Linden Flower Powder
Manufacturer, Supplier & Exporter: MEDIOCON INC
Name: Bronopol
CAS No: 52-51-7
Molecular Weight: 199.99 g/mol
Molecular Formula: C₃H₆BrNO₄
Synonyms:
2-Bromo-2-nitropropane-1,3-diol, BNPD, Bronopol preservative, Bronocot, Myacide BT, Pyceze.
Appearance:
White to pale yellow crystalline powder.
Solubility:
Highly soluble in water
Slightly soluble in ethanol
Practically insoluble in non-polar solvents
Introduction to Bronopol
Bronopol is a widely used antimicrobial preservative that exhibits strong bactericidal properties. It is particularly effective against Gram-negative bacteria, making it a valuable ingredient in pharmaceutical, cosmetic, and industrial formulations.
Bronopol works by releasing formaldehyde in small controlled amounts, which disrupts microbial cell metabolism and prevents bacterial growth.
MEDIOCON INC, a reputed Manufacturer, Supplier, and Exporter of Bronopol, produces high-quality material suitable for pharmaceutical, cosmetic, and industrial applications.
Uses of Bronopol
Bronopol is used in a wide variety of industries due to its strong antimicrobial activity.
Pharmaceutical Applications
Preservative in topical pharmaceutical formulations
Used in antiseptic creams and lotions
Used in ophthalmic solutions in controlled concentrations
Cosmetics and Personal Care
Preservative in shampoos
Used in conditioners and hair care products
Preservative in creams and lotions
Used in face washes and skincare formulations
Industrial Applications
Preservative in cooling tower water systems
Used in oil and gas industry biocides
Used in paints and coatings to prevent microbial contamination
Used in paper mills and pulp processing
Agricultural Applications
Used in crop protection formulations
Preservative in pesticide solutions
Because of its excellent stability and antimicrobial activity, Bronopol is a reliable preservative across multiple industries.
How is Bronopol Manufactured by MEDIOCON INC Synthesized?
Bronopol is produced through controlled chemical synthesis involving bromination and nitration reactions.
Step 1: Raw Material Selection
High-purity raw materials such as nitromethane derivatives and brominating agents are selected.
Step 2: Bromination Reaction
The organic intermediate undergoes bromination to introduce a bromine atom into the molecular structure.
Step 3: Nitration and Hydroxylation
The compound is nitrated and hydroxyl groups are incorporated to form 2-bromo-2-nitropropane-1,3-diol.
Step 4: Crystallization
The synthesized product is crystallized under controlled conditions to obtain pure Bronopol crystals.
Step 5: Filtration and Drying
The crystals are filtered, washed, and dried using specialized drying systems.
Step 6: Milling and Packaging
The dried product is milled into uniform powder and packaged under controlled conditions.
MEDIOCON INC ensures strict adherence to GMP standards and international quality protocols during the entire manufacturing process.
Different Dosage Forms of Bronopol Manufactured by MEDIOCON INC
Bronopol can be incorporated into multiple dosage forms depending on the application.
Pharmaceutical Dosage Forms
Topical creams
Antiseptic lotions
Ophthalmic preparations
Gel formulations
Cosmetic Dosage Forms
Shampoos
Conditioners
Face washes
Moisturizers
Body lotions
Industrial Forms
Powder preservative
Aqueous solution
Industrial antimicrobial additive
How Bronopol Dosage Forms are Prepared
Preparation methods vary depending on the product type.
Creams and Lotions
Bronopol is dissolved in water phase.
Mixed with emulsifiers and oils.
Homogenized to form stable emulsions.
Shampoo Formulation
Bronopol is added during the cooling stage.
Mixed uniformly with surfactants.
Industrial Solutions
Bronopol powder is dissolved in water.
The solution is filtered and stabilized.
Proper formulation ensures antimicrobial activity and product stability.
Appropriate Dosage Levels
Typical usage concentrations:
Cosmetic Products
0.01% – 0.1%
Industrial Applications
0.05% – 0.2%
Pharmaceutical Formulations
As per regulatory guidelines and formulation requirements.
Always follow recommended formulation guidelines and regulatory limits.
Effects and Side Effects of Bronopol
Effects
Strong antimicrobial activity
Effective preservative against bacteria
Enhances product shelf life
Prevents contamination in formulations
Possible Side Effects
Skin irritation in sensitive individuals
Allergic reactions in rare cases
Eye irritation if improperly used
Precautions
Avoid excessive concentrations
Follow cosmetic regulatory limits
Use protective measures during industrial handling
Qualitative Testing of Bronopol by MEDIOCON INC
To ensure high product quality, Bronopol is tested using advanced analytical methods.
Analytical Methods
HPLC (High Performance Liquid Chromatography)
Determines purity and active content.
Infrared Spectroscopy (IR)
Confirms molecular structure.
UV Spectroscopy
Detects impurities and degradation products.
Chromatographic Analysis
Ensures absence of contaminants.
These tests guarantee consistent product quality.
Tests Performed on Bronopol
Bronopol produced by MEDIOCON INC undergoes strict quality testing.
Physical Tests
Appearance
Color
Solubility
Melting point
Chemical Tests
Assay (Purity)
pH value
Residual solvents
Microbiological Tests
Microbial load
Pathogen detection
Contaminant Testing
Heavy metals
Bromide impurities
These tests ensure compliance with international quality standards.
Challenges in Manufacturing Bronopol API
Manufacturing Bronopol involves several technical challenges:
Chemical Stability
Bronopol can degrade in high temperature or alkaline environments.
Moisture Sensitivity
Proper moisture control is required during storage and processing.
Impurity Control
Maintaining high purity levels requires precise reaction control.
Regulatory Compliance
Manufacturers must follow strict environmental and chemical regulations.
MEDIOCON INC uses advanced manufacturing technology to overcome these challenges.
Challenges in Manufacturing Bronopol Dosage Forms
Maintaining uniform distribution in formulations
Preventing chemical degradation
Compatibility with other ingredients
Avoiding excessive formaldehyde release
Ensuring long-term product stability
Proper formulation techniques are essential to address these challenges.
Packaging of Bronopol Manufactured by MEDIOCON INC
Bronopol is packaged to maintain stability and prevent moisture exposure.
Packaging Options
25 kg HDPE drums
Fiber drums with inner polyethylene liners
Customized packaging for export orders
Proper packaging ensures safe transportation and long shelf life.
Shelf Life of Bronopol
Bronopol typically has a shelf life of 24 months when stored under proper conditions.
Storage Conditions
Store in a cool, dry place
Protect from moisture and heat
Keep container tightly closed
Avoid direct sunlight
Label Claim Requirements
The label for Bronopol manufactured by MEDIOCON INC includes:
Essential Information
Product Name: Bronopol
CAS Number: 52-51-7
Molecular Formula
Net Weight
Manufacturing Date
Expiry Date
Safety Information
Handling precautions
Storage instructions
Hazard warnings
Manufacturer Information
Company name, address, and contact details.
Where Can Bronopol Manufactured by MEDIOCON INC be Procured?
FOR API
MEDIOCON INC
Manufacturer, Supplier & Exporter
Add: B-2, ARCH SARTHAK BUILDING, N-7 CIDCO
CHATRAPATI SAMBHAJI NAGAR-431003
MAHARASHTRA, INDIA
Mob/Whatsapp:
+91-8007719681 Sales Department:
+91-9309999757 sales@mediocon.com
+91-9834786939
Purchase Department: purchase@mediocon.com
Marketing Department: mktg@mediocon.com
HR Department:hr@mediocon.com
Accounts Department:accounts@mediocon.com
Factory Address:
Plot No 11, Shendra MIDC
Aurangabad-431154
Maharashtra, India
Website: www.mediocon.com
Email: info@mediocon.com
GST No: 27DHUPM2366D1ZZ
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