Nevirapine Intermediate (2,3-Dichloro-5-Trifluoromethyl Pyridine) – CAS 69045-84-7: Complete Guide for Pharmaceutical Applications

Nevirapine Intermediate (CAS 69045-84-7) – Complete Overview

Introduction to 2,3-Dichloro-5-Trifluoromethyl Pyridine

What is Nevirapine Intermediate?

If you’re involved in the pharmaceutical chemicals industry, you already know that every life-saving drug begins with a strong foundation—and that foundation often comes in the form of high-quality chemical intermediates. One such essential compound is 2,3-Dichloro-5-Trifluoromethyl Pyridine (CAS 69045-84-7), widely recognized as a key Nevirapine intermediate.

Nevirapine-Intermediate-2-3-Dichloro-5-Trifluoromethyl-Pyridine– CAS-69045-84-7-Complete-Guide-for-Pharmaceutical-Applications

This compound plays a vital role in the Nevirapine API manufacturing process, making it a highly demanded product in the global pharmaceutical market. With the growing demand for HIV treatment drugs and antiretroviral therapy, the importance of this intermediate has increased significantly. Its unique chemical composition allows it to act as a reliable precursor in synthesizing complex molecules used in modern medicine.

Importance in Pharmaceutical Industry

The pharmaceutical sector relies heavily on high-purity API intermediates to ensure consistency, safety, and effectiveness in drug production. This compound is widely used in antiretroviral drug manufacturing, particularly for producing Nevirapine, a critical medication in HIV treatment.

In today’s competitive market, pharmaceutical companies actively search for reliable suppliers of Nevirapine intermediates, ensuring they meet global standards like GMP compliance and pharmaceutical-grade purity. This makes CAS 69045-84-7 chemical suppliers highly relevant in both domestic and international markets.

Chemical Identity and Properties

Molecular Structure and Formula

The molecular formula of 2,3-Dichloro-5-Trifluoromethyl Pyridine is C6H2Cl2F3N, and it belongs to the class of pyridine derivatives. The presence of chlorine substituents and a trifluoromethyl group (-CF₃) significantly enhances its chemical reactivity and stability.

This unique structure makes it highly suitable for pharmaceutical synthesis and positions it as a crucial compound in the production of active pharmaceutical ingredients (APIs).

Physical and Chemical Properties

Understanding its physical and chemical properties is essential for safe handling and industrial application. This compound typically appears as a colorless to pale yellow liquid and exhibits excellent solubility in organic solvents.

Property	Value
Molecular Formula	C6H2Cl2F3N
Molecular Weight	215.98 g/mol
Appearance	Colorless to yellow liquid
Density	1.549 g/mL
Solubility	Soluble in organic solvents

These properties make it ideal for bulk pharmaceutical production and chemical synthesis applications.

Manufacturing and Synthesis

Industrial Production Process

The production of Nevirapine intermediates involves advanced chemical processes that ensure high yield and purity. Typically, the synthesis includes chlorination and fluorination reactions applied to pyridine derivatives under controlled conditions.

Manufacturers focus on optimizing production to meet the increasing demand for bulk drug intermediates, ensuring cost efficiency without compromising quality. This is especially important for companies involved in generic drug manufacturing.

Raw Materials and Reaction Pathways

The synthesis process requires high-quality raw materials such as:

Chlorinated pyridine derivatives
Fluorinating agents
Industrial-grade catalysts

Maintaining strict control over reaction conditions ensures the final product meets pharmaceutical-grade specifications and supports large-scale production needs.

Applications in Pharmaceuticals

Role in Nevirapine API Synthesis

One of the most important applications of this compound is in the synthesis of Nevirapine API, a widely used drug for managing HIV infections. It acts as a key intermediate, enabling the formation of the final active compound through multiple reaction steps.

This makes it an essential component for pharmaceutical companies focusing on antiretroviral drug production and HIV treatment solutions.

Use in Antiretroviral Drugs

The increasing global need for HIV medications has significantly boosted the demand for Nevirapine raw materials and intermediates. Countries like India have become major hubs for pharmaceutical exports, making the availability of such intermediates even more critical.

Other Industrial Applications

Agrochemical Industry Uses

Beyond pharmaceuticals, this compound is also used in the agrochemical industry. It acts as an intermediate in the production of:

Crop protection chemicals
Herbicides
Pesticides

Its chemical properties make it suitable for synthesizing compounds that improve agricultural productivity.

Specialty Chemicals and Research

Researchers and chemical manufacturers also utilize this compound in specialty chemical synthesis and R&D applications. Its versatility allows it to be used in developing new compounds and innovative materials.

Safety and Handling Guidelines

Storage Conditions

Proper storage is essential to maintain product quality. This compound should be stored:

In a cool environment (2–8°C)
Away from moisture and sunlight
Under controlled atmospheric conditions

These practices ensure stability and extend shelf life.

Hazard Classification

Like many industrial chemicals, this compound requires careful handling. It is considered:

An irritant
Harmful if inhaled
Potentially hazardous to the environment

Using appropriate personal protective equipment (PPE) is mandatory during handling and transportation.

Market Demand and Trends

Global Demand for API Intermediates

The demand for API intermediates is growing rapidly due to the expansion of the pharmaceutical sector. Key drivers include:

Rising demand for generic medicines
Increasing healthcare awareness
Growth in pharmaceutical manufacturing hubs

This has led to a surge in demand for Nevirapine intermediate suppliers globally.

Growth in Pharmaceutical Manufacturing

India plays a significant role in the global pharmaceutical supply chain. With increasing exports and domestic demand, the need for high-quality pharmaceutical intermediates continues to rise.

Quality Standards and Specifications

Purity Levels and Testing

Maintaining high purity is crucial in pharmaceutical applications. This compound is typically supplied with:

Purity ≥ 97%
Quality testing through advanced analytical methods

Ensuring consistent quality helps manufacturers produce safe and effective drugs.

Regulatory Compliance

Compliance with international standards like GMP is essential for pharmaceutical-grade chemicals. Reliable suppliers ensure their products meet all necessary regulatory requirements.

Why Choose Mediocon Inc for Supply

Company Overview

Mediocon Inc, founded in 2018, is a trusted name in the chemical supply industry. The company serves a wide range of industries including pharmaceuticals, nutraceuticals, and industrial manufacturing.

With a strong presence in both domestic and international markets, Mediocon Inc is known for delivering:

High-quality chemical products
Competitive pricing
Reliable supply chain solutions

Product Portfolio

Mediocon Inc specializes in:

Nutraceutical Ingredients – vitamins, herbal extracts, probiotics
Pharmaceutical Chemicals – APIs, intermediates, excipients
Industrial Chemicals – acids, solvents, salts
Dyes & Pigments – colorants and specialty chemicals

The company focuses on providing end-to-end chemical solutions tailored to industry needs.

Conclusion

The role of 2,3-Dichloro-5-Trifluoromethyl Pyridine (CAS 69045-84-7) in the pharmaceutical industry is both critical and irreplaceable. As a key Nevirapine intermediate, it supports the production of essential antiretroviral drugs used worldwide.

With increasing demand for pharmaceutical intermediates, choosing a reliable supplier becomes essential. Companies like Mediocon Inc ensure consistent quality, timely delivery, and compliance with global standards, making them a preferred partner in the chemical industry.

FAQs

1. What is Nevirapine intermediate used for?

It is primarily used in the manufacturing of Nevirapine API and plays a crucial role in HIV drug production.

2. What is the CAS number of 2,3-Dichloro-5-Trifluoromethyl Pyridine?

The CAS number is 69045-84-7, used for global chemical identification.

3. What industries use this compound?

It is widely used in pharmaceutical, agrochemical, and specialty chemical industries.

4. What purity is required for pharmaceutical applications?

A minimum purity of 97% or higher is generally required.

5. How is this chemical stored safely?

It should be stored in a cool, dry place (2–8°C) under controlled conditions.

6. Why should I choose Mediocon Inc?

Mediocon Inc offers high-quality products, reliable delivery, competitive pricing, and global supply capabilities, making it a trusted supplier.