Salicylic Acid 69-72-7 Manufacturer Supplier Exporter, MEDIOCON INC

 

 

 

Salicylic Acid Manufactured by MEDIOCON INC

 

   Name: Salicylic Acid

CAS No: 69-72-7

Molecular Weight: 138.12 g/mol

Molecular formula:  𝐶₇𝐻₆𝑂₃

Synonyms : Salicylic acid's most common other name is 2-Hydroxybenzoic Acid, also known as o-Hydroxybenzoic Acid, which describes its chemical structure; it's also referred to as a Beta Hydroxy Acid (BHA) in skincare, and its name comes from Latin for willow tree (salix).

Appearance : Salicylic acid appears as a white to off-white crystalline solid or powder, sometimes as fine needles, with a faint, aspirin-like odor, and a bitter taste, becoming light tan or yellow if degraded by light. It's generally odorless, but its crystalline form can vary, and it slowly dissolves in water, sinking and mixing gradually.  

 Solubility :  Salicylic acid has low solubility in cold water but becomes much more soluble in hot water, making it ideal for recrystallization, and it's also readily soluble in organic solvents like ethanol, ether, chloroform, and glycerin; its water solubility increases significantly with temperature (e.g., ~0.2 g/100mL at 20°C to ~7.7 g/100mL in boiling water) and depends on pH, being increased in alkaline conditions by forming salts. 

Uses : Salicylic acid is a common topical medication and a beta hydroxy acid (BHA) used to treat a variety of skin conditions due to its keratolytic (skin-peeling) and anti-inflammatory properties. It is available in many over-the-counter and prescription forms, including gels, creams, lotions, pads, soaps, and shampoos. 

Common Uses of Salicylic Acid

Salicylic acid's primary function is to help the skin shed its outer layer, unclog pores, and promote new cell growth. 

·       Acne Treatment: It is widely used to treat and prevent various types of acne, including pimples, blackheads, and whiteheads. Its oil-soluble nature allows it to penetrate deep into the pores to dissolve oil (sebum) and debris.

·       Wart, Corn, and Callus Removal: In higher concentrations, salicylic acid is a common, non-invasive home treatment for softening and removing common and plantar warts, as well as calluses and corns on the feet.

·       Dandruff and Seborrheic Dermatitis: Salicylic acid shampoos and lotions help control dandruff and seborrheic dermatitis by breaking down the built-up scales and flakes on the scalp.

·       Psoriasis: It is used to manage the scaly, thick patches associated with psoriasis and other conditions that cause thickened skin (like ichthyosis), helping to remove scales and improve the penetration of other medications.

·       Skin Texture and Pigmentation: As an exfoliant, regular use can help refine skin texture, minimize the appearance of fine lines, fade dark spots and acne scars, and create a brighter, more even complexion.

·       Keratosis Pilaris: Salicylic acid lotions can help smooth the rough bumps on the back of arms and thighs associated with keratosis pilaris. 

Important Considerations

·       Consult a Healthcare Provider: Always follow the directions on the product label or those given by your doctor. Do not use high-concentration products on large areas of the body or on sensitive skin without professional advice.

·       Side Effects: Common side effects include dry skin, redness, irritation, or a mild stinging sensation.

·       Precautions: Avoid contact with eyes, mouth, and open wounds. Salicylic acid can make your skin more sensitive to sunlight, so using sunscreen and protective clothing is recommended during the day. 

 

 

  How Salicylic Acid is manufactured by MEDIOCON INC Synthesized?

While the specific proprietary process for MEDIOCON INC. isn't publicly detailed, salicylic acid is commercially synthesized via the Kolbe-Schmitt reaction, involving reacting sodium phenoxide (from phenol and sodium hydroxide) with carbon dioxide under heat and pressure, followed by acidification with sulfuric acid to yield salicylic acid. Modern industrial methods focus on improving yields and sustainability using techniques like liquid-phase dehydration and advanced catalysts for greener, continuous production. 

 

 

What are the different  dosage forms of Salicylic Acid Manufactured  by  MEDIOCON INC?

 MEDIOCON INC primarily acts as a wholesaler and manufacturer of Active Pharmaceutical Ingredients (APIs) and intermediates, and it appears to offer Salicylic Acid in powder form for further processing by other companies. 

Available search results do not indicate that MEDIOCON INC manufactures finished, specific dosage forms of Salicylic Acid (such as creams, gels, or liquids) for direct patient use under its own brand name. Instead, it supplies the raw ingredient to other pharmaceutical companies. 

If you are looking for available dosage forms in general, salicylic acid is commonly found in a wide variety of topical over-the-counter and prescription products, including: 

·       Creams

·       Gels

·       Liquids/Solutions

·       Lotions

·       Ointments

·       Foams

·       Shampoos

·       Pads, plasters, or medicated bandages

 

 

 How Salicylic Acid Manufactured by MEDIOCON INC Dosage Forms are prepared?

MEDIOCON INC is a manufacturer and supplier of pharmaceutical intermediates, and while the exact details of their proprietary manufacturing processes are not publicly available, the preparation of salicylic acid dosage forms generally follows established pharmaceutical techniques. 

Salicylic acid itself is typically produced industrially via the Kolbe-Schmitt reaction, but its various dosage forms (such as ointments, gels, and lotions) are prepared using distinct formulation methods. 

General Manufacturing of Salicylic Acid Dosage Forms 

The method for preparing a specific dosage form depends heavily on its intended use (e.g., topical, oral precursor to aspirin) and required properties like solubility, stability, and release rate. 

·       Ointments and Creams: These are semi-solid preparations, often used topically.

o   The base (e.g., petrolatum, lanolin derivatives, or an oil-in-water emulsion vehicle) is typically melted or prepared first.

o   The salicylic acid powder is then incorporated into the melted mixture or base using continuous stirring to ensure uniform distribution.

o   The mixture is allowed to cool, often mixed further on an ointment slab, and then transferred to suitable containers for packaging.

·       Gels and Solutions: These are often used for clear, water-based or hydroalcoholic applications.

o   Key to these formulations is proper solubilization, as salicylic acid has low water solubility. Solubilizing agents like ethanol, glycols, or specific emollients are used.

o   For gels, acid-stable gelling agents or polymers (e.g., polyethylene glycols) are used to achieve the desired viscosity and consistency.

o   The ingredients are weighed, mixed, and processed (sometimes with heating, as in the fusion method for some gels) until a clear, homogeneous solution or gel is formed.

·       Other Forms: Salicylic acid can also be an intermediate for other drugs like aspirin (acetylsalicylic acid), which involves further chemical synthesis to create new compounds and subsequent formulation into tablets or capsules. 

MEDIOCON INC Specifics

As a bulk manufacturer of pharmaceutical intermediates, MEDIOCON INC likely supplies the raw salicylic acid powder to other companies for their final product formulation. Their production focuses on large-scale, continuous industrial preparation of the active ingredient itself, involving the initial chemical steps of synthesizing the compound from raw materials like phenol and sodium hydroxide via the Kolbe-Schmitt reaction. 

 

 

What are the appropriate Dosage forms of Salicylic Acid Manufactured  by  MEDIOCON   INC?

MEDIOCON INC is a manufacturer and wholesaler of cosmetic raw materials, including salicylic acid, and does not appear to manufacture finished, regulated dosage forms like creams or solutions. As such, it does not have specific "appropriate dosage forms" of salicylic acid under its own product line in the same way a pharmaceutical company would. 

The company primarily operates as a supplier of ingredients for other manufacturers to use in their own products. 

Salicylic acid in general is available in a variety of topical dosage forms in the market, used by various brands. These typically include: 

·       Gels

·       Solutions/Liquids

·       Creams

·       Lotions

·       Ointments

·       Foams

·       Pads/Strips/Discs/Plasters/Patches

·       Soaps/Cleansers/Shampoos 

These general forms treat conditions such as acne, psoriasis, dandruff, corns, calluses, and warts.

 

When should Salicylic Acid Manufactured by MEDIOCON INC be taken?

Salicylic acid is a topical medication and the timing and frequency of use depend entirely on the specific product type (cream, gel, wash, etc.) and the condition being treated. It is not a medication that is "taken" orally in its common form manufactured by companies like Medicon Inc., but rather applied to the skin. 

Determining the appropriate time and frequency to apply salicylic acid manufactured by MEDIOCON INC is contingent on the specific product formulation and the condition being treated. Salicylic acid is a topical medication and is applied to the skin, not ingested orally. 

General Application Guidance

Adherence to the specific instructions provided on the product label or by a healthcare professional is essential. 

 

 

 What are the effects And Side effects of Salicylic Acid Manufactured by MEDIOCON INC?

Mediocon Inc is a supplier of pharmaceutical ingredients and chemicals, including salicylic acid as an Active Pharmaceutical Ingredient (API), but does not appear to manufacture finished, branded salicylic acid products for end-users. The effects and side effects are therefore general to the active ingredient itself, regardless of the specific manufacturer. 

Effects of Salicylic Acid

Salicylic acid is a beta-hydroxy acid known for its keratolytic (exfoliating) and comedolytic (pore-clearing) properties. It is widely used in various topical products. 

·       Acne Treatment: It helps clear and prevent pimples, blackheads, and whiteheads by penetrating the skin, unclogging pores, and reducing inflammation.

·       Skin Exfoliation: It softens and loosens dry, scaly, or thickened skin, allowing dead skin cells to shed more readily.

·       Other Conditions: Depending on the concentration and formulation, it is used to treat conditions such as psoriasis, dandruff, corns, calluses, and warts. 

Potential Side Effects

Side effects are generally associated with topical use and can vary based on skin sensitivity, concentration, frequency of use, and the specific product (e.g., wash, cream, peel). 

Common Side Effects (usually mild)

·       Skin irritation, dryness, or peeling.

·       Redness or itching.

·       Mild stinging or burning sensation.

·       Increased sensitivity to the sun (sun protection is recommended). 

Serious Side Effects (rare)

In rare cases, especially when used over large body areas, for prolonged periods, or on broken skin, salicylic acid can be absorbed into the bloodstream and cause salicylate toxicity (salicylism). 

If any of these serious symptoms occur, stop use and seek immediate medical help:

·       Confusion, severe headache, or unusual tiredness.

·       Nausea, vomiting, or diarrhea.

·       Rapid or difficulty breathing.

·       Ringing or buzzing in the ears (tinnitus) or hearing loss.

·       Signs of an allergic reaction: hives, itching, throat tightness, or swelling of the face, lips, or tongue. 

Always follow the specific instructions on the product label or those provided by a healthcare provider to ensure safe use. 

 

 

 How is Salicylic Acid Manufactured by MEDIOCON  INC  Tested Qualitatively?

MEDIOCON INC, like other pharmaceutical manufacturers, employs standard industry qualitative tests and advanced analytical techniques to verify the identity and purity of its salicylic acid. 

Standard Qualitative Tests

·       Melting Point Analysis: The melting point of pure salicylic acid is consistently around 158°C (316°F). A sharp melting point within the standard range is a strong indicator of purity, while a lower or wide range suggests impurities.

·       Ferric Chloride (FeCl₃) Test: This classic test is used to detect the presence of phenolic hydroxyl groups. Salicylic acid has a free phenol group, which reacts with iron(III) ions to form a distinct purple or violet complex. The formation of this color confirms the identity of salicylic acid. In contrast, pure aspirin (acetylsalicylic acid), which does not have a free phenolic group, would not produce this color.

·       Solubility and Physical Appearance: The product is checked for appearance as a white crystalline powder and its solubility in various solvents (e.g., sparingly soluble in cold water, more soluble in ethanol) to ensure it meets established physical specifications. 

 

 

   Which tests are performed on Salicylic Acid Manufactured by  MEDIOCON INC ?

Information regarding specific quality control tests performed by MEDIOCON INC is not publicly available in the provided search results. Companies typically do not publish proprietary manufacturing and QC protocols. 

However, the quality control of salicylic acid for pharmaceutical or cosmetic use generally adheres to official pharmacopoeia standards (like USP or EP) and industry-standard practices, which typically include the following tests: 

·       Identification Tests:

o   Appearance and Color: Checking that the product is a white, crystalline powder or fine needles, and the color of its solution is clear and within specified limits.

o   Ferric Chloride Test: A qualitative test where salicylic acid produces a characteristic deep blue-violet color with a ferric chloride solution.

o   Melting Point Analysis: Determining the melting point, which should be in a specific range (typically 158°C to 160°C) to confirm identity and purity.

o   Spectroscopy: Using techniques such as Fourier-Transform Infrared Spectroscopy (FTIR) or Nuclear Magnetic Resonance (NMR) for structural confirmation.

·       Purity and Impurity Analysis:

o   Assay (Purity Percentage): Quantifying the actual salicylic acid content (typically 99.0% minimum, often 99.5% or higher) using methods like acid-base titration or High-Performance Liquid Chromatography (HPLC).

o   Phenol Content Limit Test: Ensuring that the residual phenol, a potential impurity from the manufacturing process, does not exceed a maximum limit (e.g., 0.02% or 0.10%).

o   Other Impurities: Testing for other related substances and potential contaminants using advanced chromatography methods like HPLC or LC-MS.

o   Sulfates Limit: Checking for the maximum percentage of sulfates.

·       Physical and Chemical Properties:

o   Solubility: Confirming that the product dissolves as expected in various solvents like water, ethanol, and chloroform.

o   pH Value: Measuring the pH of a saturated aqueous solution.

o   Loss on Drying/Water Content: Ensuring the moisture content is within acceptable limits. 

For specific product details from MEDIOCON INC, it would be necessary to consult the company's official product data sheet or Certificate of Analysis (COA), which can often be obtained directly from the manufacturer or found on the MEDIOCON INC website

 

 

What are the challenges in manufacturing of Salicylic Acid Manufactured by MEDIOCON  INC ’s Dosage forms?

Mediocon Inc primarily functions as a manufacturer and exporter of pharmaceutical intermediates and ingredients, rather than a producer of finished salicylic acid dosage forms. Therefore, the specific challenges would relate to the production of high-purity Salicylic Acid API (Active Pharmaceutical Ingredient), which generally include: 

·       Purity and By-product Removal: The synthesis process, often involving the Kolbe-Schmitt reaction, can produce impurities and unwanted by-products (e.g., anthranilic acid isomers) that must be meticulously removed using filtration and purification processes to meet stringent pharmaceutical quality standards (EUGMP, USFDA, etc.).

·       Process Consistency: Achieving consistent results in the chemical conversion requires precise control over reaction conditions, such as temperature and pressure, as variations can affect the purity, yield, and final physical properties (like crystal size) of the salicylic acid.

·       Handling Toxic Materials: The manufacturing process involves various chemicals and intermediates, some of which may produce toxic gases. Proper and robust ventilation systems are essential to ensure workplace safety and compliance with health standards.

·       Quality Control & Testing: Batch manufacturing requires rigorous quality control at various stages, which can involve significant "hold times" for offline testing. Ensuring reliable dissolution testing outcomes for the raw material is also a known challenge, requiring careful calibration.

·       Stability of Intermediates: Ensuring the stability of the compound during processing and storage is critical, as salicylic acid can sublime (turn directly from solid to gas) if exposed to high temperatures, potentially affecting the final product's quantity and quality. 

While Mediocon Inc supplies the ingredient, manufacturing finished dosage forms (like specific gels or ointments) involves additional challenges at the formulator level, such as: 

·       Formulation Stability: Ensuring the final product remains stable at room temperature and over time can be difficult, as some formulations (e.g., specific gels) may be unstable or experience separation of components.

·       Drug Release Consistency: Achieving a consistent and predictable rate of drug release from the final product is a key challenge, which is influenced by factors like the particle size of the salicylic acid and the manufacturing process (e.g., fusion temperature for ointments)

 

                                                                 

What is shelf life Of Salicylic Acid Manufactured by MEDIOCON INC

The shelf life of Salicylic Acid from a specific manufacturer like MEDIOCON INC isn't directly listed, but typical raw Salicylic Acid can last years (e.g., 3-4 years) when pure and stored well, while formulated products (like soaps) might be 6 months; for your specific product, check the label or contact MEDIOCON INC for their stated shelf life and storage conditions, as factors like moisture and light greatly affect stability. 

 

What should the label claim for Salicylic Acid Manufactured by MEDIOCON INC Include?

For Salicylic Acid from MEDIOCON INC, the label claim needs to specify if it's an active ingredient (drug) or cosmetic, its exact concentration (e.g., 0.5%, 2%, 3%), its specific use (acne treatment, preservative, etc.), its role (keratolytic, exfoliant), and must follow regulations like CDSCO in India, including proper warnings and directions, especially regarding concentration limits in different products (face creams up to 2%, hair products up to 3%). 

 

Where can Salicylic Acid Manufactured by MEDIOCON INC are procured?

Salicylic Acid Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Salicylic Acid Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Salicylic Acid Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Salicylic Acid Manufactured by MEDIOCON INC product, regardless of the procurement source.