Bronopol: Complete Manufacturing, Uses, and Quality Guide by MEDIOCON INC – Manufacturer, Supplier & Exporter

 

Manufacturer, Supplier & Exporter: MEDIOCON INC

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Name: Bronopol

CAS No: 52-51-7

Molecular Weight: 199.99 g/mol

Molecular Formula: C₃H₆BrNO₄

Synonyms:
2-Bromo-2-nitropropane-1,3-diol, BNPD, Bronopol preservative, Bronocot, Myacide BT, Pyceze.

Appearance:
White to pale yellow crystalline powder.

Solubility:

• Highly soluble in water

• Slightly soluble in ethanol

• Practically insoluble in non-polar solvents

Introduction to Bronopol

Bronopol is a widely used antimicrobial preservative that exhibits strong bactericidal properties. It is particularly effective against Gram-negative bacteria, making it a valuable ingredient in pharmaceutical, cosmetic, and industrial formulations.

Bronopol works by releasing formaldehyde in small controlled amounts, which disrupts microbial cell metabolism and prevents bacterial growth.

MEDIOCON INC, a reputed Manufacturer, Supplier, and Exporter of Bronopol, produces high-quality material suitable for pharmaceutical, cosmetic, and industrial applications.

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Uses of Bronopol

Bronopol is used in a wide variety of industries due to its strong antimicrobial activity.

Pharmaceutical Applications

1. Preservative in topical pharmaceutical formulations

2. Used in antiseptic creams and lotions

3. Used in ophthalmic solutions in controlled concentrations

Cosmetics and Personal Care

1. Preservative in shampoos

2. Used in conditioners and hair care products

3. Preservative in creams and lotions

4. Used in face washes and skincare formulations

Industrial Applications

1. Preservative in cooling tower water systems

2. Used in oil and gas industry biocides

3. Used in paints and coatings to prevent microbial contamination

4. Used in paper mills and pulp processing

Agricultural Applications

1. Used in crop protection formulations

2. Preservative in pesticide solutions

Because of its excellent stability and antimicrobial activity, Bronopol is a reliable preservative across multiple industries.

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How is Bronopol Manufactured by MEDIOCON INC Synthesized?

Bronopol is produced through controlled chemical synthesis involving bromination and nitration reactions.

Step 1: Raw Material Selection

High-purity raw materials such as nitromethane derivatives and brominating agents are selected.

Step 2: Bromination Reaction

The organic intermediate undergoes bromination to introduce a bromine atom into the molecular structure.

Step 3: Nitration and Hydroxylation

The compound is nitrated and hydroxyl groups are incorporated to form 2-bromo-2-nitropropane-1,3-diol.

Step 4: Crystallization

The synthesized product is crystallized under controlled conditions to obtain pure Bronopol crystals.

Step 5: Filtration and Drying

The crystals are filtered, washed, and dried using specialized drying systems.

Step 6: Milling and Packaging

The dried product is milled into uniform powder and packaged under controlled conditions.

MEDIOCON INC ensures strict adherence to GMP standards and international quality protocols during the entire manufacturing process.

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Different Dosage Forms of Bronopol Manufactured by MEDIOCON INC

Bronopol can be incorporated into multiple dosage forms depending on the application.

Pharmaceutical Dosage Forms

1. Topical creams

2. Antiseptic lotions

3. Ophthalmic preparations

4. Gel formulations

Cosmetic Dosage Forms

1. Shampoos

2. Conditioners

3. Face washes

4. Moisturizers

5. Body lotions

Industrial Forms

1. Powder preservative

2. Aqueous solution

3. Industrial antimicrobial additive

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How Bronopol Dosage Forms are Prepared

Preparation methods vary depending on the product type.

Creams and Lotions

1. Bronopol is dissolved in water phase.

2. Mixed with emulsifiers and oils.

3. Homogenized to form stable emulsions.

Shampoo Formulation

1. Bronopol is added during the cooling stage.

2. Mixed uniformly with surfactants.

Industrial Solutions

1. Bronopol powder is dissolved in water.

2. The solution is filtered and stabilized.

Proper formulation ensures antimicrobial activity and product stability.

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Appropriate Dosage Levels

Typical usage concentrations:

Cosmetic Products

0.01% – 0.1%

Industrial Applications

0.05% – 0.2%

Pharmaceutical Formulations

As per regulatory guidelines and formulation requirements.

Always follow recommended formulation guidelines and regulatory limits.

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Effects and Side Effects of Bronopol

Effects

1. Strong antimicrobial activity

2. Effective preservative against bacteria

3. Enhances product shelf life

4. Prevents contamination in formulations

Possible Side Effects

1. Skin irritation in sensitive individuals

2. Allergic reactions in rare cases

3. Eye irritation if improperly used

Precautions

• Avoid excessive concentrations

• Follow cosmetic regulatory limits

• Use protective measures during industrial handling

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Qualitative Testing of Bronopol by MEDIOCON INC

To ensure high product quality, Bronopol is tested using advanced analytical methods.

Analytical Methods

HPLC (High Performance Liquid Chromatography)

Determines purity and active content.

Infrared Spectroscopy (IR)

Confirms molecular structure.

UV Spectroscopy

Detects impurities and degradation products.

Chromatographic Analysis

Ensures absence of contaminants.

These tests guarantee consistent product quality.

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Tests Performed on Bronopol

Bronopol produced by MEDIOCON INC undergoes strict quality testing.

Physical Tests

• Appearance

• Color

• Solubility

• Melting point

Chemical Tests

• Assay (Purity)

• pH value

• Residual solvents

Microbiological Tests

• Microbial load

• Pathogen detection

Contaminant Testing

• Heavy metals

• Bromide impurities

These tests ensure compliance with international quality standards.

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Challenges in Manufacturing Bronopol API

Manufacturing Bronopol involves several technical challenges:

Chemical Stability

Bronopol can degrade in high temperature or alkaline environments.

Moisture Sensitivity

Proper moisture control is required during storage and processing.

Impurity Control

Maintaining high purity levels requires precise reaction control.

Regulatory Compliance

Manufacturers must follow strict environmental and chemical regulations.

MEDIOCON INC uses advanced manufacturing technology to overcome these challenges.

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Challenges in Manufacturing Bronopol Dosage Forms

1. Maintaining uniform distribution in formulations

2. Preventing chemical degradation

3. Compatibility with other ingredients

4. Avoiding excessive formaldehyde release

5. Ensuring long-term product stability

Proper formulation techniques are essential to address these challenges.

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Packaging of Bronopol Manufactured by MEDIOCON INC

Bronopol is packaged to maintain stability and prevent moisture exposure.

Packaging Options

• 25 kg HDPE drums

• Fiber drums with inner polyethylene liners

• Customized packaging for export orders

Proper packaging ensures safe transportation and long shelf life.

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Shelf Life of Bronopol

Bronopol typically has a shelf life of 24 months when stored under proper conditions.

Storage Conditions

• Store in a cool, dry place

• Protect from moisture and heat

• Keep container tightly closed

• Avoid direct sunlight

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Label Claim Requirements

The label for Bronopol manufactured by MEDIOCON INC includes:

Essential Information

1. Product Name: Bronopol

2. CAS Number: 52-51-7

3. Molecular Formula

4. Net Weight

5. Manufacturing Date

6. Expiry Date

Safety Information

1. Handling precautions

2. Storage instructions

3. Hazard warnings

Manufacturer Information

Company name, address, and contact details.

Where Can Bronopol Manufactured by MEDIOCON INC be Procured?

FOR API

MEDIOCON INC
Manufacturer, Supplier & Exporter

Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO
CHATRAPATI SAMBHAJI NAGAR-431003
MAHARASHTRA, INDIA

Mob/Whatsapp:
+91-8007719681      Sales Department:
+91-9309999757      sales@mediocon.com

+91-9834786939

Purchase Department:  purchase@mediocon.com

Marketing Department: mktg@mediocon.com

HR Department:hr@mediocon.com

Accounts Department:accounts@mediocon.com

Factory Address:

Plot No 11, Shendra MIDC
Aurangabad-431154
Maharashtra, India

Website: www.mediocon.com

Email: info@mediocon.com

GST No: 27DHUPM2366D1ZZ