P-TOLYL ACETIC ACID CA.622-47-9 , Manufacturer, supplier, exporter MEDIOCON INC

 

 

P-TOLYL ACETIC ACID  CA., Manufactured by MEDIOCON INC

 

 Name : P-TOLYL ACETIC ACID  CA.,

CAS No:    622-47-9

Molecular Weight 150.17 g/mol

Molecular formula  C₉H₁₀O₂

·       Synonyms: 

o   (4-Methylphenyl)acetic acid

o   2-(4-Methylphenyl)acetic acid

o   4-Methylbenzeneacetic acid

o   4-Tolylacetic acid

o   p-Methylphenylacetic acid

o   Benzeneacetic acid, 4-methyl-

o   NSC 65595 

·       P-tolylacetic Acid | 622-47-9 | Chemical Bull Pvt. Ltd.

 

Appearance:   Typically a white to beige fine crystalline powder or solid

 Solubility : Typically a white to beige fine crystalline powder or solid Soluble in caustic alkalies (hot alkali solutions).

o   Slightly soluble in acids, including hydrofluoric acid (HF).

Use :

• It is used as a chemical intermediate in organic and pharmaceutical synthesis..

 

 How is  P-TOLYL ACETIC ACID  CA.,manufactured by MEDIOCON INC Synthesized?

P-Tolyl Acetic Acid (PTAA) is typically synthesized by hydrolyzing p-tolylacetonitrile (4-methylphenylacetonitrile) under acidic or basic conditions, a common industrial route for its simple operation and scalability, involving reacting the nitrile with water and an acid or base, followed by acidification (if basic) and purification, yielding the carboxylic acid. While Mediocon Inc. isn't detailed, general methods focus on converting the nitrile group to a carboxyl group, often via intermediate steps like reaction with strong acids (e.g., H2SO4) or alkali, then crystallization. 

Common Synthesis Method (Hydrolysis of Nitrile)

1.    Starting Material: 4-Methylphenylacetonitrile (p-tolylacetonitrile).

2.    Hydrolysis: The nitrile is reacted with water in the presence of a strong acid (like sulfuric acid) or a strong base (like NaOH) at elevated temperatures (e.g., 90-150°C).

3.    Work-up & Isolation:

1.             If basic hydrolysis is used, the resulting salt is acidified with a mineral acid (like HCl) to pH 1-2 to precipitate the free p-tolylacetic acid.

2.             If acidic hydrolysis is used, the mixture is often diluted with water or an organic solvent (like toluene/ethyl acetate) to extract the product.

4.    Purification: The crude product is usually purified by recrystallization (e.g., from ethanol/water mixtures) and drying to obtain high-purity p-tolylacetic acid. 

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What are the different  dosage forms  of   P-TOLYL ACETIC ACID  CA.,Manufactured  by  MEDIOCON INC?

·       in,Tetracycline,Penicillin,Cephalosporins ,Hormones,Amino acids and derivatives,Aminoglycoside,Macrolides,Sulfon amides,Chloramphenicols,Lincomycin,Respira tory system drugs,Antipyretic analgesic,Digestive system drugs,Cardiovascular system drugs,Central nervous system drugs,Anesthetics,Other antiinfective drug,Antiparasitic,Other active pharmaceutical ingredients,Pharmaceutical IntermediatesNanopowder

 How P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON INC   Dosage Forms are prepared?

P-Tolyl Acetic Acid (PTAA) is a chemical intermediate (CAS No. 622-47-9), and Mediocon Inc. is a supplier and manufacturer of pharmaceutical intermediates. It is not a final medicinal product with defined "dosage forms" prepared by Mediocon Inc.. 

The company supplies the raw chemical ingredient to other pharmaceutical manufacturers, who then use it to synthesize various drugs and prepare specific dosage forms (e.g., tablets, capsules, liquids). 

The preparation of a final dosage form from P-Tolyl Acetic Acid generally involves the following broad steps performed by a separate pharmaceutical company:

1.    Drug Synthesis: P-Tolyl Acetic Acid is used as a chemical building block in the synthesis of complex active pharmaceutical ingredients (APIs), such as certain anti-inflammatory agents.

2.    Formulation: The synthesized API is combined with various excipients (binders, fillers, disintegrants, lubricants, etc.) to create a specific drug formulation. This process can involve techniques like:

·       Melt granulation: The components are combined by melting a binder material.

·       Spray drying: The drug is dissolved in a solvent mixture and sprayed to form a powder.

·       Direct compression: Powders are blended and compressed into tablets.

3.    Dosage Form Manufacturing: The formulated mixture is processed into the final form, such as tablets, capsules, or a liquid solution.

4.    Packaging: The finished dosage forms are packaged for distribution and use. 

For specific details on how Mediocon Inc. manufactures the intermediate chemical itself, you would need to contact the company directly via their official website or other business channels, as this information is often proprietary. 

What are the appropriate Dosage forms of P-TOLYL ACETIC ACID  CA.,Manufactured  by  MEDIOCON   INC?                

·       P-tolyl acetic acid (PTAA), or 4-methylphenylacetic acid, is primarily an intermediate chemical used in organic synthesis and the manufacture of Active Pharmaceutical Ingredients (APIs) such as dextromethorphan. It is not an active drug itself, but a raw material supplied to pharmaceutical manufacturers, typically as a white crystalline powder. 

·       As an intermediate chemical, it does not have "appropriate dosage forms" for direct medical use by patients. MEDIOCON INC likely manufactures or supplies this chemical in bulk form (e.g., powders or solutions for manufacturing) for B2B (business-to-business) purposes. 

·       The final dosage form of any medication incorporating a derivative of PTAA as an API is determined during the drug formulation process by the pharmaceutical company that uses it. 

·       For details on the product specifications and form supplied by the manufacturer, one would need to consult the specific product documentation or contact MEDIOCON INC directly. 

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When should P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON INC be taken?

P-TOLYL ACETIC ACID CA. is likely a chemical reagent or an intermediate for synthesizing other products and not a direct human medication. Therefore, it is not something intended to be "taken" by a person, and there are no general instructions for its dosage or administration. 

Information indicates that:

·       P-tolylacetic acid (PTAA) is primarily used as an intermediate in the synthesis of various complex compounds for the pharmaceutical, agricultural, and polymer industries.

·       It serves as a reagent in laboratories for specific chemical reactions and research, such as in the preparation of certain amines or in studies related to bronchial epithelial sodium channels.

·       It may have some in vitro (lab setting) anticancer activity, but this is for research purposes, not human consumption.

·       The manufacturer, MEDIOCON INC, is described as a supplier of pharmaceutical intermediates, confirming its role in the chemical supply chain rather than consumer medication. 

You should not ingest or use P-TOLYL ACETIC ACID CA. as a medicine. If you are experiencing a medical condition, consult a healthcare professional for advice and appropriate treatment. If you are handling this substance in a professional capacity, you must follow the safety data sheets and established laboratory protocols

 What are the effects And Side effects of P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON INC?

Effects and Uses

P-tolyl acetic acid itself is generally not a "medical drug" with direct effects on the human body in the way a final pharmaceutical product is. Instead, its "effects" are primarily its chemical properties that make it useful as a precursor or intermediate in manufacturing processes. 

·       Pharmaceutical Intermediate: It is a key starting material for the synthesis of complex pharmaceutical ingredients, notably Dextromethorphan, an active ingredient in many cough medicines.

·       Organic and Agrochemical Synthesis: It is used as a building block for creating other organic compounds, pesticides, and herbicides.

·       Research: It is used in laboratory research for applications such as the study of protein interactions and drug development. 

Potential Side Effects and Hazards (Raw Chemical Exposure)

When handled as a raw chemical, the primary "side effects" are related to industrial exposure and are considered hazards. 

·       Skin and Eye Irritation: Direct contact with the substance can cause skin and serious eye irritation.

·       Respiratory Irritation: Inhalation of dust or vapors may cause irritation of the nose, throat, and lungs, leading to coughing and difficulty breathing.

·       Ingestion: Ingestion can cause gastrointestinal discomfort and potential toxicity if consumed in large quantities.

·       Safety Precautions: Due to these hazards, it requires proper handling with protective equipment like gloves and eye shields, and storage in a cool, dry, well-ventilated area. 

  How is P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON  INC  Tested Qualitatively?

Here’s how qualitative testing is generally done for a chemical like p-tolylacetic acid (the compound you’re referring to as P-Tolyl Acetic Acid CA “manufactured by Mediocon Inc”). I couldn’t find a specific publicly available quality test specification exactly for Mediocon Inc.’s lot, but the following outlines the typical qualitative identification methods used in chemical quality control and organic analysis for such an aromatic carboxylic acid product:

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   Which tests are performed on P-TOLYL ACETIC ACID  CA.,Manufactured by  MEDIOCON INC ?

The specific quality control tests performed on P-TOLYL ACETIC ACID CA. manufactured by MEDIOCON INC are not detailed in publicly available search results. Manufacturers like Mediocon Inc., a global supplier of pharmaceutical chemicals and intermediates, typically provide this information on a Certificate of Analysis (CoA) or product data sheet, which is usually accessible to their customers upon request or delivery of the product. 

However, based on standard industry practices for a chemical intermediate like p-tolylacetic acid, the typical tests performed would likely include:

·       Assay/Purity: Determining the purity level, often through methods like Gas Chromatography (GC) or High-Performance Liquid Chromatography (HPLC).

·       Melting Point (Mp): Verifying the physical property (p-tolylacetic acid typically melts around 88-92 °C).

·       Appearance: Visual inspection for color and form (e.g., a white or off-white solid).

·       Identification: Confirming the chemical structure, potentially using techniques like Mass Spectrometry (MS) or Nuclear Magnetic Resonance (NMR).

·       Water Content: Measuring moisture levels, often using Karl Fischer titration.

·       Residual Solvents: Ensuring that any solvents used during manufacturing are below International Council for Harmonisation (ICH) limits, typically via Headspace Gas Chromatography (GC).

·       Heavy Metals: Testing for trace amounts of heavy metals or other inorganic impurities. 

For precise information regarding the tests and specifications for a specific batch, it is recommended to contact Mediocon Inc. directly and request the Certificate of Analysis (CoA) for the product. 

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What are the challenges in manufacturing of P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON  INC ’s Dosage forms?

·       p-Tolylacetic acid is generally made via oxidation of aromatic precursors (e.g., p-methylbenzyl compounds); such oxidative reactions are sensitive to temperature, oxygen supply and impurity levels.

·       Impurities can significantly slow reactions or generate undesired by-products that complicate purification. Free Patents Online

Side Reactions

·       In large-scale oxidations, over-oxidation, aromatic ring attack, or incomplete reactions can occur — leading to colored impurities or compounds that are hard to separate. Evergreensino Chemical Co., Ltd.

Heat & Mass Transfer

·       Chemical processes that work at lab scale may have hot spots, poor mixing, and inefficient oxygen transfer at industrial scale:

o   This can cause yield loss, non-uniform product formation, and safety issues (e.g., runaway oxidation). Benchchem

Purification Bottlenecks

·       Separating p-tolylacetic acid from unreacted materials, oxidized by-products, and solvents often requires multiple distillations or crystallizations — increasing cost and complexity.

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What is shelf life Of P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON INC? 

1.    Check the Product Label: The expiration or retest date should be printed on the bottle or container.

2.    Consult the Certificate of Analysis (CoA): This document, provided with the product batch, will list the exact shelf life or retest date.

3.    Contact MEDIOCON INC directly: Reach out to their technical support or sales department for product-specific details. 

General Information for p-Tolyl Acetic Acid:

·       Synonym: 4-Methylphenylacetic acid.

·       CAS Number: 622-47-9.

·       Typical Storage: Room Temperature (RT). 

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What should the label claim for P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON INC   Include?

1.    Product Identification:

·       Name: p-Tolyl Acetic Acid.

·       Synonyms (if any): (e.g., 4-Methylphenylacetic acid).

·       Manufacturer: Manufactured by MEDIOCON INC.

·       CAS Number: (e.g., 156-38-7 - You'll need to confirm the exact CAS number).

2.    Quality & Purity:

·       Assay: e.g., 99% (or specific purity level).

·       Quality Level: e.g., Quality Level 100 (Reagent Grade).

3.    Safety & Handling (GHS/Hazard):

·       Pictograms: (e.g., Exclamation Mark for irritant).

·       Signal Word: Warning/Danger.

·       Hazard Statements (H-Codes): H315 (Causes skin irritation), H319 (Causes serious eye irritation).

·       Precautionary Statements (P-Codes): P280 (Wear protective gloves/clothing/eye protection), P305+P351+P338 (IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing).

·       Physical Hazards: Keep away from heat, sparks, open flames; store away from strong oxidizers/bases.

4.    Usage & Storage:

·       Intended Use: Pharmaceutical Intermediate, Fine Chemical.

·       Storage: Store in a cool, dry place, tightly closed.

5.    Regulatory (India Specific):

·       BIS Certification: Mention if certified under IS 695:2020 (for Acetic Acid related products) to show quality compliance. 

Where can P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON INC are procured?

P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the P-TOLYL ACETIC ACID  CA.,Manufactured by MEDIOCON INC product, regardless of the procurement source.