Tyrosine 60-18-4 Manufacturer, Supplier, Exporter, MEDIOCON INC.

 

 

Tyrosine  Manufactured by MEDIOCON INC

 

   Name: Tyrosine 

CAS No: 60-18-4

Molecular Weight: 181.19 g/mol

Molecular formula:  C₉H₁₁NO₃

Synonyms : 2-amino-3-(4-hydroxyphenyl)propanoic acid

 

Appearance : Tyrosine's appearance is typically a white to colorless crystalline powder or needle-like crystals. 

  

 Solubility : Tyrosine has very low solubility in neutral water (around 0.45 g/L at 25°C) but becomes much more soluble in solutions of extreme pH (acidic or alkaline), organic solvents like DMSO, or as its salt (e.g., disodium salt), with solubility increasing significantly with temperature and pH adjustment. It's considered moderately hydrophilic but its low water solubility makes it challenging for cell culture media. 

 

·       Uses : Stress & Cognitive Function: Helps maintain working memory, focus, and alertness during demanding or stressful situations by replenishing neurotransmitters.

·       Mood & Depression: Acts as a precursor to dopamine and norepinephrine, potentially elevating mood and combating depression symptoms, say the Cleveland Clinic Health Essentials.

·       Thyroid & Melanin Production: Essential for making thyroid hormones (regulating metabolism) and melanin (skin/hair color).

·       Athletic Performance: May improve exercise capacity, particularly in hot conditions, by preventing fatigue.

·       PKU Management: Used in medical foods for people with PKU to prevent tyrosine deficiency. 

Sources & Forms

·       Dietary: Found in high-protein foods like meat, fish, dairy, eggs, nuts, beans, and whole grains.

·       Supplements: Available as L-tyrosine, often in pre-workout formulas or standalone capsules. 

Considerations

·       Evidence Strength: Strongest evidence supports its role in stress-induced cognitive decline; other uses like weight loss or narcolepsy have less conclusive research. 

 

 

  How Tyrosine  is manufactured by MEDIOCON INC Synthesized?

Information regarding the specific method MEDIOCON INC uses to manufacture or synthesize tyrosine is not publicly available in the provided search results. The company is a manufacturer of pharmaceutical intermediates and general nutraceutical raw materials, but the precise details of their L-tyrosine synthesis process are proprietary or not disclosed in the general business information and product lists found. 

In general, L-tyrosine is commercially produced using three primary methods in the pharmaceutical industry: 

·       Fermentation: This method involves culturing L-tyrosine-producing bacterial strains (e.g., Corynebacterium glutamicum) in a nutrient medium.

·       Enzymatic Synthesis: L-tyrosine can be synthesized from precursors like pyruvate, ammonia, and phenol in a reaction catalyzed by the enzyme tyrosine phenol lyase.

·       Extraction: Tyrosine can be extracted from protein hydrolysates. 

While the general industry methods are known, MEDIOCON INC's specific process for manufacturing its L-tyrosine product, including whether it uses chemical synthesis, fermentation, or enzymatic methods, is not specified in the search results. For specific technical details, it would be necessary to contact the company directly through their official channels, likely found on the MEDIOCON INC website. 

 

 

 

What are the different  dosage forms of Tyrosine  Manufactured  by  MEDIOCON INC?

Tyrosine in general is available in various common dosage forms across the pharmaceutical and nutraceutical industries, including: 

·       Tablets

·       Capsules

·       Powders (often effervescent or for general application)

·       Solutions and injectable forms 

For more specific information on products or services, you can directly contact the company via their official website at mediocon.com. 

 

 

 How Tyrosine  Manufactured by MEDIOCON INC Dosage Forms are prepared?

Manufacturing of Dosage Forms

Companies that purchase the L-tyrosine API from suppliers like Mediocon Inc use it to create finished products, which can include: 

·       Capsules/Tablets: For oral administration, L-tyrosine powder is typically blended with excipients (inactive ingredients like binders, fillers, and lubricants) and then either compressed into tablets or filled into capsules. The specific process involves blending, granulation (if needed), compression, and potentially film coating.

·       Oral Powders/Granules: L-tyrosine can also be prepared as effervescent powders or granules by blending with specific acids and sodium bicarbonate, which are designed to be dissolved in water before ingestion.

·       Intravenous (IV) Solutions: For hospital use, L-tyrosine is dissolved in water for injection along with other amino acids, electrolytes, and dextrose to create sterile liquid formulations for parenteral nutrition. The manufacturing process involves dissolution under controlled conditions (e.g., nitrogen gas protection), pH adjustment, filtration (to ensure sterility), and terminal sterilization in infusion bottles. 

In summary, Mediocon Inc provides the high-purity L-tyrosine powder, but the final steps for creating a specific dosage form are performed by the companies producing the finished pharmaceutical or nutritional supplement products.

 

 

What are the appropriate Dosage forms of Tyrosine  Manufactured  by  MEDIOCON   INC?

powder is then used by other pharmaceutical and nutraceutical companies to manufacture a variety of final dosage forms. 

Commonly available dosage forms of Tyrosine on the general market (not necessarily manufactured by Mediocon Inc) include:

·       Capsules

·       Tablets (including effervescent tablets)

·       Oral powders

·       Intravenous solutions (typically as an ingredient in multi-amino acid mixtures) 

For specific information on what dosage forms their customers produce using their ingredients, you would need to contact Mediocon Inc directly through their official website or the contact details provided on trade platforms. 

 

 

When should Tyrosine  Manufactured by MEDIOCON INC be taken?

Information on tyrosine supplements, including when to take them, is for general knowledge and should not be taken as medical advice. Always consult with a healthcare provider before starting any new supplement regimen.

Tyrosine is an amino acid that plays a role in the production of neurotransmitters like dopamine and norepinephrine. Some general guidelines exist regarding when tyrosine might be taken to potentially support focus and alertness, particularly in stressful situations: 

·       Timing: Some sources suggest taking tyrosine earlier in the day, as its stimulating effects may interfere with sleep if taken later.

·       Absorption: For potentially optimal absorption, it is sometimes suggested to take tyrosine away from major meals.

·       Purpose: Timing may be aligned with when its effects on cognitive function during stress are desired, such as before mentally demanding tasks or exposure to physical stressors. 

It is important to note that the optimal timing can vary depending on individual needs and health conditions.

Important Considerations

·       Consult a Healthcare Provider: The information provided here is general guidance. A doctor can determine the appropriate use based on your specific health status and any other medications you may be taking.

·       Medication Interactions: Tyrosine may interact with certain medications, including MAOIs (a type of antidepressant), thyroid hormone medications, and levodopa (used for Parkinson's disease). These should not be taken without medical supervision.

·       Potential Side Effects: While generally considered safe for short-term use in appropriate amounts, potential side effects can include nausea, headaches, and fatigue. 

For detailed, product-specific instructions, refer to the information provided by the manufacturer, MEDIOCON INC, on the product packaging, or consult with a healthcare professional.

 

 

 What are the effects And Side effects of Tyrosine  Manufactured by MEDIOCON INC

General Effects of Tyrosine Supplements

Tyrosine is an amino acid precursor to important brain neurotransmitters like dopamine, norepinephrine, and epinephrine, which play a role in mood, alertness, and cognitive function. 

·       Mental Performance & Alertness: Tyrosine may improve mental performance and increase alertness, particularly in stressful conditions such as sleep deprivation, military training, or cold exposure.

·       Memory: It may protect memory and reasoning abilities when under stress or multitasking.

·       Stress Management: It can help maintain neurotransmitter levels during periods of physical stress, potentially mitigating stress-induced cognitive decline.

·       Other potential uses (with insufficient evidence): Tyrosine has been studied for a range of other conditions including depression, Parkinson's disease, chronic fatigue syndrome, and weight loss (usually in combination with other ingredients), but there is currently insufficient evidence to support its use for these purposes alone. 

General Side Effects of Tyrosine Supplements

Tyrosine is considered possibly safe for most adults when taken in medicinal amounts (up to 150 mg/kg daily) for up to three months. Common side effects are generally mild and may include: 

·       Nausea

·       Headache

·       Fatigue/tiredness

·       Heartburn

·       Joint pain 

More serious side effects may be signs of an allergic reaction (hives, difficulty breathing, swelling of the face, lips, tongue, or throat), which require immediate medical attention. 

Important Precautions and Interactions

·       Thyroid Disorders: Do not take tyrosine supplements if you have an overactive thyroid (hyperthyroidism) or Graves' disease, as it might increase thyroid hormone levels too much.

·       Medication Interactions: Tyrosine can interact with certain medications:

o   Levodopa: Tyrosine may decrease the absorption and effectiveness of Levodopa (used for Parkinson's disease). Doses should be separated by at least two hours.

o   Thyroid hormone medications: Taking tyrosine with thyroid hormone pills might result in too much thyroid hormone in the body.

o   MAOIs: Avoid tyrosine if you are taking monoamine oxidase inhibitors (MAOIs) for depression, due to a potential risk of high blood pressure, though more research is needed on this interaction.

·       Pregnancy and Breast-feeding: There is insufficient reliable information on safety during pregnancy or breastfeeding; it is best to avoid use beyond food amounts. 

Always consult with a healthcare professional before taking any new supplement, especially if you have existing medical conditions or are taking other medications. 

 

 

 How is Tyrosine  Manufactured by MEDIOCON  INC  Tested Qualitatively?

MEDIOCON INC likely uses standard pharmaceutical quality control methods for Tyrosine, as specific proprietary qualitative tests are not publicly disclosed. These methods, following pharmacopeial standards (like USP or EP), commonly include colorimetric tests and chromatographic techniques. 

Common Qualitative Tests for Tyrosine

Qualitative testing of Tyrosine generally focuses on confirming its identity and the absence of specific impurities. Standard tests often include: 

·       Colorimetric Tests: These tests rely on specific chemical reactions that produce a distinct color in the presence of the phenolic group in tyrosine.

o   Millon's Test: Tyrosine reacts with Millon's reagent (mercuric ions in acidic conditions) to produce a red color complex, indicating the presence of the phenolic group.

o   Xanthoproteic Test: Aromatic amino acids like tyrosine undergo nitration with concentrated nitric acid to yield yellow nitro-derivatives. Adding an alkali solution (like NaOH) changes the color to orange, confirming the presence of the aromatic ring.

o   Nitrosonaphthol Test: Tyrosine reacts with nitrosonaphthol in an acid medium to give a purple-red colored complex.

·       Chromatographic Methods: These are widely used in modern pharmaceutical quality control for both qualitative identification and quantitative analysis due to their high selectivity and sensitivity.

o   Thin-Layer Chromatography (TLC): This method is typically used to identify the compound by comparing its retention factor (Rf value) to that of a known reference standard (e.g., a USP or EP standard) and to check for related substances/impurities.

o   High-Performance Liquid Chromatography (HPLC): While often used for quantitative analysis, HPLC can also confirm the identity of tyrosine by comparing retention times with an analytical standard.

·       Physical Property Analysis:

o   Melting Point Determination: L-Tyrosine is a white crystalline powder with a specific melting point range (around 345-347°C, with decomposition).

o   Solubility Tests: Tyrosine's solubility in different solvents (e.g., water, alcohol) is a key identifying characteristic. 

Manufacturers such as MEDIOCON INC use these tests as part of their quality control process to ensure the product meets purity, stability, and safety standards before market release. The specific analytical methods used are detailed in the product's Certificate of Analysis (COA). 

 

 

 

   Which tests are performed on Tyrosine  Manufactured by  MEDIOCON INC ?

The specific quality control tests performed on Tyrosine manufactured by MEDIOCON INC are proprietary to the company and generally outlined in their internal documentation and the Certificate of Analysis (CoA) for each product batch. 

However, based on standard pharmaceutical and chemical industry practices, the quality control of L-tyrosine typically involves a range of tests to ensure purity, potency, and compliance with pharmacopoeial specifications (e.g., USP, EP). Common tests for L-tyrosine as an active pharmaceutical ingredient (API) or a component in formulations include: 

·       Purity and Identity:

o   High-Performance Liquid Chromatography (HPLC): Used to quantify L-tyrosine content and detect impurities.

o   Spectrophotometry/UV Absorbance: Tyrosine exhibits maximum absorbance at a specific ultraviolet wavelength (around 283 nm), which is used for detection and quantification. Spectrophotometric methods, sometimes using derivatization with reagents like NBD-Cl, are standard for L-tyrosine analysis in formulations.

o   Fourier-Transform Infrared Spectroscopy (FT-IR): Used for validation and confirmation of the compound's structure and identity.

o   Specific Color Tests (Qualitative): Traditional biochemical tests like Millon's test or the Xanthoproteic test, which detect the phenolic ring of tyrosine, may be used for qualitative presence checks, though instrumental methods are more common for quality control in manufacturing.

o   Thin-Layer Chromatography (TLC): A method used to check for related substances and impurities.

·       Physical and Chemical Properties:

o   Solubility: Testing to confirm the expected solubility in various solvents (e.g., water, acid, alkali).

o   Loss on Drying: Measures residual moisture content.

o   Ash Content: Determines the amount of inorganic residue remaining after ignition.

o   pH Measurement: Ensures the substance falls within an acceptable pH range when in solution.

o   Specific Rotation/Optical Rotation: Confirms the stereochemical purity and the presence of the L-isomer versus the D-isomer.

·       Safety and Efficacy:

o   Heavy Metal Testing: Ensures levels of heavy metals are within safe limits.

o   Microbiological Testing (Bioburden): Checks for bacterial or fungal contamination to meet safety standards. 

Customers or partners interested in the precise specifications and test results for a specific batch can typically obtain the Certificate of Analysis directly from MEDIOCON INC's quality assurance department or through their product listing on a B2B platform like Pharmaoffer.com. 

 

 

 

What are the challenges in manufacturing of Tyrosine  by MEDIOCON  INC ’s Dosage forms?

Tyrosine-Specific Challenges

·       Solubility Issues: L-tyrosine's solubility is highly dependent on pH, decreasing significantly at neutral and alkaline conditions, which can complicate formulation.

·       Concentration Limits: High concentrations of L-tyrosine can inhibit certain bioproduction processes due to its decreased solubility, which can impact manufacturing efficiency if the API is produced biotechnologically.

·       Quantification and Quality Control: Developing efficient and cost-effective methods for quantifying Tyrosine in pharmaceutical products is an ongoing analytical challenge. Expensive equipment and long analysis times can be limitations of traditional analytical methods.

·       Biotechnological Production: When producing L-tyrosine using microbial strains, a key challenge is overcoming natural cellular regulatory mechanisms that limit overproduction, requiring sophisticated genetic engineering and process optimization. 

General Dosage Form Manufacturing Challenges

·       API and Excipient Compatibility: Ensuring compatibility between the active ingredient (Tyrosine) and other excipients within the same dosage form is crucial to avoid interactions that can affect solubility, dissolution, and overall stability.

·       Stability and Preservability: The API and final product must be stable during shelf-life, handling, and transportation. Formulations must be robust enough to withstand external conditions like temperature and moisture changes.

·       Dose Uniformity: A critical manufacturing challenge is ensuring the even distribution of API throughout each dosage unit, particularly as production scales up.

·       Process Scale-up: Transitioning from research and development to commercial-scale manufacturing often requires significant formulation changes and process revalidation.

·       Regulatory Compliance: Adhering to strict regulatory standards (such as FDA guidelines) requires robust quality control strategies and comprehensive documentation.

·       High-Concentration Formulations: If a high concentration of Tyrosine is needed for a specific dosage, challenges can include increased viscosity and potential aggregation issues, which complicate both manufacturing and administration. 

 

 

What is shelf life Of Tyrosine  by MEDIOCON INC

The general shelf life for L-tyrosine is typically 2 years if stored under recommended cool, dry conditions in a closed container. 

However, the specific shelf life of Tyrosine by MEDIOCON INC would be indicated by the expiry date on the product label. Manufacturers determine this date based on their specific stability testing and packaging. 

For best results:

·       Store the product in a cool, dry place.

·       Keep the container tightly closed to avoid exposure to moisture or air.

·       Follow any specific temperature guidance provided on the label (some products recommend 2-8°C storage). 

 

 

What should the label claim for Tyrosine  Manufactured by MEDIOCON INC Include?

Mandatory Label Elements

The required statements must be placed on the principal display panel (PDP) or the information panel (IP) and be prominent, conspicuous, and easy to read. 

·       Statement of Identity: The product name (e.g., "L-Tyrosine Dietary Supplement") must be displayed clearly on the PDP.

·       Net Quantity of Contents: The amount of the product in the package (e.g., "100 Capsules" or "Net Wt 500g") must be stated.

·       "Supplement Facts" Panel: This panel must list:

o   Serving Size and Servings Per Container.

o   Each Dietary Ingredient (Tyrosine in this case) by its common or usual name.

o   Quantitative Amount per Serving (e.g., "500 mg L-Tyrosine").

o   Percent Daily Value (%DV), if a Daily Value has been established by the FDA. For Tyrosine (an amino acid without an established DV), an asterisk (*) should be used to refer to a footnote stating "Daily Value Not Established".

o   Mandatory nutrients with DVs (e.g., Vitamin D, calcium, iron, potassium) if present in a measurable amount or added for supplementation.

·       Other Ingredients: Any ingredients not declared in the "Supplement Facts" panel (e.g., fillers, binders, flavorings, gelatin) must be listed in a general ingredient list below the panel, in descending order of predominance by weight.

·       Name and Place of Business: The name and address of MEDIOCON INC (manufacturer, packer, or distributor) must be on the label.

·       Adverse Event Reporting Information: A domestic U.S. address or phone number must be included so consumers can report serious adverse events. 

 

 

 

Where can Tyrosine  Manufactured by MEDIOCON INC are procured?

Tyrosine  Manufactured by MEDIOCON INC   can be procured from various sources, depending on your location and requirements. Here are some options:

FOR API

MEDIOCON INC

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO

CHATRAPATI SAMBHAJI NAGAR-431003, MAHARASHTRA, INDIA

Mob/Whatsapp No: +91-8007719681, +91-9309999757, +91-9834786939

Sales Department: Email: sales@mediocon.com

Purchase Department: Email: purchase@mediocon.com

Marketing Department: Email: mktg@mediocon.com

HR Department: Email: hr@mediocon.com

Accounts Department: Email: accounts@mediocon.com          

Factory Address: Plot No 11, Shendra MIDC, Aurangabad-431154, Maharashtra, India Website:  www.mediocon.com 

Email id:info@mediocon.com           

GST No: 27DHUPM2366D1ZZ

For Dosage Forms :

- Online Marketplaces: You can find Tyrosine  Manufactured by MEDIOCON INC   products on online marketplaces like Amazon or e- commerce websites specializing in pharmaceuticals or skincare products.

Local Pharmacies or Skincare Stores: You can also check with local pharmacies or skincare stores in your area for Tyrosine  Manufactured by MEDIOCON INC products.

Remember to ensure the quality and authenticity of the Tyrosine  Manufactured by MEDIOCON INC product, regardless of the procurement source.