TITANIUM (IV) OXIDE ANATASE -325 Manufacturer , exporter, supplier by MEDIOCON INC

 

 

TITANIUM (IV) OXIDE ANATASE -325 Manufactured by MEDIOCON INC

 

   Name: TITANIUM(IV) OXIDE ANATASE, -325

CAS No:   1317-70-0

Molecular Weight:  79.866 g/mol

Molecular formula :TiO₂

Synonyms: Titanium dioxide, titanium(IV) oxide, titania, Pigment White 6 (PW6), CI 77891, E171 (when used as a food coloring).

Appearance:  white fine powder. 

 Solubility :   Insoluble in water, dilute acids, and organic solvents. Slowly soluble in hot concentrated sulfuric acid and hydrofluoric acid.

Use :

Primarily used as a white pigment and opacifier in paints, coatings, plastics, papers, inks, and cosmetics (sunscreens). Also used in acid-resistant vitreous enamels, welding rod coatings, and as a photocatalyst in various applications

 

 How is  TITANIUM(IV) OXIDE ANATASE, -325 manufactured by MEDIOCON INC Synthesized?

• Sulfate Process: This older, batch process involves digesting ilmenite ore or titanium slag in concentrated sulfuric acid. A series of steps including chemical reduction, purification, hydrolysis to form titanium hydrate, and final calcination (heating) at 900–1000°C yields the final anatase titanium dioxide pigment.
• Chloride Process: This continuous process requires a higher-purity ore (rutile or synthetic rutile) which is chlorinated at high temperatures (850–1000°C) to produce titanium tetrachloride

TiCl4TiCl sub 4

TiCl4

is then purified and burned with air or oxygen at even higher temperatures (1200–1370°C) to produce

TiO2TiO sub 2

TiO2

. This method typically yields the rutile form, but specific conditioning can produce anatase. 

Laboratory/Specialty Synthesis Methods 

For smaller-scale production or specific high-purity applications, such as for the "trace metals basis" product offered by Mediocon (similar to the product code T 7609 mentioned in a source), various wet-chemical methods are used to control particle size and crystal structure (anatase): 

• Sol-Gel Method: This is a common method for synthesizing nano-sized anatase particles at lower temperatures. It typically involves the hydrolysis of a titanium alkoxide precursor (e.g., titanium tetra isopropoxide) in the presence of water and a solvent, often with an acid or organic modifier to control the reaction and prevent agglomeration.
• Hydrothermal Synthesis: Titanium oxide can be prepared using hydrolysis of titanyl sulfate or titanium tetrachloride under high temperature and pressure in an aqueous solution.

What are the different  dosage forms  of   TITANIUM(IV) OXIDE ANATASE, -325 Manufactured  by  MEDIOCON INC?

Mediocon Inc. manufactures TITANIUM(IV) OXIDE ANATASE, "-325" exclusively in a powder form. It is not produced as a finished pharmaceutical "dosage form" by this manufacturer, but rather as a raw material or an ingredient for use in other applications, including potential pharmaceutical manufacturing. 

Key points regarding the product:

·       Form: It is supplied as an anatase powder with a particle size of -325 mesh (meaning the particles can pass through a 325 mesh sieve). The average diameter is approximately 45 µm.

·       Use: As a raw material, it is used by other companies who then incorporate it into various final products, such as pharmaceutical tablets, capsules, creams, and coatings.

·       Manufacturer Role: Mediocon Inc. acts as a manufacturer and supplier of pharmaceutical raw materials, API intermediates, and industrial chemicals. 

You can find more details on the company's offerings on their official website or their IndiaMART profile. 

.

 How TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC   Dosage Forms are prepared?

TITANIUM(IV) OXIDE ANATASE, -325" manufactured by MEDIOCON INC is likely sold as a raw material in powder form for use in pharmaceutical manufacturing processes, not as a pre-prepared "dosage form" itself. Titanium dioxide is widely used in solid oral dosage forms (like tablets and capsules) as a colorant, opacifier, and to ensure batch-to-batch homogeneity of appearance. 

The raw titanium dioxide material is processed by pharmaceutical manufacturers using methods such as film coating or suspension preparation to incorporate it into final dosage forms: 

·       Tablet Coating: Titanium dioxide is a key ingredient in the coating solutions applied to tablets. The manufacturing process involves preparing a suspension or solution of the titanium dioxide powder along with other excipients (binders, film-forming polymers, etc.), which is then sprayed onto the tablet cores in specialized coating equipment. The -325 mesh size indicates a very fine powder, which aids in creating a uniform suspension and smooth coating.

·       Capsule Preparation: It is also used in the manufacturing of opaque capsule shells.

·       Suspensions: The finely divided particles can be kept in suspensions used for various pharmaceutical applications. 

In summary, the MEDIOCON INC product is an intermediate or raw material supplied as a fine powder, and its "dosage form" is ultimately determined by the specific formulation and manufacturing process employed by the pharmaceutical company that purchases it. 

What are the appropriate Dosage forms of TITANIUM(IV) OXIDE ANATASE, -325 Manufactured  by  MEDIOCON   INC?                

The Titanium(IV) oxide anatase powder supplied by MEDIOCON INC is an excipient used primarily as a colorant and opacifier in various oral solid and semi-solid dosage forms. 

The appropriate dosage forms for which this material is used as an ingredient include: 

·       Tablets (used in film-coatings and as a colorant)

·       Hard capsules

·       Soft capsules

·       Granules/powders for oral solution and oral suspensions

·       Oral paste/gel (primarily in veterinary medicinal products) 

This specific product from MEDIOCON INC, described as "-325" mesh, is a powder. It is typically incorporated into a formulation during the manufacturing process of these dosage forms. 

When should TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC be taken?

A method of improving the stability, mitigating degradation, including oxidation, or both of photo or thermosensitive ingredients of cosmetics, personal care and pharmaceutical / medicinal compositions or of cosmetics, personal care, and pharmaceutical / medicinal compositions containing photo or thermosensitive ingredients , wherein said photo or thermal sensitive ingredients are selected from photo or thermo sensitive sunscreen actives, colorants, dyes, organic pigments, tocopherols, organic peroxides, polyunsaturated color compounds, antioxidants, flavor ingredients, fragrances, vitamins, thickening agents polymeric that have no unsaturation, and oils and waxes, said method comprises the addition of an effective amount of a compound according to the following formula I: ** Formula ** where R1 and R2, which may be the same or different, are independently H or a linear or branched alkyl or alkoxy of 1 to 8 carbon atoms and R3 is a linear lower alkyl The branched 2 to 8 carbon atoms of the photo or thermosensitive ingredient or cosmetic, personal care, pharmaceutical / medicinal compositions containing the same or both.

 What are the effects And Side effects of TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC?

The effects and side effects of Titanium(IV) Oxide Anatase, -325 from MEDIOCON INC are related to general titanium dioxide properties, with health concerns primarily linked to inhalation and, potentially, ingestion, due to its fine particle size ("-325" refers to a very fine mesh size). Dermal exposure typically poses minimal risk on healthy skin. 

Effects and Uses

Titanium(IV) oxide (TiO₂) in its anatase form is a white powder widely used as a pigment, opacifier, and in various industrial and scientific applications due to its high reactivity and surface area. 

·       Pigment and Opacifier: Provides whiteness and opacity in paints, cosmetics, plastics, papers, inks, pharmaceuticals (tablet coatings, capsules), and some foods.

·       UV Resistance/Absorption: Used in sunscreens and materials to absorb UV light.

·       Scientific/Industrial: Utilized in photocatalysis and as a standard light-scattering suspension in laboratory settings. 

Side Effects and Health Risks

The primary health concerns stem from exposure to fine or nano-sized particles, as the physical characteristics (size, shape, crystal phase) influence toxicity. The anatase form may be more cytotoxic to certain cells than the rutile form. 

·       Inhalation (Primary Risk):

o   Respiratory Problems: Inhaling the dust can irritate the eyes, nose, and throat. Long-term exposure can lead to chronic bronchitis, shortness of breath, wheezing, and coughing.

o   Cancer Risk: The International Agency for Research on Cancer (IARC) classifies airborne, unbound particles of respirable-size titanium dioxide as a Group 2B carcinogen (possibly carcinogenic to humans) based on animal studies that showed lung tumors.

o   Lung Damage: Can cause lung inflammation and potentially fibrosis.

·       Ingestion:

o   While historically used as a food additive (E171), the European Food Safety Authority (EFSA) concluded in 2021 that it can no longer be considered safe for consumption due to potential genotoxicity (ability to damage DNA).

o   Animal studies indicate that ingested nanoparticles can accumulate in organs, potentially causing intestinal inflammation, liver and kidney dysfunction, and damage to neurons.

  How is TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON  INC  Tested Qualitatively?

The specific qualitative testing procedures used by MEDIOCON INC are proprietary and not publicly available, but standard industry practices for titanium(IV) oxide powder involve a variety of tests to confirm its identity, phase, and purity

. 

Standard Qualitative Testing for Titanium Dioxide (Anatase) 

Qualitative testing of titanium(IV) oxide, anatase grade, typically focuses on verifying its chemical composition, crystal structure, and physical properties. 

• X-Ray Diffraction (XRD): This is the definitive qualitative method for confirming the presence of the anatase crystal structure and ensuring the absence (or minimal presence) of the rutile or brookite phases. The unique diffraction pattern acts as a fingerprint for the material's crystalline form.
• Fourier Transform Infrared Spectroscopy (FTIR): FTIR is used to identify the characteristic O-Ti-O bonding in the anatase morphology and to detect the presence of any residual organic species (which might be present if the material was manufactured using a sol-gel method and calcination was incomplete).
• Chemical Identification Test (Peroxo Complex Formation): A chemical test can be performed by digesting the sample in concentrated sulfuric acid and then adding hydrogen peroxide (

H2O2cap H sub 2 cap O sub 2

𝐻2𝑂2

). The formation of a characteristic yellow-to-orange colored peroxo complex indicates the presence of titanium ions.

• Whiteness and Color Assessment: As titanium dioxide is a primary white pigment, its whiteness is a crucial quality indicator. This is often assessed visually or using a whiteness meter to ensure it meets the required standards, which is a key physical characteristic for its use in paints, coatings, and pharmaceuticals.
• Solubility Test: Titanium dioxide is notably insoluble in water and most dilute acids. A simple test would involve attempting to dissolve a sample in water to confirm this characteristic.
• Particle Size Verification: The "-325 mesh" specification refers to the particle size (meaning the powder passes through a 325 mesh sieve, roughly <45 µm average diameter). While often a quantitative measurement, a simple sieve analysis qualitatively confirms the general fineness of the powder.

   Which tests are performed on TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by  MEDIOCON INC ?

For MEDIOCON INC's Titanium(IV) Oxide Anatase (-325 mesh), standard quality tests likely focus on its physical form (powder, particle size -325 mesh), chemical purity (assay $\ge$99%), crystal structure (anatase), and trace metal content, with specific functional tests (like dispersibility, UV absorption, photocatalysis) depending on its intended use (e.g., pharma, cosmetics, industrial pigment), often involving X-ray Diffraction (XRD) for crystal form, SEM for morphology, and assays for heavy metals. 

Key Tests Performed (General for this Type of TiO2)
Tests generally ensure the material meets specifications for purity, particle characteristics, and performance, as suggested by similar products. 

1.    Identity & Purity:

·       Assay: Verifying high purity, often $\ge$99% (e.g., trace metals basis).

·       X-Ray Diffraction (XRD): Confirming the anatase crystal structure and checking for rutile/brookite impurities.

2.    Physical Properties:

·       Particle Size Analysis: Confirming the "-325 mesh" (fine powder) specification, indicating controlled particle size.

·       Scanning Electron Microscopy (SEM): Visualizing particle morphology and agglomeration.

·       Specific Surface Area: Measured via BET analysis, crucial for photocatalytic/dispersing properties.

3.    Trace Element Analysis:

·       Inductively Coupled Plasma (ICP) Spectroscopy: Detecting and quantifying trace metals (e.g., Pb, As, Hg, Cd) for safety, especially for food/pharma grades.

4.    Functional Performance (Application-Dependent):

·       Photocatalytic Activity: Testing degradation of pollutants (like ibuprofen) if used for environmental applications.

·       Optical Properties: Assessing light scattering/whiteness for pigment use.

·       Toxicity Tests (if for Pharma/Food): Ames test for genotoxicity, cytotoxicity assays (though often debated in 2D vs. 3D models). 

What are the challenges in Manufacturing of Banana Extract Manufactured by MEDIOCON   INC API?

Manufacturing banana extract as an API by MEDIOCON INC API likely faces general API challenges like strict regulatory compliance (FDA, WHO-GMP), maintaining process consistency and quality control, ensuring sustainable sourcing of raw biomass, efficient downstream processing (extraction & purification) to get high yields and purity, and overcoming supply chain disruptions for raw materials like banana biomass, plus the added complexity of scaling up natural product extraction. 

Here are the key challenge areas:

1. Sourcing & Supply Chain:

·       Raw Material Consistency: Ensuring a steady, high-quality supply of banana biomass (peels, pseudostems, etc.) as feedstock, which can vary with seasons, weather, and geography, poses a major hurdle.

·       Sustainability: Managing the large volumes of biomass waste generated from banana cultivation and processing sustainably is crucial to avoid environmental issues. 

2. Extraction & Purification (Downstream Processing):

·       Yield & Purity: Developing cost-effective, high-yield methods to extract specific bioactive compounds while separating them from impurities is a significant technical challenge.

·       Scale-Up: Scaling laboratory extraction methods (like microwave-assisted extraction or using green solvents) to industrial levels without introducing new impurities or losing efficiency requires careful process optimization. 

3. Quality & Regulatory Compliance:

·       Batch-to-Batch Variability: Natural products are prone to variability; ensuring consistent API quality (potency, impurity profile) across batches is a core challenge.

·       Global Standards: Meeting stringent regulations from bodies like the FDA (US) and WHO-GMP (World Health Organization Good Manufacturing Practices) requires robust quality systems and continuous updates. 

4. Process Technology & Economics:

·       Process Intensification: Implementing efficient, potentially continuous, extraction and separation technologies (e.g., continuous crystallization, membrane separation) can reduce costs but requires significant investment and expertise.

·       Cost-Effectiveness: Balancing advanced technology and sustainable practices with competitive pricing in the global API market is a constant challenge. 

5. Environmental Impact:

·       Waste Management: Handling byproduct streams from the extraction process and treating pharmaceutical wastewater sustainably are critical concerns for modern API manufacturers. 

What are the challenges in manufacturing of TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON  INC ’s Dosage forms?

The primary manufacturing challenges for dosage forms containing titanium(IV) oxide anatase from suppliers like MEDIOCON INC relate to regulatory compliance, achieving consistent and optimal product quality attributes (like whiteness and opacity), and addressing the technical complexity of reformulation when alternatives are required. 

Key Challenges in Manufacturing

·       Regulatory Hurdles: The European Food Safety Authority (EFSA) concluded in 2021 that food-grade titanium dioxide (E171) can no longer be considered safe for food use, leading to a ban in the EU. This creates a significant challenge for globally operating pharmaceutical companies, which must navigate disparate international regulations and potentially reformulate products for specific markets.

·       Maintaining Product Quality and Performance: Titanium dioxide (TiO₂) provides unique properties, including high refractive index, exceptional whiteness, opacity, and protection of the active pharmaceutical ingredient (API) from UV light, which are difficult to replicate with alternative materials. Replacing it often results in:

o   Color Fading and Variability: Alternative coatings may lack the color stability of TiO₂, leading to inconsistent product appearance.

o   Processing Issues: Substitutes may not work well in high-speed manufacturing equipment or be compatible with standard coating systems, affecting manufacturing efficiency.

o   Loss of Functionality: Finding alternatives that provide the same level of opacity and light protection is challenging, potentially impacting the stability and shelf-life of the drug product.

·       Particle Size and Form Consistency: The specific "anatase, -325" designation refers to a particular crystal form and particle size (passing through a 325 mesh screen). Maintaining a consistent particle size distribution and crystal phase (anatase is metastable and can transform to rutile at high temperatures) is crucial for reproducible performance and quality control.

·       Scale-Up Risk: While alternatives might show promise in lab settings, scaling up production often introduces unforeseen technical complexities, cost issues, and stability problems.

·       Potential for Impurities and Toxicity Concerns: Although typically considered safe when not inhaled or ingested in large quantities, the use of fine-particle or nano-sized TiO₂ in dosage forms raises concerns about potential accumulation in organs. Manufacturers must ensure high purity, specifically removing trace transition metals and heavy elements, to meet stringent pharmaceutical specifications. 

What is the Packing for TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC?

TITANIUM(IV) OXIDE ANATASE, -325 is typically packed in various sizes, including:

- 25Kg Bag: Commonly used for industrial and pharmaceutical applications

- 20 Kg Bag: Also available for specific requirements

- 100g, 500g, and 2Kg: Smaller packs for laboratory and research purposes

- Drum: Used for larger quantities, often in pharmaceutical manufacturing

The packaging may vary depending on the supplier and intended use

What is shelf life Of TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC? 

The novel gel-coat with added titanium dioxide and alumina particles described in this patent is directly applicable in the field of construction for the external part of construction material surfaces or urban elements, in the transport sector, given that this type of material possesses photocatalytic properties that allow it to break down NOx currently found in large cities. Moreover, said novel material possesses self-cleaning, biocidal and deodorising properties that allow applications in the maritime transport sector, where it may help to overcome the resistance induced by the attachment of marine life to the hulls of boats, and may reduce the costs of cleaning same.

What should the label claim for TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC   Include?

For Titanium(IV) Oxide Anatase -325 by MEDIECON INC, label claims should include its chemical identity (Titanium Dioxide, TiO2), crystal form (Anatase), particle size (<-325 mesh), purity (e.g., 99%), manufacturer, and appropriate hazard/safety info (like inhalation warnings if applicable, though EU regs are changing) for its intended use, as it's a white pigment for coatings, plastics, inks, or cosmetics, often regulated by bodies like FDA, ECHA, or Health Canada depending on application. 

Key Information to Include on the Label:

1.    Product Name: Titanium(IV) Oxide, Anatase.

2.    Chemical Formula: TiO2 (Titanium Dioxide).

3.    Particle Size: "-325 mesh" (indicating very fine powder).

4.    Manufacturer: MEDICON INC.

5.    Purity/Grade: Specify purity (e.g., 99%) or grade (e.g., Qualified Grade).

6.    Crystal Form: Anatase (important for optical properties).

7.    Physical Form: Soft, white dry powder.

8.    CAS Number: 13463-67-7 (for regulatory identification).

9.    Intended Use: (e.g., Pigment for Paints & Coatings, Cosmetic Ingredient, Food Additive if applicable). 

 

Where can TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC are procured?

TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the TITANIUM(IV) OXIDE ANATASE, -325 Manufactured by MEDIOCON INC product, regardless of the procurement source.