOCON INC?

The effects and side effects of L-ascorbic acid manufactured by MEDIOCON INC are the same as those associated with the generic compound (Vitamin C), as there is no indication of a product-specific formulation that alters these effects. 

Effects of L-Ascorbic Acid (Vitamin C)

L-ascorbic acid is an essential water-soluble vitamin that acts as an antioxidant and is crucial for numerous bodily functions. 

·       Prevention and treatment of scurvy: The primary medical use is to prevent or treat vitamin C deficiency.

·       Collagen synthesis: It is vital for producing collagen, a protein necessary for healthy skin, bones, teeth, gums, and blood vessels, and for wound healing.

·       Antioxidant action: It helps protect cells from damage caused by free radicals and oxidative stress.

·       Iron absorption: It enhances the absorption of non-heme iron (from plant-based foods).

·       Immune system support: It helps boost immune system function. 

Side Effects of L-Ascorbic Acid

L-ascorbic acid is generally considered safe when taken within recommended dosages. Side effects usually occur with high or excessive doses (typically over 2 grams daily). 

Common side effects (usually with high doses):

·       Nausea and vomiting

·       Stomach cramps, abdominal pain, and diarrhea

·       Heartburn or acid reflux

·       Headache

·       Flushing or redness of the skin

·       Difficulty falling or staying asleep (insomnia) 

Less common or rare, but potentially serious side effects:

·       Kidney stones: High doses may increase the risk of kidney stones, particularly in individuals with a history of kidney problems or those prone to recurrent renal calculi.

·       Interference with medical tests: It can affect the accuracy of certain lab tests, such as blood glucose and stool occult blood tests.

·       Hemolysis: In people with a specific enzyme deficiency (G6PD deficiency), large amounts of vitamin C can cause the breakdown of red blood cells.

·       Iron overload issues: It can increase iron absorption, which is a concern for people with iron-related blood disorders like hemochromatosis. 

It is always recommended to follow the dosage instructions on the product label or consult a healthcare professional for personalized advice, especially if you have underlying health conditions or are taking other medications

 

 

 How is L-Ascorbic acid  Manufactured by MEDIOCON  INC  Tested Qualitatively?

MEDIOCON INC is a manufacturer of active pharmaceutical ingredients that likely follows standard industry testing protocols. While the specific, proprietary methods of MEDIOCON INC are not publicly available, qualitative testing of L-ascorbic acid in a manufacturing setting typically involves Identification tests as per pharmacopeial standards (USP, BP, IP) and instrumental methods like Infrared (IR) spectroscopy. 

Standard Qualitative Testing Methods for L-Ascorbic Acid 

Pharmaceutical companies generally use a combination of standard tests to confirm the identity of L-ascorbic acid raw material and finished products. These include:

·       Color Reaction Test: A common and simple test involves adding the sample to a 0.05M iodine solution. The characteristic color of iodine is discharged because L-ascorbic acid is a strong reducing agent and reacts with the iodine.

·       Infrared (IR) Spectroscopy: The infrared spectrum of the sample is compared to the spectrum of a certified Ascorbic Acid Reference Standard (WRS). If the spectra are concordant, the identity is confirmed.

·       Physical Appearance and Solubility:

o   Appearance: L-ascorbic acid is typically a white or pale yellow powder or crystal.

o   Solubility: It is freely soluble in water, sparingly soluble in alcohol, and practically insoluble in chloroform, ether, and benzene.

·       Melting Point Determination: Pure L-ascorbic acid has a specific melting point range (around 190-192°C with decomposition), which can be used as an identification criterion.

·       Foreign Particles Inspection: The substance is visually inspected against a white and black background to ensure it is free from foreign particles.

·       Chromatographic Identification: Techniques like High-Performance Liquid Chromatography (HPLC) or High-Performance Thin Layer Chromatography (HPTLC) are used for both quantitative assay and identification. The retention time or Rf value of the sample is compared to that of a standard. 

These qualitative tests ensure the material is the correct chemical entity before it proceeds further in the manufacturing process and that the final product meets regulatory quality standards.

 

 

   Which tests are performed on L-Ascorbic acid  Manufactured by  MEDIOCON INC ?

MEDIOCON INC, as a manufacturer and wholesaler of active pharmaceutical ingredients (APIs) and cosmetic raw materials, performs quality control tests on its L-Ascorbic acid to ensure it meets specific pharmacopeia standards such as the USP, BP, IP, or Ph. Eur.. 

The specific tests generally performed on L-Ascorbic acid include: 

Standard Quality Control Tests 

·       Appearance (Description): Visual inspection to confirm the product is a white or almost white powder.

·       Solubility: Testing to ensure it dissolves freely in water and sparingly in ethanol, as expected.

·       Assay (Purity): This is a critical test to determine the concentration of L-Ascorbic acid. Common methods include:

o   Titration: A traditional redox titration method using an oxidant solution like 2,6-dichlorophenol-indophenol (DCPIP) or potassium iodate.

o   High-Performance Liquid Chromatography (HPLC): A highly sensitive and specific method often using UV detection to quantify the exact amount and check for impurities.

o   UV Spectrophotometry: Measuring absorbance at a specific wavelength (e.g., 243 nm or 265 nm).

·       Moisture Content (Loss on Drying): Determines the amount of water present in the powder to ensure stability and quality.

·       pH: Measuring the pH of a specified solution (e.g., 1% solution) to ensure it falls within a specific range (e.g., 5.0-8.0, though L-ascorbic acid solutions are naturally acidic).

·       Melting Point: L-Ascorbic acid has a specific melting point with decomposition around 190°C, which is a key physical identifier. 

Additional Tests for Specific Grades

Depending on the intended use (pharmaceutical, cosmetic, or food additive), additional tests may be conducted: 

·       Heavy Metals Analysis: Testing for limits of impurities like lead and arsenic, especially important for pharmaceutical and food use.

·       Microbiological Tests: Ensures the product is safe for use by checking for total plate count, yeast, mould, E. coli, and Salmonella.

·       Stability Testing: While not a test on a single batch, manufacturers conduct shelf-life and stability studies to provide appropriate packaging and storage recommendations (e.g., storage in a cool, dry place, protection from light and air). 

 

What are the challenges in manufacturing of L-Ascorbic acid  by MEDIOCON  INC ’s Dosage forms?

While information specific to MEDIOCON INC.'s internal operations is limited, the primary challenges in manufacturing L-Ascorbic acid (vitamin C) dosage forms, faced by the pharmaceutical industry including companies like MEDIOCON INC., revolve around instability and poor physical properties. 

The key manufacturing challenges are:

·       Environmental Sensitivity: L-Ascorbic acid is highly sensitive and prone to degradation when exposed to external factors such as light, heat, oxygen, and moisture. This instability can lead to a loss of potency and product integrity over time.

·       Poor Flow and Compressibility: The raw powder form of ascorbic acid typically exhibits poor flow and compressibility characteristics. This makes the ingredient difficult to process efficiently into uniform and robust solid dosage forms like tablets using standard manufacturing techniques such as direct compression, often requiring the use of specialized excipients or alternative manufacturing methods.

·       Aqueous Instability: Ascorbic acid is unstable in aqueous solutions, with degradation being a primary cause of quality changes. This presents a significant challenge for liquid dosage forms (e.g., syrups, injections) or processes involving water.

·       Interaction with Excipients/Ions: The compound can interact with other ingredients in a formulation, such as transition metal ions or certain excipients, which can accelerate its degradation.

·       Processing Challenges: Traditional formulation methods might be unsuitable for industrial scale production due to the compound's fragility. For example, some stabilization techniques developed in laboratories, such as specific liposomal methods, are difficult to industrialize. 

To overcome these challenges, manufacturers often employ strategies such as:

·       Using Stabilizers: Incorporating appropriate stabilizing agents or antioxidants into the formulation.

·       Encapsulation: Shielding the ascorbic acid from sensitive environments by encapsulating it within a protective layer or matrix.

·       Controlling the Environment: Manufacturing and packaging the product under controlled conditions (e.g., low oxygen, specific pH, climate control).

·       Excipient Selection: Utilizing specialized excipients, such as directly compressible starch, to improve the powder properties for manufacturing (e.g., tablet compression). 

 

What is shelf life Of L-Ascorbic acid  by MEDIOCON INC?

The specific shelf life for L-Ascorbic acid provided by MEDIOCON INC is not available in the search results. The shelf life of L-ascorbic acid can vary depending on its form (powder, tablet, solution), purity, packaging, and storage conditions. 

General industry standards for L-ascorbic acid powder under proper storage conditions (cool, dry, sealed container, away from light) typically range from 2 to 3 years from the date of manufacturing. 

To get the exact shelf life, you should:

·       Refer to the product labeling or technical data sheet provided with your specific batch of L-Ascorbic acid from MEDIOCON INC.

·       Contact MEDIOCON INC directly for product specifications. You can reach them via their website at mediocon.com or email at sales@mediocon.com.

 

 

What should the label claim for L-Ascorbic acid  Manufactured by MEDIOCON INC Include?

For L-Ascorbic acid manufactured by MEDIOCON INC, the required label information depends on whether the product is classified as a dietary supplement, a food ingredient, or a cosmetic ingredient. Assuming it is for consumer use as a dietary supplement, the label must comply with U.S. Food and Drug Administration (FDA) regulations.

 

Where can L-Ascorbic acid  Manufactured by MEDIOCON INC are procured?

L-Ascorbic acid  Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find L-Ascorbic acid  Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for L-Ascorbic acid  Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the L-Ascorbic acid  Manufactured by MEDIOCON INC product, regardless of the procurement source.